Coated conductors formed from the high-temperature superconducting (HTS) material REBCO (REBa2Cu3O7−δ) enable energy-efficient and high-power-density delivery of electricity, making them key materials for clean energy generation, conversion, transmission and storage. Widespread application of HTS coated conductor wires requires operation at high temperatures in wide-ranging magnetic fields, as well as low-cost processing. In this Review, we investigate different processing methods and applications of HTS coated conductors, highlighting advances in laboratory-scale conductor processing and performance, and examining commercial potential. We discuss how the nanostructure of the HTS material impacts wire performance across different application regimes, and how the nanostructure and performance are related to the inherent supersaturation levels of the respective processing method. We outline approaches to decrease wire cost and improve wire performance in the critical application regime (20–40 K, >1 T magnetic field), and examine emerging and potential future applications of HTS coated conductors.