High Mismatch Research Articles

Abstract TP169: Presence of a Mismatch Perfusion Profile in Large Core Ischemic Stroke Over Time Significantly Varies by Mismatch Definition

Introduction: The prevalence of Mismatch (MM) profiles on admission perfusion imaging in large core ischemic strokes, stratified by time since last known normal (LKN) and MM profile definition, is not well described. Methods: We used a retrospective multicenter study of patients with anterior circulation large vessel occlusion, baseline MR or CT perfusion (MRP, CTP), and definitive LKN within 24 hours. We studied four MM profile definitions: 1) Mismatch ratio (MR)≥1.2, penumbral volume (Pen)≥10ml, and (if CTP) core volume defined by CBF<30%; 2) MR≥1.8, Pen≥15ml, CBF<30%; 3) MR≥1.2, Pen≥10ml, CBF<38%; 4) MR≥1.8, Pen≥15ml, CBF<38%. Two definitions of large core were evaluated (≥50ml or ≥70ml; defined as CBF<30% or CBF<38% on CTP and as ADC ≤620x10 -6 mm 2 /s on MRP). We used the Cochran-Armitage Trend Test to evaluate for trends in MM presence over time and McNemar Test to compare MM profiles for differences in prevalence. Results: Of 2012 patients included, 49% were male, median age was 75 (IQR 64-84), median baseline NIHSS was 15 (8-20), median time from LKN to imaging was 5.7 hours (1.8-8), 44% had CTP. In patients with cores ≥50ml and ≥70ml (Figures 1&2), MM profile defined by MR≥1.2 and Pen≥10ml was more prevalent than MM defined by MR≥1.8 and Pen≥15ml (P<0.001). MM prevalence decreased over time in three of four MM profiles in the ≥50ml core group but only one MM profile in the ≥70ml group (P<0.001 in all comparisons). In all core sizes (Figure 3), there was a significant trend toward decreased MM prevalence over time in all four profiles (P<0.0001) and between the MR≥1.2 and Pen≥10 vs MR≥1.8 and Pen≥15 profiles (P<0.001 in all comparisons). Similar significant differences between the MR≥1.2 and Pen≥10 vs MR≥18 and Pen≥15 existed in CTP only, MRP only, and witnessed onset only subgroup analyses (P<0.001 for all). Conclusions: MM is more prevalent when defined as MR≥1.2 and Pen≥10ml than when defined as MR≥1.8 and Pen≥15ml, especially in large cores. MM prevalence decreases over time in all core sizes, though trends are less clear with increasing infarct size. Understanding real-world prevalence of MM in large core strokes may help contextualize results of recent trials, while clarifying the optimal definition and prevalence of MM in the large core population is of import to future prospective study design. This study is limited by potential bias in favor of higher MM presence due to one site’s patient transfer acceptances contingent on favorable CTP profiles.

The association between serum tacrolimus concentrations and BK viruria in kidney transplant recipients

The objective of this study was to examine the association between serum tacrolimus trough levels and the detection of BK viruria in kidney transplant recipients. We conducted a retrospective study and included kidney transplant recipients who underwent BK viruria screening during 2018–2021. Serum tacrolimus trough levels, urine BK viral load, and potential risk factors were collected. Statistical analysis was performed to identify the association between the serum tacrolimus trough levels and the detection of BK virus in urine (defined as positive BK viruria), as well as to determine the cumulative incidence and risk factors for BK viruria. Out of 243 recipients, 76 had positive BK viruria. The average serum tacrolimus trough level was significantly higher among the positive BK viruria group compared to the BK viruria-negative group. High HLA mismatch was identified as a risk factor for BK viruria. Approximately half of the recipients with average serum tacrolimus trough levels exceeding 10 ng/mL would develop BK viruria early. This study found an association between the average serum tacrolimus trough level and the detection of BK viruria. High HLA mismatch and an average serum tacrolimus trough level exceeding 10 ng/mL should be regarded as a risk for BK viruria.

On the stresses associated with heterointerfaces

ABSTRACT Considering the formation of misfit dislocations in systems with both high and low lattice mismatch, the Peierls–Nabarro mechanism is first introduced to deal with periodic dislocations. The effect of interfacial misfit dislocations on the interior of the crystal is then investigated using exact elasticity solutions. The core structure of the misfit dislocation is then given, and it is emphasised that the stress field inside the crystal can be determined under certain combinations of material constants so as to determine the atomic configuration of the material. An application of the theoretical results to interfacial dislocations of a BN/AlN heterojunction is shown, and the reliability of theory is verified by first-principles calculations.

