The Northwestern Corner of the Tarim Basin (hereinafter the NOCTB) is surrounded by the Pamir salient, the south Tian Shan Mountains, and the Tarim Basin. The tectonic settings of these three structures dominate the crustal deformation patterns and seismic events in the NOCTB and its adjacent regions. We integrated the GPS and InSAR measurements to derive a large-scale three-dimensional velocity map of the NOCTB. The GPS data obtained during 38 campaigns between 1992 and 2013 were used to derive a horizontal velocity field. 149 Envisat ASAR images observed along four satellite tracks between 2003 and 2011 were processed to get a line of sight rate map based on the small baseline subset time series analysis method and a homogeneous isotropic model. Finally, we modeled the dip angle, slip rate, and locking depth of selected faults. The results indicate that the crustal convergence is not uniformly distributed across the NOCTB: more than 50% of the N–S shortening is absorbed by the Tian Shan Mountains in the southwest, whereas the N–S shortening rates are low and therefore the strain accommodations are smaller in the east of the NOCTB. The vertical displacement rates in the NOCTB range from −2 to 3 mm/year with different magnitudes in different areas. The main uplift areas are located on the junction region between frontal MPT and the southwestern STT including the Kazkeaerte fault, Aikenerte fault, the Southern Artux fault, and part areas in north of the Kalping fault. The main subsident areas are located on central belt of STT including the Totgumbaz–Alpaleh fault, Nothern Artux fault, the southwestern Karatieke fault, and the north of Puchang/Piqiang fault. Compared with the substantial N–S shortening rate of ~10 mm/year, the vertical rate across each fault ranges from approximately −1 to 1 mm/year, suggesting that vertical movement in NOCTB area is relatively moderate at present. Both the horizontal and vertical rates show obvious changes across the Kazkeaerte fault and the Kuzgong fault, revealing that the basin–mountain junction region between the Pamir, the Tarim Basin, and the south Tian Shan Mountains is subject to accumulate strain and triggers stronger earthquakes. The Kuzgong fault plays an important role of transforming the crustal movements between the southwestern end of the STT and the north frontal MPT. The displacement field from geodetic observations could not find any evidence that the Puchang/Piqiang fault is a geological boundary of Kepingtage nappe. The modeled fault geometry and slip rate imply that three faults in the NOCTB are slipping at 6–10 mm/year along a decollement fault that dips at 19°–27° and is locked at a shallow depth of 6–10 km, whereas some other faults are undergoing a status of interseismic slip deficit.