High-resolution X-ray Imaging Research Articles

Mn(II)-Based Metal Halide with Near-Unity Quantum Yield for White LEDs and High-Resolution X-ray Imaging.

Metal halides have drawn great interest as luminescent materials and scintillators due to their outstanding optical properties. Exploring new types of phosphors with easy production processes, excellent photophysical properties, high light yields, and environmentally friendly compositions is crucial and quite challenging. Herein, a novel Mn(II)-based metal halide (4-BTP)2MnBr4 was produced using a facile solvent evaporation method, which exhibited a strong green emission peaking at 524 nm from the d-d transition of tetrahedral-coordinated Mn2+ ion and a near-unity quantum yield. The prepared white light-emitting diode device has a wide color gamut of 100.7% NTSC with CIE chromaticity coordinates of (0.32, 0.32). In addition, (4-BTP)2MnBr4 demonstrates excellent characteristics in X-ray scintillation, including a high light yield of 98 000 photons/MeV, a sensitive detection limit of 37.4 nGy/s, excellent resistance to radiation damage, and successful demonstration of X-ray imaging with high resolution at 21.3 lp/mm, revealing the potential for application in diagnostic X-ray medical imaging and industry radiation detection.

High-Resolution X-ray Image from Copper-Based Perovskite Hybrid Polymer.

Cs3Cu2I5 nanocrystals (NCs) are considered to be promising materials due to their high photoluminescence efficiency, lack of lead toxicity, and X-ray responsiveness. However, during the crystallization process, NCs are prone to agglomeration and exhibit uneven size distribution, resulting in several light scattering that severely affect their imaging resolution. Herein, we successfully developed a high-resolution scintillator film by growing copper-based perovskite NCs within a hybrid polymer matrix. By leveraging the ingenious integration of polyvinylidene fluoride (PVDF) and polymethyl methacrylate (PMMA), the size and distribution uniformity of Cs3Cu2I5 NCs can be effectively controlled. Consequently, a high spatial resolution of 14.3 lp mm-1 and a low detection limit of 105 nGy s-1 are achieved, and the scintillator film has excellent flexibility and stability. These results highlight the promising application of Cs3Cu2I5 scintillator films in low-cost, flexible, and high-performance medical imaging.

Uncovering the First AGN Jets with AXIS

Jets powered by AGN in the early Universe (z≳6) have the potential to not only define the evolutionary trajectories of the first-forming massive galaxies but to enable the accelerated growth of their associated SMBHs. Under typical assumptions, jets could even rectify observed quasars with light seed formation scenarios; however, not only are constraints on the parameters of the first jets lacking, observations of these objects are scarce. Owing to the significant energy density of the CMB at these epochs capable of quenching radio emission, observations will require powerful, high angular resolution X-ray imaging to map and characterize these jets. As such, AXIS will be necessary to understand early SMBH growth and feedback. This White Paper is part of a series commissioned for the AXIS Probe Concept Mission; additional AXIS White Papers can be found at the AXIS website.

Probing Energy-Funneling Kinetics in Nanocrystal Sublattices for Superior X-Ray Imaging.

Long-lasting radioluminescence scintillators have recently attracted substantial attention from both research and industrial communities, primarily due to their distinctive capabilities of converting and storing X-ray energy. However, determination of energy-conversion kinetics in these nanocrystals remains unexplored. Here we present a strategy to probe and unveil energy-funneling kinetics in NaLuF4:Mn2+/Gd3+ nanocrystal sublattices through Gd3+-driven microenvironment engineering and Mn2+-mediated radioluminescence profiling. Our photophysical studies reveal effective control of energy-funneling kinetics and demonstrate the tunability of electron trap depth ranging from 0.66 to 0.96 eV, with the corresponding trap density varying between 2.38×105 and 1.34×107 cm-3. This enables controlled release of captured electrons over durations spanning from seconds to 30 days. It allows tailorable emission wavelength within the range of 520-580 nm and fine-tuning of thermally-stimulated temperature between 313-403 K. We further utilize these scintillators to fabricate high-density, large-area scintillation screens that exhibit a 6-fold improvement in X-ray sensitivity, 22 lp/mm high-resolution X-ray imaging, and a 30-day-long optical memory. This enables high-contrast imaging of injured mice through fast thermally-stimulated radioluminescence readout. These findings offer new insights into the correlation of radioluminescence dynamics with energy-funneling kinetics, thereby contributing to the advancement of high-energy nanophotonic applications.

