Highest Number Of Publications Research Articles

Bibliometric analysis of bone metastases from lung cancer research from 2004 to 2023.

Bone metastases of lung cancer (BMLC) severely diminish patients' quality of life due to bone-related events, and the lack of clear guidelines globally regarding medical and surgical treatment significantly reduces patient survival. While knowledge about BMLC has grown exponentially over the past two decades, a comprehensive and objective bibliometric analysis remains absent. A comprehensive bibliometric analysis was conducted on relevant literature on BMLC extracted from the Web of Science database from 2004 to 2023 by Biblioshiny, VOSviewer, Scimago Graphica, CiteSpace, and Microsoft Office Excel Professional Plus 2016 software. 936 papers related to BMLC were extracted from the Web of Science Core Collection (WoSCC). The number of publications, countries, institutions, global collaborations, authors, journals, keywords, thematic trends, and cited references were then visualized. Finally, the research status and development direction in the last 20 years were analyzed. This study included a total of 936 papers on BMLC from 2004 to 2023. There has been a steady increase in global publications each year, peaking in 2021. China had the highest number of publications, followed by Japan and the United States. Additionally, China had the most citations with an H-index of 35, while the US followed with an H-index of 34, highlighting their significant contributions to the field. "Frontiers in Oncology" had the highest number of publications. CiteSpace analysis identified "lung cancer," "bone metastasis," and "survival" as the top high-frequency keywords, encapsulating the core research focus. Keyword clustering analysis revealed six main clusters representing the primary research directions. Burst analysis of keywords showed that "skeletal complications" had the highest burst intensity from 2005 to 2013, while recent research trends include "immunotherapy" and "denosumab," with bursts from 2021 to 2023. Trend topic analysis indicated that "non-small cell lung cancer," "immunotherapy," and "immune checkpoint inhibitors" represent the cutting-edge research directions in this field. This article reveals the current status and trend of research on BMLC, which is increasing worldwide. China and the United States have contributed the most, but international cooperative research on BMLC should be strengthened. The pathogenesis, early prevention, and individualized treatment of BMLC need to be strengthened for further study, and immunotherapy is the next hotspot of lung cancer bone metastasis research.

Research Trends and Development Patterns in Microgreens Publications: A Bibliometric Study from 2004 to 2023

This article presents a general overview of scientific publications in the field of microgreens using bibliometric tools. Data were collected from the Web of Science database (from Clarivate Analytics) in the period from 2004 to 2023, covering 20 years of scientific publications. The results are presented in the form of tables, graphs, and charts to analyze the development of microgreens publications. The countries with the greatest influence on the microgreens topic are the USA, Italy, and India, which have the highest number of publications in the analyzed period with 133, 76, and 38 publications, respectively. On the other hand, the authors with the highest number of publications are Raphael, Y. (University Naples Federico II-Italy), De Pascale, S. (University Naples Federico II-Italy), and Luo, Y. (ARS, Food Quality Laboratory, Environmental Microbial & Food Safety Lab, USDA-USA). The journals with the highest productivity in microgreens are HortScience (American Society of Horticultural Science), Horticulturae (MDPI), and Foods (MDPI), with publication numbers of 49, 27, and 23, respectively. Regarding the relationship of the documents in this study with United Nations Sustainable Development Goals (SDGs), the large majority of documents can be linked to SDG 2 (Zero Hunger), followed by SDG 13 (Climate Action) and SDG 3 (Good Health and Well Being). As a final remark, the mapping, trends, and findings in this work can help to establish logical paths for researchers in the field of microgreens.

Bibliometric Analysis of the Research Status and Global Trends in Behavioral and Psychological Symptoms of Dementia in Alzheimer's Disease from 2002 to 2022.

