You have accessJournal of UrologyStone Disease: Basic Research1 Apr 20112141 A HIND III POLYMORPHISM OF FIBRONECTIN GENE IS ASSOCIATED WITH NEPHROLITHIASIS Metin Onaran, Akin Yilmaz, Ilker Sen, Mehmet Ali Ergun, Ahmet Camtosun, Bora Kupeli, Sevda Menevse, and Ibrahim Bozkirli Metin OnaranMetin Onaran Ankara, Turkey More articles by this author , Akin YilmazAkin Yilmaz Ankara, Turkey More articles by this author , Ilker SenIlker Sen Ankara, Turkey More articles by this author , Mehmet Ali ErgunMehmet Ali Ergun Ankara, Turkey More articles by this author , Ahmet CamtosunAhmet Camtosun Ankara, Turkey More articles by this author , Bora KupeliBora Kupeli Ankara, Turkey More articles by this author , Sevda MenevseSevda Menevse Ankara, Turkey More articles by this author , and Ibrahim BozkirliIbrahim Bozkirli Ankara, Turkey More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.2352AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Fibronectin is a nonionic urinary macromolecule which is a possible protector in nephrolithiasis. We evaluated the association between fibronectin gene (FN1) polymorphisms and calcium oxalate nephrolithiasis as a genetic risk factor. METHODS Genomic DNA of 143 calcium oxalate nephrolithiasis patient and 154 healthy controls were screened for the polymorphisms (HaeIII b, MspI and HindIII) of FN1 gene using polymerase chain reaction – restriction fragments length polymorphism (PCR-RFLP) method(Figure 1). Allele and genotype frequencies were compared between the groups. RESULTS Although the observed differences between distribution of genotypes of AA, AB, BB (for HaeIII b) and CC, CD, DD (MspI) were not significant, FF genotype for HindIII showed significant difference when compared with both EF and EE+EF genotype (p=0.00202 and p=0.00203 respectively) (Table 1). CONCLUSIONS The results of our study revealed that HindIII polymorphism of the FN1 gene is highly associated with calcium oxalate stone disease. This association makes FN a good candidate for further studies about the etiology of stone disease, and in the future it could be a candidate marker for evaluating the genetic risks in patients with nephrolithiasis. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e857 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Metin Onaran Ankara, Turkey More articles by this author Akin Yilmaz Ankara, Turkey More articles by this author Ilker Sen Ankara, Turkey More articles by this author Mehmet Ali Ergun Ankara, Turkey More articles by this author Ahmet Camtosun Ankara, Turkey More articles by this author Bora Kupeli Ankara, Turkey More articles by this author Sevda Menevse Ankara, Turkey More articles by this author Ibrahim Bozkirli Ankara, Turkey More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...