Higher Saturation Levels Research Articles

Fluctuations Driven by Multicomponent Pickup Ion Distributions in the Outer Heliosheath

Abstract The stability of a realistic multicomponent pickup ion (PUI) velocity distribution derived from a global model of neutral atoms in the heliosphere, which treats hydrogen and helium atoms self-consistently and includes equations for electrons and helium ions, is investigated using linear instability analysis and hybrid simulations. Linear instability analysis shows that the excited oblique mirror waves and the parallel/quasi-parallel Alfvén-cyclotron (AC) waves have lower growth rates than those obtained previously by A. Mousavi et al. for the PUI velocity distributions given by J. Heerikhuisen et al. The PUI scattering by each of the two modes alone is studied. In contrast to the previous investigations, our current simulations using the updated realistic distributions indicate that mirror waves alone do not effectively scatter PUIs in pitch angle. Instead, they primarily contribute to reducing the thermal spread anisotropy of the PUIs originating from the neutral solar wind. The unstable AC waves exhibit lower growth rates but higher saturation levels than the mirror waves. Two-dimensional (2D) simulation results show that when all unstable waves are present, the predominant contributor to the fluctuating magnetic field energy is the AC mode. The AC waves quickly scatter the PUIs with pitch angles away from 90∘ toward isotropy, while the PUIs near 90∘ pitch angle maintain a degree of anisotropy within our simulation timeframe. Moreover, several 1D and 2D hybrid simulations with different numbers of particles per cell are performed to examine the impact of numerical noise on PUI scattering. Finally, the implications of these results for the Interstellar Boundary Explorer energetic neutral atom ribbon are discussed.

Sphingomyelin-enriched milk phospholipids offer superior benefits in improving the physicochemical properties, microstructure, and surface characteristics of infant formula

Phospholipids from different sources have varying chemical compositions, but how they contribute to different properties of infant formula is unclear. In this study, four types of phospholipids, milk phospholipids (MPLs), soybean phospholipids (SBPLs), sunflower phospholipids (SFPLs), and egg yolk phospholipids (EYPLs), were added to infant formula to investigate their physicochemical properties, microstructure, and surface characteristics. MPLs uniquely offer high sphingomyelin and saturated fatty acid levels. The MPL-based emulsion had the smallest particle size (334.50 nm), lowest stability constant (0.30), and highest viscosity among all groups tested. Furthermore, the abundance of sphingomyelin in MPLs allowed for a denser interfacial film and the complete phospholipid-coated structure of lipid droplets in infant formula emulsion. This consequently improved the microstructure and fat encapsulation of the powder, leading to significantly lower surface fat content in the MPL group. Therefore, the proper selection of phospholipids is crucial for modulating the stability and surface characteristics of infant formula.

Cancer-associated foam cells hamper protective T cell immunity and favor tumor progression in human colon carcinogenesis

BackgroundColorectal cancer (CRC) remains a significant healthcare burden worldwide, characterized by a complex interplay between obesity and chronic inflammation. While the relationship between CRC, obesity and altered lipid metabolism is...

Time-harmonic finite element model for brushless doubly-fed induction machine in natural operating mode

The natural mode of operation for the brushless doubly-fed induction machine is a particular instance of synchronism at a so-called natural rotor velocity when one stator winding is powered by an AC and the other by a DC voltage source. Consequently, in addition to the rotating magnetic field, there exists a magnetic field that is fixed to the stator frame of reference. Analysis in this specific mode is essential as the natural velocity arises from the choice of pole numbers, thereby determining machine efficiency. However, this presents a significant challenge when it comes to mathematical modeling using complex-valued steady-state models through either equivalent-circuit or finite element analysis. This paper presents a study on the extension of the recently-proposed steady-state complex-valued finite element model for the brushless doubly-fed induction machine to enable its application in the natural operating mode. A high correlation with the data obtained from a time-stepping model is obtained for the extended model when subjected to both low and high levels of saturation of the magnetic circuit. This extension makes the whole approach applicable in all operating conditions and modes of the brushless doubly-fed induction machine. Considering the nearly two orders of magnitude lower computational costs associated with analysis via the proposed model compared to time-stepping analysis, it is particularly useful in scenarios that involve extensive computations and require multiple cases to be considered such as design sensitivity analysis, topology optimization or a connection with machine learning techniques.

