Homeopathic Drugs Research Articles

High Dilutions of Homeopathic Drugs Interact with Human Serum Albumin as Revealed by Electronic Spectroscopy

Homeopathy uses drugs in extreme dilutions that are mostly devoid of the original drug molecules. Drug-induced water structures are thought to be responsible for their therapeutic effect. We have already observed that homeopathic potencies first interact with serum albumin, which is present in the oral mucosa. In this experimental study, we have shown that the homeopathic potencies of three drugs, Bryonia alba (Br), Rhux toxicodendron (Rt), and Thuja occidentalis (Th), initiate their action on Human Serum Albumin (HSA). The potency-HSA complexation has been observed by electronic spectroscopy. The control, HSA plus water, shows only one peak at 216 nm, but the potencies plus HSA show two peaks, one at 205 nm and another around 265 nm. The first peak is due to the peptide bond. The first peak in the control shows a marked red shift. The second peak at higher wavelength is due to the aromatic amino acids. The first peak with the potencies shows a marked blue shift, possibly due to a change induced by the potencies on the peptide bond. Unlike water control the potencies interact with aromatic amino acids. It is evident that the complexes made up of HSA and potency are different from those of the control. This means that homeopathic potencies are not ordinary water. It is concluded that water control interacting with HSA shows a single peak in UV-spectra at lower wavelength, but homeopathic potencies show one additional peak at a higher wavelength besides the peak at the lower wave length. HDs can produce effects on aromatic amino acids. The mother tinctures and their HDs show marked differences from each other in their electronic spectra.

A series of homeopathic remedies-related severe drug-induced liver injury from South India.

Homeopathic remedies are highly diluted formulations without proven clinical benefits, traditionally believed not to cause adverse events. Nonetheless, published literature reveals severe local and non-liver-related systemic side effects. We present the first series on homeopathy-related severe drug-induced liver injury (DILI) from a single center. A retrospective review of records from January 2019 to February 2022 identified 9 patients with liver injury attributed to homeopathic formulations. Competing causes were comprehensively excluded. Chemical analysis was performed on retrieved formulations using triple quadrupole gas chromatography-mass spectrometry and inductively coupled plasma atomic emission spectroscopy. Males predominated with a median age of 54 years. The most typical clinical presentation was acute hepatitis, followed by acute on chronic liver failure. All patients developed jaundice, and ascites were notable in one-third of the patients. Five patients had underlying chronic liver disease. COVID-19 prevention was the most common indication for homeopathic use. Probable DILI was seen in 77.8%, and hepatocellular injury predominated (66.7%). Four (44.4%) patients died (3 with chronic liver disease) at a median follow-up of 194 days. Liver histopathology showed necrosis, portal and lobular neutrophilic inflammation, and eosinophilic infiltration with cholestasis. A total of 29 remedies were consumed between 9 patients, and 15 formulations were analyzed. Toxicology revealed industrial solvents, corticosteroids, antibiotics, sedatives, synthetic opioids, heavy metals, and toxic phyto-compounds, even in 'supposed' ultra-dilute formulations. Homeopathic remedies potentially result in severe liver injury, leading to death in those with underlying liver disease. The use of mother tinctures, insufficient dilution, poor manufacturing practices, adulteration and contamination, and the presence of direct hepatotoxic herbals were the reasons for toxicity. Physicians, the public, and patients must realize that Homeopathic drugs are not 'gentle placebos.'