Several reviews on behavioral and psychological symptoms (BPSDs) in patients with Alzheimer's disease (AD) have summarized the current state of this field, but global trends are unclear. This study utilized CiteSpace to provide a global overview of the current state of research on AD and its BPSDs and to predict future research trends in the field. Data were retrieved from the Web of Science Core Collection. Bibliometric and cooccurrence analyses were performed using CiteSpace software. In total, 787 valid publications were included in the analysis. Publications on AD and BPSD have shown an increasing trend since 2002. The United States and the University of Toronto were the countries and institutions with the highest total number of publications, respectively. Japan and China were the second and third most influential in the field. Clive Ballard was the top author in terms of the number of publications. Journal of Alzheimer's Disease had the highest number of publications on this topic. Co-occurrence analysis showed that AD, behavioral symptoms, cognitive impairment, and early markers are hot topics in this area. Non-drug management of BPSDs, pharmacological treatment, and physiotherapy will be a hot topic in this field in the future. Our study visualized the relevant articles over the past 21 years to detect global hotspots and trends. Our findings may help researchers to identify research hotspots in this field and will help in the selection of appropriate research topics, while possibly leading to cross-regional cooperation.

Research Trends on Writing Skill in Arabic Language; A Bibliometric Analysis

This study examines the trends in research on Arabic writing skills from 2011 to 2024 using a bibliometric approach. Data from 32 Scopus-indexed publications were analyzed to identify citation trends, geographical distribution, journal rankings, and research focuses. Data collection techniques included comprehensive searches in bibliographic databases, and data analysis was conducted using bibliometric methods such as citation analysis and co-authorship network analysis. The results show a significant increase in related publications, highlighting the importance of communicative approaches and international collaboration in enhancing writing skills. Specifically, the highest number of cited publications (NCP) occurred in 2020, with an NCP of 6. The highest number of citations from 2011 to 2024 was recorded in 2020, reaching 28. Additionally, 2020 had the highest number of publications, totaling 7, indicating a significant impact of research during that year. Saudi Arabia is the most significant country in research related to writing skills in Arabic. Furthermore, the study categorizes research focuses into three main clusters: students, e-learning, and supporting technologies for Arabic language learning. These insights provide a valuable framework for educators and researchers, guiding future research directions and developing more effective and inclusive teaching methodologies that cater to diverse learning needs. The study concludes that fostering international collaboration and leveraging advanced technologies are essential for the continued enhancement of Arabic writing skills education, ensuring that learners are well-equipped to meet contemporary challenges and advancing the field in a meaningful way.

Visualisation of Studies on Knee Injuries in Football: A Bibliometric Analysis.

Football is a popular sport on a global scale, and injuries sustained by football players have become a significant concern for sports physicians and researchers. Among these injuries, knee injuries are a commonly encountered problem in football players with long-term effects. This paper aims to perform a visual mapping and a bibliometric analysis of research on knee injuries in football, examining the current state and research trends. For this purpose, all publications from the Social Sciences Citation Index (SSCI), Science Citation Index Expanded (SCIE), Emerging Sources Citation Index (ESCI), and Arts & Humanities Citation Index (AHCI) within the Web of Science database were analysed. VOSviewer 1.6.18 was utilised for visualising bibliometric data. A total of 2159 publications were included in the study. The analysis covers publication year, authors, citation counts, and distributions among publishing journals. Authors, institutions, and international relationships were investigated, and keyword analysis, bibliometric coupling, and co-citation network analyses were conducted. The findings reveal that the United States and Australia are the countries with the highest number of publications. From 2018, there has been a noticeable increase in the number of publications. Citation and publication counts reached their peak in 2021. Turkey takes the 28th rank in terms of citation and centrality. The keywords "soccer," "football," "knee", and "anterior cruciate ligament" were found to be intensively used with high centrality. In conclusion, visual mapping through bibliometric analysis highlights the magnitude and diversity of research in the field of knee injuries in football. It emphasises the need for further studies in this area for future researchers, shedding light on important research areas. Moreover, it provides insights into the prevention of such injuries in football players and the development of effective treatment strategies by fostering more knowledge and understanding of knee injuries.