Genome-wide meta-analysis associates donor-recipient non-HLA genetic mismatch with acute cellular rejection post-liver transplantation.

Acute cellular rejection (ACR) remains a common complication causing significant morbidity post-liver transplantation. Non-human leukocyte antigen (non-HLA) mismatches were associated with an increased risk of ACR in kidney transplantation. Therefore, we hypothesized that donor-recipient non-HLA genetic mismatch is associated with increased ACR incidence post-liver transplantation. We conducted an international multicenter case-control genome-wide association study of donor-recipient liver transplant pairs in 3 independent cohorts, totaling 1846 pairs. To assess genetic mismatch burden, we calculated sum scores for single-nucleotide polymorphism (SNP) mismatch based on all non-HLA functional SNPs, specifically SNPs coding for transmembrane or secreted proteins as they more likely affect the immune system. We analyzed the association between the non-HLA mismatch scores and ACR in a multivariable Cox regression model per cohort, followed by a weighted meta-analysis. During the first year post-transplantation, 90 of 689 (13%), 161 of 720 (22%), and 48 of 437 (11%) recipients experienced ACR in cohorts 1-3, respectively. Weighted meta-analyses showed that higher mismatch in functional non-HLA SNPs was associated with an increased incidence of ACR (HR 5.99; 95% CI: 1.39-20.08; p=0.011). Moreover, we found a larger effect of mismatch in SNPs coding for transmembrane or secreted proteins on ACR (HR 7.54; 95% CI 1.95-28.79; p=0.003). Sensitivity analyses showed that imputed HLA mismatch did not affect the associations between both non-HLA mismatch scores and ACR. Donor-recipient mismatch of functional non-HLA SNPs overall and, especially, of SNPs encoding transmembrane or secreted proteins correlated with 1-year ACR post-liver transplantation. Identifying high-risk immunological burdens between pairs may prevent early graft rejection and aid in personalizing immunosuppressive therapy. Future studies are, however, needed to validate our findings using a genotyped HLA cohort.

Design of Human and Implanted Knee Model using Anthropometric Data for Total Knee Replacement

Objectives: The objective of this study is to estimate the mismatch error between the human knee and implanted knee for total knee replacement with the help of data analysis considering the anthropometric and implant data for the Indian population. Methods: Anthropometric data collected for 150 cases from the hospital was contrasted with the typical implant data from the Johnson & Johnson Company and Zimmer. In the data collected for 150 cases, 91 were female patients and 59 were male patients. The maximum cases were for osteoarthritis and rheumatoid arthritis. For each patient—male and female—the mismatch error was computed separately. Major focus of the study was laid on the femoral condyle. Results: Zimmer implant mismatch errors were computed as follows: -1.18 for A/P and 4.95 for M/L in patients who were male; -5.6 for A/P and -3.3 for M/L in patients who were female and male. -3.4 for A/P and -0.4 for M/L in female patients; 1.85 for A/P and 8.18 for M/L in male patients was the mismatch error computed for Johnson & Johnson implants. The total discrepancy in implant results was 1.83 for men and -4.4 for women for Zimmer, and 5.01 for men and -1.89 for women for Johnson & Johnson. A mismatch of -19 (for females), -15 (for men) was identified for Zimmer, and -11 (for females), -7 (for males) was found for Johnson & Johnson. The femoral condyle was the cause of several inaccuracies. Conclusion: On the basis of results from data analysis it was found that female patients were more into pray of high mismatch errors. Also, femoral condyle mismatch was majorly responsible for the improper fitting of implants error. So, a 3-D model was developed using Slicr3r to justify that the gap between the implant and implanted knee must not exceed 2mm for femoral condyle in order to get the best fit. A patent on Asymmetric Prosthetic Tibial Component is available to explain a similar concept.

A Narrative Review of the Role of Immunotherapy in Metastatic Carcinoma of the Colon Harboring a BRAF Mutation.