Cytotoxic Effects of Homeopathic Preparations on Human Tumor Cells In Vitro

Abstract: The aim of this work was to conduct an in vitro assessment of the possible cytotoxic effects of homeopathic drugs and consider possible mechanisms. Background: Homeopathy is still widely used as a complementary (alternative) medicine in different countries throughout the world. However, the method raises a lot of scientific debate about its effectiveness and mechanisms of action. This is especially true concerning the use of homeopathy in cancer treatment. Objective: This work aimed to comparatively assess the cytotoxic effect of homeopathic remedies on tumor cell cultures. Materials and Methods: We studied different dilutions of homeopathic medicines: Hydrastis, Conium and Carcinosinum. Cell lines of prostate cancer PC-3, breast cancer MDA-MB-231, and lymphoblastic leukemia Jurkat were used as model tumor objects. Standard colorimetric MTT test and cytometric analysis of cells were used here to assess the viability and parameters of apoptosis of cells. Results: Comparative assessment of the cytotoxic and apoptosis-inducing effects did not reveal significant differences in the viability of tumor cells in the groups exposed to homeopathic preparations among themselves and in comparison with the control group. The effects of the action of homeopathic remedies are shown only in the form of trends. Some possible mechanisms of the obtained results are considered. Conclusion: The results obtained in vitro indicated the absence of a direct cytotoxic effect in the studied homeopathic preparations. Despite the objective data, this does not allow us to make a final conclusion about the absence of antitumor activity of these drugs in vivo, since the possible or potential effects depend on the parameters of a living organism that are difficult to control and are often based only on hypothetical mechanisms. Some aspects of the action of homeopathy probably cannot be reproduced in vitro.

Homeopathy as a saviour for urolithiasis: A narrative review shading light on pathophysiology of renal stones and homeopathy drugs

Kidney stone disease is a crystal concretion formed generally within the kidneys. It is an accumulative urological disorder of human health, affecting about 12% of the world population. Higher risk of kidney failure which has been associated with end stage renal failure. Calcium oxalate, which forms at Randall's plaque on the renal papillary surfaces, is the most common type of kidney stone. Stone formation is highly prevalent, with rates of up to 14.8% and increasing, and a recurrence rate of up to 50% within the first 5 years of the initial stone incident. The formation of the stone is a complex process which results from numerous physiochemical events such as, super saturation, nucleation, growth, aggregation, and retention of urinary stone constituents within tubular cells. Several therapies are being performed for kidney stone treatment, including thiazide diuretics, allopurinol, painkillers, dietary changes, shock-wave treatment, ureterenooscopic and percutaneous nephrolithotomy, and ureterenooscopic and percutaneous nephrolithotomy in severe cases. However, the side effects that these treatments possess and reoccurrence of the disease have motivated researchers to search for better and safer options. Homeopathic drugs as well as several medicinal plants display antiurolithiatic activity and thus perform an important role in treatment of kidney stone disease. Therefore, the present review thereby wants to bring to the attention the wonderful results that homeopathy is offering in cases of urolithiasis in a very non-invasive and economical way which is not yet popularized.

Revamping homoeopathy from Drug and Cosmetic Act of 1940 to New Drugs, Medical Devices and Cosmetics Bill, 2022; A perspective. of 1

Government of India at its 72nd year of republic had drafted the new bill entitled “New Drugs, Medical Devices and Cosmetics Bill 2022” which seeks to replace the existing “Drugs and Cosmetics Act, 1940”. Earlier in this Act, Chapter V mentions the support of regulatory authority for Ayurveda, Siddha, Unani drug. However the new draft of bill includes Sowa Rigpa and Homoeopathic drugs and proposes to develop new innovative drugs by establishing their scientific research board. Owing to the new suggestions put forth in this new draft an opinion is addressed in this letter concerned with quality standards, drug proving trials, safety standards and efficacy standards for homoeopathic drugs.

The effects of tarantula cubensis extract on renal ischemia reperfusion injury in rats.

