The HindIII polymorphism in the lipoprotein lipase gene predicts type 2 diabetes risk among Chinese adults

Abstract

Objective We aimed to investigate the polymorphism HindIII of the lipoprotein lipase (LPL) gene to explore whether it had a potential role in susceptibility to type 2 diabetes mellitus (T2DM) among Han Chinese, and whether this effect was influenced by regulating LPL or other risk factors. Methods Overall, 654 Han Chinese adults were selected from a community-based cross-sectional study using a stratified cluster random sampling. Genotyping was performed using the PCR–RFLP technique, and the metabolic variables were measured using standard methods. Results Individuals with the HindIII H−/H− genotype tended to have higher pre-heparin LPL (PrLPL) and lower triglyceride levels but an unexpected higher prevalence of T2DM compared with the H+/H+ genotype carriers. The association between the H−/H− genotype and T2DM risk remained unchanged across all subgroups of lipids/glucose-related RF. In a recessive model, the H−/H− genotype conferred a 2.12-fold increased risk [odds ratio (OR): 3.12; 95% confidence interval (CI): 1.18–8.27] for T2DM after controlling for age and sex, and increased further after additionally adjusting for traditional RFs, and PrLPL (OR = 4.45; 95% CI = 1.51–13.07). Conclusions This study indicated that Chinese adults with the LPL gene HindIII H−/H− genotype had a significantly increased risk of T2DM, even if they had favorable lipid profiles.