Aim: This study aims to determine the relationship of the premenstrual syndrome to the performance ICU (intensive care unit) nurses in Makassar hospitals. Methods: This is quantitative research with the observational method using a cross-sectional study, samples were taken as many as 36 people as respondents conducted by using proportionate random sampling. Data collected through observation, interview and documentation by using questionnaire SPAF questionnaire (The short Premenstrual Assessment Form) and menstrual diary Result: Female result in the intensive care unit who premenstrual syndrome have less performance the correlation value of 0,522, significant with p-value 0,001 Conclusion: This study showed that there is a relationship between premenstrual syndrome to the performance ICU (intensive care unit) nurses in Makassar city hospital