Present paper investigates the flow of Oldroyd-B nanofluid due to stretching cylinder. Heat transfer aspects are expressed by nonlinear radiation and non-uniform heat source/sink. Analysis of Soret and Dufour effects are emphasized. Brownian movement and thermophoresis phenomena are retained. Characteristics of mass transfer subject to first-order chemical reaction is examined. Consideration of suitable transformations yields ordinary differential systems. Relevant problem is solved by Optimal homotopic approach. The concept of minimization is employed by defining the average squared residual errors. Behavior of various physical variables on dimensionless velocity, temperature and concentration fields are determined. In addition, the rates of heat and mass transfer are studied through graphs. Here, we noticed a growth in velocity, temperature and concentration for larger values of curvature parameter.