The evolution of simulation-based medical education research: From traditional to virtual simulations

BackgroundSimulation-based medical education (SBME) is a widely used method in medical education. This study aims to analyze publications on SBME in terms of countries, institutions, journals, authors, and keyword co-occurrence, as well as to identify trends in SBME research. MethodsWe retrieved the Publications on SBME from the Web of Science Core Collection (WoSCC) database from its inception to January 27, 2024. Microsoft Excel 2019, CiteSpace, and VOSviewer were used to identify the distribution of countries, journals, and authors, as well as to determine the research hotspots. ResultsWe retrieved a total of 11272 publications from WoSCC. The number of documents published in 2022 was the highest in the last few decades. The USA, the UK, and Canada were three key contributors to this field. The University of Toronto, Stanford University, and Harvard Medical School were the top major institutions with a larger number of publications. Konge, Lars was the most productive author, while McGaghie, William C was the highest cited author. BMC Medical Education has the highest number of publications among journals. The foundational themes of SBME are “Patient simulation,” “extending reality,” and “surgical skills.” ConclusionsSBME has attracted considerable attention in medical education. The research hotspot is gradually shifting from traditional simulations with real people or mannequins to virtual, digitally-based simulations and online education. Further studies will be conducted to elucidate the mechanisms of SBME. The utilization of SBME will be more rationalized.

Bibliometric and scientometric analysis of acarological publications in Türkiye between the years 1992-2023

A bibliometric and scientometric analysis of acarological studies conducted in Türkiye between 1992 and 2023 were performed by searching the Clarivate Thomson Reuters WoS database using 525 keywords. The first publication from Türkiye appeared in WoS in 1992. A total of 1,344 articles, 52 reviews, 30 progress reports, eight letters, eight early access documents, seven editorials, three conference abstracts and one note were found. The 1,453 articles written by Turkish scientists were published in 420 different sources (books, journals, etc.) with an annual growth rate of 16.3% and an average number of references of 10.39. Overall, 149 (10.25%) of the publications were written by a single author, while the remaining 1,304 articles had an average of 4.36 authors and 23.47% of them were written in collaboration with international experts. With some slight fluctuations, the number of publications increased over the years, with the highest number of publications being recorded in 2021 and 2023. Again, a steady increase in total and annual citations was observed, with some slight fluctuations. Systematic and Applied Acarology and International Journal of Acarology were the journals with the highest number of publications, while Experimental and Applied Acarology (n=1,202) was the journal with the highest number of citations to Turkish publications. Experimental and Applied Acarology and Veterinary Parasitology were the journals with the highest H-index. The most prolific authors were Salih Doğan (n=77), İsmail Döker (n=67) and Sultan Çobanoğlu (n=64), while the most cited publications were those of Salih Doğan, Nusret Ayyıldız and Adem Keskin. Münir Aktaş, Salih Doğan and Adem Keskin were the authors with the highest H-index. With 199 publications, Ankara University was the institution with the highest number of publications. The 1,453 publications were produced in collaboration with researchers from 87 countries. The highest number of collaborative publications was with researchers from the United States of America (n=89). The Scientific and Technological Research Council of Türkiye was the institution that founded the highest number of studies.

Knowledge mapping of macrophage and its role in aneurysm from 1999 to 2022: A bibliometric analysis

BackgroundVarious factors play crucial roles in aneurysm development and prognosis. Macrophages have recently emerged as a major research focus. Despite the numerous studies on the role and function of macrophages in aneurysm pathogenesis, no bibliometric analyses have focused on this topic. ObjectiveThis study aimed to analyze articles related to macrophages and aneurysms to reveal trends, hotspots, and new frontiers in macrophage-related aneurysm research. MethodsWe retrieved and incorporated 1211 articles from the Science Citation Index Expanded database of the Web of Science Core Collection between 1999 and 2022. The data were analyzed and visualized using CiteSpace and VOSviewer, and Microsoft Excel 2019 was used to plot the data. ResultsThe most influential articles were published between 1999 and 2022, with a total citation count of 43870. This study encompassed a comprehensive analysis of 74 research directions. The year with the highest number of publications was 2021 when 109 articles were published. 'ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY' journal has made significant contributions by publishing the highest number of articles (99 articles), while funding support primarily came from the National Institutes of Health and United States Department of Health and Human Services. The United States exerted a substantial influence within this field, with a total publication count of 453 publications and the highest centrality value (0.63). Recent studies have focused on understanding the developmental processes underlying aneurysms and devising preventive measures to effectively impede disease progression. ConclusionsOur analysis demonstrates the rapid growth in research exploring the relationship between macrophages and aneurysms over the past two decades. Continued exploration and collaboration among different specialties and manufacturers will facilitate innovative approaches for effective management strategies that target patients with diverse forms of aneurysms.