Geologic and thermal conductivity analysis based on geophysical test and combined modeling

Strata thermal conductivity (λe) influences efficiency of medium-depth ground heat exchangers. However, a systematic approach to the acquisition of λe is still lacking. Hence, stratigraphic heat conduction was analyzed using geophysical test in Shenyang, combined with composite modeling. Cenozoic strata (0–730m) exhibited an average λe of 1.32 W·m−1·K−1 due to higher porosity and mud content; Archaean (730–2500m) strata displayed a higher λe of 2.80 W·m−1·K−1, due to dense quartz sandstone with lower porosity and mud content. The CBHE in Shenyang can achieve excellent heat extraction relying on good thermal conduction. Spearman correlation revealed strong negative correlations between λe and acoustic time difference, permeability, and porosity, while positive correlations were observed with depth, resistivity, wave speed, and rock skeleton. Higher rock skeleton thermal conductivity intensified the decrement effect of mud content on λe, while higher mud content diminished the enhancement effect of rock skeleton thermal conductivity. As porosity increased, the decline in λe slowed, particularly pronounced at higher saturation levels. λe exhibited a gradual decrease with temperature, with a more notable change rate observed at lower porosity levels. Principles for enhancing thermal conduction were elucidated through a three-phase analysis. These findings provide foundation for the study and design of medium-depth boreholes.

Effect of saturation tone on spectral EDFA gain spectrum

Accurate characterization of spectral gain of C-band EDFAs in WDM system design is crucial; however, traditional methods often require expensive WDM equipment. This study presents a cost-effective alternative, validated through both experimental measurements and simulations, that utilizes a weak signal probe and a carefully selected saturation tone. By comparing results with a 32-channel WDM reference, we demonstrate that the proposed method achieves high accuracy. The optimal saturation tone wavelength depends on the pump wavelength (980 nm or 1480 nm) and configuration (forward or bidirectional). Nevertheless, a good fit with the reference can be obtained in all scenarios, especially at higher saturation levels. This work provides valuable insights for developing affordable and efficient EDFA gain measurement techniques.

Impacts of Varying Sowing Dates on the Profitability and Production of Cultivars of Pigeonpea (Cajanus cajan L. Mill sp.)

At the experimental farm of the College of Agriculture, Badnapur, VNMKV, Parbhani, a suitable range of field experiments were done during the kharif season, with an optimal time of sowing. The experiment was carried out using five varieties in the sub plot, V1-BSMR-736, V2-BSMR-853, V3-BDN-711, V4-BDN-708, and V5-Vipula, and four sowing dates in the main plot, D1: (15 th June), D2: (30 th June), D3: (15 th July), and D4: (30th July). The soil had a medium-black color, a clayey texture, a high base saturation level, an alkaline reaction, and a higher concentration of total soluble salts. It also had low levels of nitrogen and phosphorus and high levels of potassium and lime. The dibbling method of sowing was used. According to the experiment's results, sowing of pigeonpea on June 15 th was the best date to achieve greater yield metrics, specifically number of pods per plant, pod weight plant-1 (g), grain weight plant-1 (g), and test weight (g). in addition to economic indicators including GMR (119080 Rs ha-1), NMR (96573 Rs ha-1), and B:C (5.29), in addition to harvest index (HI), biological yield (kg ha-1) and seed yield (kg ha-1). Comparatively speaking to the other kinds, the pigeonpea variety BSMR-736 was shown to be very prolific.

Molecularly engineering a lipid nanoregulator destroying the last defense of ferroptosis in breast cancer therapy

Ferroptosis, as a uniquely regulated form of cell death, has garnered significant interest in the field of oncology. Most ferroptosis inducers facilitate the intracellular buildup of lipid peroxidation by inhibiting glutathione peroxidase 4 (GPX4). However, the high saturation level of membrane lipids can shield cancer cells from reactive oxygen species-induced damage, preventing lipid peroxidation triggered by GPX4 inhibitors. Herein, we precisely constructed a lipid nanoregulator of RSL3 and Orlistat through a molecular engineering strategy. In this nanosystem, Orlistat functions as a “dual enhancer”, significantly enhancing both the assembly capability and the anti-tumor effectiveness of RSL3. Orlistat can significantly enhance the synthesis of polyunsaturated fatty acids and reduce the saturation level of lipid membranes by inhibiting fatty acid synthase (FASN). Consequently, Orlistat successfully dismantles the final defense (lipid membrane protection), synergistically amplifying ferroptosis with RSL3-induced GPX4 depletion. As expected, the lipid nanoregulator demonstrates a potent antitumor activity in 4T1 tumor-bearing mice. This study represents an effective paradigm for ferroptosis-driven antitumor nanotherapeutics.

