Higher Food Intake Research Articles

The association of dietary inflammatory potential with sarcopenia in Chinese community-dwelling older adults

BackgroundDietary-induced inflammation is potentially associated with sarcopenia. Nevertheless, few studies have investigated the structure of the inflammatory diet and its correlation with muscle function and performance in both the upper and lower limbs. This study was performed to explore the association of the dietary inflammatory index (DII) with sarcopenia and its diagnostic parameters.MethodsWe conducted a cross-sectional survey on a sample of 515 Chinese community-dwelling older adults selected through multistage cluster sampling from three districts in Shanghai. DII scores were calculated using a validated food frequency questionnaire. Sarcopenia and its diagnostic parameters were determined based on the definition set by the Asian Working Group on Sarcopenia (AWGS).ResultsThe mean age of study participants was 71.31 ± 4.71 years. The prevalence of sarcopenia in the cohort was 12.4%. Older adults in the highest DII quartile had a 3.339 times increased risk of sarcopenia compared to those in the lowest quartile (OR Quartile4vs1:3.339, 95%CI: 1.232, 9.052, p-trend: 0.004) after adjusting for confounding factors. Additionally, a more pro-inflammatory diet was associated with lower appendicular skeletal muscle index (ASMI) (OR Quartile4vs1: 3.005, 95%CI: 1.275, 7.318, p-trend: 0.005), a higher 5-times sit-stand test time score (OR Quartile4vs1: 4.942, 95%CI: 1.745, 13.993, p-trend: 0.005), and lower gait speed (OR Quartile4vs1: 2.392, 95%CI: 1.104, 5.185, p-trend: 0.041) after adjusting for confounding factors. However, there was no significant association between DII, handgrip strength, and Short Physical Performance Battery (SPPB) score in either the unadjusted or adjusted model.ConclusionThis study found that the association between consuming a more pro-inflammatory diet and sarcopenia in Chinese community-dwelling older adults was mainly due to underlying low intakes of dietary energy, protein, and anti-inflammatory foods, and not due to the high intake of pro-inflammatory foods. Meanwhile, DII was more highly correlated with lower limb muscle strength and performance compared to upper limb muscle strength.

Examining Nutrition Knowledge, Skills, and Eating Behaviours in People with Severe Mental Illness: A Cross-Sectional Comparison among Psychiatric Inpatients, Outpatients, and Healthy Adults

Compared to the general population, people with severe mental illness (SMI) have an increased risk of weight gain and metabolic syndrome, but also of malnutrition, in part due to unhealthy lifestyle behaviours. The aim of this cross-sectional study was to identify barriers to healthy eating, including nutrition knowledge and skills in people with SMI. For this purpose, we compared the means of anthropometric data such as body mass index, waist-to-hip ratio, and interview data on nutrition knowledge and skills, health-related variables, eating behaviours, personality, motivation, and attitudes in 65 inpatients and 67 outpatients of the Psychiatric Hospital of the University of Zurich and 64 healthy adults using ANOVA and chi-squared tests. The results showed that patients with SMI had worse nutritional status and lifestyle compared to the healthy controls, including disordered (e.g., night eating) and unhealthy (e.g., high intake of sugary foods) eating habits. However, levels of nutrition knowledge, cooking and food skills, and motivation to eat healthily were not significantly lower in the psychiatric patients than in the healthy adults and were not associated with weight change. Based on our findings, nutritional support for people with SMI is urgently needed and should include not only educational but also behavioural and long-term approaches.