A scientometrics analysis and visualization of refractory gastroesophageal reflux disease.

Refractory gastroesophageal reflux disease (refractory GERD) is a heterogeneous disease characterized by unresponsiveness or poor efficacy to proton-pump inhibitors (PPIs). This chronic disorder substantially weakens patients' mental wellbeing and quality of life, increasing the financial burden on society. Multiple articles have been reported in this area. However, literature involving scientometric analysis of refractory GERD is absent. Therefore, it is necessary to understand the evolution of research themes and the main hotspots of refractory GERD through bibliometric methods. All documents related to refractory GERD based on the WOS Core Collection from January 2000 to November 2023 were selected for analysis. Citespace V 6.1 R6, VOSviewer V 1.6.20, and Scimago Graphica V 1.0.38 were used to perform bibliometric analysis. We collected a total of 241 research articles from 36 countries and 322 institutions, contributed by over 1,000 authors. Over the last 20years, the number of articles in this field has increased year by year, and since 2011, the number of publications has increased dramatically, with 85.89% of the papers. These countries are led by the United States and Japan. GUT had the highest number of citations and DIGESTION had the highest number of publications. Research on standardized diagnosis and management, mechanisms, novel monitoring methods, and innovative drugs and procedures for refractory GERD are the main topics and hotspots in this field. This study also found that neuroimmune interaction is closely related to refractory GERD, which may be a new direction for future mechanism research. Our study is the first bibliometric analysis of the global literature on refractory GERD. This research provides valuable insights for researchers, enabling them to quickly understand the research frontier and hot topics of this field.

Bibliometric analysis of functional magnetic resonance imaging studies on chronic pain over the past 20 years.

The utilization of functional magnetic resonance imaging (fMRI) in studying the mechanisms and treatment of chronic pain has gained significant popularity. However, there is currently a dearth of literature conducting bibliometric analysis on fMRI studies focused on chronic pain. All the literature included in this study was obtained from the Science Citation Index Expanded of Web of Science Core Collection. We used CiteSpace and VOSviewer to analyze publications, authors, countries or regions, institutions, journals, references and keywords. Additionally, we evaluated the timeline and burst analysis of keywords, as well as the timeline and burst analysis of references. The search was conducted from 2004 to 2023 and completed within a single day on October 4th, 2023. A total of 1,327 articles were retrieved. The annual publication shows an overall increasing trend. The United States has the highest number of publications and the main contributing institution is Harvard University. The journal PAIN produces the most articles. In recent years, resting-state fMRI, the prefrontal cortex, nucleus accumbens, thalamus, and migraines have been researched hotspots of fMRI studies on chronic pain. This study provides an in-depth perspective on fMRI for chronic pain research, revealing key points, research hotspots and research trends, which offers valuable ideas for future research activities. It concludes with a summary of advances in clinical practice in this area, pointing out the need for critical evaluation of these findings in the light of guidelines and expert recommendations. It is anticipated that further high-quality research outputs will be generated in the future, which will facilitate the utilization of fMRI in clinical decision-making for chronic pain.

Use of comics in the promotion of school children’s health: a scoping review

This scoping review provides an analysis of the available experiences on the use of comics to promote the health of school children. It was registered in the Open Science Framework (OSF) under DOI: doi.org/10.17605/OSF.IO/Z5VX6. Seventeen studies were used, including articles, theses and dissertations. The results present the main characteristics of the studies such as year; country; sample characteristics; study design; description of actions and population/sample. The target population of each selected study was children younger than 10 years. The sample number of the studies ranged between 47 and 881 children. Fifteen studies developed the interventions in schools. 44.4% of the selected studies were published between 2011 and 2020, and the continents with the highest number of publications were South America and North America, with 33.3% each. Regarding the type of study, 55.6% used the non-randomized experimental method and 35.3% had themes related to specific diseases. The experiences that were considered successful were conditioned to the organizational structure of the use of comic books and how they were offered to school children.