Renal ischemia-reperfusion (IR) related acute kidney injury (AKI) is an important health problem and has not yet been fully treated. Tarantula cubensis extract (TCE) is a homeopathic drug that has antiinflammatory and antioxidant effects. This study aimed to investigate the effects of TCE on renal ischemia-reperfusion injury in rats. This study was carried out on 48 Spraque-Dawley male rats, which were divided into six groups. The first, second, and third groups were control, sham, and IR groups, respectively. Group four received IR and 0.2 mL of 96% ethanol. Group five and six received ischemia and reperfusion and TCE 0.01 and 0.1 mg per rat (which correspond to approximately 0.04 mg/kg, and 0.4 mg/kg), respectively. Tumor necrosis factor alpha (TNF-α), interleukin-1beta (IL-1β), total antioxidant status (TAS), and total oxidant status (TOS) levels in renal tissue were measured by enzyme-linked immunosorbent assay (ELISA). Oxidative stress index (OSI) was obtained by proportioning TAS and TOS. Superoxide dismutase (SOD), myeloperoxidase (MPO) activities, and malondialdehyde (MDA) levels were determined by manual spectrophotometric methods. The histopathological changes were evaluated via hematoxylineosin and immunohistochemical staining. In IR group, renal tissue TNF-α and IL-1β levels were significantly higher than control group (p < 0.0001 for both), and low(p < 0.0001 for both) and high dose (p < 0.0001 for both) TCE administration decreased these markers. Low and high doses of TCE decreased OSI values compared with IR group (p = 0.04 and p = 0.001 respectively). Although TCE decreased MDA levels, it was not statistically significant. MPO levels significantly decreased. In addition, TCE has been found to prevent hemorrhage, cast formation, and dilatation caused by IR in renal tissues stained with hematoxylin-eosin. And also, the most intense nuclear factor kappa B (NFκB) and caspase-3 immunopositivity found in IR group was decreased in both of the TCE groups. Although TCE showed a protective effect by inhibiting inflammation against IR damage in renal tissues, there was no clear effect on oxidative stress. Larger and more detailed studies are needed to clarify the issue.

Allergic Contact Stomatitis from Homeopathic Preparations (Arsenicum Album 30c) Used as Prophylaxis Against COVID 19

Contact stomatitis or stomatitis venenata is defined as an oral mucosa contact allergy caused by persistent contact with a pathogenic substance. Arsenic album 30 was advised as a “preventive and prophylactic remedy” against coronavirus disease-19 (COVID-19) by The Ministry of AYUSH (Ayurveda, Yoga and Naturopathy, Unani, Siddha, and Homeopathy), Government of India. We present a case of a 68-year-old man who suffered ulcers on the left buccal mucosa and tongue after taking arsenic album 30c for 10 days sublingually. This is, to the best of our knowledge, the first recorded incidence of allergic contact stomatitis caused by a homeopathic drug used to treat COVID-19. This case report emphasizes the need for obtaining a history, being aware of the composition of any new items, and reporting allergies or medicines provided to the patient.

Role of homoeopathic organopathic drugs in preventing cardiovascular diseases

Role of homoeopathic organopathic drugs in preventing cardiovascular diseases

Efficacy of homoeopathic medicine candida albicans 200C in the treatment of fungal infection (Tinea)

Dermatophyte infections are common worldwide, and dermatophytes are the prevailing causes of fungal infection of the skin, hair, and nails. In a country like India, where there’s a deficit of original studies of dermatophytosis and its treatment, it’s getting unstintingly clear that experience- grounded treatment of dermatophytosis is ruling the roots and is proving to be more effective than the standard guidelines handed in current literature that one frequently considers most valid and substantiation grounded. Homoeopathic system is having a different conception for treating the case, it’s grounded on the underpinning principles and the tradition is done using the summation of symptom. As Homoeopathy is a system of drug which work on alleviation, the humeral or the vulnerable medium of the body from its latent or overt response, it’s thereby the stylish form of drug to treat skin conditions. So, then disquisition was carried out using Homoeopathic drug Candida Albicans 200C energy on subjects who had Fungal Infection (Tinea). This study was conducted in 2 study settings for 90 days to assess efficacy of Homoeopathic drug Candida Albicans 200C in the treatment of Fungal Infection (Tinea). Assessment of subjects was done using Fungal Infection (Tinea) Assessment Performa every 10th day during course of study. After study period the recorded data shown that, Homoeopathic drug Candida Albicans 200C is effective in treating Tinea Infection which are acute in nature than that of habitual Tinea infection

