Holistic Strategy Research Articles

Empowering adolescents living with perinatally-acquired HIV: tailored CD4+ count assessment for optimized care, the EDCTP READY-study.

The elevated rate of AIDS-related mortality in Sub-Saharan Africa among adolescents living with HIV (ALHIV) is influenced by various factors, notably immunosuppression, within a framework of limited therapeutic alternatives. We aimed to enhance the management of pediatric HIV by assessing the immune response and associated factors in perinatally-infected ALHIV on antiretroviral therapy (ART) in Cameroon. A cohort study was conducted from 2018-2020 among 271 ART-experienced ALHIV in Cameroon. Sociodemographic data, immunological (CD4), and virological (plasma viral load, PVL) responses were measured at enrolment (T0), 6-months (T1), and 12-months (T2) using PIMA CD4 (Abbott/Pantech (Pty) Ltd) and Abbott Applied Biosystem platform (Real-Time PCR m2000RT) respectively. Immunological failure (IF) was defined as absolute CD4 < 250 cells/mm3, and Virological failure (VF) as PVL ≥ 1,000 copies/ml. A linear mixed-effects model with R version 4.4.1 was used to estimate both fixed and random effects, with significance set at p < 0.05. Of the 271 perinatally-infected ALHIV enrolled over three phases, females were predominant (55.7, 55.1, and 56.0%); median age was 14 (IQR: 12-17); majority of the participants were followed-up in urban areas (77.5, 74.5, and 78.6%); and the age distribution favored older adolescents (48.7, 61.2, and 58.5%). Most participants achieved clinical success (93.1, 89.7, 88.9%), predominantly on first-line ART (80.8, 66.2, and 53.0%), with good adherence (64.2, 58.9, and 64.5%). Most participants had secondary education (67.2, 70.1, and 67.5%). Median CD4+ counts fluctuated overtime, with values of 563 (IQR: 249.0-845.0), 502 (IQR: 319.0-783.5), and 628 (IQR: 427.5-817.5), respectively. Of note, being male was linked to a reduction in CD4+ count compared to females, [-200.63 (-379.32 to -21.95), p = 0.028]. Similarly, late adolescence was associated with lower CD4+ counts compared to early adolescence, [-181.08 (-301.08 to -61.09), p = 0.003]. Moreover, participants experiencing VF showed significantly lower CD4+ counts compared to those with undetectable viral loads, [-353.08 (-465.81 to -240.36), p < 0.001]. Additionally, there was a marginally significant interaction between male gender and secondary educational level, [209.78 (-6.94-426.51), p = 0.058]. Among perinatally-infected ALHIV, age, gender, educational level, and virological status are key factors influencing their immune health and treatment outcomes. Prioritizing targeted interventions and close monitoring within these subgroups is crucial for optimal management, employing holistic care strategies that consider not only medical interventions but also psychosocial support and education.

THE NEW WORK REVOLUTION: TECH, TELECOMMUTING, AND FLEXIBILITY REWRITE THE RULES

The rapid transformation of workplace dynamics, driven by technological advancements and evolving workforce expectations, has been significantly accelerated by the global COVID-19 pandemic. Telecommuting and workplace flexibility have emerged as critical trends, reshaped traditional organizational structures and influenced employee experiences. This paper explores the intersection of these trends with technological innovations, assessing their implications for organizational success and sustainability. Through a comprehensive analysis of 261 academic publications sourced from the Web of Science Core Collection, this study employs both trend analysis and sentiment analysis to examine the evolving discourse on telecommuting and flexibility. The trend analysis reveals the increasing adoption and prominence of these models in scholarly research, highlighting key moments of growth and decline in publication activity. Sentiment analysis further elucidates the prevailing attitudes towards these trends, uncovering both optimistic perspectives—emphasizing benefits such as enhanced productivity, employee well-being, and work-life balance—and critical views that focus on challenges, including professional isolation, technological dependence, and the erosion of organizational cohesion. The findings demonstrate the dual role of technology as both an enabler and barrier to the successful implementation of flexible work models. The study concludes by discussing the long-term implications of these trends for leadership, organizational culture, and future research, emphasizing the need for holistic strategies that address both the opportunities and challenges posed by telecommuting and workplace flexibility.