PEMANFAATAN MEDIA WORDWALL UNTUK MENINGKATKAN HASIL BELAJAR PESERTA DIDIK PADA MATA PELAJARAN BAHASA INDONESIA

In the junior high school level, Indonesian language subjects, students consider text and literature-based learning to have a high level of saturation. Especially when in an environment students have low literacy. In reality, language and literature learning is a subject that requires concentration and astuteness in understanding the meaning of texts, both fiction and non-fiction. This research aims to analyze the influence of Wordwall learning media in improving Indonesian language learning outcomes for students in class VIII A of SMP Negeri 1 Slogohimo. The subjects of this research were 24 students in class VIII A of SMP Negeri 1 Slogohimo. The research method uses a quantitative and qualitative approach (mixed method). The type of research is classroom action research with research stages consisting of planning, implementing actions, observing and reflecting. Research instruments with tests, observations and questionnaires. Research data obtained from the pretest and posttest is in the form of a percentage of each respondent's total score and the average. The research results show that there is an increase in learning outcomes with the application of Wordwall media

Features of the gas transport function of blood in hyperpigmentations of the skin

BACKGROUND: Acquired hyperpigmentation is widespread in the population and significantly affects the quality of life of the patients. It is known that one of the clinical signs of skin hyperpigmentation is localized hyperkeratosis in the lesion associated with a high level of cell proliferation and cell saturation with melanin. Cellular proliferation and hyperkeratosis are associated with increased local metabolism rates. AIM: Study of erythrocyte gas transport function in women with skin hyperpigmentation compared to the control group. MATERIALS AND METHODS: To achieve the objective, the concentrations of lactic acid, pyruvic acid and 2,3-diphosphoglycerate levels in venous blood erythrocytes were investigated. RESULTS: The phenomenon of skin hyperpigmentation is accompanied by a restructuring of blood cell metabolism aimed at preserving oxygen and energy homeostasis of skin structures. The obtained data indicate redistribution of oxygen in cellular structures and tissues, which is accompanied by a significant increase in lactate concentration and formation of local tissue hypoxia. CONCLUSION: The formation of skin pigmentation is considered as a physiological mechanism in response to inflammation, mainly associated with ultraviolet radiation. The general strategy of the course of the inflammatory process under normal regulation or dysregulation has similar features, but there are also differences. It seems necessary to further study systemic adaptation mechanisms in dysregulation and formation of skin hyperpigmentation.

Agricultural drainage pipe in Guadua angustifolia: implications of Manning roughness in Pitalito forest stands

Water extraction in agricultural fields with high saturation levels requires drainage systems that increase land preparation costs, so looking for new options for materials that function as drainage pipes that provide a better technical–economic relationship is crucial. In this study, Manning roughness values were analyzed in the culms of Guadua angustifolia considering three factors: flow, section, and location site of the forest stands. This study was carried out in the rural area of the municipality of Pitalito; the characterization of culms was made based on the Colombian technical standards (NTC) 5726 and 5727, the cutting and elaboration of test pieces according to the NTC 5525, and finally, the hydraulic tests were carried out. The roughness values oscillated between 0.1089 and 0.0337 according to the different flow evaluated values in the laboratory tests, between 0.1004 and 0.0356 for the sections analyzed, and between 0.0909 and 0.0533 according to the sample extraction area. The multifactor ANOVA established a significant relationship for the flow and section on the Manning n roughness, while the zone was insignificant.

Comparison of different frost models with hygrothermal simulations to better understand frost damage in porous building materials

Frost damage is one of the most important degradation phenomena of brick facades. Evaluating the risk of frost damage in advance is of utmost importance considering the difficulty of repairing frost damage without replacing the materials, which may not be an option for protected heritage facades. Various performance criteria and methods have been developed over the past decades to assess the risk of frost damage. However, these methods are derived from frost tests under extreme conditions, such as high saturation levels and very low freezing temperatures, and do not represent realistic conditions for mild climates. In 2019, Feng et al. tested four different bricks under milder conditions to understand the relationship of frost damage with freezing temperature and saturation degree. The research in this paper combines the results of Feng's study with hygrothermal simulations, which prove to be a valuable tool for assessing the risk of deterioration of facades of masonry buildings. In this paper, the frost decay assessment methods like the Fc-index, GC-factor and counting the critical freeze-thaw cycles are examined, discussed and finally dismissed. Finally, a more representative frost decay risk assessment method is proposed.

