The structure of the bone is very complex and heterogeneous; this causes different mechanical and biological properties in its longitudinal and transverse directions. For example, the modulus of elasticity and the permeability of the trabecular bone in a longitudinal and radial direction can vary up to several times. Therefore, implant design that matches these differences is necessary to maximize compliance with the host bone. Given that, in this study, a gyroid structure that generally is used in bone scaffolds was modified to design anisotropic scaffolds. Therefore, the gyroid triply periodic minimal surface trigonometric function was manipulated, and five different architectures were denoted as G(-50), G(-25), G(0), G(+25), and G(+50) with a constant porosity of 80% were developed. The effective elastic moduli of the models were calculated using finite element analysis. The results showed an anisotropicity rate of 0.21, 0.62, 1.50 and 2.23 in elastic moduli for G(-50), G(-25), G(+25) and G(+50) models respectively. As well, the permeability of the models was calculated using computational fluid dynamics (CFD) analysis. Anisotropic models showed different permeability in longitudinal and transverse directions. Longitudinal permeability to lateral direction rate were 0.67, 0.80, 1.25 and 1.47 for G(-50), G(-25), G(+25) and G(+50) models respectively.