Polite Language on Facebook: Maintaining Ethics in Interactions on Social Media

The objective of this study was to examine the present condition of politeness in language usage on Facebook, determine the factors that impact the use of polite language, and suggest approaches to promote civility in digital interactions. Using a qualitative methodology, the data collection process involved analyzing the content of posts and comments from public Facebook pages and groups. Additionally, semi-structured interviews were conducted with users to gather their personal experiences and perceptions. Our analysis of the content uncovered notable disparities in the levels of politeness observed. Community-oriented groups demonstrated elevated levels of politeness, likely attributed to their shared interests and established norms. Conversely, discussions centered around political matters were more susceptible to impoliteness, largely influenced by the anonymity of participants and the intensity of emotions involved. Interviews emphasized the significance of cultural variations, the design features of Facebook, and the crucial role of personal responsibility in upholding politeness. Effective moderation and well-defined guidelines were determined to be essential in handling discourteous conduct. The results highlight the importance of adopting a holistic strategy towards digital communication, encompassing the promotion of cultural sensitivity, the improvement of digital literacy, and the development of ethical platform features. These measures aim to cultivate a more respectful and constructive online environment.

Artificial Intelligence Enabled Supply Chain Management: Unlocking New Opportunities and Challenges

This paper delves deeper into the potential of Artificial Intelligence (AI)-enabled Supply Chain Management (SCM) as a groundbreaking technology capable of revolutionizing supply chain operations and ushering in a new era of possibilities. In today's dynamic business landscape, where agility and efficiency are paramount, AI plays a pivotal role in redefining how supply chains operate. The journey commences with an in-depth exploration of AI's fundamental concepts and its manifold applications within SCM, shedding light on its adaptability across various aspects of the supply chain, from demand forecasting to inventory optimization. Moreover, this paper illuminates the myriad benefits that AI brings to SCM practitioners. These advantages encompass heightened operational efficiency through real-time data analysis, cost reduction through predictive maintenance and optimized routing and a superior customer experience resulting from improved demand prediction and personalized service offerings. However, acknowledging the transformative power of AI in SCM, we must also acknowledge the hurdles in its implementation. This paper underscores the significant challenges that organizations may face while integrating AI into their SCM processes, ranging from data quality issues and concerns regarding privacy and security to the need for domain-specific human expertise. To address these hurdles effectively, the paper proposes a comprehensive framework. This framework encompasses a holistic strategy that aligns AI initiatives with organizational goals, governance and ethics considerations to ensure responsible AI deployment, and a clear roadmap that guides the implementation journey from inception to full integration. In conclusion, this paper offers valuable insights into the opportunities and challenges that AI-powered SCM presents in the ever-evolving business landscape. By providing practical recommendations, it equips organizations with the knowledge and tools needed to successfully harness the potential of AI in their supply chain operations, ultimately paving the way for enhanced competitiveness and sustainability in the future.

Community perception of watershed management as a strategy for food security improvement: Case study of Qersa District, Ethiopia

The importance of community-based watershed management for food security and rural development is increasingly recognized. However, the comprehensive nature of the strategy is not well understood. The study examined the perspectives of different stakeholders and their level of coordination in implementing the watershed approach. Data was collected from 63 individuals with diverse professional backgrounds at different organizational hierarchies and 337 farmers from three different micro watersheds. The findings of the study showed that professionals and farmers have different views. About 36.0% of professionals and 12.6% of farmers see it as a holistic strategy for rural development, 7.0% of professionals and 40.0% of farmers see it as a way to conserve soil and water, and the rest see it as natural resource management. The chi-square test analysis revealed significant correlations between organizational affiliation, hierarchies, work experience, and field of study among professionals at significance levels of 0.05 and 0.01, with no significant differences observed among farmers in the three micro watersheds. The diverse viewpoints of professionals and farmers highlight the inadequate understanding and lack of consensus among stakeholders regarding watershed management principles, hindering the transformation of this strategy into a comprehensive food security initiative. The study also revealed limited collaboration among various organizations and departments in supporting the management of local watersheds, which can be attributed to the lack of accountability. This highlighted the need for improved collaboration and communication among different groups involved in implementing watershed management plans. The study also identified the need for capacity-building to enhance the knowledge and skills of professionals and farmers involved in watershed management. To effectively use the watershed approach as a holistic strategy to address food security, fostering greater coordination and communication among stakeholders, robust institutional arrangement, education, and awareness-creation initiatives must be strengthened at all levels.

