During the development of the Chengdu–Chongqing Urban Agglomeration (CCUA) in China, PM2.5 pollution severely threatened public health, presenting a significant environmental challenge. This study employs a novel spatial interpolation method known as High Accuracy Surface Modeling (HASM), along with the geographical detector method, local and regional contributions calculation model, and the Hybrid Single–Particle Lagrangian Integrated Trajectory model to analyze the seasonal spatial distribution of PM2.5 concentrations and their anthropogenic driving factors from 2014 to 2023. The transport pathway and potential sources of seasonal PM2.5 concentrations were also examined. The results showed the following: (1) HASM was identified as the most suitable interpolation method for monitoring PM2.5 concentrations in the CCUA; (2) The PM2.5 concentrations exhibited a decreasing trend across all seasons, with the highest values in winter and the lowest in summer. Spatially, the concentrations showed a pattern of being higher in the southwest and lower in the southeast; (3) Industrial soot (dust) emissions (ISEs) and industry structure (IS) were the most important anthropogenic driving factors influencing PM2.5 pollution; (4) The border area between the eastern part of the Tibet Autonomous Region and western Sichuan province in China significantly contribute to PM2.5 pollution in the CCUA, especially during winter.
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