Patients affected by metastatic carcinoma of the colon/rectum (mCRC) harboring mutations in the BRAF gene (MBRAF) respond poorly to conventional therapy and have a prognosis worse than that of patients without mutations. Despite the promising outcomes of targeted therapy utilizing multi-targeted inhibition of the mitogen-activated protein kinase (MAPK) signaling system, the therapeutic efficacy, especially for the microsatellite stable/DNA proficient mismatch repair (MSS/PMMR) subtype, remains inadequate. Patients with MBRAF/mCRC and high microsatellite instability or DNA deficient mismatch repair (MSI-H/DMMR) exhibit a substantial tumor mutation burden, suggesting a high probability of response to immunotherapy. It is widely acknowledged that MSS/pMMR/mCRC is an immunologically "cold" malignancy that exhibits resistance to immunotherapy. The integration of targeted therapy and immunotherapy may enhance clinical outcomes in patients with MBRAF/mCRC. Efforts to enhance outcomes are exclusively focused on MSS/DMMR-BRAF mutant cancers, which constitute the largest proportion. This review evaluates the clinical efficacy and advancement of novel immune checkpoint blockade therapies for MSI-H/DMMR and MSS/PMMR BRAF mutant mCRC. We examine potential indicators in the tumor immune milieu for forecasting immunotherapeutic response in BRAF mutant mCRC.

Influence of HLA mismatch between donors and recipients on postoperative outcomes in cadaveric lung transplantation.

Generally, HLA matching between donors and recipients is not performed in lung transplantation (LTx). Therefore, whether HLA mismatch between donors and recipients (D/R mismatch) influences postoperative outcomes after LTx remains uncertain. In this study, we investigated the influence of D/R mismatch on postoperative outcomes after cadaveric LTx (CLT). A total of 140 CLT procedures were performed between 2012 and 2020. After excluding 5 recipients with preformed DSA and 1 recipient undergoing re-LTx, 134 recipients were enrolled in this retrospective study. The postoperative outcomes were compared between recipients with higher and lower D/R mismatches. The median D/R mismatch (A/B/DR loci) was 4.0 (range, 1-6). When dividing these 134 recipients into two groups (H group [D/R mismatch ≥ 5, n = 57] and L group [D/R mismatch ≤ 4, n = 77]), there were no significant differences in the patient backgrounds. The lengths of hospital and intensive care unit stays were similar (p = 0.215 and p = 0.37, respectively). Although the overall survival was not significantly better in the H group than in the L group (p = 0.062), chronic lung allograft dysfunction-free survival was significantly better in the H group than in the L group (p = 0.027). Conversely, there was no significant difference in the cumulative incidence of de novo donor-specific anti-HLA antibodies(dnDSAs) between the two groups (p = 0.716). No significant difference in dnDSA development was observed between patients with higher and lower D/R HLA mismatches. Given the favorable outcomes in the high HLA mismatch group, CLTs can be performed safely in recipients with high D/R HLA mismatches.

One-class anomaly detection through color-to-thermal AI for building envelope inspection

Characterizing the energy performance of building components and locating anomalies is necessary for effectively refurbishing existing buildings. It is often challenging because defects in building envelopes deteriorate without being visible. Passive infrared thermography (PIRT) is a powerful tool used in building inspection. However, thermal image interpretation requires significant domain knowledge and is prone to artifacts arising from a complex interplay of factors. As a result, PIRT-based inspections require skilled professionals, and are labor-intensive and time-consuming. Artificial intelligence (AI) holds great promise to automate building inspection, but its application remains challenging because common approaches rely on extensive labeling and supervised modeling. It is recognized that there is a need for a more applicable and flexible approach to leverage AI to assist PIRT in realistic building inspections. In this study, we present a label-free method for detecting anomalies during thermographic inspection of building envelopes. It is based on the AI-driven prediction of thermal distributions from color images. Effectively the method performs as a one-class classifier of the thermal image regions with a high mismatch between the predicted and actual thermal distributions. The algorithm can learn to identify certain features as normal or anomalous by selecting the target sample used for training. The proposed method has unsupervised modeling capabilities, greater applicability and flexibility, and can be widely implemented to assist human professionals in routine building inspections or combined with mobile platforms to automate the inspection of large areas.

