Homeopathic Drugs Research Articles

A Review of Traditional and Modern Approaches in Pharmacovigilance for Hypertension and Kidney Disease Treatments

Pharmacovigilance plays a crucial role in monitoring the safety of herbal, homeopathic, and allopathic drugs, particularly for treatments of hypertension and kidney diseases. The global increase in complementary and alternative medicine use alongside conventional therapies necessitates a thorough understanding of potential interactions and side effects. Current pharmacovigilance systems for herbal and homeopathic remedies face unique challenges compared to established allopathic drug monitoring processes. Recent research on allergic reactions to these diverse therapeutic approaches reveals varying prevalence, mechanisms, and clinical implications. Regulatory frameworks governing these treatment modalities differ across countries, highlighting the need for harmonized international standards. Emerging technologies, including artificial intelligence and big data analytics, show promise in enhancing adverse drug reaction (ADR) detection and prevention. Integration of findings from multiple disciplines provides healthcare professionals, researchers, and policymakers with insights into ensuring safe use of herbal, homeopathic, and allopathic drugs in managing hypertension and kidney diseases. This review summarizes current knowledge, identifies research gaps, and proposes future directions for improving pharmacovigilance across these diverse therapeutic approaches

Evaluation of Homoeopathic Drugs against Sclerotium rolfsii Sacc. in Groundnut (Arachis hypogea L.)

Evaluation of Homoeopathic Drugs against Sclerotium rolfsii Sacc. in Groundnut (Arachis hypogea L.)

Argemone Mexicana is a Plant with Anti-Cancer & Anti-Inflammatory Properties. A Review of its Traditional uses & Scientific Evidence

Argemonea Mexicana, generally known as the Mexican prickly poppy of the family Papavaraceae, is a plant that's well known for its medicinal quality. The plant is set up in tropical regions and is used in Ayurvedic, Unani, Siddha and Homeopathic drug practies, Each part of the plant contains bioactive composites that help in treating a variety of affections similar as' HIV', malaria, ringworm infection, fungal Infections & cancer. The plant has been studied in vivo & in vitro the results have been positive. The Plant also contains composites like berberine, argemonine & protopine, which are known for their restorative action. It's considerably used traditionally for the treatment of multitudinous conditions.Aregmone Mexicana is reported to have antimicrobial exertion, crack mending capacity in rats, larvicidal and chemosterilant exertion, and Nematicidal & allelopathic eventuality. In Mexico Infusion of the upstanding part of the plant is used as hypoglycemic. Chemical disquisition of the plant has revealed the presence of alkaloids, amino acids, phenolics, & adipose acids. The upstanding corridor of the plant contain" Isoquinoline" and" Benzylisoquinoline ” alkaloids. Medicinal plant are extensively used in the treatment of habitual conditions, metabolic conditions, and cancer. Argemone Mexicana L.(A. mexicana), substantially set up in the remains of Marathwada( Maharashtra, India), has been used in the treatment of speech diseases. In this research, cold water, and methanolic extricates were arranged from the Argemone mexicana stem and taken off. These extricates were tried for their antifungal and anticancer exercises. The antifungal action was tried exercising the Agar well dispersion strategy, whereas the anticancer motion against eternalized cell lines was examined by the Erythrosin blue experiment.

