Holographic Analysis Research Articles

TCT-376 Holographic Mixed Reality Image Analysis vs CT Reconstruction for Assessment of Aortic Valve Complex in Patients Undergoing TAVR

TCT-376 Holographic Mixed Reality Image Analysis vs CT Reconstruction for Assessment of Aortic Valve Complex in Patients Undergoing TAVR

The use of mixed reality technology for the objective assessment of clinical skills: a validation study

BackgroundMixed Reality technology may provide many advantages over traditional teaching methods. Despite its potential, the technology has yet to be used for the formal assessment of clinical competency. This study sought to collect validity evidence and assess the feasibility of using the HoloLens 2 mixed reality headset for the conduct and augmentation of Objective Structured Clinical Examinations (OSCEs).MethodsA prospective cohort study was conducted to compare the assessment of undergraduate medical students undertaking OSCEs via HoloLens 2 live (HLL) and recorded (HLR), and gold-standard in-person (IP) methods. An augmented mixed reality scenario was also assessed.ResultsThirteen undergraduate participants completed a total of 65 OSCE stations. Overall inter-modality correlation was 0.81 (p = 0.01), 0.98 (p = 0.01) and 0.82 (p = 0.01) for IP vs. HLL, HLL vs. HLR and IP vs. HLR respectively. Skill based correlations for IP vs. HLR were assessed for history taking (0.82, p = 0.01), clinical examination (0.81, p = 0.01), procedural (0.88, p = 0.01) and clinical skills (0.92, p = 0.01), and assessment of a virtual mixed reality patient (0.74, p = 0.01). The HoloLens device was deemed to be usable and practical (Standard Usability Scale (SUS) score = 51.5), and the technology was thought to deliver greater flexibility and convenience, and have the potential to expand and enhance assessment opportunities.ConclusionsHoloLens 2 is comparable to traditional in-person examination of undergraduate medical students for both live and recorded assessments, and therefore is a valid and robust method for objectively assessing performance. The technology is in its infancy, and users need to develop confidence in its usability and reliability as an assessment tool. However, the potential to integrate additional functionality including holographic content, automated tracking and data analysis, and to facilitate remote assessment may allow the technology to enhance, expand and standardise examinations across a range of educational contexts.

Generalized proofs of the first law of entanglement entropy

In this paper, we develop generalized proofs of the holographic first law of entanglement entropy using holographic renormalization. These proofs establish the holographic first law for non-normalizable variations of the bulk metric; hence, relaxing the boundary conditions imposed on variations in earlier works. Boundary and counterterm contributions to conserved charges computed via covariant phase space analysis have been explored previously. Here, we discuss in detail how counterterm contributions are treated in the covariant phase approach to proving the first law. Our methodology would be applicable to generalizing other holographic information analyses to wider classes of gravitational backgrounds.

Adulterant Detection in Peppermint Oil by Means of Holographic Photopolymers Based on Composite Materials with Liquid Crystal.

Diffraction gratings are recorded in a holographic photopolymer containing nematic liquid crystal and peppermint oil. The presence of the oil modifies the polymerization and the holographic response. The composite containing oil adulterated with triethyl citrate obtains a diffraction efficiency related to the oil’s purity. The results obtained suggest the possibility of developing a holographic chemical analysis method for quality control of raw materials.

Off-axis electron holography: Materials analysis at atomic resolution

Abstract In high-resolution off-axis electron holography, the correction of coherent aberrations allows the quantitative interpretation of the amplitude and phase of the object wave up to the information limit of the electron microscope. Since the measured object phase is directly related to the projected atomic potential for sufficiently thin samples, off-axis electron holography is expected to allow distinguishing of different elements in the reconstructed phase image (“holographic materials analysis”). This has already been verified with the example of Ga and As. However, simulations of the atomic phase shift reveal that the interpretation of the measured phase shift in terms of atomic species is generally rather complex. The findings suggest that, in some cases, the requirements as to lateral resolution and phase detection limit will be met only by electron microscopes of the next generation.

