Abstract
Ubiquitously expressed transcript (UXT), known as androgen receptor trapped clone 27 (ART-27), is a widely expressed transcription factor in humans and rats, which has been reported to be associated with various biological processes, including cell proliferation, apoptosis, autophagy, and signal transduction. Here, 68 articles from databases like PubMed, SinoMed, and CNKI were retrieved to summarize the research progress of UXT from its discovery to recent years. Results indicate that UXT is highly expressed in various tumor tissues and closely related to tumor development and also plays a vital role in immune regulation by modulating the CGAS-STING1 and NF-κB signaling pathways. The loss of UXT function is linked to the progression of retinal degenerative diseases, highlighting its importance for retinal health. Additionally, UXT is involved in the reproductive system, particularly in spermatogenesis and testis development, and even may be associated with neurodegenerative, cardiovascular, and liver diseases. The potential application of UXT as a reference gene in experimental design is also discussed. The conclusion emphasizes that UXT, as a multifunctional protein, plays a significant role in cell biology and disease development, making it a potential target for disease research and treatment. Future research will delve into the specific mechanisms of UXT action, potentially offering new opportunities for clinical diagnosis and treatment.
Published Version
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