ВОЗМОЖНОСТИ ТЕРАПИИ КАШЛЯ У ДЕТЕЙ

Acute respiratory infections (ARI) are the main reason for morbidity in childhood. In ca. 90% of cases, they are accompanied by cough. The purpose of this research was to study the effectiveness and safety of the STODAL® drug in the treatment of cough in children. Materials and methods used: a multicenter prospective observational non-randomized clinical study was conducted involving 1000 outpatients with ARI aged 2 to 7 y/o and whose cough duration did not exceed 3 days from the onset of the disease. All of them were prescribed and treated with the complex homeopathic anticough drug on the day of their visit to pediatric practitioner in the outpatient hospital facilities. The patients were divided into two age groups as follows: G1 (n=500) of children aged 2 to 4 y/o and G2 (n=500) of children aged 4 years and 1 day old to 7 y/o. Results: on the 7th day of the therapy, a statistically significant decrease in the severity of daytime cough was noted: in G1 the severity of cough decreased by 1.51 points (from 2.16 to 0.65 points, p<0.001) and by 1.56 points (from 2.24 to 0.68 points, p<0.001) in G2. There was no difference in the reduction in daytime cough severity between the groups (p=0.158). The severity of night cough in G1 decreased by 1.16 points (from 1.64 to 0.48 points, p<0.001) and by 1.25 points (from 1.71 to 0.46 points, p<0.001) in G2. There were no differences in the dynamics of the severity of night cough between the groups as well (p=0.135). The proportion of patients whose cough resolved completely or became clinically insignificant on the 7th day of treatment was 98%, these patients were therefore considered recovered. Cough treatment was rated positively by 95.1% of parents/caretakers. Adverse events (AEs) were reported in 5 patients (0.5% of all cases) and there were no serious AEs among them. Conclusion: the effectiveness and safety of the STODAL® drug in the treatment of cough in ARI in children aged 2 to 7 y/o allows recommending a homeopathic drug with complex anti-inflammatory, antitussive and antimicrobial action for its inclusion in the treatment regimens starting from the first days of the disease.

Evaluation of Anti-Cancer Potential of Homeopathic Medicines by In-Vitro Study on Human Breast, Lung and Colorectal Cancer Cells

The purpose of this study is to assess the cytotoxic effects of homoeopathic drugs on cancer cell lines by In-vitro experiment. Background: Homoeopathy is a renowned therapeutic approach in many nations across the world. However, the approach has sparked much scientific discussion concerning its efficacy and methods of action. This is particularly true when it comes to the application of homeopathy in cancer treatment. Objective: The purpose of this study was to evaluate the cytotoxic effect of homoeopathic remedies on cancer cells and to emphasise the therapeutic effects of 50 Millesimal potencies. Materials & Methods: Carcinosinum, Conium maculatum, and Asterias rubens were the drugs used in 0/1 potency against the MCF 7 breast cancer cell line. Carcinosinum, Nitric acid, and Ruta were the drugs in 0/1 potency used against the HCT 116 colorectal cancer cell line and the NCI-H460 lung cancer cell line. 90% alcohol medicated on poppy-sized globules, dried fully and used as a control for all cell lines. The cytotoxicity has been assessed using the standard MTT test. Results: The LC50 values of the medicines tested on breast and lung cancer cells were not obtained up to 40000 ppm concentrations, as a result, cytotoxicity evaluation was not possible. The LC50 values of the medicines tested on Colo-rectal cancer cells were obtained around 20,000 ppm concentration and showed a gradual increase in Cell Death with increasing Concentration of exposure of the drugs. As a result, these drugs revealed cytotoxic qualities as well as anti-cancer actions. Conclusion: Despite the objective facts, we cannot reach a definite conclusion about the anti-cancer effectiveness of these drugs in vitro because several aspects of homeopathy's action are unlikely to be replicated in In-vitro study. Determination of reasons for the same or understanding the molecular mechanism of resistance of the cell lines to the cytotoxic effects of the drugs were not within the purview of the study and these can be addressed in future studies. Keywords: Homeopathy, Cancer, MCF-7, HCT 116, NCI-H 460, In-Vitro, Carcinosinum, Conium maculatum, Asteria rubens, Ruta graveolens, Nitric acid, 50 Millesimal Potency, MTT Assay.

Plant Sources of Formulated Homoeopathic Drugs

A survey was conducted in the homoeopathic pharmacies in Chennai to study the plant sources of formulated homoeopathic drugs that are common and popularly sold in commercial outlets. This study deals with 127 homoeopathic medicinal plants that are used in various formulated preparations such as cosmetics, drops, oils, ointments, powders, tablets and tonics. Medicinal plants that are exclusively used as mother tinctures diluted and prescribed by homoeopathic practitioners for treatment are excluded. Many practitioners of homoeopathic system prescribe formulated drugs manufactured by the pharmaceutical companies that specialize in homoeopathic drugs. Another survey was conducted to explore the most frequent prescriptions given by the homoeopathic practitioners in Tamil Nadu. Plant sources of these prescriptions are studied. It is found that 34 of these plant sources are commonly used as ingredients in many formulated drugs sold in the commercial outlets.