Electron Mass Is Specified by Five Fundamental Constants, <i>a</i>, <i>ħ</i>, <i>G</i>, Λ, and Ω<sub>Λ</sub>, from Quantum Mechanics and General Relativity

Electron mass has been considered a fundamental constant of nature that cannot be calculated from other constants such as Planck’s constant ħ and gravitational constant G. In contrast, holographic analysis takes account of the finite amount of information available to describe the universe and specifies electron mass to six significant figures in terms of five fundamental constants: fine structure constant a, ħ , G, cosmological constant Λ, and vacuum fraction ΩΛ of critical density. A holographic analysis accounts for charge conservation, mass quantization, and baryon/antibaryon ratio. A holographic analysis relates electromagnetism and gravitation, specifies electron Compton wavelength in terms of Planck length and cosmological event horizon radius, and has implications for charged Standard Model fermion masses, minimum stellar mass at redshift z, and use of continuum mathematics in a discontinuous universe.

55 Years of Holographic Non-Destructive Testing and Experimental Stress Analysis: Is there still Progress to be expected?

Holographic methods for non-destructive testing, shape measurement, and experimental stress analysis have shown to be versatile tools for the solution of many inspection problems. Their main advantages are the non-contact nature, the non-destructive and areal working principle, the fast response, high sensitivity, resolution and precision. In contrast to conventional optical techniques such as classical interferometry, the holographic principle of wavefront storage and reconstruction makes it possible to investigate objects with rough surfaces. Consequently, the response of various classes of products on operational or artificial load can be examined very elegantly. The paper looks back to the history of holographic metrology, honors the inventors of the main principles, discusses criteria for the selection of a proper inspection method, and shows exemplary applications. However, the main focus is on modern developments that are inspired by the rapid technological process in sensing technology and digitization, on current applications and future challenges.

Integrated self-referencing single shot digital holographic microscope and optical tweezer

Digital holographic microscopy is a single-shot technique for quantitative phase imaging of samples, yielding thickness profiles of phase objects. It provides sample features based on their morphology, leading to their classification and identification. However, observing samples, especially cells, in fluids using holographic microscopes is difficult without immobilizing the object. Optical tweezers can be used for sample immobilization in fluids. The present manuscript provides an overview of our ongoing work on the development of a compact, low-cost microscopy system for digital holographic imaging of optically trapped samples. Integration of digital holographic microscopy system with tweezers is realized by using the optical pickup unit extracted from DVD burners to trap microsamples, which are then holographically imaged using a highly compact self-referencing interferometer along with a low-cost, in-house developed quadrant photodiode, providing morphological and spectral information of trapped particles. The developed integrated module was tested using polystyrene microspheres as well as human erythrocytes. The investigated system offers a multitude of sample features, including physical and mechanical parameters and corner frequency information of the sample. These features were used for sample classification. The proposed technique has vast potential in opening up new avenues for low-cost, digital holographic imaging and analysis of immobilized samples in fluids and their classification.

On the Geometric Approach to the Boundary Problem in Supergravity

We review the geometric superspace approach to the boundary problem in supergravity, retracing the geometric construction of four-dimensional supergravity Lagrangians in the presence of a non-trivial boundary of spacetime. We first focus on pure N=1 and N=2 theories with negative cosmological constant. Here, the supersymmetry invariance of the action requires the addition of topological (boundary) contributions which generalize at the supersymmetric level the Euler-Gauss-Bonnet term. Moreover, one finds that the boundary values of the super field-strengths are dynamically fixed to constant values, corresponding to the vanishing of the OSp(N|4)-covariant supercurvatures at the boundary. We then consider the case of vanishing cosmological constant where, in the presence of a non-trivial boundary, the inclusion of boundary terms involving additional fields, which behave as auxiliary fields for the bulk theory, allows to restore supersymmetry. In all the cases listed above, the full, supersymmetric Lagrangian can be recast in a MacDowell-Mansouri(-like) form. We then report on the application of the results to specific problems regarding cases where the boundary is located asymptotically, relevant for a holographic analysis.