Molecular, Crystalline, and Microstructures of Lipids from Astrocaryum Species in Guyana and Their Thermal and Flow Behavior

The phase behavior of lipids extracted from Astrocaryum vulgare (AV) and Astrocaryum aculeatum (AA) pulp and kernels and their microstructural, thermal and flow properties were studied. The lipid profiles, crystal structures, microstructures, thermal stabilities and flow behaviors of these lipids provided important structure–function information that are useful to assess potential applications in the food, cosmetic and pharmaceutical industries. AV and AA fruits were sourced from the lowlands and rainforests, respectively, of Guyana. AV and AA pulp oils (AVP and AAP) were distinguished from each other in composition and unsaturation, with AVP oils being predominated by a di-unsaturated TAG (2-(palmitoyloxy)propane-1,3-diyl dioleate (POO)) and AAP oils predominated by propane-1,2,3-triyl trioleate (OOO); there were unsaturation levels of 65% and 80%, respectively. The main fatty acids in AVP oils were oleic, palmitic and stearic; for AAP, these were oleic, linoleic, palmitic and stearic. The kernel fats of AV and AA were similar in composition and had saturation levels of 80%, being mainly comprised of tri-saturated TAGs propane-1,2,3-triyl tridodecanoate (LLL) and 3-(tetradecanoyloxy)propane-1,2-diyl didodecanoate (LML). The onset of mass loss (T5%on) of AV and AA pulp oils were similar at 328 ± 6 °C, which were 31 °C ± 9 higher compared to that of the kernel fats, which demonstrated similar T5%on = 293 ± 7 °C. AA and AV pulp oils were liquid at room temperature, with melting points of −5 ± 1 °C and 3 ± 1 °C, respectively; both kernel fats were solid at room temperature, packing in β′ (90% of crystals) and β (10% of crystals) polymorphic forms and melting almost identically at 30 ± 1 °C. Pulp oils demonstrated sporadic nucleation at the onset of crystallization with slow growth into rod-shaped crystallites, leading to an approximately 50% degree of crystallization at undercooling of approximately 40K. Nucleation for kernel fats was instantaneous at undercooling of approximately 23K, demonstrating a spherulitic growth pattern incorporating crystalline lamella and a 90% degree of crystallization. Kernel fats and pulp oils demonstrated Newtonian flow behavior and similar dynamic viscosity in the melt, approximately 28.5 mPa·s at 40 °C. The lipid profiles of AVP and AAP oils were dominated by unsaturated TAGs, suggesting potential nutrition and health benefits, particularly compared to other tropical oils with higher saturation levels, such as palm oil. AAP oil in particular is as unsaturated as olive oil, contains high levels of beta carotene and provides a unique flavor profile. The AAK and AVK lipid profiles and phase transformation indicate potential for applications where a high solid fat content and medium-chain fatty acids are required. Their high lauric and myristic acid content makes them similar to industrially important tropical oils (coconut and palm kernel), suggesting their use in similar formulations. The melting point and plasticity of the kernel fats are similar to that of cocoa and shea butters, suggesting use as replacements in cosmetics, foods and confections. There is, however, the need to better understand their nutritional status and effects on health.

Fluid Flow Dynamics in Partially Saturated Paper.

This study presents an integrated approach to understanding fluid dynamics in Microfluidic Paper-Based Analytical Devices (µPADs), combining empirical investigations with advanced numerical modeling. Paper-based devices are recognized for their low cost, portability, and simplicity and are increasingly applied in health, environmental monitoring, and food quality analysis. However, challenges such as lack of flow control and the need for advanced detection methods have limited their widespread adoption. To address these challenges, our study introduces a novel numerical model that incorporates factors such as pore size, fiber orientation, and porosity, thus providing a comprehensive understanding of fluid dynamics across various saturation levels of paper. Empirical results focused on observing the wetted length in saturated paper substrates. The numerical model, integrating the Highly Simplified Marker and Cell (HSMAC) method and the High Order accuracy scheme Reducing Numerical Error Terms (HORNET) scheme, successfully predicts fluid flow in scenarios challenging for empirical observation, especially at high saturation levels. The model effectively mimicked the Lucas-Washburn relation for dry paper and demonstrated the increasing time requirement for fluid movement with rising saturation levels. It also accurately predicted faster fluid flow in Whatman Grade 4 filter paper compared with Grade 41 due to its larger pore size and forecasted an increased flow rate in the machine direction fiber orientation of Whatman Grade 4. These findings have significant implications for the design and application of µPADs, emphasizing the need for precise control of fluid flow and the consideration of substrate microstructural properties. The study's combination of empirical data and advanced numerical modeling marks a considerable advancement in paper-based microfluidics, offering robust frameworks for future development and optimization of paper-based assays.