The role of transitional probabilities in word holistic processing.

In recent years, increased attention has been devoted to visual word recognition under a perceptual expertise framework. Because the information required to identify words is distributed across the word, a holistic attentional strategy is optimal and develops with experience. It is, however, an open question the extent to which other information embedded in a word may contribute to word holistic processing, namely sublexical word properties. In the present research, we therefore explore the role of sublexical properties-specifically bigram transition probabilities-in this processing strategy. We used a common task in the holistic processing literature (i.e., composite task) and four-letter disyllabic words, where two of the bigrams reinforce the cohesiveness of each syllable and one of the bigrams reinforces the cohesiveness between the syllables. We found preliminary evidence of a role of these sublexical properties in word holistic processing.

Octopus HRD: Multidiciplinary Approach to Higher Education Human Resources Development

This study examines human resource development techniques at Raden Rahmat Islamic University in Malang, Indonesia, using a multidisciplinary approach that integrates systems theory, economics, psychology, organizational development, anthropology, sociology, and communication. Employing a qualitative, exploratory descriptive design, data was collected through structured interviews, field observations, and supporting documentation analysis. Informants were selected through purposive and snowball sampling methods, and data was analyzed using an interactive approach, involving data collection, reduction, presentation, and conclusion drawing. Triangulation ensured research validity and reliability. The findings reveal that the university adopts a holistic human resource development strategy, combining various disciplines to enhance employee skills and performance. This approach not only helps the institution achieve its performance goals but also contributes to advancements in human resource development theory and practice

Spatiotemporal distribution of cyanobacteria in relation to water chemistry of Sutlej River, Punjab (India).

In this investigation, the spatiotemporal distribution of cyanobacteria and their relationships with variations in water chemistry (physico-chemical parameters and heavy metal) of Sutlej River, Punjab (India) has been analyzed by employing multivariate statistical methods. Sutlej River exhibits a rich array of cyanobacterial diversity, comprising 28 species across 15 genera, distributed among 11 families and spanning 5 orders within the class Cyanophyceae. In terms of relative abundance, Microcystis aeruginosa (17.47%) was documented as the most abundant taxa followed by Microcystis robusta (16.55%), Merismopedia punctata (11.03%), Arthrospira fusiformis (6.67%) and Pseudanabaena galeata (3.68%). Significant variations were observed among sampling sites in most of the physico-chemical parameters. Principal Component Analysis delineated sampling sites into two discernible groups according to variations in water chemistry. River Pollution Index (RPI) showed that river water is under the unpolluted (RPI 1.5) to negligibly polluted category in the upstream sites, while moderately polluted (RPI 5.5) in the downstream sites. Heavy metal Pollution Index (HPI) revealed consistent heavy metal contamination at sites RWS7 and RWS8 across all seasons. Conversely, site RWS1 consistently exhibited lower HPI values throughout the three studied seasons. Further, Canonical Correspondence Analysis identified that pH, TDS, TA, NO3, Na, and NH4 are the key physicochemical parameters which affect the spatiotemporal distribution of cyanobacteria in the studied river system. Overall, this study will offer significant information for hydrologists, ecologists, and taxonomists to develop future holistic strategies for further monitoring of the Sutlej River and other similar habitats.

Preventing Complications in Children: Blood Transfusions in Pediatric HIV Management

Children living with HIV face unique challenges that significantly impact their health and development, with anemia being one of the most prevalent complications. Blood transfusions have emerged as a vital therapeutic intervention for managing anemia in pediatric HIV patients, providing immediate correction of hemoglobin levels and alleviating debilitating symptoms. This review explores the role of blood transfusions in preventing complications associated with HIV, emphasizing their importance in improving health outcomes and enhancing the quality of life for affected children. The mechanisms through which blood transfusions confer benefits include enhanced oxygen delivery to tissues, improved immune function, and support for growth and development. Clinical evidence highlights the effectiveness of transfusions in reducing hospitalization rates and promoting adherence to antiretroviral therapy (ART). Furthermore, integrating blood transfusions into comprehensive care models fosters a multidisciplinary approach that addresses the medical, nutritional, and psychosocial needs of pediatric patients, ensuring a holistic management strategy. Keywords: Pediatrics, HIV, blood transfusions, anemia, immune function, HIV management