Analysis of The Effects of Artificial Sweeteners on Diabetes and Obesity

With the gradual expansion of the population of diabetes and obesity, type II diabetes is more common in obese patients, and the most worrying is the increasing number of type II diabetes among adolescents and young adults. People have had to look for ways to stop or delay the onset of diabetes, and artificial sweeteners, which cause good sweetness properties and high safety without the associated high-calorie content of sugar, are widely used in the food sector as the main way to address high sugar food intake. However, despite the very widespread use of artificial sweeteners, obesity and diabetes have not been reduced as expected, and even their numbers continue to increase rapidly. In recent years, with more in-depth research on artificial sweeteners, it is gradually found that artificial sweeteners have many adverse effects on diabetes and obesity. This article describes consumers in more detail from different perspectives on the effects of artificial sweeteners and concludes that artificial sweeteners do affect insulin resistance and gut microbes, which are detrimental to diabetics and obese people. However, whether all artificial sweeteners have a significant adverse effect on the human body needs to be further investigated.

Vegetable and high natrium food intake, nutritional status and metabolic syndrome among adolescents in makassar, Sulawesi Selatan, Indonesia

Vegetable and high natrium food intake, nutritional status and metabolic syndrome among adolescents in makassar, Sulawesi Selatan, Indonesia

The relationship between dietary patterns and insomnia in young women.

There is mounting evidence that eating habits affect sleeping patterns and their quality. The goal of this study was to evaluate the associations between major dietary patterns, identified using principal component analysis (PCA) and insomnia in young women. The study subjects comprised 159 healthy young women aged 18-25 years. Neuropsychological assessment was performed using standard instruments, including a cognitive ability questionnaire (CAQ), depression and anxiety stress scales (DASS-21), insomnia severity index (ISI), Epworth sleepiness scale (ESS), and quality of life questionnaire (QLQ). Dietary patterns were obtained from a 65-item validated food frequency questionnaire (FFQ) in this study, using PCA. Two major dietary patterns were identified that were termed: "Traditional" and "Western." The Western pattern was characterized by a high intake of snacks, nuts, dairy products, tea, fast foods, chicken, and vegetable oils. Subjects with moderate/severe insomnia were found to have lower scores for total cognitive ability task, nocturnal sleep hours, and physical and mental health, but higher scores for depression, anxiety, stress, and daytime sleepiness compared to those without insomnia (p < 0.05). After adjustment for potential confounders, high adherence to the Western dietary pattern was associated with higher odds of insomnia (OR = 5.9; 95% confidence intervals: 1.9-18.7; p = 0.003). Our findings indicated adherence to Western pattern may increase the odds of insomnia. Prospective research is required to determine the feasibility of targeting dietary patterns to decrease the odds of insomnia.

Higher Intakes of Nutrients are Associated with Improved Health-Related Quality of Life among Individuals with Comorbidities

There is a dearth of evidence on the association between nutrient intakes and health-related quality of life (HRQOL) among populations with comorbidities. Thus, this study aimed to identify the relationships between nutrient intake and HRQOL in a Korean population with comorbidities (4,136 adults aged ≥18 years). The EuroHRQOL five-dimension questionnaire (EQ-5D) and 24-hour recall methods were used to measure HRQOL and nutrient intake, respectively. Multivariable-adjusted logistic and linear regression models, marginal effects, and cutoff levels were applied to assess associations between nutrient intake and each dimension and the EQ-5D-3L index, as well as interactions of nutrient intake with comorbidities and sex for HRQOL. Interactions were identified between vitamin C, total vitamin A, potassium consumption, and sex for problems with depression and anxiety, problems with pain and discomfort, and any problem. Interactions were observed between monounsaturated fatty acids (MUFA) and sodium intake and comorbidities for problems with mobility and self-care problems among participants with comorbidities, respectively; between vitamin B1, vitamin B3, potassium, saturated fatty acids (SFA), fat, and cholesterol intake and comorbidities for problems with pain and discomfort; and between vitamin B1, MUFA, potassium, fiber, SFA, fat, and carbohydrate intake and comorbidities for any problems. Our findings found higher nutrient intake is associated with enhanced HRQOL in the Korean adult population. More work is needed to improve QOL by quitting smoking, eating more nutritional meals, and exercising regularly.

Effects on Serum Hormone Concentrations after a Dietary Phytoestrogen Intervention in Patients with Prostate Cancer: A Randomized Controlled Trial.

