Homeopathic Research Articles

An Individualistic Homoeopathic Approach in a Case of Infected Epidermal Naevus—A Case Report

AbstractNaevi are circumscribed developmental defects or the lack of one or more components of the skin that manifest as overgrowths or hamartomas derived from embryonic ectoderm. The majority of naevi are present at birth or appear soon after birth. Naevi can be infected by various organisms, particularly by Staphylococcus, without other systemic involvement, similar to the skin. A 30-year-old male patient presented with an infected, painful congenital epidermal naevus on the anterior side of his right thigh. He experienced severe itching, burning, and sudden blister formation. After treatment, the infection completely resolved, leaving the naevus without any complications. Possible causal attribution of these changes was determined using the Modified Naranjo Criteria (score: 8 out of 13). No recurrence of further infection was reported in the next year, demonstrating the positive curative role of individualized homeopathic treatment in a case of infected epidermal naevus.

A Case of FIBROADENOMA Cured with Individualized Homoeopathic Medicine- Evidence Based Homoeopathy

Introduction: Fibro-adenomas are the most common benign tumor of female breast having distinct clinical and Histopathological findings. This case report of fibroadenoma highlights clinical presentation along with proper investigation reports like ultrasound, individualized homoeopathic treatment provided and ongoing follow-up. Palpable mass, nodular swelling, pain, redness and changes in the breast appearance along with fibrous and glandular tissue components are emphasized for proper diagnosis. Homoeopathic literature shows that case of fibro-adenoma had been successfully treated with individualized homoeopathic medicine. Individualized homoeopathic approach to breast fibro-adenoma ensures improved outcomes in mental, emotional as well as physical wellbeing. Case summary: The case report presented here wasa 23 year old female patient, from Repertory OPD, Homoeopathy Hospital, North Eastern Institute of Ayurveda and Homoeopathy, Shillong. The patient was treated with individualized homoeopathic medicine (Phosphorous30, 200) for one year, with significant improvement and progressively decreases in size of tumor.

Exploring the Efficacy of Homeopathic Medicines in Treating Uterine Fibroids: A Comprehensive Review

Abstract: Introduction: Uterine fibroids are a common gynaecological condition affecting women worldwide, often leading to significant morbidity and impacting quality of life. While conventional treatment options exist, there is growing interest in alternative therapies such as homeopathy. Objective: The objective of this review paper is to assess the effectiveness of homeopathic medicines in treating uterine fibroids through the analysis of recent clinical trials and observational studies, aiming to provide insights into the potential role of homeopathy as a complementary or alternative therapy for uterine fibroids. Methodology: A thorough search of databases such as PubMed, Google Scholar, Scopus, and pertinent medical journals was undertaken to locate recent studies on the efficacy of homeopathic medicines for uterine fibroids. Only studies meeting predefined inclusion criteria, including randomized controlled trials, prospective observational studies, and systematic reviews, were included in the review process. Result: Recent studies investigating the efficacy of homeopathic medicines in treating uterine fibroids consistently demonstrated positive outcomes, including symptom alleviation, reduction in fibroid size, and improved quality of life. Various remedies showed effectiveness across various potencies. Symptom severity scales, including the Visual Analogue Scale (VAS), Numerical Rating Scale (NRS), and Verbal Multidimensional Scoring System (VMSS), were utilized to assess pelvic pain, menstrual bleeding, and discomfort. Quality of life measures like the WHOQOL-BREF scale provided insights into overall well-being. Conclusion: In conclusion, homeopathic medicines show promise as a safe and effective treatment option for uterine fibroids, offering personalized care and improving quality of life. However, more research, including larger trials and long-term studies, is needed to confirm these findings and understand the underlying mechanisms better.