Bibliometric analysis of neuroepithelial stem cells and brain ischemia

Objective: This bibliometric analysis aims to summarize the progress of neuroepithelial stem cells (NESCs) therapy in brain ischemia and provide insights for future research. Methods: Relevant literature was first screened from the Web of Science Core Collection with keywords “neuroepithelial stem cells” and “brain ischemia”, Then the research trends in these fields were analyzed by using VOSviewer, Pajek, Microsoft Excel, and bibliometric online analysis platform. Results: In total, 12 publications on NESCs and brain ischemia were identified, and “stem cells” is the most frequent keyword. A total of 6 countries and regions have published articles in this field, among which the UK has the largest number of publications (5 Articles), followed by the USA and China. The University of Florida is the institution with the highest number of publications. Regarding author contribution, Hodges H published the highest number of articles, with 69.8 citations. The highest-ranking journal was Neurobiology of Disease with 2 publications, while the most cited journal was Neuroscience with 4.00 average citations per item. Conclusions: This study provides a comprehensive analysis of NESC therapy in brain ischemia. In the past decade, the number of articles in this field has decreased slowly, but at the same time, the application of NESCs and ischemia has provided new methodological ideas for the clinical treatment of brain ischemia.

Simulation of Hospital Waste Supply Chain in the Context of Industry 4.0—A Systematic Literature Review

Supply chain management is a crucial task for all companies, as it is essential to respond to increased demand and competitiveness. An exponential increase in hospital waste can cause very significant risks to both humans and the environment if it is not treated adequately. In this way, the efficient management of this waste can bring benefits and prevent an increase in the likelihood of disease occurring. With the growth of technology, there are various tools available to improve decision-making in the supply chain. Simulation, one of the pillars of Industry 4.0, is one of the tools being used. With the complexity of systems increasing, hybrid simulation provides more precise solutions to problems. The aim of this article is therefore to systematically research and analyze the literature on the use of simulation/hybrid simulation in supply chains in the health sector. In this way, 20 articles that approach simulation as a decision support tool in hospital waste supply chains were analyzed in the context of Industry 4.0. The results indicate that the years 2020 and 2023 had the highest number of publications (with five each) and that countries such as China and Indonesia had the highest number of documents on this topic (with five each). The topics in this research area with more related documents were environmental sciences, computer sciences and medicine. This research highlights the fundamental role of simulation approaches in improving the performance of supply chains in the healthcare sector, promoting resilience and improving healthcare outcomes for patients.

Research progress of airway inflammation in asthma: A bibliometric analysis.

In recent years, the prevalence of asthma has gradually increased and the number of asthmatics worldwide has reached 358 million, which has caused huge economic loss. Airway inflammation is an important feature of asthma, and international research in this field has a high degree of heat. Therefore, this paper uses the bibliometric method to systematically review and visualize the literature in this field, aiming to provide some reference value for follow-up related research. To retrieve the research literature on airway inflammation in asthma from 2003 to 2022 in the Web of Science Core Collection database. The bibliometric method was used to systematically analyze the included literature data by using visualization analysis software such as CiteSpace (6.2. R4) and VOSviewer (1.6.19). A total of 1892 articles published in 423 journals were included in this study, from 1912 institutions in 62 countries/regions. The number of articles published between 2003 and 2022 showed a trend of fluctuating growth. The country with the largest number of articles published was China (558,29.49 %), followed by the United States (371,19.61 %) and Korea (212,11.21 %). Gibson, Peter G is the author with the highest number of publications, and Journal of Allergy and Clinical Immunology is the most published journal. This study systematically reveals the state of the literature in the field of airway inflammation in asthma over the past 20 years. The exploration of inflammatory cell components, pathway molecules and biological agents are research hotspots in this field and should be further studied.

Research priorities and trends in pulmonary tuberculosis in Latin America: A bibliometric analysis