Phytoestrogens have been suggested to have an anti-proliferative role in prostate cancer, potentially by acting through estrogen receptor beta (ERβ) and modulating several hormones. We primarily aimed to investigate the effect of a phytoestrogen intervention on hormone concentrations in blood depending on the ERβ genotype. Patients with low and intermediate-risk prostate cancer, scheduled for radical prostatectomy, were randomized to an intervention group provided with soybeans and flaxseeds (∼200 mg phytoestrogens/d) added to their diet until their surgery, or a control group that was not provided with any food items. Both groups received official dietary recommendations. Blood samples were collected at baseline and endpoint and blood concentrations of different hormones and phytoestrogens were analyzed. The phytoestrogen-rich diet did not affect serum concentrations of testosterone, insulin-like growth factor 1, or sex hormone-binding globulin (SHBG). However, we found a trend of decreased risk of increased serum concentration of estradiol in the intervention group compared to the control group but only in a specific genotype of ERβ (p = 0.058). In conclusion, a high daily intake of phytoestrogen-rich foods has no major effect on hormone concentrations but may lower the concentration of estradiol in patients with prostate cancer with a specific genetic upset of ERβ.

Efektivitas Pemberian Cookies Tepung Kelor dengan Penambahan Tepung Ubi Banggai dan Tepung Kedelai sebagai Alternatif Makanan Tambahan dalam Meningkatkan BB pada Balita Wasting

Background : The health status of infants and toddlers is a determinant of the quality of human resources. In toddlerhood, growth and development occur very quickly, so a high intake of nutrients is needed. Provision of nutrition that is not optimal for toddlers will cause nutritional problems, one of which can occur is wasting (undernutrition). Indonesia is a developing country that has malnutrition problems including wasting. A public health problem is considered serious if the prevalence of wasting is between 10.0-14.0% and is considered critical if it is ≥15.0%3.Objective: The aim of this research is to produce PMT cookies for toddlers with the addition of moringa flour, Banggai’s sweet potato flour and soybean flour and to analyze the effectiveness of giving cookies made from moringa flour with the addition of Banggai’s sweet potato flour and soybean flour on weight gain in toddlers wasting.Methods: The study used a quasi-experimental one group pre and post-test. Respondents in this study were wasting toddlers in Donggala district. The research was carried out from July to October 2022.Result: The results showed that the selected cookie formulation was based on organoleptic tests on 30 panelists with 70% wheat flour, 10% moringa flour, 10% Banggai’s sweet potato flour and 10% soybean flour. With a moisture content of 3.41%, ash content of 0.364%, protein 37.4% and fat 4.86%. The stages of giving interventions showed that the result value was p = 0.000 (&lt;0.5) this means that giving cookies had an effect on increasing the respondent's body weight. There was an increase in weight in wasting toddlers.Conclusions: The conclusion is that cookies contain nutrients that can increase weight in toddler wasting.

Risk assessment of phthalate metabolites accumulated in fish to the Indo-Pacific humpback dolphins from their largest habitat

Food has consistently been shown to be an important source of exposure to environmental pollutants, drawing attention to the health risks of pollutants in marine mammals with high daily food intake. Here, the dietary exposure risks posed to the Indo-Pacific humpback dolphins from the Pearl River Estuary (PRE), China, by fourteen phthalate metabolites (mPAEs) were evaluated for the first time. On the basis of liquid chromatography-mass spectrometry (LC-MS/MS) analysis, the levels of ∑14mPAEs in ten main species of prey fish (n = 120) of dolphins ranged from 103.0 to 444.5 ng/g wet weight (ww), among which Bombay duck contained a significantly higher body burden of ∑14mPAEs than other prey species. Phthalic acid (PA), monooctyl phthalate (MnOP), monononyl phthalate (MNP), monoethyl phthalate (MEP), monoethylhexyl phthalate (MEHP), mono (5-carboxy-2-ethylpentyl) phthalate (MECPP), monobutyl phthalate (MBP), and monoisobutyl phthalate (MiBP) all had a trophic magnification factor (TMF) greater than unity, indicating the biomagnification potential of these mPAEs in the marine ecosystem of the PRE. A dietary exposure assessment based on the adjusted reference dose values of phthalates (PAEs) showed that bis (2-ethylhexyl) phthalate (DEHP) and dibutyl phthalate (DBP) may pose a high (HQ > 1) and medium (0.01 < HQ < 1) risk to the dolphin adults and juveniles, respectively. Our results highlight the potential health risks of mPAEs to marine mammals through dietary routes.