An Experimental Study on Efficacy of Ultra-Diluted Phytolacca decandra in Growth-Promoting Effect on Cicer areitinum (Chickpea) Seeds through Hydroponics

Homoeopathic dilutions are applied to plants to boost their active constituents, cleanse them, speed up their growth and fruit production, enhance their metabolism, and control illnesses. The purpose of this known research prospective study was to evaluate that how homoeopathic medicines worked. Cicer arietinum L. was the subject of this controlled, experimental, prospective investigation to determine the impact of the homoeopathic drugs Phytolacca decandra Mother tincture (MT) and 30CH, 200CH on plant development. This research aids in evaluating and establishing the function of homoeopathy in plant growth propagation. Cicer areitinum seeds were grown on the Research Facilitation centre, Sarada Krishna Homoeopathic Medical College campus in a specified location. These were divided into four groups: 30 Seeds each were soaked with Phytolacca decandra Mother tincture, Phytolacca decandra 30CH, Phytolacca decandra 200CH, and Phytolacca decandra 200CH, Plain alcohol. Germination index calculated. Control Group, Phytolacca decandra 30CH, Phytolacca decandra 200CH treated as nutrient medium in separate Beakers and chickpea plant were grown in hydroponics. The entire plant was measured for Root length, Shoot length after 20 days. Chlorophyll content assessed. After 5 days, Seeds treated with Phytolacca decandra shows higher germination rate than seeds treated with plain alcohol. The seeds treated with Phytolacca decandra 200 CH have growth promoting effect on Cicer areitinum L (Chick pea) seed. Cicer areitinum was the subject of this controlled, experimental, prospective investigation to determine the impact of the homoeopathic drugs Phytolacca decandra Mother tincture (MT) and 30CH, 200CH on plant development. This research aids in evaluating and establishing the function of homoeopathy in plant growth propagation.

Quantitative assessment of antioxidant potential of selected homeopathic preparations in clinical practice.

Antioxidant property like radical scavenging is a primary target to elucidate the efficacy mechanism of a drug against diseases linked to oxidative stress such as cancer, metabolic disorders, rheumatoid arthritis, etc. In alternative therapies, homeopathy is one of the preferred choices by patients and clinicians due to its potential to cure chronic and complex illnesses. However, the efficacy of homeopathic preparations at high diluted potencies attracts rational criticism due to insufficient scientific knowledge supporting the mechanism of action. Therefore, an attempt was made to estimate the total phenolic content (TPC) and radical scavenging activity of clinically prescribed homeopathic drugs. With gallic acid as a reference control, mother tinctures (MTs) and different potencies of Eucalyptus globulus (EG), Syzygium jambolanum (SJ), Ruta graveolens (RG), and Thuja occidentalis (TO) were used to perform Folin-Ciocalteu test, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), and 2,2-diphenyl-1-picrylhydrazyl (DPPH) assays. The results showed TPC of MTs equivalent to µg/mL of gallic acid viz; EG (4,872.5±133.2), SJ (8,840.5±14.8), RG (985.6±39.1), and TO (341.5±19.5) with significant ABTS and DPPH radical scavenging potential. Whereas 30C and 200C potencies of each homeopathic drug showed undetectable phenolic content and insignificant radical scavenging potential compared to vehicle control, i.e.,alcohol 90% (2.0±1.5). The reported efficacy of 30C and 200C potencies of homeopathic medicines against oxidative stress-related illnesses might be due to mechanisms other than radical scavenging. Furthermore, the assays studied can be helpful in drug standardization and quality control of MTs that are used as starting material in homeopathic preparations.