Exploring the Role of Homeopathy in Rheumatoid Arthritis: A Comprehensive Review

Background: Rheumatoid arthritis (RA) is a prevalent and debilitating chronic condition, affecting approximately 1–2% of the population. It is characterized by systemic inflammation and primarily targets the flexible, synovial joints, leading to symptoms such as joint swelling, stiffness, pain, and reduced functionality. Aim/Objective: This review aims to explore the role of homeopathic interventions in the management of RA, focusing on the potential benefits of homeopathic consultations in improving patient outcomes and well-being. Specifically, the objective is to investigate how homeopathy, as a holistic approach to healthcare, addresses the multifaceted nature of RA and its impact on patients' lives. Methodology : A comprehensive search of electronic databases including PubMed, SCOPUS, and Google Scholar was conducted to identify relevant literature on homeopathic treatments for RA. Keywords such as 'Rheumatoid arthritis,' 'Homeopathy,' and related terms were utilized. Result: The initial database search yielded a substantial number of records, from which relevant studies were selected based on predefined inclusion criteria. After screening for duplicates and applying exclusion criteria, a total of 13 studies were included in the review. These studies encompassed RCT, Observational studies, randomized open-label interventional Study, In Vitro studies and clinical trials, providing insights into the potential benefits of homeopathy in RA management. Conclusion: Homeopathy shows promise as an adjunctive therapy for RA, considering the holistic nature of the disease.

Homoeopathic dilution of Berberis vulgaris and Urinary calculi: A Case Series

Introduction- Consequent upon the changing lifestyle the incidence of urinary calculus is emerging as one of the alarming problems around the globe. Apart from modern management, homoeopathy provides an alternative and effective means for its management. In this case series Six successfully treated cases of urinary calculi are presented which shows how potentized homoeopathic medicine Berberis vulgaris (Berb-v) is effective in expelling and mitigating urinary calculi. Case summary- After proper case taking Berb-v in diluted and potentised form was prescribed specifically in pre-diagnosed six cases. They were followed up for varied periods of time at 15 to 20 days intervals after first enrolment. Calculi were expelled with diminution of symptoms. However, more and more randomized control trials and other basic researches are needed to evaluate and explore the effectiveness of Berb-v in urinary calculi.

Characterisation of Aqueous Ultra-high Homeopathic Potencies: Nanoparticle Tracking Analysis.

Over the past decade, research using various methods has claimed the material nature, including nanoparticles (NPs), of high homeopathic potencies. The current study aims to verify these findings using NP tracking analysis (NTA). Six independent serial dilutions of commonly used homeopathic medicines-either soluble (Gelsemium, Pyrogenium, Kalium mur) or insoluble (Cuprum, Argentum, Silicea)-were prepared according to European Pharmacopoeia standards. We compared the homeopathic dynamisations (DYNs) in pure water with their potentised controls and with simple dilutions (DIL) up to 30cH/10-60. We also tested the influence of the container (glass or PET) on the solvent controls. We observed the presence of particles from 20 to 300-400 nm in all DYNs, DILs and controls, except in pure unstirred water. The sizes and size distributions of NPs in high homeopathic potencies were smaller than those in controls for soluble sources and larger for insoluble sources, even above 11cH. The opposite behaviour was observed in the number of NPs. When comparing DYN and DIL, the number, size, presence of aggregates or chains and brightness of NPs increased with DYNs, which was also observed above 11cH. Many NPs scattered light of low intensity, indicating the presence of material particles. The container had a significant effect on the number and size of NPs, indicating the involvement of the atmosphere and leaching processes. Homeopathic medicines contain NPs with specific properties, even when diluted beyond Avogadro's number. Homeopathic potentisation is not a simple dilution. The starting material, the solvent used, the type of container and the manufacturing method influence the characteristics of these NPs. The nature of these NPs is not known, but most likely they are a mixture of nanobubbles and elements from the atmosphere and container, including insoluble ones.

