SOX4, SOX11 and SOX12 are the members of group C of Sry-related HMG box proteins. Inspite of being discovered more than 15 years ago, their molecular properties and functions are not completely understood. Humans and mice contain 20 SOX genes and 8 are present in Drosophila. Our phylogenetic tree result shows that SOX4 and SOX12 in Primates and Rodentia are more closely related to each other with a few exceptions. Phylogenetic tree based on the amino acid sequences of HMG box domain showed that SOX4 in Homo sapiens belongs to the same cluster and is closely related with SOX11 of Homo sapiens and Mus musculus. Protein compositional result reveals that random coil and alpha helix are the most abundant forms in all the cases. A negative GRAVY value indicates the hydrophilic nature of the protein, with its sub-cellular localization predicted to be within the nucleus, hence they cannot be a membrane protein. Analysis of SOXC molecular features shows that SOX4, SOX11 and SOX12 are single-exon genes, with N-terminal Sry-related HMG box (SOX) domain and a C-terminus transactivation domain (TAD). Their expression analysis revealed some overlapping expression pattern in some cancers like breast adenocarcinoma, esophageal adenocarcinoma, squamous cell lung carcinoma etc. Studies looking at the sites where SOX genes are located may provide useful information on their potential role in cancers. In humans, SOX4, SOX11 and SOX12 are located on chromosome 6, 2 and 20 respectively and in mouse they are located on chromosome 13, 12 and 2 respectively.