Оптимізація лікування гострого тонзилофарингіту в дитячому віці

Acute tonsillopharyngitis (ATP) in children is an actual and not fully solved problem, which has interdisciplinary importance and requires optimization of diagnosis and treatment to improve the prognosis of the disease and the quality of life of children. Purpose - to optimize the tactics of treatment of children with ATP by supplementing the complex of therapy with drugs of anti-inflammatory and immunomodulatory action with the evaluation of clinical and immunological markers of the effectiveness of the proposed treatment. Materials and methods. We monitored 51 hospitalized children with a clinical diagnosis of ATP. All children underwent a complex clinical and paraclinical examination with the determination of C-reactive protein (CRP) in the blood serum upon admission to the hospital, and on the 7th day of treatment, the serum concentration of interleukin (IL) -4, -6, -8, tumor necrosis factor α (TNFα), and interferon-γ (γ-IFN) as markers of therapy effectiveness. The patients were randomly divided into 2 clinical groups: the Group 1 was formed by 28 patients (average age - 8.0±0.9 years, the share of boys - 53.5±6.1%) with ATP, who received standard treatment and standardized extract of Pelargonium sidoides EPs® 7630 (Umckalor) and the complex homeopathic drug Tonsilotren in age-related doses according to the instructions. The remaining 23 children formed the clinical Group 2 (average age - 8.7±1.0 years (p&gt;0.05), the share of boys - 56.5±8.3% (p&gt;0.05), and received the same standard treatment for ATP and served as a comparison group. The groups were matched for the main clinical characteristics. Results. We obtained significantly better results of treatment of children with ATP when using the combination of the drugs Umckalor and Tonsilotren in complex therapy, which are proven by the presence of statistically reliable chances of a milder clinical course of the disease on the 3rd day of treatment (assessment of the severity of ATP - &lt;26 points): attribute risk - 59.8%, relative risk - 2.8 (95% CI: 1.1-7.2), odds ratio - 25.6 (9.0-72.6). The effectiveness of the proposed therapy was confirmed on the 7th day of treatment by the probably lower content of pro-inflammatory markers IL-8 (15.2±5.4 pg/ml vs 37.6±7.6 pg/ml) and γ-IFN (21.8±2.3 pg/ml vs. 30.0±1.2 pg/ml) compared to standard treatment, as well as twice lower TNF-α concentration (2.1±0.5 pg/ml vs. 4.5±2.5 pg/ml). The use of the combination of the drugs Umckalor and Tonsilotren was accompanied by a statistically significant reduction in the risk of maintaining a high serum concentration of pro-inflammatory cytokines (CRP - &gt;10.0 mg/l, γ-IFN and IL-8&gt;10.0 pg/ml) in relation to the standard treatment: absolute risk reduction - 20.8%, relative risk reduction - 32.3% with the minimum required number of patients to treat - 3.1. Conclusions. In the complex treatment of children with ATP, the use of a combination of the standardized extract of Pelargonium sidoides EPs® 7630 (Umckalor) and the complex homeopathic drug Tonsilotren demonstrated better effectiveness compared to the same standard treatment. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.

Homeopathy for seasonal allergic rhinitis: rationale, design and methods of the three-armed randomized controlled HOMEOSAR trial

BackgroundPatients with seasonal allergic rhinitis (SAR) frequently use homeopathic therapy. Although there is some evidence that homeopathy may be effective in treating symptoms of SAR, there is a lack of high-quality clinical trials. Therefore, the aim of the homeopathy for SAR (HOMEOSAR) trial is to determine the efficacy of individualized or standardized homeopathic drug treatment compared to placebo regarding rhinitis-related quality of life in patients with SAR.MethodsThis randomized, placebo-controlled, double-blind, three-armed intervention study will be conducted at two university hospital outpatient clinics for complementary and integrative medicine in Berlin and in 12 office-based practices specializing in homeopathic treatment in Germany. A total of 270 patients with clinical symptoms of SAR and positive allergy test to birch and grass pollen will receive homeopathic anamnesis and subsequently be randomized into (a) standardized homeopathic drug treatment with Galphimia Glauca (potency D6), (b) individualized homeopathic drug treatment (D6), or (c) placebo. All three groups can receive on-demand rescue medication as needed. Treatment will consist of two consultations and daily intake of the study medication for 4 weeks during the pollen season. The primary outcome is the mean overall score of the Rhinitis Quality of Life Questionnaire (RQLQ) in weeks 3 and 4, analyzed using analysis of covariance (adjusted for baseline RQLQ overall score and study center). A closed testing procedure will be used to control the overall type I error comparing the 3 treatment groups. Secondary outcomes include the overall RQLQ and its seven domain scores, responder status (decrease in RQLQ overall score of at least 0.5 points compared to the baseline value), use of rescue medication, intensity of total and individual SAR symptoms based on visual analog scale, generic health-related quality of life, safety, utilization of health care resources and associated costs. In addition, a qualitative data analysis is planned.ConclusionThe results of our study will contribute to clarifying the possible therapeutic effects of homeopathic drug treatment for patients with SAR.Trial registrationThis study has been registered in the German Clinical Trial Registry with trial ID DRKS00018081 on June 09, 2020.