Association between ultra-processed foods and recurrence of depressive symptoms: the Whitehall II cohort study

ABSTRACT Objectives To examine the association between high intakes of ultra-processed foods (UPF) and recurrence of depressive symptoms (DepS) in a Western non-Mediterranean country and its contribution to the overall diet-depression relationship. Methods Analyses were carried out on British participants from the Whitehall II cohort. Present analyses were restricted to white participants N = 4554 (74% men, mean age = 61; SD = 5.9). UPF consumption was estimated from a 127-item food frequency questionnaire using the NOVA classification, and cumulative average of UPF intakes (g/day) over 11 years of exposure (1991/1994–2002/2004) was computed. Recurrent DepS after measurement of UPF was defined as having two or more episodes of DepS (the Center for Epidemiologic Studies Depression Scale (CES-D) score ≥ 16 or antidepressants use) during four phases of follow-up (2002/2004–2015/2016). Results Over the follow-up, 588 (12.9%) cases of recurrent DepS were observed. After adjusting for socio-demographic factors, health behaviours and health status, participants in top quintile of UPF intakes [mean 33% of total daily intakes in grams] had 31% higher odds of recurrent DepS (odds ratio 1.31; 95% CI 1.04–1.64) compared to participants in the four lowest quintiles of UPF [mean 18.1% of total daily intakes in grams]. Additional analyses showed that associations between adherence to several diet quality measures and recurrent DepS were partially attenuated (17–27%) by UPF intakes. Conclusion In this British population, high intakes of ultra-processed foods were associated with increased odds of recurrent depressive symptoms and contributed to the overall diet quality-depressive symptoms association.

The COVID-19 Pandemic, Rising Inflation, and Their Influence on Dining Out Frequency and Spending

High intake of food away from home is associated with poor diet quality. This study examines how the COVID-19 pandemic period and Food Away from Home (FAFH) inflation rate fluctuations influenced dining out behaviors. Approximately 2800 individuals in Texas reported household weekly dining out frequency and spending. Responses completed prior to the COVID-19 pandemic (2019 to early 2020) were compared to the post-COVID-19 period (2021 through mid-2022). Multivariate analysis with interaction terms was used to test study hypotheses. From the COVID-19 period (before vs. after), the unadjusted frequency of dining out increased from 3.4 times per week to 3.5 times per week, while the amount spent on dining out increased from $63.90 to $82.20. Once the relationship between dining out (frequency and spending) was adjusted for FAFH interest rate and sociodemographic factors, an increase in dining out frequency post-COVID-19 remained significant. However, the unadjusted increase in dining out spending did not remain significant. Further research to understand the demand for dining out post-pandemic is warranted.

