Job burnout is a major issue that influences employees’ performance, job satisfaction and their overall well-being. There is limited evidence that points towards poor profession status and general dissatisfaction amongst community pharmacists. This study aimed to investigate burnout and associated factors amongst community pharmacists in Jordan. The study was conducted via an online questionnaire composed of three main domains: demographics, occupational factors and Copenhagen burnout inventory (CBI) and a total of 400 community pharmacists participated. Total burnout scores amongst the participants were elevated (49.72 ± 16.65), with 43% exhibiting a high total burnout level. Burnout scores negatively correlated with age, exercise level, perceived sleep quality and financial status, while positively correlated with body mass index. Living alone status had elevated odds for high burnout compared to living with family or roommate(s). Regarding occupational factors, burnout level negatively correlated with the number of pharmacies the participants have worked in, working hours per day, how sufficient they perceive their salary to be and how much they enjoy working in a community pharmacy setting. On the other hand, a positive correlation was observed for the number of work days per week, requirement to work on national holidays and perceived workload. Moreover, working on night shifts and working alone both had higher odds for exhibiting high burnout levels. In conclusion, the results call for employers and policy-makers to take into consideration factors influencing burnout amongst community pharmacists for the development and implementation of interventional strategies to mitigate burnout and enhance the well-being of community pharmacists.