Improving the complex therapy of dysphonia in respiratory infections and SARS-COV-2

Significantly aggravating the clinical course and negatively affecting the quality of life of patients, voice disorders in acute respiratory viral infection (ARVI) and SARS-CoV-2 require correction of treatment. Aim. To determine the effectiveness of Homeovox® in the complex therapy of dysfunctions in patients with respiratory infections and SARS-CoV-2 Materials and methods. The clinical study was conducted by a single-stage observational method, without intervention, at the clinical base of the Department of Otorhinolaryngology of the South Ural State Medical University in the period 2022–2023. The results of a study of 45 patients who suffered from acute respiratory and coronavirus infection SARS-CoV-2, accompanied by dysphonia, are presented. Results. There was a significant difference in the results of conservative treatment of patients previously divided into 2 groups according to the study design. Thus, in the second group (n=22), in addition to medical and economic standards, who received a multicomponent homeopathic medicine in accordance with the instructions, earlier recovery periods and statistically reliable restoration of vocal function were established until complete restoration of vocal function. Standard medical and economical therapy of patients of the first (n=23) and second groups included: administration of antiviral and antihistamines, local decongestants, irrigation therapy, symptomatic treatment. Conclusion. The assessment of dysphonia on three scales: the VASH scale, the Wilson Yanagihara scale and the GRBAS classification of voice disorders confirmed the restoration of voice function and recovery at an earlier date in patients who additionally took a homeopathic drug

Acute, subacute, repeat dose toxicity and safety studies of BiosimCovex (COVID-19 Nosode) in animal model

Introduction: BiosimCovex, a coronavirus nosode’s biological preparation was sourced from preclinical samples. The study needs to investigate the acute, subacute oral toxicity of different homeopathic drugs. The acute, subacute, repeat dose toxicity and safety testing of this newly developed nosode were conducted as per the OECD and New Drug and Clinical Trial (NDCT 19) rules. Material and methods In acute, subacute, repeat dose toxicity study, the homeopathic drug was administered orally at body weight, and animals were observed for toxic symptoms for 14 days. The study design consisted of 10 animals (05 males and 05 females) in acute mice and rats, 48 animals (24 males and 24 females) in subacute/repeat dose rats, and 24 (12 males/12 females) in repeat dose rabbit studies. Results Results indicate that in the acute and subacute studies of the rat and mice, no mortalities or clinical signs were found. The body weight and body weight gain in rats were normal and decreased in mice in the acute study. The feed consumption was normal for rats and mice. In male rabbits’ body weight was decreased and in other groups body weight gain observed was normal. The clinical signs were found to be normal in rats and rabbits. Histopathology results reveal that the BiosimCovex has not produced any major reactive and toxic changes in all the systemic organs when administered by an oral route up to a high dose. Conclusion No toxicity was documented using acute, subacute, and repeat dose studies using BiosimCovex, a coronavirus nosode.

ВОССТАНОВИТЕЛЬНЫЕ ВОЗМОЖНОСТИ ПРИМЕНЕНИЯ ЭЛЕКТРО - И ФАРМАКОПУНКТУРЫ ПРИ ЛЕЧЕНИИ ПЕРИФЕРИЧЕСКОЙ НЕВРОПАТИИ ЛИЦЕВОГО НЕРВА В ОТДАЛЕННОМ ПЕРИОДЕ

The possibilities of using electropuncture and pharmacopuncture methods with homeopathic and al-lopathic drugs for the treatment of patients in the long-term period of development of peripheral neu-ropathies of the facial nerve are described. The effectiveness of the treatment was assessed, and its implementation in neurological rehabilitation practice was recommended

Establishing the Results of Homoeopathic Prescription through a Case Report of Vitiligo

A common hypo- pigmentation disorder with acquired autoimmune origins, vitiligo can have major psychological effects. According to the distribution of skin depigmentation, vitiligo has been classified into segmental and non-segmental kinds. Case Summary: A 16-year-old male patient complained of a white patch on his scalp, eye, back, and throat that had been there for 2-2.5 years. The diagnosis of miasm and the totality of symptoms led to the prescription of the homoeopathic drug Syphilinum.