Photographic Evidence of Management of Allergic Contact Dermatitis with Graphites 30C - A Case Report

One of the major occupational risks for people working in the construction or cement industries is allergic contact dermatitis, which frequently affects the workers' quality of life and results in significant financial loss. The hands of cement workers come into touch with cement on a frequent basis, making them susceptible to developing hand contact dermatitis again and making a full recovery exceedingly challenging. The contact dermatitis in homoeopathy has been the subject of numerous prior researches. This case study demonstrated the effectiveness of the homoeopathic drug Graphites 30C on allergic contact dermatitis, with slow improvement at first and full recovery at the end.

A Study on the Profile of Poisoning in the Paediatric Population in a Tertiary Care Teaching Hospital of Chitradurga Region.

Background Most poisoning events among children are preventable and the major reason is lack of supervision by adults, including poor knowledge and attitude toward storage of such items. So, the prevention policy on children's poisoning shall take into account the age group, gender, socioeconomic status, residence, and other aspects such as the knowledge and attitude of adults. The present study was conducted to describe the profile of poisoning in the paediatric population in a tertiary care teaching hospital. Methods Our observational study was retrospective and was conducted at Basaveshwara Medical College and Hospital (BMCH), Chitradurga, Karnataka, under the Department of Forensic Medicine for a duration of three months (February 2021 to April 2021). Institutional ethical approval was obtained prior to the start of the study. As our study participants were paediatric patients (0-17 years) with acute poisoning (excluding homeopathic drug ingestion), a total of 81 paediatric patients' case sheets were finally reviewed and analysed.The data of paediatric poisoning cases were collected in a predesigned study proforma andincluded details about children's age (in years), gender (male, female), residence (rural, urban), outcome (death, discharge), nature of poisoning (accidental, suicidal), and toxic agents in poisoning. The collected data were entered and analysed in the Microsoft Excel spreadsheet (Microsoft Corporation, Redmond, WA). Results The incidence of acute poisoning among the paediatric population in our teaching hospital was 1.4%. The most common age group with acute poisoning was 13-17 years (30.9%). The prevalence of acute poisoning was higher in male children (56.8%) when compared to female children (43.2%). Around three-fourths of paediatric cases (71.6%) with acute poisoning were having a rural residence. The overall mortality rate among children due to acute poisoning was 9.9%. The most common toxic agents involved in acute poisoning among children were organophosphatecompounds (35.8%), followed by organochlorine compounds (30.9%) and pyrethrum compounds (11.1%). Conclusion From this study, we concluded that acute poisoning among children is mainly accidental, and the most common toxic agentresponsible for the poisoning is pesticideor insecticide. Most poisoning events among children are preventable, and the major reason is a lack of supervision by adults, including poor knowledge and attitude toward storage of such items.