In-situ growth of Cs5Cu3Cl6I2 nanocrystals within AAO arrays for X-ray imaging

Lead-free halide perovskites have shown promising application for indirect X-ray detection as fascinating scintillator. The fabrication of pixelated scintillator films leveraging directional confinement allows high-resolution imaging, yet process complexity and the potential crystal structure damage pose challenges that compromises the corresponding scintillator performance. In this work, a facile in-situ strategy for growing scintillation perovskite of Cs5Cu3Cl6I2 within anodic aluminum oxide (AAO) membrane is developed as scintillator Cs5Cu3Cl6I2@AAO film. The as-fabricated pixelated scintillator array with an enhanced light directional confinement for high-resolution X-ray imaging is demonstrated. The corresponding film achieves a spatial resolution of approximately 20 lp mm−1 and a detection limit of 0.152 Gy·s−1. Moreover, the Cs5Cu3Cl6I2@AAO film performs excellent stability under long-term X-ray irradiation, making it a reliable option for cost-effective pixelated indirect X-ray imaging.

Monolithic integration of perovskite heterojunction on TFT backplanes through vapor deposition for sensitive and stable x-ray imaging.

Metal halide perovskites exhibit substantial potential for advancing next-generation x-ray detection. However, fabricating high-performance pixelated imaging arrays remains challenging due to the substantial dark current density and stability issues associated with common organic-inorganic hybrid perovskites. Here, we develop a vapor deposition method to create the first all-inorganic perovskite heterojunction film. The heterojunction introduction effectively reduces the dark current density of detectors to about 0.8 nA·cm-2, satisfying thin-film transistor (TFT) integration standards, while also increases sensitivity to above 2.6 × 104 μC·Gyair-1·cm-2, thus giving rise to a record low detection limit of <1 nGyair·s-1 among all polycrystalline perovskite-based x-ray detectors. The devices also demonstrate remarkable stability across multifarious demanding working conditions. Last, through monolithic integration of the heterojunction film with a 64 × 64 pixelated TFT array, we have achieved high-resolution real-time x-ray imaging, which paves the way for the application of all-inorganic perovskite in low-dose flat-panel x-ray detection.

Anomalous X-ray pulse responses in MAPbBr3 single crystal-based detectors

Organic-inorganic perovskite single crystals (SCs) are considered promising semiconductors for high-sensitivity X-ray detectors because of their strong X-ray interaction, low-temperature processability, and excellent properties such as long diffusion length, low defect density, and long carrier lifetime. However, the specific pulse response of MAPbBr3 SC-based X-ray detectors frequently exhibits a tail and over/undershoots at several conditions, which degrades the X-ray image quality; however, no detailed analysis of these characteristics has been reported thus far. For high-resolution X-ray imaging, it is necessary to obtain an ideal pulse response that is free of tails and over/undershoots. In this study, we investigated the specific X-ray responses of solution-grown MAPbBr3 SC-based X-ray detectors under various externally applied voltages. Based on the study on charge carrier dynamics, we analyzed the origin of the tail and over/undershoots in X-ray pulse response shapes. We theoretically verified that the unideal pulse response in perovskite SC-based X-ray detectors is attributed to the defect states inherent in perovskite SCs.

Growth of ultimate high-density scintillating films for high-resolution X-ray imaging at synchrotrons

Scintillators are X-ray to visible light converters applied in X-ray imaging detectors used at synchrotrons. Drastically improved performances of the 4th generation synchrotron sources enable us to perform X-ray imaging experiments at higher energies. For high spatial resolution X-ray imaging (micrometer to submicrometer), thin scintillating films are required. Consequently, especially for high X-ray energies (30keV to 100keV), the detection efficiency is limited due to the low X-ray absorption efficiency of the thin films. We have used Liquid Phase Epitaxy (LPE) to grow thin films of one of the ultimate high-density materials, Lu2Hf2O7:Eu3+, which demonstrate scintillating properties and thus combine high spatial resolution and maximized absorption efficiency. X-ray imaging experiments demonstrate that the Modulation Transfer Function (MTF) reaches 10% at 900 lp/mm, and radiographs visually confirm the promising imaging properties. We present structural, luminescent, and scintillation characterization of Lu2Hf2O7:Eu thin films grown on ZrO2:Y substrates, showing that the films crystallize in the disordered fluorite structure and the europium ions incorporate into the structure and enhance the luminescence intensity. This contribution is a first step toward developing promising ultra-dense, hafnate-based scintillating screens for high spatial resolution X-ray imaging.