Holographic and QFT complexity with angular momentum

We study the influence of angular momentum on quantum complexity for CFT states holographically dual to rotating black holes. Using the holographic complexity=action (CA) and complexity=volume (CV) proposals, we study the full time dependence of complexity and the complexity of formation for two dimensional states dual to rotating BTZ. The obtained results and their dependence on angular momentum turn out to be analogous to those of charged states dual to Reissner-Nordström AdS black holes. For CA, our computation carefully accounts for the counterterm in the gravity action, which was not included in previous analysis in the literature. This affects the complexity early time dependence and its effect becomes negligible close to extremality. In the grand canonical ensemble, the CA and CV complexity of formation are linear in the temperature, and diverge with the same structure in the speed of light angular velocity limit. For CA the inclusion of the counterterm is crucial for both effects. We also address the problem of studying holographic complexity for higher dimensional rotating black holes, focusing on the four dimensional Kerr-AdS case. Carefully taking into account all ingredients, we show that the late time limit of the CA growth rate saturates the expected bound, and find the CV complexity of formation of large black holes diverges in the critical angular velocity limit. Our holographic analysis is complemented by the study of circuit complexity in a two dimensional free scalar model for a thermofield double (TFD) state with angular momentum. We show how this can be given a description in terms of non-rotating TFD states introducing mode-by-mode effective temperatures and times. We comment on the similarities and differences of the holographic and QFT complexity results.

Preliminary Validation of Surface Reflections from Fengyun-3C Radio Occultation Data

Fengyun-3C (FY-3C) is a Global Navigation Satellite Systems (GNSS) Radio Occultation (RO) mission founded which was by China on 23 September 2013. In this study, under a specific temporal and spatial domain, we systematically compare FY-3C refractivity profiles with Constellation Observing System for Meteorology Ionosphere and Climate (COSMIC) refractivity profiles for the year 2015. The COSMIC profiles used in this study contain reflections, as identified in the Radio Occultation Meteorology Satellite Application Facility (ROM SAF) flag database. From 0 to 25 km altitude, the mean biases and relative standard deviations of the comparisons between FY-3C and COSMIC are less than 1% and 2% when COSMIC profiles present reflected signals. Radio holographic analysis is used to visualize and identify the spectra of FY-3C-reflected signals in the time-frequency domain. It is confirmed that the reflected signals in the lower troposphere and near the surface can be tracked by an FY-3C receiver. Further, most of the FY-3C events that matched with COSMIC reflected events show reflection patterns at a lower height, especially above the ocean’s surface. Under Bouguer’s rule and spherical symmetry assumptions, we reconstructed the reflected bending angle models by Abel transformation, which are valuable for reducing N-bias in the ducting layer. Three examples of FY-3C events show that the reflected bending branch is near the surface. Overall, the reflected signal of FY-3C could be used as a supplementary data portion for FY-3C atmospheric products.

A digital holography ex situ measurement characterization of plasma-exposed surface erosion from an electrothermal arc source.

Digital holography has been proposed to fulfill a need for an imaging diagnostic capable of in situ monitoring of surface erosion caused by plasma-material interaction in nuclear fusion devices. A digital holography diagnostic for 3D surface erosion measurement has been developed at Oak Ridge National Laboratory with the goal of deployment on a plasma device. A proof-of-concept in situ demonstration is planned which would involve measurement of plasma erosion on targets exposed to an electrothermal arc source. This work presents the results of an ex situ characterization of the capability and limitations of holographic imaging of targets exposed to the arc source. Targets were designed to provide a fiducial for comparison of deformed and unaffected areas. The results indicated that the average net erosion was ∼150 nm/plasma exposure, which is expected to be within the diagnostic's measurement capacity. Surface roughness averages determined by holographic image analysis showed good agreement with measurements taken with a profilometer. The limit of the holography diagnostic's x-y spatial resolution was characterized by comparison with scanning electron microscope imaging.

Guiding mechanism of platycodin D in treatment of mouse lung cancer with doxorubicin