Adjuvant Approach to Mitigate the Adverse Effects of Cancer Treatments Using Homeopathic Medicines

Background: Worldwide, cancer patients are facing problems with life-and-death decisions due to the associated severe adverse and sometimes fatal effects of existing conventional treatments. Due to the severe adverse effects of existing therapies, effective cures are progressively explored for anticancer treatment. Mostly the conventional therapies are based upon nonspecific cellular destruction properties; therefore, a treatment approach is desired to reduce the toxic burden upon normal tissues. Among all alternative medicine systems, homeopathy is one of the most popular treatments for cancer patients globally due to its minimal side effects. Methods: In this present review, we have attempted to comprehend the literature reports on homeopathic medicine in cancer treatment. Results: Homeopathy has also proved its adjuvant approach to minimizing the symptomatic consequences of cancer. However, the insufficiency of evidence and lack of recurrence of the trials cause difficulty in drawing any conclusion about homeopathy as adjuvant therapy. Based upon the etiology, the genoprotective potential of homeopathic drugs was reviewed and found inconsequential evaluation and scanty literature Conclusion: Hence, the present review gives a comprehensive summary of retrospective studies and suggests an integration of rational drug selection, standard protocols, and quantitative analysis for revealing the differential role and plausible application of homeopathy in better cancer management.

Study to assess role of homeopathy in management of CKD

Background: The incidence of Chronic Kidney Disease (CKD) is rising every single day and is presently, a global threat to mankind. Worldwide incidence is appx 1.8 million/ year, which has been doubled in the last 15 years. In India alone approximately 100 million people are already suffering from CKD. The options available with Modern Medicine are just dialysis and transplant with poor outcomes and high cost. There is not even a single pill, worldwide, in Modern Medicine, which can reduce Creatinine or Urea by even a percent. On the other hand, Homeopathy offers complete treatment for patients of CKD, for all stages.ObjectivesTo establish homeopathy as being foremost for prevention of CKD.To establish Homeopathy, not only as the safest and most effective treatment for CKD but also as first line of treatment, worldwide.To establish Homeopathy as safe, cheap and most effective alternate of Dialysis and Transplant.Establish greater role of Homeopathy in National Health Policy.Method: Randomized controlled single blind drug evaluation method was used .Only previously diagnosed cases of CKD were selected. The inclusion criteria for the study was Serum Creatinine (>1.5), Blood Urea (>40), BUN (>14) and estimated GFR (≤90).Result: A total of 1121 patients contacted the centre (NIH) for CRF. Out of them 783 patients were available for proper follow-up. 450 (57.47%) cases were improving while 185 (23.60 %) maintained status quo and 148 (18.93%) did not show any improvement.Conclusion: Homeopathic drugs were found extremely effective in enhancing the efficiency of kidney. There was marked reduction in the level of S. Creatinine and in some cases not only it reduced significantly, but also its level came down in some cases and continued to be normal. Therefore Homeopathy can be established as an alternate to prevent or reduce the frequency of Dialysis and can help to postpone Renal Transplant.

Evaluation of hypolipidemic activity of homeopathic drug Allium sativum 6C potency on different grades of dyslipidemia in Wistar albino rat models

BackgroundUnhealthy dietary patterns and lifestyle modification could exacerbate heart-related diseases, and the risk factors for cardivascular disease mortality includes dyslipidemia, hypertension, and diabetes mellitus. However, controlling cholesterol, triglycerides, and low-density lipoprotein could minimize the occurrence of risk factors. Although homeopathic preparation of Allium sativum is effective in treating various ailments, it's therapeutic usage by the homeopathic practitioners must be validated scientifically to ascertain its action. ObjectivesThe present study is designed to evaluate the hypolipidemic and anti-inflammatory activities of the homeopathic drug A. sativum 6C in mitigating dyslipidemic changes in different types of dyslipidemic rat models. MethodsAssessment of serum biochemical parameters, evaluation of liver cytokines, and immunoblot analysis of inflammatory proteins were performed in this study. ResultsAdministration of a homeopathic preparation of A. sativum 6C to different types of dyslipidemic rat model showed a significant improvement in the serum lipid profile, reduction in the activity of serum marker enzymes (AST, ALT, LDH, and ALP), and decrement in the levels of liver inflammatory cytokines (TNFα, IL-6, and IL-1β). Further, the expression of inflammatory proteins (CRP, P-Selectin, E- Selectin) down regulated in the liver of dyslipidemic animals upon administration of A. sativum 6C. However, among the various dyslipidemic models, the efficacy of A. sativum is more profound in the HCD and HFD-fed animals. Analyzing the GC–MS data of A. sativum 6C revealed that it contains some active ingredients (Undecane; 1-methylene 1H-Indene, and Oxazolam) that might be responsible for the anti-inflammatory properties of A. sativum 6C. ConclusionHomeopathic preparation of A. sativum 6C modulates the levels of serum biochemical parameters and inflammatory events in HCD-T and T2DM-T animals than in the STZ-T animals, mitigating metabolic dysfunction. Therefore, this study brings limelight to support the potency of the homeopathic drug A. sativum for therapeutic purposes in correcting metabolic dysfunction associated with the current lifestyle.

