Water, a fundamental and indispensable resource necessary for the survival of living beings, has become a pressing issue in numerous regions worldwide due to scarcity. Urban areas, where the majority of the global population resides, witness a substantial consumption of blue water, particularly in commercial buildings. This study investigates the potential for enhancing water efficiency within an ongoing high-rise office building construction situated in a tropical climate. The investigation utilizes the green building guidelines of leadership in energy and environmental design (LEED) through a case-study-based research approach. Strategies included using efficient plumbing fixtures (such as high air–water ratio fixtures and dual-flush toilets), the selection of native plants, implementing a suitable irrigation system, introducing a rainwater harvesting system (RWHS) and improving the mechanical ventilation and air conditioning (MVAC) system. The results showed a 55% reduction in water use from efficient fixtures, a 93% reduction in landscaping water needs and a 73% overall water efficiency with a RWHS from the baseline design. Additionally, efficient cooling towers and the redirection of condensed water into the cooling tower make-up water tank improved the overall water efficiency to 38%, accounting for the water requirements of the MVAC system. The findings of this study can contribute to more sustainable and water-efficient urban development, particularly in regions facing water scarcity challenges. The significance of these findings lies in their potential to establish industry standards and inform policymakers in the building sector. They offer valuable insights for implementing effective strategies aimed at reducing blue water consumption across different building types.