The Relationship Between High Folate Food Intake with Breast Cancer in Premenopausal Women and Views According to Islam

Breast cancer is a non-infectious malignancy that can attack ductal or lobular epithelial cells in the glandular tissue of the breast. Breast cancer is one of the most common types of cancer in Indonesia and the world. This study aims to determine the level of folate consumption in premenopausal women and its association with breast cancer. The research design used was case control. Premenopausal women's folate consumption levels from both groups were obtained using the Semi-quantitative Food Frequency Questionnaire. The results of the study were obtained from 76 respondents, the majority of respondents were &gt;41 years old when diagnosed with breast cancer (45.8%). Based on the results of the variable analysis, it was found that a total of 5 respondents smoked. Respondents who smoked were more in the control group with 4 respondents (80%) compared to the breast cancer group which only amounted to 1 respondent (20%). Based on the results of the analysis, it was found that only one respondent consumed alcohol and came from the breast cancer group. History of cancer in the family was found more in the breast cancer group, namely 17 respondents (73.9%). Based on these results, it can be concluded that a family history of cancer is a significant factor (p value &lt;0.05). Based on the results of an analysis of folic acid consumption by breast cancer and control groups, it was shown that in the breast cancer group, respondents with low consumption of folate were more, namely 22 respondents (55%), with a difference of 10%. Whereas in the control respondents, there were more respondents in the high consumption category, namely 16 respondents (44.4%) with a difference of 11.2%. In this study, it was found that there was no significant relationship between intake of foods high in folate and the incidence of breast cancer in premenopausal women (p value &gt; 0.05).

The Relationship Between High Folate Food Intake with Breast Cancer in Premenopausal Women and Views According to Islam

Breast cancer is a non-infectious malignancy that can attack ductal or lobular epithelial cells in the glandular tissue of the breast. Breast cancer is one of the most common types of cancer in Indonesia and the world. This study aims to determine the level of folate consumption in premenopausal women and its association with breast cancer. The research design used was case control. Premenopausal women's folate consumption levels from both groups were obtained using the Semi-quantitative Food Frequency Questionnaire. The results of the study were obtained from 76 respondents, the majority of respondents were &gt;41 years old when diagnosed with breast cancer (45.8%). Based on the results of the variable analysis, it was found that a total of 5 respondents smoked. Respondents who smoked were more in the control group with 4 respondents (80%) compared to the breast cancer group which only amounted to 1 respondent (20%). Based on the results of the analysis, it was found that only one respondent consumed alcohol and came from the breast cancer group. History of cancer in the family was found more in the breast cancer group, namely 17 respondents (73.9%). Based on these results, it can be concluded that a family history of cancer is a significant factor (p value &lt;0.05). Based on the results of an analysis of folic acid consumption by breast cancer and control groups, it was shown that in the breast cancer group, respondents with low consumption of folate were more, namely 22 respondents (55%), with a difference of 10%. Whereas in the control respondents, there were more respondents in the high consumption category, namely 16 respondents (44.4%) with a difference of 11.2%. In this study, it was found that there was no significant relationship between intake of foods high in folate and the incidence of breast cancer in premenopausal women (p value &gt; 0.05).

Downregulation of microRNA-23a confers protection against myocardial ischemia/reperfusion injury by upregulating tissue factor pathway inhibitor 2 following luteolin pretreatment in rats.

Downregulation of microRNA-23a confers protection against myocardial ischemia/reperfusion injury by upregulating tissue factor pathway inhibitor 2 following luteolin pretreatment in rats.

Serum from Adolescents with High Polyphenol Intake Exhibits Improved Lipid Profile and Prevents Lipid Accumulation in HepG2 Human Liver Cells.

The traditional Mediterranean diet (MD) is characterized by a high phenolic-rich food intake, including in particular vegetables and fruits, but also legumes, whole grain cereals, nuts, and extra virgin olive oil. Evidence for beneficial effects of polyphenols in humans depends on the amount consumed and on their bioavailability. Here, we evaluated the association between the estimated polyphenol intake by fruits and vegetables food source and serum biochemical parameters in healthy adolescents, recruited into the DIMENU research project. Categorizing adolescents into three groups according to their estimated total polyphenol intake, we found that adolescents who declared high consumption of polyphenols had a higher adherence to the MD and had a better serum lipid profile than adolescents consuming low amounts of polyphenols. Moreover, using human HepG2 liver cells treated with oleic acid as an in vitro model for studying lipid accumulation, we showed that intracellular lipid accumulation is alleviated by serum from adolescents consuming a polyphenol-rich diet following MD recommendations. Our data underline the importance of promoting adherence to the typical MD foods as a superior strategy to prevent metabolic and chronic diseases and to ensure a better quality of life among adolescents.