Tuberculosis (TB) poses a significant global public health challenge, particularly in developing countries. Over the years, scientific research has played a pivotal role in addressing this disease. In this study, we aimed to analyze and outline the trends in scientific output on TB and identify research priorities in Latin America (LA) from 1990 to 2021. Scientific production was analyzed, and the number of publications, financing sources, and journal characteristics were evaluated. Collaboration networks and keywords were visualized using mapping analysis with VOSviewer software. Research themes were prioritized by country based on co-occurrence frequency. In total, 4399 documents were identified, a significant trend was evident in the number of publications per year (R2 = 0.981), and research substantially contributed to the reduction of TB-related mortality (R2 = −0.876). Most publications were original articles (83.8 %). The International Journal of Tuberculosis and Lung Disease had the highest publication and citation rates per document. International collaboration was predominantly with the United States, France, and Canada. Brazil, Argentina, and Mexico had the highest number of publications and external collaborations. In LA, interest in researching studies related to treatment and diagnosis (32.5 %) was notably high, followed by epidemiology and screening (26.9 %). Among the 20 countries in LA, research priorities varied, with the highest emphasis on HIV/AIDS (14/20), epidemiology (9/20), anti-TB agents (6/20), and mortality (5/20). TB resistance was only considered a research priority in Brazil, Peru, and Haiti. Therefore, LA experienced significant growth in its scientific output, playing a crucial role in TB control. Strategic adaptation to the region's specific challenges was observed, particularly in HIV/AIDS coinfection, epidemiological studies, and drug resistance. This progress was achieved by outstanding international scientific collaboration. This holistic approach emphasizes the importance of research in the fight against TB in LA.

Opportunities for the development of tourism education in Indonesia: A bibliometrics analysis

The objective of this study is to analyze journal publications on tourist education in Indonesia over a 10-year period and suggest new avenues for future research. The study conducted a bibliometric analysis of 241 articles found in the Scopus database from 2003 to 2023. Bibliometric procedures were used to assess research performance and global influence, while Biblioshiny-R and VOSviewer were used to illustrate general research patterns in tourism education. Indonesia emerged as the leading country in terms of publications on tourist education, with Australia and Malaysia ranking second and third, respectively. The year 2021 had the highest number of publications on tourism education. The findings also indicate that tourism education receives relatively less emphasis compared to other tourist themes, such as sustainable tourism, agrotourism, and ecotourism. Therefore, future studies should prioritize the topic of tourist education in Indonesia. Based on the current research findings, all writers affiliated with the top nine institutions are still located on the island of Java. The three primary universities are Universitas Pendidikan Indonesia, Universitas Gadjah Mada, and Brawijaya. Furthermore, based on the analysis of the Word Cloud, it is evident that Bali and Lombok are prominent tourist sites in Indonesia that attract significant attention from researchers. This study suggests that future academics should focus on tourism education in Indonesia, with particular emphasis on expanding research beyond the islands of Java and Bali.

Bibliometric Analysis of Trends in Scientific Publication on Culture Chachapoyas

The bibliometric analysis sought to evaluate the scientific production related to the Chachapoyas culture and to provide a systematic and quantitative understanding of the current state of research in this field. Comprehensive searches were conducted in the Scopus database using the defined search criteria limiting the search to scientific articles published in scientific journals until September 2023. The results were exported in a format that allowed subsequent analysis. Relevant bibliographic data were extracted from the search results, including article title, authors, year of publication, abstract and citations. A number of bibliometric metrics were calculated, such as number of publications per year totaling 40, the number of citations per article totaling 354, and the most frequent keyword was Peru with 17 occurrences. The author with the highest number of publications was Toyne J.M. with 9 papers and the journal with the most publications was the International Journal of Osteoarchaeology with 4. The bibliometric analysis shows a constant production in the research of the Chachapoyas Culture, with international collaboration and influential studies. However, there is still much to study and discover about this important pre-Columbian culture.

A bibliometric and visualization analysis of global research status and frontiers on autophagy in cardiomyopathies from 2004 to 2023.

