Historical Perspective Research Articles

Mononuclear Phagocytes, Cellular Immunity, and Nobel Prizes: A Historic Perspective.

The mononuclear phagocyte system includes monocytes, macrophages, some dendritic cells, and multinuclear giant cells. These cell populations display marked heterogeneity depending on their differentiation from embryonic and bone marrow hematopoietic progenitors, tissue location, and activation. They contribute to tissue homeostasis by interacting with local and systemic immune and non-immune cells through trophic, clearance, and cytocidal functions. During evolution, they contributed to the innate host defense before effector mechanisms of specific adaptive immunity emerged. Mouse macrophages appear at mid-gestation and are distributed throughout the embryo to facilitate organogenesis and clear cells undergoing programmed cell death. Yolk sac, AGM, and fetal liver-derived tissue-resident macrophages persist throughout postnatal and adult life, supplemented by bone marrow-derived blood monocytes, as required after injury and infection. Nobel awards to Elie Metchnikoff and Paul Ehrlich in 1908 drew attention to cellular phagocytic and humoral immunity, respectively. In 2011, prizes were awarded to Jules Hoffmann and Bruce Beutler for contributions to innate immunity and to Ralph Steinman for the discovery of dendritic cells and their role in antigen presentation to T lymphocytes. We trace milestones in the history of mononuclear phagocyte research from the perspective of Nobel awards bearing directly and indirectly on their role in cellular immunity.

Grandes Esperanças – Afryka w polityce zagranicznej Brazylii w XXI w.

“GRANDES ESPERANÇAS” – AFRICA IN THE FOREIGN POLICY OF BRAZIL IN XXI CENTURYThe links between Brazil and African countries go far beyond official political or economic relations and date back to the beginnings of Portuguese colonisation in the New World. They are bound by the painful history of many centuries of slavery, but also the influence of the African population on Brazilian culture, religion and society. Today, Brazil is the country with the second largest population of African descent after Nigeria, yet Brazil’s policy towards Africa seems largely short-term. The aim of the following article is to show the evolution of Brazil’s policy towards Africa in these dimensions from a historical perspective, with particular emphasis on the changes in its dynamics in the 21st century and its inclusion in a broader strategy of the country’s international activity.

ESP: Cancellation of Academic and Occupational Purposes?

Changes in education and the needs of the educational space lead to changes in the norms and methods of educational processes, and as a result it turns out that new methods cancel out the old ones. Thus, the concept and methodology of teaching languages for special (professional) purposes since 1978, has been recognized worldwide as innovative and relevant for specialized vocational training of schoolchildren and youth [23]. Today, the idea of LSP has become irrelevant, according to the initiators themselves Tom Hutchinson and Alan Waters [24], and should be displaced from school disciplines into the service industry to meet the needs of specialists of other profiles. But the case should be presented in its historical perspective. To get better understanding of the unpleasant aftertaste of the initiators’ decision, we should refer to most prominent linguists of the world who contributed greatly to the development of the LSP idea in the world. An overview of the rise and fall of the idea and methods of languages for specific purposes is outlined in the book “LSP: English of Professional Communication” by Galina Gumovskaya [19].

Persistent uncertainties in optimal treatment approaches of secondary hyperparathyroidism and hyperphosphatemia in patients with chronic kidney disease.

This review is a critical analysis of treatment results obtained in clinical trials conducted in patients with chronic kidney disease (CKD) and secondary hyperparathyroidism (SHPT), hyperphosphatemia, or both. Patients with CKD have a high mortality rate. The disorder of mineral and bone metabolism (CKD-MBD), which is commonly present in these patients, is associated with adverse outcomes, including cardiovascular events and mortality. Clinical trials aimed at improving these outcomes by modifying CKD-MBD associated factors have most often resulted in disappointing results. The complexity of CKD-MBD, where many players are closely interconnected, might explain these negative findings. We first present an historical perspective of current knowledge in the field of CKD-MBD and then examine potential flaws of past and ongoing clinical trials targeting SHPT and hyperphosphatemia respectively in patients with CKD.

The artifact of cerebellar granule cell layer conglutination in veterinary medicine: a brief historical perspective and review.