This study is to observe whether platycodin D has the guiding role in treatment of mouse lung cancer with doxorubicin and explore its guiding mechanism. In vitro, platycodin D and doxorubicin(alone or in combination) were added into Lewis lung cancer(LLC) cells to detect the cell proliferation and doxorubicin uptake. Cell morphological changes were analyzed by cell holographic analysis system; cell gap junctional intercellular communication(GJIC) was tested by fluorescent yellow tracer; lyso-tracker red was used to examine lysosomal function; LC-3 B(Light chain 3 beta)and P62(heat shock 90-like protein)staining were used to test auto-phagy and autophagic degradation respectively; and P-glycoprotein(P-gp) expression was examined by Western blot. In vivo, lung solid tumor was formed in mouse LLC cells via intravenous injection. Platycodin D and doxorubicin(alone or in combination) were used to treat tumor-bearing mice for four weeks, and then the tumor size was examined, mouse survival time was recorded, doxorubicin uptake in lung tissues was tested, and lung tissues were stained for observation by HE(hematoxylin-eosin) and immunohistochemistry. The results showed that platycodin D at the experimental concentration had no effect on LLC cell proliferation but decreased LLC cell volume, promoted the cells to uptake doxorubicin and enhanced the inhibitory action of doxorubicin on cell proliferation. Platycodin D could promote GJIC and lysosomal function, increase autophagy and autophagic degradation and suppress P-gp expression. Platycodin D at the experimental dose in this study had no effect on LLC lung solid tumors in mice, increased doxorubicin uptake in lung tissues and enhanced the therapeutic efficacy of doxorubicin on lung solid tumors. Platycodin D could improve the extracellular matrix deposition in lung solid tumors, decreased the lung mucin 5 AC secretion and pulmonary vessel permeability. In summary, platycodin D had the guiding role in treating mouse lung cancer with doxorubicin, and its guiding mechanism may be associated with the promotion of cell communication, lysosomal function, and improvement of extracellular environment.

Entanglement measures for nonconformal D-branes

We study various entanglement measures associated with certain non-conformal field theories. We consider non-conformal D$p$-brane backgrounds, which are dual to these field theories, for our holographic analysis. Restricting our interests in $p=1,2,4$, we explicitly compute properties of holographic entanglement entropy and entanglement wedge cross section, $\text{E}_{W}$, corresponding to two parallel strip shaped boundary subregions in these set ups. We study low and high temperature behaviours of these quantities analytically as well as using numerical methods. In all cases, the $\text{E}_{W}$ decrease monotonically with temperature. We observe discontinuous jumps in $\text{E}_{W}$ while the width of (as well as the separation between) the subregions reach critical values in all the cases considered. However, the corresponding holographic mutual information $\texttt{I}_{M}$ continuously decreases to zero for the aforementioned configurations. We also notice that the conjectured inequality $\text{E}_{W} \geq \texttt{I}_{M}/2$ still holds for non-conformal field theories as well. We analytically determine the critical separation between these subregions that triggers a phase transition in the holographic mutual information.

Accurate real-time monitoring of high particulate matter concentration based on holographic speckles and deep learning

Accurate real-time monitoring of particulate matter (PM) has emerged as a global issue due to the hazardous effects of PM on public health and industry. However, conventional PM monitoring techniques are usually cumbersome and require expensive equipments. In this study, Holo-SpeckleNet is proposed as a fast and accurate PM concentration measurement technique with high throughput using a deep learning based holographic speckle pattern analysis. Speckle pattern datasets of PMs for a wide range of PM concentrations were acquired by using a digital in-line holography microscopy system. Deep autoencoder and regression algorithms were trained with the captured speckle pattern datasets to directly measure PM concentration from speckle pattern images without any air intake device and time-consuming post image processing. The proposed technique was applied to predict various PM concentrations using the test datasets, optimize hyperparameters, and compare its performance with a convolutional neural network (CNN) algorithm. As a result, high PM concentration values can be measured over air quality index of 150, above which human exposure is unhealthy. In addition, the proposed technique exhibits higher measurement accuracy and less overfitting than the CNN with a relative error of 7.46 ± 3.92%. It can be applied to design a compact air quality monitoring device for highly accurate and real-time measurement of PM concentrations under hazardous environment, such as factories or construction sites.

The history of holographic vibration analysis

This paper describes the evolution of holographic vibration analysis from its discovery in 1964 to its present form as a technique of digital holography. The speckle interferometer is discussed as a replacement for real-time holographic interferograms and electronic speckle pattern interferometry (ESPI) as the precursor to digital holography. The development of methods for converting vibratory (Jo) fringe patterns into numerical data is discussed along with applications to Modal Assurance Criteria (MAC) calculations. Finally, an application is presented for vibratory strain measurement in one dimension.