Autophagy is intimately associated with the development of cardiomyopathy, and has received widespread attention in recent years. However, no relevant bibliometric analysis is reported at present. In order to summarize the research status of autophagy in cardiomyopathy and provide direction for future research, we conducted a comprehensive, detailed, and multidimensional bibliometric analysis of the literature published in this field from 2004 to 2023. All literatures related autophagy in cardiomyopathy from 2004 to 2023 were collected from the Web of Science Core Collection (WOSCC), and annual papers, global publication trends and proportion charts were analyzed and plotted using Graphpad price v8.0.2. In addition, CtieSpace (6.2.4R (64 bit) Advanced Edition) and VOSviewer (1.6.18 Edition) were used to analyze and visualize these data. 2279 papers about autophagy in cardiomyopathy were accessed in the WoSCC over the last 20 years, comprising literatures from 70 countries and regions, 2208 institutions, and 10,810 authors. China contributes 56.32% of the total publications, substantially surpassing other countries, while the U.S. is ranked first in frequency of citations. Among the top 10 authors, 6 are from China and 4 are from the United States. Air Force Military Medical University was the institution with the highest number of publications; while journal of molecular and cellular cardiology (62 articles, 2.71% of the total) was the journal with the highest number of papers published in the field. Clustering of co-cited references and temporal clustering analysis showed that ferroptosis, hydrogen sulfide mitophagy, lipid peroxidation, oxidative stress, and SIRT-1 are hot topics and trends in the field. The principal keywords are oxidative stress, heart and heart-failure. The research on autophagy in cardiomyopathy is in the developmental stage. This represents the first bibliometric analysis of autophagy in cardiomyopathy , revealing the current research hotspots and future research directions in this field.

Bibliometric analysis of chimeric antigen receptor T-cell therapy

Background: CAR-T therapy refers to the genetic material with a specific antigen recognition domain and T cell activation signal is transferred into T cells through gene modification technology so that T cells are activated directly by combining with specific antigens on the surface of tumor cells, and directly kill tumor cells by releasing perforin, granzymin B, etc. This review aims to point out the emerging trends in different classes of immune cell therapies and provide insights for future research. Methods: All relevant literature on CAR-T therapy has been screened from the Web of Science and analyzed for its research trends with the help of VOS viewer, Pajek, Microsoft Excel and Endnote software, Results: According to the findings, the United States is the most productive country in this field. The institution with the highest number of publications is the University of Pennsylvania. Frontiers in Immunology is one of the most productive journals. Gottschalk Stephen publishes the largest number of articles. Keyword co-occurrence analysis shows that the current research trend is more focused on immune cell therapy as well as CAR-T, and the mechanisms and modalities were explored in CAR-T therapy. Conclusion: This study provides a comprehensive summary and analysis of global research trends in CAR-T therapy. In detail, CAR-T therapy has provided hope for tumor treatment, truly bringing new hope to the majority of tumor patients, patients with major diseases, and sub-healthy people.

Analysis and mapping of harm reduction research in the context of injectable drug use: identifying research hotspots, gaps and future directions

BackgroundHarm reduction is a crucial approach in addressing the multifaceted challenges of injectable drug use. This paper presents an analysis and mapping of the existing literature on harm reduction research in the context of injectable drug use. By reviewing a comprehensive set of scholarly articles, this study identifies research hotspots, knowledge gaps, and future directions in the field. The findings provide valuable insights for researchers, policymakers, and practitioners to guide future research efforts and inform evidence-based harm reduction interventions.MethodsData for the study was obtained from the Scopus database, using keywords and phrases related to harm reduction and injectable drug use. Validation methods were employed to verify the accuracy and comprehensiveness of the search strategy. Data analysis involved identifying growth patterns, key contributors, mapping frequent terms, identifying research hotspots, and identifying emerging research directions.ResultsA total of 971 articles were found, with a notable increase from 2015 to 2022. The International Journal of Drug Policy (n = 172, 17.7%) and the Harm Reduction Journal (n = 104, 10.7%) were the most prolific journals, and the United States (n = 558, 57.5%) had the highest number of publications. The Johns Hopkins University (n = 80, 8.5%) was the most prolific institution. Mapping of frequent author keywords revealed the main keywords, including harm reduction, HIV, hepatitis C, and opioid overdose. The highly cited articles cover a broad time span and focus on topics like naloxone distribution, HIV and hepatitis C transmission, while recent articles concentrate on emerging issues such as the impact of the COVID-19 pandemic, fentanyl-related concerns, stigma reduction, and needle and syringe programs. Both sets of articles share a common focus on harm reduction strategies, but recent publications highlight current challenges and developments in the field.ConclusionsThis study provides insights into research landscape on harm reduction in injectable drug use. Research is concentrated in high-income countries, emphasizing the need for more research in low- and middle-income countries. Recent publications focus on emerging challenges like COVID-19 and fentanyl. Research gaps highlight the need for studies in diverse populations, social determinants, program evaluation, and implementation strategies to enhance harm reduction interventions.