Cerebellar granule cell layer conglutination is a tissue artifact associated with postmortem autolysis that causes cerebellar granule cell changes once thought to be caused by degeneration and necrosis. Granule cell layer conglutination has been reported mainly in humans and cattle and rarely in other animal species, but its frequency remains vastly unknown in veterinary medicine, mostly because this postmortem change is typically not recorded in autopsy reports. Pathology trainees should be aware of autolytic tissue changes that may mimic pathologic changes in the CNS, particularly when those changes are highly selective for a specific cell population within the cerebellar cortex. Here we provide a brief historical perspective on the evolution of cerebellar granule cell layer conglutination from "enzootic cerebellar necrosis," a presumed necrotic lesion affecting granule neurons in humans and cattle, to a tissue change associated with postmortem autolysis and increased tissue acidity in the cerebellum. We also provide an update on the animal species in which cerebellar granule cell layer conglutination has been observed during our diagnostic pathology routine.

INDONESIAN FINANCIAL LAW: HISTORY AND RECENT DEVELOPMENT

The economic system and political regimes in most cases affect major changes in the financial laws of the state. Indonesia, the big country that gained its independence in 1945, had a long journey of financial struggles and challenges, particularly in the political regimes that divided into the Old Regime, the New Regime, and the Reformation Era. The objectives of this paper try to examine how Indonesia's economic system affects the state's financial policies described in legislation. Other objectives are the development of financial law in Indonesia based on the period divisions with historical perspectives. With normative legal research, this study will analyze several sources of laws and regulations on financial policies throughout the historical periods of Indonesia. In conclusion, Pancasila, and Article 33 of the Indonesian Constitution 1945 become economic constitutions that form the basis of financial policies of Indonesia. Moreover, the politics of the ruling regime strongly influenced financial law policies in Indonesia. The characteristics of monetary law changed based on the transfer of legal politics during the Old Order, New Order, and Reformation era

Leitura e escrita acadêmica na formação inicial de professores: Que letramentos?

From a historical perspective on the initial training of teachers in Brazil, a survey of research developed was carried out, locating in articles published in the last two decades the modes of functioning of the school institution, in the continuous movement of learning-teaching-learning reading and academic writing. Historically, Brazil has presented many difficulties in universalizing the learning of reading and writing in a socially significant way. In the direction of the formation of the critical citizen, we discuss the difficulties to make academic reading and writing effective as processes of forming and transforming the condition of citizenship of the Brazilian population. Proceeding with a qualitative approach, the articulation between the lines of investigation of the selected studies, which focused on teacher training, teaching work and the construction of a teacher's professional identity, were analyzed in the defense that being a teacher is to develop a work based on a solid specific training and that initial training courses should also be concerned with teacher professionalization (Nóvoa, 2017). In the case of initial training, it should allow students to go through teaching and learning experiences that are based on the use and reflection of the characteristics of academic writing, so that future teachers know how to deal with the prescriptions inherent to their work context and document their experiences, as the written record becomes part of a routine developed since initial training when the triad reading is adopted, analysis and production of academic texts as a formative and evaluative principle. In this sense, the analyses carried out reveal that academic literacy should permeate the entire initial training of teachers, with objective prescriptions, considering the autonomy of the trainer to plan and replan his classes coherently with his didactic-methodological choices (Mizukami, 2005-2006; 2000), in a political and pedagogical project committed to an education linked to more assertive teaching practices (Gatti, 2014; André et. al., 2010), with academic writing as one of the constitutive elements of a socially referenced quality education.

Lyme Disease Surveillance and Epidemiology in the United States: A Historical Perspective.

In the 40 years since Steere and colleagues first described Lyme disease, the illness has increased in incidence and distribution to become the most common vector-borne disease in the United States. Public health officials have developed, implemented, and revised surveillance systems to describe and monitor the condition. Much has been learned about the epidemiology of the illness, despite practical and logistical constraints that have encumbered the collection and interpretation of surveillance data. Future development of automated data collection from electronic health records as a source of surveillance and clinical information will address practical challenges and help answer ongoing questions about complications and persistent symptoms. Robust surveillance will be essential to monitor the effectiveness and safety of future vaccines and other preventive measures.

Current efforts and historical perspectives on classification of idiopathic inflammatory myopathies.

The classification of idiopathic inflammatory myopathies is challenging due to the large number of clinical, serological, histopathological and genetic findings, as well as the latest findings and developments in the field of myositis research. The latest official classification criteria are the 2017 European Alliance of Associations for Rheumatology (EULAR)/American College of Rheumatology (ACR) classification criteria for adult and juvenile idiopathic inflammatory myopathies, which have been extensively reviewed in recent years for their applicability, sensitivity and specificity. The sensitivity and specificity of the 2017 ACR/EULAR criteria are sometimes performing better, but usually at the same level as the previous criteria. A large number of further suggestions for amendments to the criteria have been made. In particular there is a need to revise the criteria with regard to the addition of new myositis-specific autoantibodies, newly defined subgroups (especially antisynthetase syndrome, immune medicated necrotizing myopathy and overlap myositis) and possibly the addition of further diagnostic procedures (for instance, muscle MRI or PET CT) to improve the accuracy and timeliness of the criteria. Efforts to optimize the myositis classification criteria have been extensive in recent years and a new global interdisciplinary collaboration of clinicians is currently taking place based on the previous results with the aim of revising the 2017 EULAR/ACR classification criteria.