Euclidean black saddles and AdS4 black holes

We find new asymptotically locally AdS4 Euclidean supersymmetric solutions of the STU model in four-dimensional gauged supergravity. These “black saddles” have an S1× {Sigma}_{mathfrak{g}} boundary at asymptotic infinity and cap off smoothly in the interior. The solutions can be uplifted to eleven dimensions and are holographically dual to the topologically twisted ABJM theory on S1× {Sigma}_{mathfrak{g}} . We show explicitly that the on-shell action of the black saddle solutions agrees exactly with the topologically twisted index of the ABJM theory in the planar limit for general values of the magnetic fluxes, flavor fugacities, and real masses. This agreement relies on a careful holographic renormalization analysis combined with a novel UV/IR holographic relation between supergravity parameters and field theory sources. The Euclidean black saddle solution space contains special points that can be Wick-rotated to regular Lorentzian supergravity backgrounds that correspond to the well-known supersymmetric dyonic AdS4 black holes in the STU model.

High temperature behavior of non-local observables in boosted strongly coupled plasma: a holographic study

In this work, we perform a holographic analysis to study non local observables associated to a uniformly boosted strongly coupled large N thermal plasma in d-dimensions. In order to accomplish the holographic analysis, the appropriate dual bulk theory turns out to be d+1 dimensional boosted AdS-Schwarzschild blackhole background. In particular, we compute entanglement entropy of the boosted plasma at high temperature living inside a strip geometry with entangling width l in the boundary at a particular instant of time. We also study the two-point correlators in the boundary by following geodesic approximation method. For analyzing the effect of boosting on the thermal plasma and correspondingly on both non local observables, we keep the alignment of the width of region of interest both parallel and perpendicular to the direction of the boost. We find our results significantly modified compared to those in un-boosted plasma up to the quadratic order of the boost velocity v. More interestingly, the relative orientation of the boost and the entangling width play a crucial role to quantify the holographic entanglement entropy in the boundary theory. The breaking of rotational symmetry in the boundary theory due to the boosting of the plasma along a specific flat direction causes this interesting feature.

Digital holographic interferometry investigation of liquid hydrocarbon vapor cloud above a circular well.

The current study investigates evaporation of liquid hydrocarbons from a circular well cavity of small depth. Gravimetric analysis is performed to measure the evaporation rate and digital holographic interferometry is used for the measurement of normalized mole fraction profile inside the vapor cloud above the well. Phase unwrapping has been implemented to obtain continuous phase distribution in the image plane. The Fourier-Hankel tomographic inversion algorithm is implemented to obtain the refractive index change distribution inside the object plane, i.e., vapor cloud. Four liquid hydrocarbons, i.e., pentane, hexane, cyclohexane, and heptane, are studied. The radius of circular well cavities is varied in the range of 1.5 to 12.5 mm. Results using a quasi-steady, diffusion-controlled model are compared with the experimental evaporation rate. Measured evaporation rates are higher than the diffusion-limited model calculation for all working fluids and well sizes. This difference is attributed to natural convection occurring inside the vapor cloud due to the density difference between the gas-vapor mixture and the surrounding air. Holographic analysis confirms the presence of natural convection by revealing the formation of a flat disk-shaped vapor cloud above the well surface. Experimentally obtained vapor cloud shape is different from the hemispherical vapor cloud obtained using the pure diffusion-limited evaporation model. The gradient of vapor mole fraction at the liquid-vapor interface is higher compared to that of the diffusion-limited model because of the additional transport mechanism due to natural convection. Transient analysis of the vapor cloud reveals time invariant overall shape of the vapor cloud with a reduction in average magnitude of vapor concentration inside the vapor cloud during evaporation. The existing correlation for sessile droplet cannot successfully predict the evaporation rate from a liquid well. A new correlation is proposed for evaporation rate prediction, which can predict the evaporation rate within a root mean square error of 5.6% for a broad size range of well cavity.

Quantitative Differentiation of Protein Aggregates From Other Subvisible Particles in Viscous Mixtures Through Holographic Characterization

We demonstrate the use of holographic video microscopy to detect individual subvisible particles dispersed in biopharmaceutical formulations and to differentiate them based on material characteristics measured from their holograms. The result of holographic analysis is a precise and accurate measurement of the concentrations and size distributions of multiple classes of subvisible contaminants dispersed in the same product simultaneously. We demonstrate this analytical technique through measurements on model systems consisting of human IgG aggregates in the presence of common contaminants such as silicone oil emulsion droplets and fatty acids. Holographic video microscopy also clearly identifies metal particles and air bubbles. Being able to differentiate and characterize the individual components of such heterogeneous dispersions provides a basis for tracking other factors that influence the stability of protein formulations including handling and degradation of surfactant and other excipients.