The characteristics of hot compression deformation of Ti-3.0Al-3.7Cr-2.0Fe titanium alloy have been studied by Gleeble−1500D thermal simulated test machine in the strain rates range 0.01~10s−1 and temperature range 800~950°C. The true stress-true strain curves show that the peak flow stress decrease with increase temperature and decrease strain rate. At the temperature range in the article, there is a distinct peak in the flow stress in the early stage deformation followed by a stable state at high strains. The variation of flow stress with temperature and strain rate follows the standard kinetic rate equation and the apparent activation energy is estimated to be about 214.22KJ•mol-1. The constitutive relationship of Ti-3.0Al-3.7Cr-2.0Fe alloy is obtained on the base of Arrhenius equation at the experimental conditions.