The growing demands of supramolecular hyperbranched polymers integrating noncovalent interaction and unique topological structure merits had received considerable interests in the fabrication of novel materials for advanced applications. Herein, we prepared A2B6-type POSS-containing supramolecular hyperbranched polymers with multiple morphologies including lamellar-like, branched, hollow, core-shell and porous spherical structures through regulating self-assembling monomer concentrations and solvent polarities. The incorporation of appropriate emulative guest molecules would further trigger morphological transformations (such as vesicles and spherical micelles) by synergistic effects of unique POSS aggregation ability, supramolecular complexations and hydrophilic-hydrophobic interactions. Thus, this facile and universal strategy may enable a modular nanofabrication of supramolecular hyperbranched polymers with diversiform topological structure and sophisticated multifunctionality for their potential applications.