High-resolution X-Ray imaging of small animal samples based on Commercial-Off-The-Shelf CMOS image sensors.

An automated system for acquiring microscopic-resolution radiographic images of biological samples was developed. Mass-produced, low-cost, and easily automated components were used, such as Commercial-Off-The-Self CMOS image sensors (CIS), stepper motors, and control boards based on Arduino and RaspberryPi. System configuration, imaging protocols, and Image processing (filtering and stitching) were defined to obtain high-resolution images and for successful computational image reconstruction. Radiographic images were obtained for animal samples including the widely used animal models zebrafish (Danio rerio) and the fruit-fly (Drosophila melanogaster), as well as other small animal samples. The use of phosphotungstic acid (PTA) as a contrast agent was also studied. Radiographic images with resolutions of up to (7±0.6)μm were obtained, making this system comparable to commercial ones. This work constitutes a starting point for the development of more complex systems such as X-ray attenuation micro-tomography systems based on low-cost off-the-shelf technology. It will also bring the possibility to expand the studies that can be carried out with small animal models at many institutions (mostly those working on tight budgets), particularly those on the effects of ionizing radiation and absorption of heavy metal contaminants in animal tissues.

Novel transparent NaLu2F7:Tb3+ glass-ceramics scintillator for highly resolved X-ray imaging

Due to the rapid advancements in medical radiography, nondestructive inspection, and radiation detection, there is an increasing demand for scintillators that offer both cost-effectiveness and high-resolution X-ray imaging. In this study, we have successfully synthesized transparent glass-ceramic scintillator by embedding Tb3+-doped NaLu2F7 nanocrystals in a glass matrix. This scintillator demonstrates excellent spatial resolution of 20 lp/mm in X-ray imaging due to its high transmittance (over 90% at 550 nm) and intense luminescent intensity when excited by X-ray (151% higher than that of the Bi4Ge3O12 scintillator). More significantly, the as-synthesized scintillator exhibits exceptional stabilities at high temperature, moisture levels, and moderate radiation exposure. Notably, any decline in performance caused by long-term exposure to high-dose X-ray can be fully recovered through heat treatment at 350 °C for 30 min. These findings highlight the great potential of NaLu2F7:Tb3+ glass ceramics as suitable options for high-resolution and retrievable X-ray imaging.

A detachable interface for stable low-voltage stretchable transistor arrays and high-resolution X-ray imaging

Challenges associated with stretchable optoelectronic devices, such as pixel size, power consumption and stability, severely brock their realization in high-resolution digital imaging. Herein, we develop a universal detachable interface technique that allows uniform, damage-free and reproducible integration of micropatterned stretchable electrodes for pixel-dense intrinsically stretchable organic transistor arrays. Benefiting from the ideal heterocontact and short channel length (2 μm) in our transistors, switching current ratio exceeding 106, device density of 41,000 transistors/cm2, operational voltage down to 5 V and excellent stability are simultaneously achieved. The resultant stretchable transistor-based image sensors exhibit ultrasensitive X-ray detection and high-resolution imaging capability. A megapixel image is demonstrated, which is unprecedented for stretchable direct-conversion X-ray detectors. These results forge a bright future for the stretchable photonic integration toward next-generation visualization equipment.

Correlative light and X-ray tomography jointly unveil the critical role of connexin43 channels on inflammation-induced cellular ultrastructural alterations

Non-junctional connexin43 (Cx43) plasma membrane hemichannels have been implicated in several inflammatory diseases, particularly playing a role in ATP release that triggers activation of the inflammasome. Therapies targeting the blocking of the hemichannels to prevent the pathological release or uptake of ions and signalling molecules through its pores are of therapeutic interest. To date, there is no close-to-native, high-definition documentation of the impact of Cx43 hemichannel-mediated inflammation on cellular ultrastructure, neither is there a robust account of the ultrastructural changes that occur following treatment with selective Cx43 hemichannel blockers such as Xentry-Gap19 (XG19).A combination of same-sample correlative high-resolution three-dimensional fluorescence microscopy and soft X-ray tomography at cryogenic temperatures, enabled in the identification of novel 3D molecular interactions within the cellular milieu when comparing behaviour in healthy states and during the early onset or late stages under inflammatory conditions. Notably, our findings suggest that XG19 blockage of connexin hemichannels under pro-inflammatory conditions may be crucial in preventing the direct degradation of connexosomes by lysosomes, without affecting connexin protein translation and trafficking. We also delineated fine and gross cellular phenotypes, characteristic of inflammatory insult or road-to-recovery from inflammation, where XG19 could indirectly prevent and reverse inflammatory cytokine-induced mitochondrial swelling and cellular hypertrophy through its action on Cx43 hemichannels. Our findings suggest that XG19 might have prophylactic and therapeutic effects on the inflammatory response, in line with functional studies.

