ABSTRACT Set against the booming reverse migration of scientific talents from developed nations to newly-emerged advanced economies, this study particularly examines the return of Chinese early career researchers in science, technology, engineering, and mathematics (STEM). Deploying a mixed research design that integrates quantitative and qualitative traditions, it aims to address three prominent knowledge gaps surrounding this emergent pattern of transnational academic migration. According to survey results, caring duties, career prospects, and cultural attachments have consistently emerged as the primary drivers for returnees who received PhD training in various host destinations. In contrast, economic and lifestyle concerns were of much less import to those completing the doctorate in leading Anglophone countries. Stark gender disparities were also observed, with male returnees’ desire to secure cultural familiarity and upward mobility especially evident and their use of transnational academic networks more prevalent. Moreover, participants who made the decision to return toward the end of their overseas sojourn and whose doctoral education was sponsored by the Chinese government demonstrated a significantly higher likelihood of considering onward migratory movement. While largely corroborating the quantitative findings, interview data further highlights the vital role of a justice-oriented university environment in attracting high-skilled talents from across different axes of social disadvantage. Throughout, it points to the prospective stickiness of return migration instigated amidst the radical shifts in global science. We conclude the paper with critical reflections on our empirical and methodological focus.