Individualized homeopathic medicines in the treatment of premenstrual syndrome: A double-blind, randomized, placebo-controlled trial

IntroductionBackground: Premenstrual syndrome (PMS) is a common disorder among female population that adversely affects their physical and emotional well-being. Conventional treatments for PMS may have limitations and side effects, prompting a need for complementary therapeutic approaches. This double-blind, randomized, placebo-controlled trial aimed to investigate the efficacy of individualized Homeopathic medicines (IH) in treating PMS symptoms in comparison to placebo (PL). MethodsThis study recruited female participants of reproductive age who had been experiencing premenstrual syndrome (PMS) for >3 months, from the Outpatient Department. The participants were randomly assigned to receive either IH or PL. The measured outcomes included the Shortened Premenstrual Assessment Form (SPAF) questionnaire as the primary outcome, and the Premenstrual Tension Syndrome Visual Analogue Scale (PMTS-VAS) and the Premenstrual Tension Syndrome Observer Rating Scale – Revised (PMTS-OR) as secondary outcomes. These measures were assessed at baseline and every month for 3 months. ResultsThe results showed a statistically significant reduction in total SPAF scores for the IH group compared to the placebo group (F = 11.340; P < 0.001) at month 2 (-5.5 ± 1.8, P = 0.003), and month 3 (-6.6 ± 2.0, P = 0.002). Additionally, there were significant reductions in PMTS-VAS and PMTS-OR scores in the IH compared to placebo group. Natrum muriaticum (n = 4/30, 13.3 %) was the most frequently indicated medicines in the study. Four adverse events (13.33 %) occurred in the IH group, and six adverse events (16.67 %) in the Placebo group, with no serious events reported, and no additional medicinal treatment was required for participants during the study period. ConclusionsIndividualized Homeopathic medicines were found to be significantly effective, compared to placebo in reducing PMS symptoms. Further independent replication is warranted to validate and corroborate these findings, as well as to identify the most effective Homeopathic medicines for treating PMS symptoms. Until then, clinicians may consider these findings when exploring personalized and holistic therapeutic strategies for managing PMS. Trial RegistrationCTRI/2020/11/028,796, dt. 02/11/2020

Homeopathy for Hypertension: A Comprehensive Scoping Review of the Current Evidence

Background: Hypertension is a growing health concern linked to sedentary lifestyle choices and behaviors. Homeopathy is one of the most frequently used complementary medicine for hypertension, but the state of evidence is not well characterized. This scoping review aims to map the current state of evidence and explore the range of prescription methods used in homeopathy for this condition. Methods: Three electronic databases (PubMed, Cam-Quest, Core-Hom) were systematically searched for published studies evaluating the effects of homeopathic medicines on hypertension. Only clinical trials published in English that assessed the impact of homeopathy on hypertension were included. Data were extracted and organized in a spreadsheet, capturing study population characteristics, prescription methods, outcomes, and specific homeopathic medicines used. Results: A total of 18 studies met the inclusion criteria. The primary outcome assessed in most studies was blood pressure, including systolic and diastolic measurements. Eleven studies reported a statistically significant reduction in blood pressure with homeopathic treatment. Both individualized homeopathy (n=11) and prescription based on specific remedies or complex homeopathy (n=7) demonstrated improvements in hypertension. Lifestyle modifications were consistently incorporated into the management plans in all the studies. However, most of the included studies had short treatment durations. The review provides a list of potentially helpful homeopathic medicines for future research. Conclusion: This scoping review reveals a limited number of studies that have examined the effect of homeopathic medicines in managing hypertension. In addition, determining the optimal prescription method for homeopathy in hypertension management remains challenging. Further research, including well-designed randomized controlled trials with larger sample sizes and long-term follow-up, is warranted to strengthen the evidence base.

