Association between Perfluoroalkyl Substances and Reproductive Hormones in Adolescents and Young AdultsAbstract Number:2130 Meng-Shan Tsai*, Chien-Yu Lin, Ching-Chun Lin, Ta-Chen Su, and Pau-Chung Chen Meng-Shan Tsai* Taiwan National University, Taiwan, E-mail Address: [email protected] Search for more papers by this author , Chien-Yu Lin Department of Internal Medicine, En Chu Kong Hospital, New Taipei City, Taiwan;School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan, Taiwan Search for more papers by this author , Ching-Chun Lin Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, Taiwan Search for more papers by this author , Ta-Chen Su Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, Taiwan Search for more papers by this author , and Pau-Chung Chen Department of Public Health and Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan;Department of Environmental and Occupatio, Taiwan Search for more papers by this author AbstractBackground: Perfluoroalkyl substances (PFASs) are highly bio-accumulative environmental pollutant. Some animal and epidemiological studies have proved that PFASs exposure disrupt the homeostasis of endocrine system and have health effects. The reproductive system is more susceptible and vulnerable to environmental pollutant than the other system in human body. However, few studies explore the association between PFASs and reproductive hormone in children and adolescence. Aims: The purpose of this study is to investigate the association of PFASs and reproductive hormone in young group.Methods: We recruited 540 subjects in the Young Taiwanese Cardiovascular Cohort. Serum level of PFASs were analyzed by a Waters ACQUITY UPLC system coupled with a Waters Quattro Premier XE triple quadrupole mass spectrometer; the level of serum reproductive hormone were measured by immunoluminometric assay in an architect random access assay system. We examined the association among serum level of PFASs and reproductive hormone by multiple linear regression.Results: Adjusted mean serum follicle-stimulating hormone (FSH) significantly decreased (p for trend = 0.04) across different categories (<25th, 25–50, 50-75 and >75th percentiles) of perfluorooctane sulfonate (PFOS) in male subjects aged 12-19. Female serum FSH in age 12-19 also decreased (p for trend = 0.01) across different categories of perfluoroundecanoic acid (PFUA). On the other hand, there was a significantly negative association (p for trend = 0.04) between different categories of PFOS and female serum testosterone in age 12-19.Conclusions: We found that serum concentration of PFASs was negatively associated with serum level of FSH and testosterone in Taiwan adolescent population. Further studies are needed to clarify whether these associations are causal.