One of the challenges in improving the innovative performance of higher education institutions is the proactive attitude and innovative work behavior of lecturer. This research aims to analyze the influence of proactive personality and innovative work behavior on increasing organizational innovative performance. The data analysis process uses AMOS version 22 with the SEM (Structural Equation Model) application. There are 216 lecturers as the unit of analysis from 17 private universities accredited as superior and A in Jakarta, Indonesia. Research findings show that proactive personality (PP) and innovative work behavior (IWB) have a positive and significant effect on the innovative performance of higher education. In addition, IWB plays a positive and significant role as a mediator in increasing the influence of PP on organizational innovative performance. Therefore, universities need to create a work atmosphere that supports the proactive attitude of lecturers and allows the emergence of innovative work behavior.