ОсОбеннОсти пОстнА тАЛьнОгО РОст А У ДетеЙ, РОДиВШихся с ЗАДеРжкОЙ ВнУтРиУтРОбнОгО РАЗВития

Abstract

Aim. To identify the relationship between the levels of insulin-like growth factor-1 (IGF-1) and growth hormone (GH) in the blood and the postnatal growth rate in children born with IUGR in the first 6 months of life. Material and methods. We prospectively examined 65 children: 33-term infants born with IUGR and 32 healthy full-term infants in the control group. Results and discussion. IGF-1 levels in cord blood in children with IUGR were reduced comparative to the control group. At 3-month age blood IGF-1 of children born with IUGR increases, which is higher than the control group, but in reference values. At 3-month age the level of growth hormone in children with symmetrical IUGR was significantly reduced compared with level at birth, in contrast to the group of children with asymmetric IUGR, in which GH persists on the same level. Children with «growth leap» mass had lower concentration of IGF-1 in the umbilical cord blood which is, on average, almost 2-times lower than children without a «growth leap». At 3-month age IGF-1 level dramatically increased in children with «growth leap» in children without it, on the contrast, IGF-1 level is significantly reduced. There were no differences of growth hormone levels between children with «growth leap» and without it. At 3-month age the level of growth hormone is reduced in comparison with the level of umbilical cord blood. Conclusion. Most children born with IUGR (over 87%) demonstrate accelerated growth rates after birth, the maximum increase in growth rates occur during the first 3 months of life. All groups examined at birth and at 3 months showed a large data spread of IGF-1 and GH.