Direct current stimulation as a non-invasive therapeutic alternative for treating autonomic or non-autonomic neurological disorders affecting breathing.

Direct current stimulation (DCS) is a non-invasive approach to stimulate the nervous system that is now considered a powerful tool for treating neurological diseases such as those affecting cognitive or locomotor functions. DCS, as applied clinically today, is an approach built on early uses in antiquity and knowledge gained over time. Its current usemakes use of specific devices and takes into account knowledge of the mechanisms by which this approach modulates functioning of the nervous system at the cellular level. Over the last 20years, although there are few studies, it has been shown that DCS can also modulate the breathing autonomic function. In this narrative review, after briefly providing the historical perspective and describing the principles and the main cellular and molecular effects, we summarize the currently available data regarding the modulation of ventilation, and propose that DCS could be used to treat autonomic or non-autonomic neurological disorders affecting breathing.

دور التسامح في تعزيز العلاقات الاجتماعية من المنظور الأنثروبولوجي الاجتماعي

In the field of social anthropology, the concept of tolerance plays a pivotal role in understanding the interactions of human societies. Tolerance, which is the acceptance and respect for different beliefs, practices, and opinions, is not only a moral virtue but also an important element of social cohesion. This article highlights the understanding of the importance of tolerance in an anthropological context, and its role in strengthening social bonds from a social anthropological perspective. Tolerance in the field of social anthropology includes the acceptance and respect for cultural diversity and individual differences. It is a fundamental concept that has evolved over time in human societies. Throughout history, many civilizations have struggled with the concept of tolerance, and these civilizations were often shaped by social norms and cultural practices. Tolerance was an integral part of societal values that prioritized harmony and cooperation among their members. This historical perspective highlights the fundamental relationship between tolerance and social cohesion and emphasizes the role of cultural norms in shaping attitudes toward diversity. Tolerance works to promote social cohesion by strengthening understanding and acceptance of diverse viewpoints. When individuals embrace tolerance, they are more likely to engage in constructive dialogue and break down communication barriers with others who hold opposing beliefs. This open-minded approach not only fosters empathy and mutual respect, but also contributes to conflict resolution and peaceful coexistence within society. By fostering a culture of tolerance, a society can leverage the richness of its diversity to enhance collective efforts to collaborate and solve problems.

Climate change and the taphonomic signature of Neolithic mounds: the Kur River Basin over five decades of satellite imagery coverage

ABSTRACT This paper discusses the impact of modern land use and climate change on mounded prehistoric sites, considering the evidence from Kur River Basin (southwestern Iran). By applying remote sensing and GIS techniques to historical and recent satellite imagery, we monitored an assemblage of 45 Neolithic mounds in order to map and quantify their taphonomic signatures over the last 53 years. Our results highlight that the deterioration of sites occurred as a result of landscape transformation due to land use and socio-economic dynamics that were exacerbated by current climate change. Increasing demands for fertile land and water led to the over-exploitation of sources, resulting in changing hydrological regimes and ecological systems and loss of the archaeological record. By contextualizing these processes over a historical perspective, our findings contribute to archaeological heritage management efforts.

The desmosome comes into focus.

The desmosome is a cell-cell adhesive junction that provides integrity and mechanical resistance to tissues through its attachment to the intermediate filament cytoskeleton. Defects in desmosomes cause diseases impacting the heart, epidermis, and other epithelia. In this review, we provide a historical perspective on the discovery of the desmosome and how the evolution of cellular imaging technologies revealed insights into desmosome structure and function. We also discuss recent findings using contemporary imaging approaches that have informed the molecular order, three-dimensional architecture, and associations of desmosomes with organelles such as the endoplasmic reticulum. Finally, we provide an updated model of desmosome molecular organization and speculate upon novel functions of this cell junction as a signaling center for sensing mechanical and other forms of cell stress.

Speaking Up and Being Heard: The Importance of Functional Communication and Discourse Principles in Aphasia Intervention.