Novel triterpenoid, Schidigeragenin B resourced from the mother tincture of Conium maculatum: A promising future Antidiabetic drug

As of 2021, an estimated 537 million people had diabetes worldwide, accounting for 10.5 % of the adult population, with type 2 making up about 90 % of all cases. The common antidiabetic drugs have several problems like hypoglycemia, skin rash and itching, weight gain, kidney complications, etc. So, there is a need to explore safer alternative medications from natural sources. This study examines the antidiabetic potential and metabolomic profiling of Conium maculatum, a homeopathic medicine prescribed for diabetic patients. Potent DPPH scavenging of the sample was observed with an IC50 value of 75.05 ± 6.33 μg/mL. α-Amylase and α-glucosidase enzyme inhibition by the mother tincture of Conium maculatum was evaluated through in-vitro studies, highlighting effective antidiabetic activity with IC50 values of 86.53±1.76 μg/mL and 124±7.903 μg/mL, respectively. Metabolomic profiling of the mother tincture of Conium maculatum was done by LC-MS/MS to identify a total of 47 phyto-compounds that were subjected to ADMET profiling, followed by in-silico docking and MDS with target receptors associated with diabetes. Six compounds were short-listed for in-silico docking studies with five target proteins, α-amylase, α-glucosidase, GLUT-4, GLP-1, and IRS1. Three compounds, Schidigeragenin B, 10-oxo-11-octadecen-13-olide, and Distichonic acid A, showed strong binding affinities to these protein receptors, crucial for diabetes remediation. Among these compounds, Schidigeragenin B, a novel triterpenoid shows the strongest binding affinities towards these receptors, and the ADMET properties highlighted its drug likeness. Conclusively, the present study identified Schidigeragenin B, resourced from the mother tincture of Conium maculatum, as the potent bioactive antidiabetic molecule for combating diabetes.

Возможности консервативной тактики ведения пациентов с гипертрофией и воспалением глоточной миндалины

Patients who suffer from pharyngeal tonsil hypertrophy or inflammation are very common visitors in outpatient physicians’ practice. Hypertrophy of the pharyngeal tonsil may be accompanied by persistent difficulty in nasal breathing and complications whilst adenoditis in the absence of a significant impact on the child’s quality of life and associated complications had not been regarded as a ‘pathology’ in pediatric physicians’ practice until the patient is reached the age of 7 to 9 years old. The purpose of this research was to compare the regimens of the use of the homeopathic medications in patients with pharyngeal tonsil hypertrophy or inflammation. Materials and methods used: a single-center controlled randomized observation of the use of homeopathic medications of a single active substance had been conducted in pediatric patients aged 1 to 18 y/o with pharyngeal tonsil hypertrophy or inflammation. The study included patients with pharyngeal tonsil hypertrophy or inflammation who had previously taken homeopathic single-substance medications, including in combination with standard treatment. Depending on the choice of patients (repetition of the homeopathic single-substance medications intake or prophylactic regimen) the patients were then divided into comparison groups. All of the patients had undergone both the routine examination and the ENT endoscopy, the parents’/caregivers’ satisfaction with the treatment results was then assessed using the 5-point Likert scale as well as the incidence of acute respiratory infections (ARI) in children while taking homeopathic medicines (compared to the period without taking them) and the willingness to use homeopathic medicines in the future. Results: after the ENT endoscopy (reduction in the size of the pharyngeal tonsil in 38% of cases, p≤0.001) and the parents’/caregivers’ survey (reduction in the ARI frequency in 62% of cases and high satisfaction with the treatment results), the majority of parents/caregivers have assessed the repetition of the repetition of the homeopathic single-substance medications intake as rather more effective in treatment of patients with inflammation of the pharyngeal tonsil of varying degrees of hypertrophy. Conclusion: the use of homeopathic medicines in patients with pharyngeal tonsil hypertrophy or inflammation has showed good effectiveness. According to the ENT endoscopy results before v. after the treatment and the parents’/caregivers’ survey it is preferable to repeat the homeopathic single-substance medications intake in the next adenoiditis episode. The parents’/caregivers’ readiness to go on with the homeopathic medicines’ intake ranges from 50% to 78%.