Janus-structured evaporator with multiple optimization strategies for sustainable solar desalination

Solar-driven interfacial evaporation (SIE) is an environmentally-friendly and sustainable approach to seawater desalination and offers a promising solution for addressing water scarcity challenge. However, the intricate nature of SIE technology as a complex three-phase system calls for more holistic design strategies. Therefore, we present a comprehensive optimization strategy that integrates various design concepts spanning from optical characteristics and thermal localization enhancement to thermal convection intensification. The enhancement of the localized surface plasmon resonance (LSPR) effect is initially demonstrated by uniformly introducing TiN-NH2 nanoparticles onto the SWCNTs-COOH surface, showcasing remarkable absorbance properties (95.49%). Subsequently, the integration of a dual-network hydrogel is utilized to create a Janus architecture, which can enhance the thermal localization effect with an impressive evaporative efficiency of 92.25%. Finally, perforations are introduced to further improve heat convection, resulting in an exceptional evaporation rate of TiN@CNT/GOF-H1 (3.33 kg m−2 h−1, when calculated according to the real area, the evaporation rate value is 3.75 kg m−2 h−1). Both experimental findings and numerical simulations underscores the efficacy of this multiple-optimization engineered design. Experiment conducted within a customized device has substantiated the enduring cyclic stability and pH resistance to variations, potentially facilitating the spread of practical applications. The integration of multiple optimization strategies is expected to provide valuable insights for the holistic performance enhancement of the SIE evaporators.

Ultrasound-responsive ZnS:Ag QDs loaded TiO2 biointerfaces: In situ sonodynamic antimicrobial therapy for biomedical implants

Sonodynamic therapy (SDT) is extensively utilized for its profound tissue penetration capabilities in treating deep-seated infections, yet achieving precise ultrasonic treatment at the implant surface remains challenging. Herein, details the development of a novel infection microenvironment-sensitive nano-interface (TN-HHTZ), aimed at enhancing SDT efficacy for treating implant-related infections. The ZnS:Ag quantum dots (ZnS:Ag QDs) are functionalized using tyramine-modified hyaluronic acid (HA-Tyr) and horseradish peroxidase (HRP), resulting in the formation of a hydrogen peroxide (H2O2)-sensitive composite sonosensitizer (HHTZ). HHTZ is loaded onto a titanium dioxide nanotube (TN) array to form TN-HHTZ. Upon infection, ultrasonic triggering causes the rapid release of HHTZ, which interacts with H2O2 in the infected area to form a gel, thereby enabling prolonged enrichment of ZnS:Ag QDs at the site of implant infection. The doping of Ag in ZnS:Ag QDs enhances energy conversion, enabling TN-HHTZ to generate a significant amount of reactive oxygen species (ROS) during the SDT process, thereby boosting its antimicrobial efficacy and ensuring sustained antimicrobial activity throughout the infection period. The TN-HHTZ hydrogel on the implant surface promotes bone cell proliferation and recovery, providing an innovative and holistic strategy for treating and recovering from implant-associated microbial infections.

Understanding Financial Constraints: Causes, Effects, and Strategies for Overcoming Economic Limitations

In developing countries like Nigeria, the development and sustainability of people, companies, and economies were greatly impeded by economic and financial limitations. The main causes of these constraints included the limited availability of financial resources, high interest rates, rigorous regulatory regimes, and volatile economic situations. The most severe obstacles were encountered by small and medium-sized firms (SMEs) and marginalised people, who frequently struggle to get the required funds for growth and development. The ramifications of financial limitations were extensive, resulting in less investment, hindered economic expansion, more joblessness, and worsened wealth disparity. These constraints may also sustain societal instability, thereby further eroding economic resilience. Successfully managing financial limitations requires a holistic strategy that addresses both the supply and demand dimensions of money. A crucial aspect of the supply side was enhancing loan accessibility by creating novel financial products and services specifically designed for small and medium-sized enterprises (SMEs) and marginalised groups. Both microfinance organisations and fintech solutions have shown potential for offering alternative financial methods, especially in rural regions. By improving financial literacy, people and companies may make well-informed financial choices and efficiently allocate resources on the demand side. Government actions, such as implementing regulatory changes and stabilising macroeconomic factors, are crucial for establishing a more favourable financial climate. This research aimed to acquire knowledge on the factors, consequences, and approaches for surmounting financial limitations in Nigeria. Therefore, it emphasised the need for customised solutions that took into account the distinct economic, social, and cultural circumstances of the area. By conducting a comprehensive examination of peer-reviewed literature and empirical research, this study identified significant obstacles and suggested practical suggestions to improve financial accessibility, stimulate economic growth, and guarantee sustainable development. The results emphasised the importance of implementing targeted policies and regularly assessing current methods to tackle the changing financial environment in Nigeria. Keywords: Economic limitations, Financial limitations, Developing countries, Sustainability, Small and medium-sized enterprises (SMEs).