Homoeopathy in the management of chronic kidney disease – A narrative review

Background: Chronic kidney disease (CKD) is the third fastest-growing cause of death around the world and is projected to become the fifth most common cause of years of life lost worldwide by 2040. Objective: This review was done to explore the strengths of homoeopathy in the management of CKD through pre-clinical, clinical and anecdotal evidence. Methods: A search was made for homoeopathic management of CKD in PubMed, Central Council for Research in Homoeopathy e-library, AYUSH Research Portal, EMBASE and Google Scholar. The basic search terms included ‘Homoeopathy’ or ‘homoeopathic drugs’, ‘ESRD’, ‘CRF’, ‘CKD’ and ‘Bright’s disease’. No rigid inclusion criteria was kept due to the paucity of literature on this subject concerning homoeopathy; hence, all studies were included in this review. Further, literature review, through homoeopathic repertories, was also conducted for the anecdotal evidence of frequently used homoeopathic drugs used in the management of CKD. Results: Through an online search, 11 studies were found related to the subject which included two randomised controlled trials (RCTs), eight case series/case reports and one pre-clinical study. Two RCTs focussed on symptoms/signs due to CKD such as pruritus, asthenia, lethargy and headache with positive effects. The evidence generated through case series/reports, though useful for hypothesis-generating studies, was found to have poor reporting quality. Conclusion: At present, the available evidence towards the benefits of homoeopathy in CKD is weak. Further well-designed studies are warranted.

Study of comparative efficacy of the phytotherapeutic complex against nematodes of mice

The purpose of the research is studying the efficacy of the phytotherapeutic , and homeopathic drug. Phytotherapeutic drugs have been widely used in parasitology for many years. Also, homeopathic drugs such as Cina have anti-helmintic properties. The possibility of using phytotherapeutic and high dilutions drugs during in the treatment of nematodosis disease has been studied. Two experimental parasitological disease models (aspiculuriosis and trichinelosis) were used. Trichinelosis is a common model of nematodosis of mice [1,2]. Aspiculuris tetraptera a pinworm of mice, is an important parasite in institutions with mice colonies for both research and teaching purposes. The infection is generally asymptomatic. This study aimed at to assess the protective efficiency of homeopathic drug such as Cina C6cH, sphagnum and its complex against experimental trichinosis and aspiculuriosis .&#x0D; An assay was carried out on 80 white outbred mice. These were divided into 6 groups of ten mice each. Group 1 and 4 had sphagnum q.s. per os; group 2 and 5 - desoldering dissolved in water Cina C6cH one time a day per os, the group 3 and 6 received complex sphagnum+ Cina C6cH one time a day per os. The groups 1-3 were inoculated with a dose of 80 ± 5 units of T. spiralis larva per mouse, groups 4-6 had spontaneous aspiculuriosis, group 7 had T. spiralis , group 8 had Aspiculuris tetraptera. After 60 days of trichinellosis incubation, process the mice were euthanized and dissected for evaluation. Maximum protection was obtained in the group of mice 3: T. spiralis detected larvae in animals was 650.5±25.1 larva/animal. Group N2 (Cina C6cH) presented 2840.5±183.3 larva/animal. This was less than control group (4485±430.6 larva/mouse). Also groups 4-6 of mice with aspiculuriosis showed 75%, 80% and 86% efficacy against nematodes.