A human anti-matriptase-2 antibody limits iron overload, α-globin aggregates, and splenomegaly in β-thalassemic mice

AbstractIron plays a major role in the deterioration of β-thalassemia. Indeed, the high levels of transferrin saturation and iron delivered to erythroid progenitors are associated with production of α-globin precipitates that negatively affect erythropoiesis. Matriptase-2/TMPRSS6, a membrane-bound serine protease expressed in hepatocytes, negatively modulates hepcidin production and thus is a key target to prevent iron overload in β-thalassemia. To address safety concerns raised by the suppression of Tmprss6 by antisense oligonucleotides or small interfering RNA, we tested a fully human anti-matriptase-2 antibody, RLYB331, which blocks the protease activity of matriptase-2. When administered weekly to Hbbth3/+ mice, RLYB331 induced hepcidin expression, reduced iron loading, prevented the formation of toxic α-chain/heme aggregates, reduced ros oxygen species formation, and improved reticulocytosis and splenomegaly. To increase the effectiveness of RLYB331 in β-thalassemia treatment even further, we administered RLYB331 in combination with RAP-536L, a ligand-trapping protein that contains the extracellular domain of activin receptor type IIB and alleviates anemia by promoting differentiation of late-stage erythroid precursors. RAP-536L alone did not prevent iron overload but significantly reduced apoptosis in the erythroid populations of the bone marrow, normalized red blood cell counts, and improved hemoglobin and hematocrit levels. Interestingly, the association of RLYB331 with RAP-536L entirely reversed the β-thalassemia phenotype in Hbbth3/+ mice and simultaneously corrected iron overload, ineffective erythropoiesis, splenomegaly, and hematological parameters, suggesting that a multifunctional molecule consisting of the fusion of RLYB331 with luspatercept (human version of RAP-536L) would allow administration of a single medication addressing simultaneously the different pathophysiological aspects of β-thalassemia.

Influence of Vinasse and Mechanized Harvesting on the Physical and Chemical Aspects of Soil in Paudalho Municipality - PE

Sugarcane cultivation methods and processes usually have negative impacts on the environment. However, this industry has been seeking more sustainable technologies, ranging from the adequate disposal of the organic residues produced to the elimination of pre-harvest burning and introduction of mechanized harvest. The objective of this work was to verify the influence of vinasse application and mechanized harvesting on the physical and chemical aspects of a dystrophic Red Yellow Argisol of medium texture, cultivated with sugarcane. For this, a field experiment in a Completely Randomized Design, with a factorial scheme was conducted. Four management treatments, with three replications, were evaluated: T1 - Without application of vinasse, burned cane followed by manual harvest, without irrigation; T2 - With application of vinasse, mechanized harvest, without irrigation; T3 - With application of vinasse, mechanized harvest, with irrigation; T4 - With application of vinasse, burned cane followed by manual harvest, without irrigation. Soil samples were collected in three depths (0 – 20 cm, 20 – 40 cm and 40 – 60 cm) and soil physical and chemical characteristics were determined. The data obtained were submitted to ANOVA and compared by the Tukey test (p≤0.05) of probability, using the statistical program ASSISTAT 7.7 beta. The results showed that fertigation with vinasse did not influence soil density, particle density, and total porosity. However, mechanized harvesting increased soil density and total porosity. The soil in the experimental unit without vinasse application presented a more acidic pH and high levels of aluminum saturation, causing a decrease in the availability of nutrients, and the soils treated with vinasse had an increase in nutrient availability. Therefore, the addition of vinasse can be an important strategy in maintaining and increasing long-term soil fertility in sugarcane cropping systems.

Hemoglobin variability in patients receiving EPO and roxadustat during maintenance hemodialysis: a self-control study.