A Thematic Synthesis of the Experiences of Social Prescribing Among Patients in the UK.

Social prescribing connects patients to resources or activities to meet their non-medical needs. In the UK, it is often implemented in primary care. In the social prescribing pathway, patients are directed to link workers to identify suitable solutions for their needs such as art workshops or welfare benefit guidance. Social prescribing marks a notable transition from traditional medical treatments to more comprehensive strategies focusing on holistic health and wellbeing strategies. Insights from patient experiences can improve the development of social prescribing to better meet their needs. This understanding can aid in improving the delivery and outcomes of social prescribing. To synthesise qualitative research on the experiences of social prescribing among patients in the UK. A qualitative systematic review - using thematic synthesis for peer-reviewed papers focused on experiences of social prescribing users in the UK. An exhaustive search was performed in six databases: ASSIA, CINAHL, EMBASE, MEDLINE, PSYCINFO, and SOCIAL SCIENCE CITATION INDEX via Web of Science. The CASP tool for qualitative research was used for quality assessment and PRISMA 2020 Checklist was used to ensure the report transparency. Titles and abstracts of 1,269 papers were screened. In total, 85 papers were full text-screened, and 19 studies were included in the review. Five analytical themes were developed from these papers: (a) Searching for hope in times of adversity; (b) Variability in temporal responsiveness; (c) Feeling supported and empowered by the social prescribing pathway; (d) Sustained change from a positive response; (e) Misalignment producing no response. Patients might experience lasting advantages from social prescribing if it aligns with their needs and expectations. Results highlighted the importance of matching social prescribing referral with patients' readiness to engage. Therefore, it is recommended that healthcare professionals evaluate patient suitability prior to beginning a social prescribing referral.

Learning interventions in the WHO Eastern Mediterranean region: supporting Member States to get prepared for better response to health emergencies in the region.

The Eastern Mediterranean Region (EMR) faces numerous public health risks caused by biological, chemical, man-made, and natural hazards. This manuscript aimed to assess the multifaceted interventions and strategies used to strengthen the EMR's preparedness capacities to respond properly to current and upcoming health emergencies. To address these challenges, it is crucial to implement comprehensive and robust strategic risk assessments and health emergency preparedness frameworks. The World Health Organization (WHO) takes a risk-based approach, emphasizing the significance of all-hazards emergency management and the creation of national health risk profiles using the Strategic Toolkit for Assessing Risk (STAR). Furthermore, the International Health Regulations (IHR) Monitoring and Evaluation Framework (MEF) ensures continuous learning and capacity building among Member States, enhancing their ability to manage health emergencies effectively. Key components include State Party Annual Reporting (SPAR), Joint External Evaluation (JEE), After Action Review (AAR), Intra Action Review (IAR), and Simulation Exercises (SimEx). Moreover, initiatives like One Health, Emergency Care Systems, Safe Hospitals, and Public Health Emergency Operations Centers (PHEOCs) reinforce preparedness and response capacities. Risk communication and community engagement (RCCE) strategies play a pivotal role in disseminating timely information and fostering community resilience. Furthermore, the management of Chemical, Biological, and Radiological (CBRN) incidents remains a priority, necessitating collaboration between the public health and security sectors. This comprehensive approach aims to strengthen health systems, reduce risks, and improve emergency response capabilities throughout the EMR, thereby promoting global health security and resilience. The EMR is addressing public health challenges through frameworks like IHR-MEF, and RCCE. It is strengthening emergency care systems, ensuring safe hospitals, and establishing PHEOCs. Proactive measures to address CBRN events and collaboration are enhancing resilience. The inclusion of the One Health approach underscores the EMR's holistic strategy to address the health threats at the human-animal-environment interface. This demonstrates the EMR's commitment to global health security.