The Significance of Plant-Based Foods and Intense Physical Activity on the Metabolic Health of Women with PCOS: A Priori Dietary-Lifestyle Patterns Approach

The study aimed to analyse dietary-lifestyle patterns (DLPs) and their relation with visceral obesity and other metabolic parameters in women with PCOS. A total of 140 women were diagnosed with PCOS. The KomPAN® and The ShortIPAQ questionnaires analysed the food frequency intake, health habits, economic situation, and physical activity. The dual-energy-x-ray absorptiometry (DXA) measured the visceral and total adipose tissue. The analysis distinguished three DLPs: western (WDLP), prudent (PDLP) and active (ADLP). The WDLP was characterised by high visceral fat, increased intake of animal foods, sweets and sweetened beverages, white grains, junk and fried foods, and low plant foods. High intakes of plant foods and dairy, high daily meal frequency, and intense exercise characterised PDLP. ADLP was characterised by high visceral fat, intake of plant products, intense exercise, and low intake of junk and fried food. Women with LDL &gt; 135 mg/dL had high adherence to WDLP, and with triglycerides &gt;150 mg/dL had high adherence to WDLP [OR 7.73 (CI95% 1.79; 33.2), p &lt; 0.05] and [3.70 (1.03; 13.27); p &lt; 0,05]. In conclusion, plant-based foods related to PDLP and intense physical activity offer a significantly higher chance of improving metabolic health in women with PCOS.

Contribution of natural food environments to nutritional intake and biomarker status: insights from the women of indigenous santhal communities of Jharkhand, India

BackgroundMany indigenous communities reside in biodiverse environments replete with natural food sources but show ​poor access and utilization.MethodsTo understand the links between indigenous food access, dietary intakes, and biomarkers, we conducted a cross-sectional study among women of the Santhal Community (n = 211) from 17 villages in the Godda district of Jharkhand, India. Survey methods included household surveys, dietary intake assessment (24 HDR) and micronutrient and inflammatory biomarkers' estimation.ResultsThe diversity in access to foods from different natural sources expressed as Food access diversity index was low. This led to poor consumption and thus a low Minimum Dietary Diversity. The mean nutrient intake was less than the estimated average requirement for all nutrients. Women with higher dietary diversity scores had higher nutrient intakes. Thiamine and calcium intakes were significantly higher in women consuming indigenous foods than non-consumers. One-fourth of the women had elevated levels of inflammatory biomarkers. The prevalence of iron deficiency was approximately 70%. Vitamin A insufficiency (measured as retinol-binding protein) was observed in around 33.6% women, while 28.4% were deficient. Household access to natural food sources was associated with specific biomarkers. The access to kitchen garden (baari) was positively associated with retinol-binding protein levels and negatively with inflammatory biomarkers, while access to ponds was positively associated with ferritin levels.ConclusionThe findings highlight the role of access to diverse natural foods resources, including indigenous foods, for improving nutrition security in indigenous communities. Nutrition and health programs promoting indigenous food sources should include the assessment of biomarkers for effective monitoring and surveillance.

Nutrition Interventions for the Management of Gout

Nutrition Interventions for the Management of Gout

Differences in dietary patterns related to metabolic health by gut microbial enterotypes of Korean adults.

