Event Abstract Back to Event ZNF804A polymorphism effects on hippocampus-prefrontal cortex connectivity during a working memory task: An fMRI wavelet transform coherence analysis Martin F. Gerchen1*, David Bernal Casas1 and Peter Kirsch1 1 Central Institute of Mental Health, Dep. of Clinical Psychology, Germany Even though it is known that a substantial part of the risk for developing psychiatric disorders is inheritable, the genetic and neural mechanisms underlying this heritability are only partially understood yet. The single nucleotide polymorphism (SNP) rs1344706 of the ZNF804A gene was one of the first risk polymorphisms for schizophrenia and bipolar disorder supported by genome-wide association studies. Although the molecular function of ZNF804A still needs to be fully resolved, it could be shown by human functional magnetic resonance imaging (fMRI) that rs1344706 influences functional connectivity between brain regions. In particular, functional connectivity between dorsolateral prefrontal cortex (DLPFC) and hippocampus (HC) was found to be increased during the time course of a working memory experiment in healthy risk allele carriers, resembling findings in schizophrenic subjects. However, it remains elusive whether the effect of the genotype is stable over the time course of the experiment or manifests only at specific time points. To test for nonstationary effects of rs1344706 we reanalyzed n-back fMRI data of N=120 healthy subjects, mostly also included in the aforementioned study, with continuous wavelet transformation, a method well suited for analyzing time-frequency properties of time series and identifying temporally and spectrally restricted processes. We then calculated the wavelet transform coherence between regions of interest in the DLPFC and HC and tested for genetic effects with general linear models. rs1344706 effects were found to be temporally much more restricted and of higher frequency than the time course of the experiment, showing that methods using stationarity assumptions like correlations over the whole time course might miss potentially important effects that can be pinpointed in time-frequency space. Keywords: fMRI, functional connectivity, imaging genetics, Schizophrenia, Wavelet transformation Conference: Bernstein Conference 2012, Munich, Germany, 12 Sep - 14 Sep, 2012. Presentation Type: Poster Topic: Brain disease, network dysfunction and intervention Citation: Gerchen MF, Bernal Casas D and Kirsch P (2012). ZNF804A polymorphism effects on hippocampus-prefrontal cortex connectivity during a working memory task: An fMRI wavelet transform coherence analysis. Front. Comput. Neurosci. Conference Abstract: Bernstein Conference 2012. doi: 10.3389/conf.fncom.2012.55.00145 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 11 May 2012; Published Online: 12 Sep 2012. * Correspondence: Mr. Martin F Gerchen, Central Institute of Mental Health, Dep. of Clinical Psychology, Mannheim, Germany, fungisai@web.de Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Martin F Gerchen David Bernal Casas Peter Kirsch Google Martin F Gerchen David Bernal Casas Peter Kirsch Google Scholar Martin F Gerchen David Bernal Casas Peter Kirsch PubMed Martin F Gerchen David Bernal Casas Peter Kirsch Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.