Two-gigapascal-strong ductile soft magnets

Soft magnetic materials (SMMs) are indispensable for electromechanical energy conversion in high-efficiency applications, but they are exposed to increasing mechanical loading conditions in electric motors due to higher rotational speeds. Enhancing the yield strength of SMMs is essential to prevent the degradation in magnetic performance and failure from plastic deformation, yet most SMMs have yield strengths far below one gigapascal. Here, we present a multicomponent nanostructuring strategy that doubles the yield strength of SMMs while maintaining ductility. We introduce morphologically anisotropic nanoprecipitates through dislocation-driven precipitation induced by preceding deformation during heat treatment in an iron–nickel–cobalt–tantalum material. With all dimensions of the precipitates below the magnetic domain wall width, we achieve a high precipitate number density with a large specific surface area, small interprecipitate spacing, and high lattice mismatch, which impede dislocation glide and strengthen the material. Both the matrix and precipitates are ferromagnetic, yielding a high magnetic moment. This nanostructuring approach offers a pathway to two-gigapascal-strong ductile SMMs with moderately increased coercivity that can be tolerated in exchange for significantly improved mechanical performance for sustainable electrification.

Evaluating spatial variation of accessibility to urban green spaces and its inequity in Chicago: Perspectives from multi-types of travel modes and travel time

Urban green spaces (UGS) significantly benefit public health outcomes. Providing equal access to UGS and ensuring a better match between UGS demand and supply are crucial for developing sustainable cities. This study employed the 3SFCA method and multi-source data to explore the spatial variation and equity in UGS accessibility in the City of Chicago by considering different types of UGS, travel modes, and travel time thresholds. The Gini index and spatial statistical methods are used to evaluate the inequity in and the mismatch between UGS accessibility and demand. The findings showed significant disparities in accessibility and high inequity among different types of UGS, travel modes, and travel time thresholds. The travel mode of driving and a larger travel time threshold led to more homogeneous distributions of accessibility and mild inequity but exacerbated the mismatch between UGS accessibility and demand. Census tracts in the eastern part of Chicago have consistently low accessibility with a high demand-low supply mismatch while the rest of the city had high accessibility to UGS with a low demand-high supply mismatch under certain circumstances. The findings offer insights into the spatial patterns of UGS accessibility and inequity and contribute to more effective planning policies to improve the quality of human life.

LAST BUT NOT LEAST: LAGGARD FIRMS, TECHNOLOGY DIFFUSION, AND ITS STRUCTURAL AND POLICY DETERMINANTS

AbstractUsing a unique microaggregated data set on firm‐level productivity in 13 countries from 1995 to 2014, this article provides new evidence on technology‐ and knowledge‐diffusion barriers for laggard firms. We show that, although the least productive firms benefit from a catch‐up effect, their speed of catchup is lower in digital‐ and skill‐intensive industries. This is especially true in countries with high skill mismatch, high financing frictions, and low absorptive capacity. These barriers to diffusion, combined with the rising importance of tacit knowledge and intangibles, could help explain the productivity growth slowdown observed in the last decades.

Abstract I003: Inhibitors of DHX9 RNA helicase as synthetic lethal cancer therapeutics

Abstract Over 100 modifications to RNA are known to occur in human cells, where they play critical roles in many aspects of normal cellular physiology, such as cell fate decisions and terminal differentiation, through effects on RNA biology such as protein and nucleic acid interactions. Our survey of human RNA-modifying enzymes suggests many are cancer essential enzymes with striking synthetic lethal profiles, including the DHX9 helicase. DHX9 is a multifunctional DExH-box RNA helicase which can unwind regions of double-stranded DNA and RNA helices but has a greater propensity for secondary structures such as DNA/RNA hybrids (R-loops) and DNA/RNA G-quadruplexes. DHX9 interacts with and regulates many proteins, including key members of DNA damage repair pathways. We have found that DHX9 knockdown is synthetic lethal in microsatellite high (MSI-H) or defective mismatch repair (dMMR) tumor models. A suite of assays was developed to identify and optimize potent and selective inhibitors of the DHX9 helicase, which recapitulate our findings with genetic tools. Profiling of DHX9 inhibitors across a broad panel of cancer cell lines reveals that tumor cells with mutations in the DNA damage repair genes BRCA1 and/or BRCA2 are also responsive to DHX9 inhibitor treatment in vitro and in vivo. DHX9 inhibition leads to increased RNA/DNA secondary structures such as R-loops and G-quadruplexes, resulting in subsequent DNA damage and increased replication stress, leading to cell cycle arrest and apoptosis. These results suggest that DHX9 inhibitors are a novel treatment modality for patients with defective DNA damage repair pathways such as dMMR and/or BRCA mutations. Citation Format: Serena J Silver. Inhibitors of DHX9 RNA helicase as synthetic lethal cancer therapeutics [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: RNAs as Drivers, Targets, and Therapeutics in Cancer; 2024 Nov 14-17; Bellevue, Washington. Philadelphia (PA): AACR; Mol Cancer Ther 2024;23(11_Suppl):Abstract nr I003.