The aim of this study was to investigate the hemoglobin variability in patients undergoing maintenance hemodialysis during the application of erythropoietin (EPO) and roxadustat. For this retrospective study, we analyzed the clinical records of 80 patients with renal anemia on maintenance hemodialysis (MHD) admitted to our hospital between January 2017 and December 2022. We adopted a self-control design comparing the hemoglobin variability of the values before and after roxadustat administration in each patient. The patients received EPO from January 2017 to December 2019 and roxadustat from January 2020 to December 2022. We compared the levels of serum ferritin, transferrin saturation, and hemoglobin and calculated the hemoglobin variabilities by comparing values before and after roxadustat treatments. We found higher transferrin saturation levels at different time points after the roxadustat treatments (p<0.01); meanwhile, the serum ferritin and hemoglobin levels were significantly higher after the roxadustat treatment (p<0.001). During the treatments with EPO and roxadustat, the transferrin saturation, serum ferritin, and hemoglobin levels differed significantly at different time points for each patient (p<0.05). After roxadustat administration, the hemoglobin levels were significantly higher than after EPO administration (p<0.001) and changed more rapidly after roxadustat administration than after EPO administration (p<0.05). The hemoglobin variability after roxadustat administration was significantly lower than that after EPO administration (p<0.05). Treatment with roxadustat led to higher hemoglobin levels and less hemoglobin variability than the treatment with EPO, with high transferrin saturation and higher ferritin levels in patients with renal anemia on MHD.

LEARNING METHODS TO BOOST THE MOTIVATION OF ELEMENTARY SCHOOL STUDENTS IN BELITUNG

Education is a means of learning to improve the quality of human resources, so every country is competing to improve the quality of its people by providing qualified educational facilities, especially for children in elementary schools. However, not all elementary school students have high motivation to study and achieve their goals. Due to the high level of saturation in subjects. This activity is located in Elementary School 16 Sijuk, Belitung Regency, with 120 students divided into five classes. The method of carrying out activities is divided into several stages and classes coordinated by one person in charge of activities in that class. This service provides innovation to teach students the educational game method. In addition, this service provides understanding related to professions in Indonesia to increase students' interest in learning and achieving their goals with the Dream Tree method. After this activity, elementary school students became more cheerful and excited to take part in lessons at school, even for relatively complex material such as mathematics and English. These findings show that elementary school students need regular subject matter refreshments to reduce their stress levels and boredom in learning. Thus, the subjects the teacher teaches become more effective and efficient for them.

Alternative salt frost scaling test procedure for exposure class XF2

Concrete structures in cold and moderate climates are often exposed to a combined salt frost attack, which can cause scaling damage. Consequently, numerous test procedures were developed to determine the resistance of concrete compositions against this kind of attack. These tests mimic a severe attack with high levels of saturation, which is typical for horizontal concrete elements or structures, such as concrete pavements. Very few approaches exist for testing the salt frost scaling resistance of concretes for vertical concrete elements like bridge columns, which are subjected to only moderate levels of saturation during salt frost attack (exposure class XF2). As such elements usually didn’t show notable scaling damage in practice, this hasn’t posed a problem until recently. However, the increasing use of low carbon cements with high clinker substitution rates might increase the vulnerability against salt frost exposure for such concrete elements to some extent. To ensure adequate durability it is desirable to determine the performance of the concrete in an actual test procedure instead of relying on descriptive criteria alone. Thus, a less severe test method was developed, which is based on the CDF test. It was shown that the modified test procedure can distinguish correctly between different concrete qualities. Furthermore, the applicability of an acceptance criterion for the method was investigated.

A thermal-initiated monomer binder enhancing green strength with low binder saturation for binder jetting additive manufacturing of cemented carbide

Binder jetting (BJ) additive manufacturing (AM) technology is a competitive technology for fabricating ceramic and metal parts. In most cases, a high level of binder saturation is necessary to achieve sufficient strength for the green part. However, the oversaturated binder may lead to shape distortion and excess carbon residual of the green part. To solve the problem, a novel binder consisting of HEMA (2-Hydroxyethyl methacrylate) monomer and HDDA (1,6-Hexanediol diacrylate) monomer was proposed to improve the green strength and reduce carbon residual of parts at a low level of binder saturation. The monomer binder curing under the thermal-initiated free radical induced polymerization. This paper studies the printability, pyrolysis, and curing kinetics of the monomer binder, and investigates the effect of binder saturation on the strength and dimensional accuracy of WC-12Co green parts. The experimental results show that the monomer binder enables WC-12Co green parts to achieve a transverse rupture strength (TRS) of 0.66 MPa at a low binder saturation of 20%, and exhibits high dimensional accuracy. Additionally, the binder exhibited a high pyrolysis efficiency of 97.66%, resulting in a low residual carbon content of less than 0.3 wt% after debinding. This favorable pyrolysis characteristic does not compromise the phase composition of the WC-12Co matrix during the sintering process. This paper provides a new solution for fabricating cemented carbide parts with BJ AM technology.