Bifocal photon sieve imaging in the hard x-ray region.

Hard x-rays are widely used for plasma diagnosis, nondestructive inspection, and high-resolution x-ray imaging. A typical x-ray source is a tabletop micro-focus x-ray source. Here, a bifocal photon sieve (PS) with the smallest diameter of 59.6 nm was designed and fabricated by electron-beam lithography to focus hard x-rays on variable-resolution array images. An imaging experiment at 8.39 keV demonstrates that the designed and fabricated PS has two different focal lengths. The numerous pinholes that can be optimized provide richer degrees of freedom to realize considerably more functionalities. A multi-focal PS provides the possibility of splitting x-rays and further extends interferometry from visible light to hard x-rays.

Layered Chalcogenide Scintillators Enabled by Reversible Hydrous-Induced Phase Transformation for High-Resolution X-ray Imaging.

Scintillation materials have been widely used in various fields, such as medical diagnosis and industrial detection. Chalcogenides have the potential to become a new generation of high-performance scintillation materials due to their high effective atomic number and good resistance to radiation damage. However, research on their application in radiation detection is currently very scarce. Herein, single crystals of rare earth ion-doped ternary chalcogenides NaGaS2/Eu were grown by a high-temperature solid-phase method. It exhibits unique characteristics of structure transformation by absorbing water molecules from the air. To maintain the anhydrous phase of the material, we have used a strategy of organic-inorganic composites of epoxy resin and NaGaS2/Eu to prepare devices for radiation detection and discuss the irradiation luminescence properties of the two phases. The anhydrous phase of NaGaS2/Eu demonstrates excellent sensitivity to X-rays, with a low detection limit of 250 nGy s-1, which is approximately 1/22 of the medical imaging dose. Additionally, composite flexible films were prepared, which exhibited excellent performance in X-ray imaging. These films enable clear observation of a wide range of objects with a high spatial resolution of up to 13.2 line pairs per millimeter (lp mm-1), indicating that chalcogenide holds promising prospects in the realm of X-ray imaging applications.

Preparing the In-doped lead-free Cs3Cu2I5 perovskite scintillator by a co-firing technique for its application in high-resolution X-ray imaging

The perovskite scintillators have been extensively studied recently for their merits of tunable emission spectra and simple preparation processes. However, the practical applications of perovskite scintillator-based X-ray image sensor are still impeded by inadequate radioluminescence, poor environmental stability, and low imaging resolution. Herein, we demonstrate a scalable co-firing method to fabricate high-quality lead-free Cs3Cu2I5 perovskite scintillator and an Indium (In)-doping strategy is introduced to enhance its radioluminescence performance at the same time. The In-doped Cs3Cu2I5 obtains a high PLQY of 77.9% and a relative light output of 53372 ph/MeV, which are 0.34 and 1.08 times higher than those of the undoped counterpart, respectively. The X-ray detection limit of the In:Cs3Cu2I5 can reach 150.55 nGyair/s, 36.53 times lower than the requirement for X-ray medical diagnosis. The synthesized scintillator also shows superior stability under continuous high dose X-ray irradiation of 6800 μGyair/s for 120 minutes, maintaining 95% of its initial radioluminescence intensity. Furthermore, a large-area (300 cm2) flexible perovskite scintillator film is prepared, which owns a much competitive resolution of 10 lp/mm and less distortion in X-ray imaging. This work provides a practical path for the wide application of perovskite scintillator in the field of X-ray detection and imaging in near future.

AM-SegNet for additive manufacturing in situ X-ray image segmentation and feature quantification

ABSTRACT Synchrotron X-ray imaging has been utilised to detect the dynamic behaviour of molten pools during the metal additive manufacturing (AM) process, where a substantial amount of imaging data is generated. Here, we develop an efficient and robust deep learning model, AM-SegNet, for segmenting and quantifying high-resolution X-ray images and prepare a large-scale database consisting of over 10,000 pixel-labelled images for model training and testing. AM-SegNet incorporates a lightweight convolution block and a customised attention mechanism, capable of performing semantic segmentation with high accuracy (∼96%) and processing speed (< 4 ms per frame). The segmentation results can be used for quantification and multi-modal correlation analysis of critical features (e.g. keyholes and pores). Additionally, the application of AM-SegNet to other advanced manufacturing processes is demonstrated. The proposed method will enable end-users in the manufacturing and imaging domains to accelerate data processing from collection to analytics, and provide insights into the processes’ governing physics.