A Retrospective Study on the Effectiveness of Sulphur in Lm Potency for Dermatitis in Paediatrics Age Group

Context: Children with dermatitis often complain of eczema, neurodermatitis, stasis dermatitis, atopic dermatitis, and seborrheic dermatitis, among other conditions. The purpose of the study is to determine the effectiveness of sulfur LM potency for dermatitis complaints in the pediatric age group and to emphasize the incidence of dermatitis in children. Thirty instances of dermatitis treated with sulfur LM potency were selected from the pediatric age category and gathered from Sarada Krishna Homoeopathic Medical College's in-patient and outpatient departments in Kulasekharam. According to this study, dermatitis is more common in children aged 1 to 5; 19 cases showed a significant improvement, and 22 cases improved during follow-up visits. Ten cases have impacted females and twenty cases have affected males. Kids more people with lower socioeconomic status have been impacted. Based on the study, homoeopathic drugs may be more effective in treating cases of dermatitis. With the right dosage of the medication, more over half of them 22 patients could feel better. Eight patients' conditions have persisted, and two patients' conditions have gotten worse. This outcome is consistent with a clinical investigation that found that, out of 30 instances, 10 patients were male and that homoeopathic drugs were effective in treating dermatitis in youngsters.

A prospective comparative study of the intraoperative difficulties during laparoscopic cholecystectomy in patients taking homeopathic medications for cholelithiasis versus cholelithiasis patients with no history of homeopathic medication

Background: Gallstone disease is one of the most prevalent gastrointestinal diseases with a substantial burden to health-care systems. Patients present with right upper quadrant pain, dyspepsia, nausea or vomiting. Owing to the side effects of allopathic drugs, many patients resort to homeopathic treatment for relief of pain. There are several homeopathic drugs that decrease the pain of cholecystitis as well as high cholesterol in these patients but cannot cure them off the disease. Finally, they come to general surgeon for cholecystectomy. We have noticed that performing laparoscopic cholecystectomy (LC) in these patients is difficult and time consuming. Aims and Objectives: To determine whether or not homeopathic medicine intake for treatment of cholelithiasis act as an independent factor that leads to intraoperative difficulties during LC. Materials and Methods: Study design: A prospective randomized comparative study. Study period: July 2022–December 2023 (18 months). Study groups: Group H = Patients with history of (H/O) intake of homeopathic medicines for treatment of cholelithiasis = 60 patients, Group N = Patients with no H/O homeopathic medicine intake = 60 patients. Results: Twenty-six (43.33%) patients in Group H and 11 (18.33%) patients in Group N had a difficult LC. 7 (11.67%) patients in Group H and 1 (1.67%) patient in Group N had dense adhesions around the gallbladder (GB). 13 (21.67%) patients of Group H and 3 (5%) patients of Group N had a Frozen Calot’s Triangle (fibrosis and difficult Calot’s triangle dissection). This was statistically significant. Conclusion: Our study proved that intake of homeopathic medications for the treatment of cholelithiasis leads to dense adhesions around GB as well as fibrotic adhesions leading to difficult Calot’s triangle dissection leading to a difficult LC.