When the microbiome meets One Health principle: Leading to the Holy Grail of biology and contributing to overall well‐being and social sustainability

AbstractThe convergence of microbiome science with the One Health principle heralds a transformative era in biology, prioritizing the collective well‐being of humans, animals, and the environment. This review delves into the intricate dance between microbiomes and their hosts, revealing their profound impact on health, nutrient cycles, and climate change. Championing a unified approach to health issues across diverse kingdoms of life, One Health emerges as a holistic strategy, underscored by a proposed universal balance theory, “Balance of Dynamic Factors.” This theory spotlights the equilibrium within microbial and human‐animal‐environment interactions, offering a revolutionary pathway to global health and social well‐being. It paves the way for disease prevention, health equity, and sustainability, all of which are purviews of a balanced ecological system. We navigate the challenges and opportunities of this integrative approach, culminating in a call for action for the incorporation of microbiome science into health policies, precision medicine, legislation, eco‐health projects, and education, thereby setting the stage for harmonious coexistence with our planet.

Sarcasm Detection on Social Media: Addressing the Issues of Short and Long Texts Using Machine Learning and Deep Learning Approaches

Sarcasm is a linguistic term that conveys a meaning that is different from what is meant to be said, frequently used to mock, taunt, or convey disdain. Sarcasm is a complicated social phenomenon that can be recognized by its tone of voice, exaggeration, or context. Because sarcastic discourse is nuanced, detecting sarcasm in Natural Language Processing (NLP) has become a major difficulty. This paper thoroughly examines the tradition machine learning approaches like SVM, Naive Bayes and Random Forest well as advanced deep learning methods such as RNN, LSTM, and transformer based models, like BERT, that has demonstrated superior performance used for sarcasm detection, and also the paper offers more sophisticated data preprocessing techniques that comprise several stages, each focusing on a different facet of the fragmented and informal character of the social media material. It focuses mainly on short and long texts that may be found in news headlines and social media sites like Facebook, Instagram, X (formerly known as Twitter), and others. The paper also explores various challenges like cultural and linguistic barriers, and increased use of audio and visual sarcastic content on social media. At last paper concludes with possible guidelines for future works including the development of real-time, multilingual systems to examining holistic strategies that can encompass the complexity of sarcasm in multimodal communications. Key Words: sarcasm, NLP, social media, machine learning, deep learning

Accelerated Digital Transformation of Higher Education in the Wake of COVID-19: A Systematic Literature Review

The COVID-19 pandemic has accelerated Digital Transformation (DT) across various industries, including Higher Education (HE). In response to the dynamic demands of contemporary society, Higher Education Institutions (HEIs) must swiftly adapt and transform. However, existing research has revealed a prevalent lack of strategic vision regarding DT in HE, often limited to the mere integration of technology. This study employs a Systematic Literature Review (SLR) as a methodological framework to identify and categorize DT challenges and strategies within HE accelerated after the pandemic event. Findings from this SLR highlight four distinct categories of challenges and strategies in DT: Strategic-Administrative, Teaching-Learning, Technical-Technological, and Social-Cultural. Notably, the literature tends to focus more on identifying challenges, revealing an unbalanced emphasis compared to analyzing how HEIs are actively progressing in their DT efforts. Furthermore, there is a significant absence of impact analysis regarding these DT strategies within Higher Education. To address these gaps, recommendations for future research are proposed, including i) Exploration of strategic processes in HE toward DT, ii) Empirical analysis of the Digital Maturity of HEIs, and iii) Assessment of the impact of the strategic responses of HE toward DT. In conclusion, this study underscores the urgency for a more strategic approach to DT in Higher Education, emphasizing the need to shift the focus from technology integration towards holistic, effective, and outcome-driven strategies. These recommendations aim to guide future research towards a more interdisciplinary and comprehensive understanding of DT within the realm of Higher Education.

Evaluating the Usability and Quality of a Clinical Mobile App for Assisting Physicians in Head Computed Tomography Scan Ordering: Mixed Methods Study.