Diet has a profound impact on the progression of metabolic syndrome (MetS) into various diseases. The gut microbiota could modulate the effect of diet on metabolic health. We examined whether dietary patterns related to MetS differed according to gut microbial enterotypes among 348 Korean adults aged 18-60 years recruited between 2018∼2021 in a cross-sectional study. The enterotype of each participant was identified based on 16S rRNA gut microbiota data. The main dietary pattern predicting MetS (MetS-DP) of each enterotype was derived using reduced-rank regression (RRR) models. In the RRR models, 27 food group intakes assessed by a semi-quantitative food frequency questionnaire and MetS prediction markers including triglyceride to high-density lipoprotein cholesterol (TG/HDL) ratio and homeostatic model assessment for insulin resistance (HOMA-IR) were used as predictor and response variables, respectively. The MetS-DP extracted in Bacteroides enterotype (B-type) was characterized by high consumption of refined white rice and low consumption of eggs, vegetables, and mushrooms. The MetS-DP derived among Prevotella enterotype (P-type) was characterized by a high intake of sugary food and low intakes of bread, fermented legumes, and fermented vegetables. The MetS-DP of B-type was positively associated with metabolic unhealthy status (OR T3 vs. T1 = 3.5; 95% CI = 1.5-8.2), comparing the highest tertile to the lowest tertile. Although it was not significantly associated with overall metabolic unhealthy status, the MetS-DP of P-type was positively associated with hyperglycemia risk (OR T3 vs. T1 = 6.2; 95% CI = 1.6-24.3). These results suggest that MetS-DP may differ according to the gut microbial enterotype of each individual. If such associations are found to be causal, personalized nutrition guidelines based on the enterotypes could be recommended to prevent MetS.

A Clinical Trial on the Welfare Effects of Administering Meloxicam to 10-21 Day Dairy Calves Following Caustic Paste Disbudding.

Caustic paste disbudding (CPD) is widely utilized for calves, which has been known to result in adverse effects on the calves and ethical concerns related to animal welfare, despite the use of local anesthetics. The administration of meloxicam has been demonstrated to provide benefits in alleviating pain and inflammation in juvenile calves under nine days old and subjected to CPD. Nonetheless, there is a scarcity of literature documenting the beneficial impact of meloxicam in alleviating pain in calves aged over nine days that have undergone CPD. Therefore, the objective of this clinical trial was to evaluate the efficacy of administering meloxicam and lidocaine for cornual nerve block together in mitigating the deleterious effects of CPD, as opposed to using lidocaine alone in calves older than nine days. Thirty Holstein calves, aged between 10 and 21 days, were enrolled and randomly assigned to 1 of 2 treatments: lidocaine alone (Placebo), lidocaine and normal saline treatment before CPD, and lidocaine plus meloxicam (MX), lidocaine and 0.5mg/kg of meloxicam treatment prior to CPD. The researchers were blind to the treatment of calves to control the subjective error. The occurrences of actions associated with pain, which included head shaking, head rubbing, ear flicking, tail flicking, kicking, and head passing through the fence, were recorded. Physiological performance, including the respiration rate, heart rate, rectal temperature, mechanical nociceptive threshold (MNT), food intake, and daily activity level, was monitored. Hematological conditions were ascertained through the use of routine blood tests and enzyme-linked immunosorbent assay. The generalized linear mixed model (GLMM) was employed to analyze the data. The research findings revealed that applying the CPD procedure significantly elevated the frequencies of tail flicking, head shaking, and kicking, resulted in increases in respiratory rate, heart rate, daily active steps, and food intake and a decrease in MNT, and led to alterations in hematological markers, including platelet counts, mean platelet volume, prostaglandin E2, constitutive nitric oxide synthase, and hydroxyl radical. Considerable benefits, such as lower heart rates, higher food intake, and MNTs, as well as lower levels of white blood cell counts, lymphocyte counts, hemoglobin, mean platelet volume, prostaglandin E2, tumor necrosis factor-α, constitutive nitric oxide synthase, malondialdehyde, and hydroxyl radical, were observed in the calves that received meloxicam treatment in response to CPD. The findings of the study indicate that the co-administration of lidocaine and meloxicam provides obvious benefits in mitigating pain, inflammation, and oxidative stress in calves aged over nine days and undergoing CPD. This endorses the use of meloxicam during the disbudding and dehorning procedures of calves.