Dermatomyositis &amp; Homoeopathy

In the month of February 2024, India lost a budding actor in the name of Suhani Bhatnagar who was a part of the popular movie ‘Dangal’. She was only 19 years of age. Unfortunately, she had ‘Dermatomyositis’, a rare inflammatory disease. She was treated with steroids but in vain. It is here that the article focuses on the use of homoeopathy of AYUSH in this rare disease. Homoeopathy has already proved its efficacy during the COVID 19 pandemic where it subdued the inflammation in the body. Thereafter, the disease could not progress to the lungs. Applying the concept of anti inflammatory approach, homoeopathy can deal with the issue of ‘Dermatomyositis’. It is to be noted that along with the homoeopathic medicines, all other supportive therapies like fluid management, temperature management &amp; blood circulation management. At the end of the article, a homoeopathic protocol is mentioned that can be used in this rare disease.

Unveiling the Immunostimulatory Potential of Rhus Toxicodendron in Immunocompromised Balb/C Mice Induced with Cyclophosphamide.

This study investigated how Rhus toxicodendron (RT) (6C, 30C, and 200C) can boost the immune system of BALB/c mice that were given cyclophosphamide (CPM), which is an anticancer drug that weakens the immune system. RT, known for its historical use in traditional homeopathic remedies, has demonstrated immunomodulatory and anti-inflammatory effects in various experimental models. To test the immune-boosting effects of RT, CPM (80 mg/kg) was given intraperitoneally to mice on days 4, 8, and 12 of the study but not to the normal control group. CPM-induced immunosuppression led to significant decreases in red blood cell (RBC), white blood cell (WBC), and hemoglobin (Hb) levels, and reduced spleen and thymus indices. Phagocytic activity, cytokine concentrations, and spleen architecture were also adversely affected. RT treatment, particularly at 200C, significantly ameliorated these effects, improving RBC, WBC, and Hb levels. Furthermore, RT partially prevented CPM-induced atrophy of immune organs. Treatment positively influenced cytokine production at both the protein and mRNA levels, restoring immune balance. Histopathological results confirmed that RT stimulated the immune system. The cells were more stable, and the white pulp in the spleen was arranged in a regular pattern. These findings suggest that RT may serve as an adjunctive immunostimulant therapy for conditions characterized by immunosuppression. However, further investigations in other immunocompromised states must validate these results before considering human clinical trials.

Use of Homeopathy in Patients Suffering from Long COVID-19 (LONGCOVIHOM): A Case Series

In some patients, coronavirus (COVID-19) can cause symptoms that last weeks or even months after the infection has gone. Long COVID-19 was defined as a confirmed initial COVID-19 infection, the presence of signs and symptoms more than four weeks after initial infection, and the persistence or appearance of signs and symptoms that another condition cannot explain and did not exist before infection. This study aimed to describe the effect of adjunctive individualized homeopathic treatment delivered to Long COVID-19 patients with previously confirmed symptomatic SARS-CoV-2 infection. Fifteen female consecutive patients with Long COVID-19 were documented. The mean age was 48.5 ± 13.5 (SD) years. The symptoms of Long COVID-19 were diverse. None of the patients showed identical symptoms. All but one patient, hence 93.3%, experienced a timely improvement to complete healing after individualized homeopathic treatment, characterized by modified Naranjo criteria of at least 8 points. The average time until improvement/remission was 47.6 ± 34.6 days, and the median was 37 days. Our observations suggest that adjunctive individualized homeopathic treatment might be considered for patients suffering from Long COVID-19 even with severe long-term sequelae of COVID-19.

Exploring the Role of Homeopathic Intervention in Post-COVID Functional Gastrointestinal Disorders: A Case Series of 12 Patient Profiles.