This article acknowledges Audrey Holland's influence on aphasiology as it specifically relates to the emergence of a strengths-based perspective on the everyday communication of people with aphasia. We explore a historical perspective, as well as current ways in which everyday communicative events are approached in both clinical and research practice. The term "functional communication" is synonymous with Audrey's work, with linguistically-based discourse analysis and therapy both viewed as natural companions and extensions of the concept within aphasiology. Audrey's focus on the interactional side of communication and psychosocial impacts of aphasia, as well as her expertise in analysis and measurement, contributed to the coalescing of impairment-based and social communication approaches, encompassing a true sense of humanity and connectedness. Her application of these in international contexts was also noteworthy. In this article, we hope to capture principles of aphasia management that underpin current clinical practice, and also move beyond the traditional clinic context to consider aphasia groups that have had such a key role in promoting successful social communication by and with people with aphasia. We suggest future directions to further promote the principles advocated by Audrey Holland in assisting people with aphasia to move forward with confidence with their conversation partners, friends, and communities.

Interplay between childhood socioeconomic status and current job insecurity: A dual-contextual approach to decent work and well-being.

Grounded in the psychology of working theory, the link between economic constraints and decent work is well established. However, previous studies did not incorporate a developmental framework when examining this relationship. Drawing on a life history perspective, this study explored how childhood socioeconomic status (SES) is associated with well-being through decent work. We adopted a dual-contextual approach, examining the interaction between childhood SES and current job insecurity as a predictor of decent work and well-being. Using data collected from 417 workers in South Korea, we tested a moderated mediation model. The results revealed significant indirect relationships between childhood SES and job and life satisfaction through decent work, particularly among individuals with higher job insecurity. Notably, these findings remained significant even after controlling for participants' current SES. Overall, our findings suggest that in contexts where job insecurity is prevalent, an individual's childhood SES is distinctly associated with decent work and well-being, independent of their current SES. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Holistic Pragmatism: the Chinese Approach on International Relations

Different geographical environments produce different histories, cultures, civilizations, philosophies, and mentalities, all of which have an enormous impact on their decision-making and foreign policy-making. Thousands of years of social norms and tradition have shaped Chinese people's holistic and pragmatic thinking and approach, determining China's policymakers' objective and overall approach to state governance and international relations. Above all, China, as a civilizational state that has been unified for thousands of years, distinguishes itself from the Western nation-states formed in modern times through continuous wars and peace treaties. Consequently, China has formed different perceptions and interpretations of national and international affairs, and distinct approaches and decision-making processes in terms of inter-state and international interactions and conflict management. By studying various dimensions of Chinese history, culture and philosophy, as well as analyzing its foreign policy-making and active participation in global affairs, this study argues that holistic pragmatism has pervaded China's domestic and foreign policy-making, influencing Chinese policymakers’ decision-making and people's thinking habits. This highlights the necessity to broaden the academic scope of international relations to encompass diverse geographical, cultural and historical perspectives, thereby providing a more comprehensive and profound understanding of international relations in our interconnected world.

Deep disagreement across moral revolutions

Moral revolutions are rightly coming to be recognised as a philosophically interesting and historically important mode of moral change. What is less often acknowledged is that the very characteristics that make a moral change revolutionary pose a fundamental challenge to the possibility of moral progress. This is because moral revolutions are characterised by a diachronic form of deep moral disagreement: moral agents on either side of a moral revolution adopt different standards for assessing the merits of a moral argument, and according to the standards they adopt, agents on neither side of the revolution ought to accept the arguments being put forward by those on the other. This threatens to undermine the progressive status of many of our most celebrated historical examples of moral revolutions: if a moral revolution only looks progressive in light of a change in evaluative standards it itself brought about, then moral progress seems relative to a particular historical perspective; if prior to a moral revolution taking place the moral arguments in its favour fall short of the relevant standards, moral revolutions can never be the outcome of rational argumentation. This apparent relativism and irrationality sits uncomfortably alongside our common-sense intuition that the moral revolutions upon which our contemporary moral worldview rests count as genuine moral progress. In this paper, I deepen currently popular Kuhnian-inspired accounts of moral revolution by incorporating Wittgensteinian ideas from Philosophical Investigations and On Certainty. The result is an original way of thinking about deep moral disagreements, moral revolutions, and moral progress.