Role of Drug Remedies in Attention Deficit Hyperactivity Disorder (ADHD): A Case Series

Introduction: ADHD is the most common neurobe havioral disorder in children which comprises of 3 types: inattentive/hyperactive-impulsive/combined type. There are varied drugs in homoeopathy belong ing to narcotic groups which seems to be effective in these type of cases. These groups have various alka loids whose main sphere of action is on CNS or PNS as stimulant, depressor or hypnotic. Case summary: Here, 3 cases are presented with different types of ADHD as diagnosed by Vanderbilt Diagnostic Scale. In all these cases homoeopathic drug remedies were prescribed on the basis of totality of symptoms. Marked improvement in all the cases substantiate the effectiveness of homoeopathy especially drug remedies in these type of behavioural problems when given constitutionally.

USAGE OF HOMEOPATHIC TREATMENTS FOR PLANT PATHOGEN CONTROL, AN OVERVIEW OF THE HISTORY AND TRENDS: A COMPREHENSIVE REVIEW

The extensive use of synthetic chemical fertilizers in agriculture is causing environmental problem. In this situation it is desirable to find out suitable agents, which would increase plant growth without compromising with the quality of food and of soil. This paper represents the history and trends of homeopathic drugs utilized in the control of plant pathogens in plant pathology. This method started with the pioneering work of kolisko in 1923 on wheat germination and Junker in 1928 on growth of microorganisms. Literature search on the Homeopathic drugs in the control of plant pathogens, which have shown the anti-fungal, anti-viral, anti-bacterial properties have been reviewed in this present paper. From the literature during the present study the different homeopathic drugs were found were used in agriculture. The contents of the article cover all the scientific reports published in Agricultural sectorfrom 1966 to till dates. A total 120 papers have been reported from homeopathic treatments used in Agriculture. Amongst these Arsenicum album, Natrum muriaticum, Cina, Thujawere found as the most used compounds. The science of homeopathy has great potentials and could give a new direction that requires attention of the researchers in alternative agriculture. This review discusses the experimental evidence relating to the use of homeopathic drugs in plant pathology, with view to assess the potential of homeopathy in agriculture.

A Concise review on management of Type 2 Diabetes Mellitus with Homoeopathic drugs

A Concise review on management of Type 2 Diabetes Mellitus with Homoeopathic drugs

RETRACTED ARTICLE: Arsenic album 30C exhibits crystalline nano structure of arsenic trioxide and modulates innate immune markers in murine macrophage cell lines

Macrophages are associated with innate immune response and M1-polarized macrophages exhibit pro-inflammatory functions. Nanoparticles of natural or synthetic compounds are potential triggers of innate immunity. As2O3 is the major component of the homeopathic drug, Arsenic album 30C.This has been claimed to have immune-boosting activities, however, has not been validated experimentally. Here we elucidated the underlying mechanism of Ars. alb 30C-mediated immune priming in murine macrophage cell line. Transmission Electron Microscopy (TEM) and X-ray diffraction (XRD) used for the structural analysis of the drug reveals the presence of crystalline As2O3 nanoparticles of cubic structure. Similarly, signatures of M1-macrophage polarization were observed by surface enhanced Raman scattering (SERS) in RAW 264.7 cells with concomitant over expression of M1 cell surface marker, CD80 and transcription factor, NF-κB, respectively. We also observed a significant increase in pro-inflammatory cytokines like iNOS, TNF-α, IL-6, and COX-2 expression with unaltered ROS and apoptosis in drug-treated cells. Enhanced expression of Toll-like receptors 3 and 7 were observed both in transcriptional and translational levels after the drug treatment. In sum, our findings for the first time indicated the presence of crystalline As2O3 cubic nanostructure in Ars. alb 30C which facilitates modulation of innate immunity by activating macrophage polarization.

