In recent decades, many small Italian historic centers—particularly those situated inland—have witnessed a population decline due to inadequate access to public services and facilities. However, this depopulation has also allowed many centers to retain their distinctive features, now conferring upon them great cultural–historical and landscape value. New quality-of-life-centered economic models present the development of accessible public services as a necessity. Such a process could catalyze the recovery and growth of these centers, which continue to be deserted, regardless of their value. This paper considers combined solutions, including sustainable mobility, digital accessibility, networked services, and technological devices by applying them to trans-scalar studies with the goal of achieving sustainable outcomes. Some of the proposed solutions are the resolution of irregular ground levels, the use of electric vehicles, the creation of sharing models, the physical overhaul of routes, and the retrofitting of minor buildings for inclusive use in a comprehensive human-centered approach toward regeneration. This study is in line with the European guidelines for sustainable and intelligent mobility, whose goal is for at least one hundred European cities to become accessible to all and shifted to zero-emission mobility. Here, sustainable and smart mobility is understood not only as an improvement of environmental and social conditions, but also as a catalyst for environmental and social improvements and as an opportunity to enhance the livability of smaller, geographically isolated historic centers, moving toward a new economy of urban reclamation.