The development of single-stage high pressure ratio centrifugal compressors for small gas turbine engines is hindered by compressor flow instabilities with various temporal and spatial scales. In this paper, the effect of a self-recirculation casing treatment device for suppressing various scales of flow instability has been discussed. Rig tests of a high pressure ratio centrifugal compressor with and without a casing treatment device are performed, and transient pressure signals are measured at endwalls by fast response pressure transducers. By analyzing measured pressure signals in both time and frequency domain, the casing treatment device is found effective in eliminating rotating instability and stall at the impeller inlet at low speeds, as well as suppressing surge of the compression system at middle and high speeds. The flow recirculation process generated inside the casing treatment device removes the vortical structures at the impeller inlet tip section, therefore eliminating the regional rotating instability and stall. Besides, the casing treatment device turns the pressure rise characteristics of the impeller more negative by enhancing the impeller work input, but turns that of the vaned diffuser more positive by increasing the incidence at the vaned diffuser inlet. Combining both effects, mild surge and the deep surge are suppressed.