Among the numerous factors contributing to health care providers' engagement with mobile apps, including user characteristics (eg, dexterity, anatomy, and attitude) and mobile features (eg, screen and button size), usability and quality of apps have been introduced as the most influential factors. This study aims to investigate the usability and quality of the Head Computed Tomography Scan Appropriateness Criteria (HAC) mobile app for physicians' computed tomography scan ordering. Our study design was primarily based on methodological triangulation by using mixed methods research involving quantitative and qualitative think-aloud usability testing, quantitative analysis of the Mobile Apps Rating Scale (MARS) for quality assessment, and debriefing across 3 phases. In total, 16 medical interns participated in quality assessment and testing usability characteristics, including efficiency, effectiveness, learnability, errors, and satisfaction with the HAC app. The efficiency and effectiveness of the HAC app were deemed satisfactory, with ratings of 97.8% and 96.9%, respectively. MARS assessment scale indicated the overall favorable quality score of the HAC app (82 out of 100). Scoring 4 MARS subscales, Information (73.37 out of 100) and Engagement (73.48 out of 100) had the lowest scores, while Aesthetics had the highest score (87.86 out of 100). Analysis of the items in each MARS subscale revealed that in the Engagement subscale, the lowest score of the HAC app was "customization" (63.6 out of 100). In the Functionality subscale, the HAC app's lowest value was "performance" (67.4 out of 100). Qualitative think-aloud usability testing of the HAC app found notable usability issues grouped into 8 main categories: lack of finger-friendly touch targets, poor search capabilities, input problems, inefficient data presentation and information control, unclear control and confirmation, lack of predictive capabilities, poor assistance and support, and unclear navigation logic. Evaluating the quality and usability of mobile apps using a mixed methods approach provides valuable information about their functionality and disadvantages. It is highly recommended to embrace a more holistic and mixed methods strategy when evaluating mobile apps, because results from a single method imperfectly reflect trustworthy and reliable information regarding the usability and quality of apps.

The cell rejuvenation atlas: leveraging network biology to identify master regulators of rejuvenation strategies.

Current rejuvenation strategies, which range from calorie restriction to in vivo partial reprogramming, only improve a few specific cellular processes. In addition, the molecular mechanisms underlying these approaches are largely unknown, which hinders the design of more holistic cellular rejuvenation strategies. To address this issue, we developed SINGULAR (Single-cell RNA-seq Investigation of Rejuvenation Agents and Longevity), a cell rejuvenation atlas that provides a unified system biology analysis of diverse rejuvenation strategies across multiple organs at single-cell resolution. In particular, we leverage network biology approaches to characterize and compare the effects of each strategy at the level of intracellular signaling, cell-cell communication, and transcriptional regulation. As a result, we identified master regulators orchestrating the rejuvenation response and propose that targeting a combination of them leads to a more holistic improvement of age-dysregulated cellular processes. Thus, the interactive database accompanying SINGULAR is expected to facilitate the future design of synthetic rejuvenation interventions.

The Influence of Visionary Leadership, Motivation, and Work Culture on Work Commitment and Performance of Education Staff at Doctor Husni Ingratubun University (UNINGRAT) In Tual City

The purpose of this study is to test, analyze and find out the influence of work culture, visionary leadership and work motivation on performance through work commitment at UNINGRAT Tual. In this study, visoner leadership, work motivation, organizational culture, work commitment, performance will be analyzed. Based on the type of research, this research is a study that explains the causal relationship between variables or so-called explanatory research, which is research to find out and explain the influence between existing variables and continues with hypothesis testing. In addition, this study is included in descriptive research, because it provides a descriptive explanation of the variables to be studied. The sample in this study is all Education Personnel at UNINGRAT Tual City which totals 150 people. The results of the study found that visionary leadership and work motivation positively and significantly increased the work commitment of education staff at Doktor Husni University UNINGRAT Tual, but did not have a direct impact on their performance. An inclusive and collaborative work culture has been shown to improve performance, but it does not affect work commitment. In addition, work commitment has proven to be an important mediator between visionary leadership and work motivation to performance, showing that highly motivated and highly committed education personnel tend to have better performance. On the other hand, visionary leadership and work motivation do not significantly improve performance directly, mainly due to the limitations of flexibility and resources at UNINGRAT. These findings highlight the need for a holistic management strategy to improve the performance and commitment of education personnel in this unique higher education environment.