At the Knot of Presence: Weaving with the embodied knowledge of my artistic palette in Liza Lim's One and the Other (Speculative Polskas for Karin)

This artistic research exposition unfolds the shared work between Australian composer Liza Lim and Swedish violinist Karin Hellqvist, from the viewpoint of Hellqvist as performer and co-creator. Together, the artists have created the violin solo work One and the Other (Speculative Polskas for Karin) (2021–22). The Swedish folk music tradition that Hellqvist has carried with her since her childhood, and especially the polska dance, serves as their point of departure. This tradition resides in Hellqvist’s body and performance practice as embodied knowledge – a term introduced by Maurice Merleau-Ponty (1962), and it becomes their main path of research. A central concept in the reflections is the ‘artistic palette’ – a concept created by Hellqvist to conceptualise the skills and abilities used in creative work. Hellqvist’s embodied knowledge connected to the tradition is woven into the work through explorations of elements as the specific pulse of the polska and its ornamentation. Furthermore, those embodied skills are explored as decoupled in the third movement, capturing indeterminate aspects. The main question addressed is how the embodied knowledge of Hellqvist’s artistic palette serves as resource and inspiration in the shared process and how it affects the ontology of One and the Other (Speculative Polskas for Karin). Topics of distributed creativity, shared work as mycelial structure, instrument-building, ownership, and temporal ecology are being unpacked in the light of the artistic palette. The artistic research exposition unfolds a compositional process whereby the performer is participating actively, thus problematising the view of where creativity may be located in compositional work. It comprises written reflections, audio examples, pictures, and video material from the creative process as well as a video of the whole work. The research context comprises historical and aesthetic perspectives, as well as recent research on performer creativity and embodiment. <style> /* rules to make button only show up in META */ .download-accessible { display:none; } .meta-right-col .download-accessible { display: inline-block; padding: 9px; margin-bottom:25px; border: 1px solid black; background-color:white; } </style> <a class="download-accessible" href="/profile/download-media?work=2936353&file=2959705" title="This accessible PDF is a derivative of the original which it is meant to support and not replace.">Download Accessible PDF</a>

Value Added Tax on Financial Services in the EU: The Complete Story

The paper provides an extensive overview of the VAT exemption of financial services in the EU. The topic is surrounded by conceptual and practical challenges. The main issues are presented in a retrospective plan. They have been clearly defined and discussed since the very inception of the EU VAT system. The difficulties this tax regime is faced with today reveal the logical sequence that can be traced as far back as the 1970s. In its first part, the paper looks at the topic from a historical perspective, exploring the inclusion of financial services within the scope of the first VAT rules. Further insight is subsequently provided on the application of the VAT exemption over the past decades until the present-day rules. At its core, the text relies mostly upon the CJEU case law. Capital issues for VAT fiscal neutrality are also given careful consideration. This is the major concern inspiring the Commission’s attempts and proposals for VAT reforms. After a concise examination of the efforts to revise the legislation, the paper focuses on the most recent developments in the financial industry, which is a major stakeholder concerned by the recent aspirations of Brussels.

Cultural Representations in Border Literature: Reflecting on Harka Gurung’s Vignettes of Nepal

This article explores the issues raised in Harka Gurung’s Vignettes of Nepal and analyzes them from historical perspectives. Cultural activities of the different geographical locations of Nepal that Gurung explores in the book are based on border, culture and the literature. Culture is a part of social practices interlinked to the cultural activities that connect people and literature of a society or a cultural community under a chain of social/socio-cultural activities. There might be different kinds of cultural groups within the same geographical border but they have the same kind of humanitarian values. However, they have some conflicting borders because of the space on performances and understanding of the cultural critics. Here, border refers to both the cultural community’s line as well as geographical territory. Many people respect to each-other’s culture but some of them disrespect borderland culture and literature that creates social disharmony in the name of cultural identity. Culture is a part of literary activities that helps to generate the literature and every literature is based on the culture. Gurung’s Vignettes of Nepal incorporates twenty essays based on different geographical borderlands, cultural practices and literature. He begins his essays from west of Kathmandu and concludes them coming to the east. In this study, this researcher selects particularly a few essays based on cultural borderland. Border, culture and literature are inseparable and so this study is on cultural cum ethno-geographical methodology as it studies the behavioral things of the people of different cultural communities. Objective of this paper is to show the connectivity of literature in the cultural borderland. To achieve the research goal, this study centers on historical places and observes cultural practices in Nepal. This researcher applies Mary Anderson and Dor Bahadur Bista’s ideas as supporting tools to the research in addition to Shalom H. Schwartz’s theory based on universal human values and cross-cultural psychologies. Finding of this paper is that the humanitarian cultures of the borders are key subjects to create the socio-cultural harmonies that help to generate the literature.