Abstract
Background: CAR-T therapy refers to the genetic material with a specific antigen recognition domain and T cell activation signal is transferred into T cells through gene modification technology so that T cells are activated directly by combining with specific antigens on the surface of tumor cells, and directly kill tumor cells by releasing perforin, granzymin B, etc. This review aims to point out the emerging trends in different classes of immune cell therapies and provide insights for future research. Methods: All relevant literature on CAR-T therapy has been screened from the Web of Science and analyzed for its research trends with the help of VOS viewer, Pajek, Microsoft Excel and Endnote software, Results: According to the findings, the United States is the most productive country in this field. The institution with the highest number of publications is the University of Pennsylvania. Frontiers in Immunology is one of the most productive journals. Gottschalk Stephen publishes the largest number of articles. Keyword co-occurrence analysis shows that the current research trend is more focused on immune cell therapy as well as CAR-T, and the mechanisms and modalities were explored in CAR-T therapy. Conclusion: This study provides a comprehensive summary and analysis of global research trends in CAR-T therapy. In detail, CAR-T therapy has provided hope for tumor treatment, truly bringing new hope to the majority of tumor patients, patients with major diseases, and sub-healthy people.
Published Version
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