Preparation and optimization of La0.6Sr0.4Fe1-yCoyO3-δ cathodes for intermediate temperature solid oxide fuel cells

It is shown in this work that a synthetic route based on the auto-combustion of an ethylene glycol-metal nitrate polymerized gel precursor can be efficiently used to easily produce a range of La0.6Sr0.4Fe1-yCoyO3-δ nanopowders at moderate temperatures. We have been able to determine on air-sintered samples the effect of sintering temperature on the microstructure. At sintering temperatures as low as 1100 to1200 °C, grains are well defined with a uniform round spherical morphology and have a homogeneous sub-micrometer size distribution showing a highly densified microstructure. The electronic conductivity and thermal expansion coefficients (TEC) of sintered LSFC samples have been determined according to the variation of Fe/Co composition. Both measures clearly increase with the Co content. These materials also must exhibit chemical stability with electrolytes, most commonly used for intermediate temperature solid oxide fuel cells (IT-SOFCs). In this way, the material as obtained is optimized in terms of chemical homogeneity and good stoichiometric control, microstructural characteristics of sintered samples, and finally the adequate Cobalt content to avoid high TEC mismatch with other components of the SOFC. This is a crucial issue as it causes an important thermo¬mechanical stress; promote extensive microcraking and significant performance degradation. Finally, these cathodes must exhibit acceptable electrochemical parameters for use in IT-SOFC.

Low Hysteresis Vanadium Dioxide Integrated on Silicon Using Complementary Metal‐Oxide Semiconductor Compatible Oxide Buffer Layer

VO2 undergoes a metal‐insulator transition (MIT) at ≈70 °C, which induces large variations in its electrical and wavelength‐dependent optical properties. These features make VO2 a highly sought‐after compound for optical, thermal, and neuromorphic applications. To foster the development of VO2‐based devices for the microelectronic industry, it is also imperative to integrate VO2 on silicon. However, high lattice mismatch and the formation of silicates at the interface between VO2 and Si degrade the quality and functionality of VO2 films. Moreover, VO2's polymorphic nature and stable VO phases pose integration issues. To address these challenges, the MIT of VO2 thin films integrated on Si with a complementary metal‐oxide semiconductor‐compatible HfxZr1−xO2 (HZO) buffer layer is investigated. Using in situ high‐resolution X‐ray diffraction and synchrotron far‐infrared spectroscopy, combined with multiscale atomic and electronic structure characterizations, it is demonstrated that VO2 on the HZO buffer layer exhibits an unusually low thermal hysteresis of ≈4 °C. In these results, the influence of strain on M2 phase nucleation, which controls the hysteresis, is unraveled. Notably, the rate of phase transition is symmetric and does not change for the heating and cooling cycles, implying no incorporation of defects during cycling, and highlighting the potential of an HZO buffer layer for reliable operation of VO2‐based devices.

Effect of various interlayers in NiTi to TC4 dissimilar joints by magnetic pulse welding

Magnetic pulse welding (MPW) has gained wide attention recently. In this paper, the connection of NiTi/TC4 dissimilar materials was achieved by adding pure Al, Cu, and Ni interlayers using MPW technology, and microstructure characterization and mechanical property tests were conducted to evaluate the joints. The results show that the atomic diffusion in the welding process plays a key role in the interface formation process. The interfacial morphology of joints consists of wavy and flat interfaces, and the mechanical interlocking of the wavy interface gives the joints excellent mechanical properties. The joints with the pure Al interlayer have the best mechanical properties, and the tensile shear force is 2.168 kN; the fracture forms of joints with different interlayers are all ductile fractures. In addition, the calculation results of the edge-to-edge crystal matching model show that the side with the high interface mismatch rate is where the joint failure problem occurs frequently.

Visible light infrared matching algorithm based on improved SuperPoint and linear converter

In order to solve the problems of high difficulty and mismatch rate in heterogeneous image matching of visible light and infrared images, a deep learning matching algorithm based on improved SuperPoint and linear transformer is proposed. The algorithm first introduces the idea of feature pyramid to construct a feature description branch based on the SuperPoint network structure, and trains it based on the hinge loss function, so as to better learn the multi-scale deep features of visible light and infrared images and increase the similarity of image point pair descriptors with the same name; in the feature matching module, the linear transformer is used to improve the SuperGlue matching algorithm and aggregate features to improve matching performance. The proposed algorithm is experimentally verified on multiple data sets. The results show that compared with the existing algorithms, the algorithm achieves better matching results and improves the matching accuracy.