Comprehensive Study on Mineral Processing Methods and Mineral Technical Economics of Manganese Ore in Chongqing Chengkou.

Chongqing Chengkou manganese deposit is a large carbonate-type manganese deposit in the upper reaches of the Yangtze River, located in Gaoyan Town, Chengkou County, Chongqing. In order to improve the recovery rate of low-grade manganese ore and concentrate grade index, achieve efficient utilization of mineral resources, and sustainable development of Gaoyan manganese ore deposit in Chengkou, Chongqing, China, in this paper, by means of optical microscope analysis, high-resolution X-ray tomography technology, three-dimensional image analysis technology, X-ray diffraction analysis, X-ray fluorescence spectrum analysis, and technical and economic analysis, the occurrence state and process mineralogy of manganese are studied, and the technical and economic analysis of flotation, high-intensity magnetic separation, and gravity separation are carried out. It provides a reference for other mining enterprises to choose the most suitable beneficiation method according to the specific mineral species.

High-rate, high-resolution single photon X-ray imaging: Medipix4, a large 4-side buttable pixel readout chip with high granularity and spectroscopic capabilities

The Medipix4 chip is the latest member in the Medipix/Timepix family of hybrid pixel detector chips aimed at high-rate spectroscopic X-ray imaging using high-Z materials. It can be tiled on all 4 sides making it ideal for constructing large-area detectors with minimal dead area. The chip is designed to read out a sensor of 320 × 320 pixels with dimensions of 75 μm× 75 μm or 160 × 160 pixels with dimensions of 150 μm× 150 μm. The readout architecture features energy binning of the single photons, which includes charge sharing correction for hits with energy spread over adjacent pixels. This paper presents the specifications, architecture, and circuit implementation of the chip, along with the first electrical measurements.

Thermally Activated Delayed Fluorescence (TADF)-active Coinage-metal Sulfide Clusters for High-resolution X-ray Imaging.

The study of facile-synthesis and low-cost X-ray scintillators with high light yield, low detection limit and high X-ray imaging resolution plays a vital role in medical and industrial imaging fields. However, the optimal balance between X-ray absorption, decay lifetime and excitonic utilization efficiency of scintillators to achieve high-resolution imaging is extremely difficult due to the inherent contradiction. Here two thermally activated delayed fluorescence (TADF)-actived coinage-metal clusters M6 S6 L6 (M=Ag or Cu) were synthesized by simple solvothermal reaction, where the cooperation of heavy atom-rich character and TADF mechanism supports strong X-ray absorption and rapid luminescent collection of excitons. Excitingly, Ag6 S6 L6 (SC-Ag) displays a high photoluminescence quantum yield of 91.6 % and scintillating light yield of 17420 photons MeV-1 , as well as a low detection limit of 208.65 nGy s-1 that is 26 times lower than the medical standard (5.5 μGy s-1 ). More importantly, a high X-ray imaging resolution of 16 lp/mm based on SC-Ag screen is demonstrated. Besides, rigid core skeleton reinforced by metallophilicity endows clusters M6 S6 L6 strong resistance to humidity and radiation. This work provides a new view for the design of efficient scintillators and opens the research door for silver clusters in scintillation application.

Multi-phase retrieval of methane hydrate in natural sediments by cryogenic x-ray computed tomography.

In this study, we observed natural methane (CH4) hydrate sediments, which are a type of unconventional natural gas resources, using x-ray computed tomography (CT). Because CH4 hydrates are formed by hydrogen bonding of water molecules with CH4, material decomposition becomes challenging when CH4 hydrates coexist with liquid or solid water in natural sediments. Tri-contrast (absorption, refraction, and scattering) imaging was performed via diffraction enhanced x-ray CT optics using monochromatic synchrotron x rays. The quantitative characterization of the contrast changes successfully enabled the decomposition of CH4 hydrates coexisting with frozen seawater (ice) in natural sediments obtained from the Okhotsk Sea. This study reveals complementary structural information about the microtexture and spatial relation among CH4 hydrates, ice, and pores by utilizing the distinct physical properties of x rays when passing through the materials. These results highlight the exceptional capabilities of high-resolution multicontrast x-ray tomography in materials science and geoscience applications.