Simple SummaryInsufficient energy and nutrient ingestion of primiparous lactating sows causes excess body weight loss and oxidative stress and compromises piglet growth. Two strategies to enhance the daily intake of dietary energy and nutrients were compared with a standard lactation diet to understand the potential modes of action. We found that feeding on either high-quality or flavor plus multi-enzyme diets both improved sow feed digestibility and consequently increased the growth of piglets. In addition, the flavor plus multi-enzyme diet also improved the antioxidant capacity and health of sows. The data suggest that dietary supplementation with flavor and multi-enzymes may be more promising than a high-quality diet from a health and economic perspective like enhancing utilization of cereal byproducts and thus reducing expenditure of corn and soybeans.This study was aimed to explore how a high-quality diet or a flavor plus multi-enzyme diet affects the feed intake, nutrient digestibility and antioxidation capacity of lactating sows and the growth of their progeny. Thirty primiparous sows were randomly assigned to three treatments from d 2 of lactation until weaning (d 21): control (CON), with a basal diet; high quality (HQ), with 200 kcal/kg higher net energy than CON; or the CON diet supplemented with 500 mg/kg flavor and 100 mg/kg multi-enzymes (F + E). Sows fed with the HQ or F + E diets improved piglets’ live weight (p < 0.05) and average daily weight gain (p < 0.10), litter weight gain (p < 0.10) and piglet growth to milk yield ratio (p < 0.10). Compared with CON, the HQ and F + E groups increased the digestibility of ether extract, ash, neutral detergent fiber, crude fiber and phosphorus (p < 0.10), and the HQ group also increased dry matter, gross energy, crude protein, acid detergent fiber and energy intake (p < 0.05). Compared with CON, the F + E group decreased serum urea nitrogen and aspartate aminotransferase (p < 0.05) and enhanced superoxide dismutase, catalase and glutathione peroxidase, but it decreased malondialdehyde in milk supernatant (p < 0.05).