Mismatch between fixed classroom furniture and anthropometric measurements among university students: Relationships to ergonomic risk.

Appropriate arrangement of classroom ergonomics is necessary for maintaining health and improving academic performance, learning, and motivation. We aimed to determine the anthropometric measurements and ergonomic risk levels of students during a handwriting activity on a fixed desk and chair and to analyze the mismatch and relationships between these factors. This study included 149 university students (female:73, male:76). Anthropometric measurements (lower and upper extremity length, shoulder height, elbow-rest height, hip-popliteal length, popliteal height, knee height, the distance between tragus and wall, and between acromion and wall) were done with a tape measure. The Rapid Upper Limb Assessment (RULA) tool was conducted to determine the ergonomic risk level while students wrote a standard text on a fixed desk and chair as if they were taking notes in the classroom. The mismatch was evaluated between backrest height and sitting shoulder height, seat height, and popliteal height. The Pearson Chi-Square and the Spearman Correlation test were used for statistical analysis. The median values of the participants' age, height, weight, and BMI were 22 years, 1.70 m, 68 kg, and 23.18 kg/cm2, respectively. Most students had inadequate ergonomic posture while writing on fixed furniture at the university (Median RULA grand score: 4). More mismatches for seat height (54.4%) were found in high ergonomic risk levels but mismatches for backrest height did not follow a similar result. More investigation should be conducted with prospective studies including interventions like adjustable furniture.

A three-dimensional rubber-steel phononic crystal for broad and low-frequency vibration attenuation

Elastic metamaterials and phononic crystals have the potential for vibration isolation applications due to wave band gaps where elastic waves cannot propagate. However, their real-life application may be compromised by the narrow band gaps of the former and the high frequencies of the latter. In the current study, we present a three-dimensional frame structure made of steel and rubber elements that presents a wide complete band bag at low frequency. The structure provides extreme vibration isolation because it combines band gaps with high impedance mismatch between steel and rubber damping. The manufacturing process of the proposed frame structure is widely used in mounting pads, and its cost is relatively low. It provides reasonable structural strength, which makes its application in real life possible. The dynamic behavior predicted with spectral and finite element models is validated with experimental results.

Scalable InGaN nanowire µ-LEDs: paving the way for next-generation display technology.

Ever-increasing demand for efficient optoelectronic devices with a small-footprinted on-chip light emitting diode has driven their expansion in self-emissive displays, from micro-electronic displays to large video walls. InGaN nanowires, with features like high electron mobility, tunable emission wavelengths, durability under high current densities, compact size, self-emission, long lifespan, low-power consumption, fast response, and impressive brightness, are emerging as the choice of micro-light emitting diodes (µLEDs). However, challenges persist in achieving high crystal quality and lattice-matching heterostructures due to composition tuning and bandgap issues on substrates with differing crystal structures and high lattice mismatches. Consequently, research is increasingly focused on scalable InGaN nanowire µLEDs representing a transformative advancement in display technology, particularly for next-generation applications such as virtual/augmented reality and high-speed optical interconnects. This study presents recent progress and critical challenges in the development of InGaN nanowire µLEDs, highlighting their performance and potential as the next-generation displays in consumer electronics.

Ergonomic compatibility between sewing workstation and Bangladeshi apparel workers

Prolonged sitting with awkward posture during sewing results in musculoskeletal disorders among sewing operators. This study aimed to identify the compatibility of the sewing furniture with operators’ anthropometry. Therefore, 13 anthropometric measurements of 368 sewing operators were collected and compared with sewing furniture dimensions. The results showed that all anthropometric measurements other than hip breadth were larger for male participants. In addition, statistical analysis performed on the collected data showed significant variation compared to the existing dimensions of sewing machines. Results also indicated a high mismatch for different dimensions of the sewing table and chair, such as seat height, seat width, seat depth, table depth, etc. For this reason, sewing operators often experience musculoskeletal disorders. Finally, this study recommends some guidelines for designing the sewing workstation, which might act as a basis for manufacturers or importers to set provisions for sewing machines.