The reliability of monorail crane braking system has an important influence on braking safety, high-speed and heavy-load operation, which poses great challenges to braking safety, and it is necessary to evaluate its braking reliability accurately and efficiently. Firstly, the dynamic performance and thermal-mechanical coupling characteristics of high-speed and heavy-load monorail crane under different braking parameters were analyzed. Secondly, the random response model of braking distance and braking temperature was established by combining the design of experiment method (DoE) and Dendrite Net (DD). Finally, the high-order moment saddlepoint approximation (SPA) method was used to evaluate the emergency braking reliability of the monorail crane. The results can provide a reference for the selection of key parameters and the evaluation of braking safety of the monorail crane braking system under high-speed and heavy-load conditions.