Role of inductive and deductive logic in the discovery of different action of a homoeopathic drug or a new drug in homoeopathy

Role of inductive and deductive logic in the discovery of different action of a homoeopathic drug or a new drug in homoeopathy

Homeopathic preparation of Allium sativum abrogates OxLDL mediated atherogenic events in macrophages: An invitro and in silico approach

BackgroundOxidized LDL (OxLDL), the key player in atherogenesis modulates endothelial dysfunction, initiates monocyte recruitment, accentuates foam cell formation, and flares up inflammatory and apoptotic events. Even though homeopathic preparation of Allium sativum has been proved to be an anti-inflammatory, anti-apoptotic and anti-atherogenic agent, its mechanism of action on abrogating OxLDL mediated foam cell formation is yet to be explored. ObjectiveThis study was designed to bring out the role of homeopathic preparation of Allium sativum in curbing OxLDL mediated cellular inflammation in IC-21 cells exposed with OxLDL. Materials and methodsOxLDL was used to induce oxidative damage in the IC-21 macrophage cells. Assessment of inflammatory cytokines, localization of NFκB, detection of apoptosis and the in silico analysis were performed in this study. ResultsThe current study portrays the efficacy of homeopathy medicine as an anti-inflammatory agent, in reducing the levels of inflammatory cytokines and its mRNA expression, suppressing the activity of NFκB and preventing apoptosis in OxLDL treated IC-21 cells. ConclusionTo conclude, homeopathic preparation of Allium sativum 6C and 30C potencies are capable of controlling the transcriptional activity of NFκB and apoptosis in IC-21 cells exposed to OxLDL. These results implicate that Allium sativum homeopathic drug can be used as anti-inflammatory agent in reducing atherogenic events as it is capable of preventing OxLDL-mediated injury to macrophages.

A Cantharis potency acts on heat exposed bovine serum albumin as revealed by FT-IR spectroscopy

In a series of experiments we have demonstrated that high dilution of homeopathic drugs produces distinct effects on plants and animals in-vivo through the medium of water. High dilutions (HDs) of a drug prepared by serial dilution with a solvent medium 1:100, followed by mechanical agitation in several steps are called potencies. Water molecules play an important role on protein structure and function. We focused our observation on water molecules associated with BSA. High dilution (HD) of a homeopathic drug is thought to be specific water structure which produces therapeutic effects on man. HDs also produce effects on animals, plants and even proteins in aqueous solution. What is the primary target of HDs on organisms or on protein? The present study addresses this question. Cantharis 30 cH, a homeopathic potency used for burn injuries, has been tested on bovine serum albumin (BSA) in-vitro. The protein has been exposed to heat at 750C for 10 mins, cooled down to room temperature and then treated with Cantharis 30 cH. The treatment was done by two methods, direct and indirect through water. The results from both the methods are almost similar. The treated and untreated protein solutions were analysed by Fourier Transform Infra-Red (FT-IR) spectroscopy. The treatment effect was evident on water molecules associated with BSA. The results indicate that Cantharis 30 cH interacts with water molecules which in turn influence BSA. It is concluded that the homeopathic potency converts first water structure which then affects the protein. Based on the results on this experiment we can assumes that the primary target of all homeopathic potencies is water which constitutes the major component of all living organisms. All biomolecules are suspended in water.

An Evidence-Based Case Report of Female Infertility Treated with Individualised Homoeopathic Medicine

Abstract Introduction Infertility is defined as the failure to conceive within 1 or more years of regular unprotected coitus. The World Health Organization (WHO) estimates the overall prevalence of primary infertility in India to be between 3.9 and 16.8%. Medical therapy includes the treatment of reversible endocrine or infectious causes of subfertility. In the medical literature, case reports of infertility are scanty. We aimed to report a case treated with homoeopathic constitutional medicine in a lady suffering from infertility. Case summary A female patient, aged 30, married for 6 years, presented with a complaint of having no issue despite treatment of infertility for a couple of years by a reproductive endocrinologist. Subsequent investigations showed that her ovarian reserve was inadequate. She was encouraged to undergo in vitro fertilisation because her husband's semen analysis report was normal. She decided to take homoeopathic treatment and received individualised care based on the holistic tenets of homoeopathy. After 3 months of treatment with the constitutional homoeopathic drug Natrum muriaticum, she became pregnant and gave birth to a healthy boy at term. This case report demonstrates the beneficial effects of individualised homoeopathy on infertility. The Modified Naranjo Criteria score (MONARCH) showed causal attribution of changes in her condition to the homoeopathic treatment.