In the last 2 years of the pandemic, a wide range of cases of post-COVID functional gastrointestinal disorders (PC-FGIDs) has been reported. This case series aimed to investigate the role of homeopathic intervention in the treatment of PC-FGIDs. This is a retrospective analysis of the clinical data of individuals who had suffered from PC-FGIDs that were diagnosed based on clinical symptoms using the Gastrointestinal Symptoms Rating Scale (GSRS) and treated exclusively with individualized homeopathic medicines. Cases that had undergone regular monthly assessment using the GSRS and had a Post-COVID-19 Functional Status (PCFS) score for up to 3 months were considered. Thirty cases were screened and twelve were included according to the study criteria. The mean age of seven women and five men was 36 years. GSRS and PCFS scores showed marked improvement in each of 10 cases within the 3-month treatment period. Homeopathic intervention proved beneficial in 10 of 12 patients with PC-FGIDs. The findings may help researchers plan future controlled clinical studies in this field.

Efficacy of Homoeopathic Medicines in Management of Cancer Patients

Efficacy of Homoeopathic Medicines in Management of Cancer Patients

A Review of Traditional and Modern Approaches in Pharmacovigilance for Hypertension and Kidney Disease Treatments

Pharmacovigilance plays a crucial role in monitoring the safety of herbal, homeopathic, and allopathic drugs, particularly for treatments of hypertension and kidney diseases. The global increase in complementary and alternative medicine use alongside conventional therapies necessitates a thorough understanding of potential interactions and side effects. Current pharmacovigilance systems for herbal and homeopathic remedies face unique challenges compared to established allopathic drug monitoring processes. Recent research on allergic reactions to these diverse therapeutic approaches reveals varying prevalence, mechanisms, and clinical implications. Regulatory frameworks governing these treatment modalities differ across countries, highlighting the need for harmonized international standards. Emerging technologies, including artificial intelligence and big data analytics, show promise in enhancing adverse drug reaction (ADR) detection and prevention. Integration of findings from multiple disciplines provides healthcare professionals, researchers, and policymakers with insights into ensuring safe use of herbal, homeopathic, and allopathic drugs in managing hypertension and kidney diseases. This review summarizes current knowledge, identifies research gaps, and proposes future directions for improving pharmacovigilance across these diverse therapeutic approaches

Homoeopatjic Approach to Acne and Case Study with Homoeopathic Therapeutics

Acne/ Pimples is one of the commomest skin disorder. It has been estimated70% population have clinically evidence of Acne at some stage during adolescence. When patient comes to homeopathic consultant., problem should never be tackled only with superficial, local acting remedies. Instead, deep acting constitutional remedies should be prescribed as soon as the complete totality is available Acne is a chronic inflammatory characterized clinically by papules comedones and pustules occur on face. This case report will help to increase knowledge and homeopathic students &amp; practitioners, so that they can use the homeopathic remedies in similar complaints.

Population-level trends in self-reported healthcare utilization among older adults in Mexico with and without cognitive impairment

BackgroundOlder adults with cognitive impairment exhibit different patterns of healthcare utilization compared to their cognitively healthy counterparts. Despite extensive research in high-income countries, similar studies in low- and middle-income countries are lacking. This study aims to investigate the population-level patterns in healthcare utilization among older adults with and without cognitive impairment in Mexico.MethodsData came from five waves (2001–2018) of the Mexican Health and Aging Study. We used self-reported measures for one or more over-night hospital stays, doctor visits, visits to homeopathic doctors, and dental visits in the past year; seeing a pharmacist in the past year; and being screened for cholesterol, diabetes, and hypertension in the past two years. Cognitive impairment was defined using a modified version of the Cross Cultural Cognitive Examination that assessed verbal memory, visuospatial and visual scanning. Total sample included 5,673 participants with cognitive impairment and 34,497 without cognitive impairment interviewed between 2001 and 2018. Generalized Estimating Equation models that adjusted for time-varying demographic and health characteristics and included an interaction term between time and cognitive status were used.ResultsFor all participants, the risk for one or more overnight hospital stays, doctor visits, and dental visits in the past year, and being screened for diabetes, hypertension, and high cholesterol increased from 2001 to 2012 and leveled off or decreased in 2015 and 2018. Conversely, seeing a homeopathic doctor decreased. Cognitive impairment was associated with higher risk of hospitalization (RR = 1.13, 1.03–1.23) but lower risk of outpatient services (RR = 0.95, 0.93–0.97), cholesterol screening (RR = 0.93, 0.91–0.96), and diabetes screening (RR = 0.95, 0.92–0.97).No significant difference was observed in the use of pharmacists, homeopathic doctors, or folk healers based on cognitive status. Interaction effects indicated participants with cognitive impairment had lower risk for dental visits and hypertension screening but that these trajectories differed over time compared to participants without cognitive impairment.ConclusionsWe identified distinct population-level trends in self-reported healthcare utilization and differences according to cognitive status, particularly for elective and screening services. These findings highlight the necessity for policy interventions to ensure older adults with cognitive impairment have their healthcare needs met.

