The dry forests of northern Peru, in the regions of Piura, Tumbes, Lambayeque, and La Libertad, have experienced significant changes as a result of deforestation and changes in land use, leading to the loss of biodiversity and resources. This work analyzed for the first time the changes in vegetation cover and land use of the Pómac Forest Historical Sanctuary (PFHS), located in the department of Lambayeque (northern Peru). The employed approach was the random forest algorithm and visually interpreted Landsat satellite images for the periods 2000–2002, 2002–2004, and 2004–2008. Gain and loss rates were computed for each period, and the recovery process was assessed using the normalized difference vegetation index (NDVI) and enhanced vegetation index (EVI). Results indicate an expansion of agricultural land during each period, resulting in the deforestation of 102.6 hectares of dense dry forest and 739.9 hectares of open dry forest between 2000 and 2008. The degree of reforestation in the cleared areas was measured using the NDVI and EVI indices, revealing an improvement from 0.22 in NDVI in 2009 to 0.36 in 2022, and from 0.14 to 0.21 in EVI over the same period. This study is expected to pave the way for executing land management plans, as well as the use and conservation of natural resources in the PFHS in a sustainable manner.