Retrospective analysis of 60 Autism Spectrum Disorder cases

SummaryAutism Spectrum Disorder (ASD) is a neurodevelopmental disorder with challenges in social communication and repetitive/restricted sensory-motor behaviours and early intervention during the critical brain development phase can significantly manage this condition. This retrospective analysis was conducted to understand the impact of homoeopathy on specific developmental domains in the treatment of ASD and to determine what areas it may benefit when used alongside other supportive therapies, to improve the long-term outcomes of the affected children. Methods The records of 60 cases diagnosed with ASD and treated with homoeopathic medicines, along with supportive therapies, that showed clinically significant improvement, were taken for analysis. Documented follow-ups for a period of 3–4 years of these cases were observed and analysed. The Indian Scale for Assessment of Autism has been used to score and analyse the progress of the children. Results The cases were divided according to age into 3 categories – 2 to 5 years, 6 to 9 years and 10 to 12 years for analysis. Significant improvement in the 2–5 years age group was seen in all developmental domains but the highest in speech-language &amp; communication, the 6–9 years group in cognitive component, 10–12 years group in behaviour, which was also supported statistically by a significant p value (&lt;0.05). Conclusion The analysis evaluated the impact of homeopathy on ASD, showing benefits in speech, language, and cognitive development, particularly in younger children, holding promise for homoeopathy in early intervention for long-term developmental outcomes.

Evaluation of Add-On Individualized Homeopathic Medicines Products in the Treatment of Symptomatic COVID-19 Managed at Home: A Double Blind, Placebo-Controlled, Randomized, Exploratory Clinical Trial

Homeopathy has shown promise in fighting epidemics, leading to potential applications in the COVID-19 clinical cases. To assess the impact of add-on individualized homeopathic medicinal products (IHMP) in improving clinical outcomes and time to medical discharge in COVID-19 patients. A prospective, double-blind, randomized, placebo-controlled, parallel-group exploratory clinical trial was conducted in a São Paulo state municipality, Brazil, between February and July 2021. 82 (unvaccinated) patients with confirmed SARS-CoV-2 infection and manageable mild to moderate COVID-19 symptoms were randomly assigned to placebo or IHMP groups. Utilizing unique global COVID-19 symptom scores, a symptom assessment was performed. Statistical analysis involved 68 patients (36 IHMP; 32 placebo). No significant initial disparity existed in total COVID-19 symptom scores between the groups. The IHMP group exhibited a significantly shorter mean time from initial appointment to medical discharge compared to placebo (p &lt; 0.05: IHMP 74.5 hours (+/- 57.47, 95% CI: 55.73-93.27); placebo 137.42 hours (+/- 87.85, 95% CI: 106.98-167.86)). Employing the chi-square trend test at selected time points (74.5 and 137.42 hours, corresponding to mean discharge times), COVID-19 scores demonstrated sustained IHMP-associated reductions (p &lt; 0.05). COVID-19 symptom scores and time to medical discharge were significantly reduced by treatment with IHMP compared to placebo, suggesting a potential role for IHMP in managing mild to moderate COVID-19 symptoms at home.