High Loading Rates Research Articles

Amphiphilic diblock copolymers of polyisobutylene-b-poly(2-ethyl-2-oxazoline) via cationic polymerization

A series of amphiphilic polyisobutylene-b-poly (2-ethyl-2-oxazoline) (PIB-b-PEOX) diblock copolymer/Ag nanoparticle composites were successfully in-situ synthesized via cationic ring-opening polymerization of 2-ethyl-2-oxazoline (EOX) with high initiation efficiency by using allyl bromide end functionalized polyisobutylene (PIB-allylBr) as a macroinitiator and AgClO4 as a coinitiator. The microphase separation formed in the resulting PIB-b-PEOX diblock copolymers due to the thermodynamic imcompability of hydrophilic PEOX segments and hydrophobic PIB segments. The micromorphology of phase separation is dependent on the copolymer composition, in which sea-island micromorphology formed for PIB118-b-PEOX80 and bicontinuous phase micromorphology formed for PIB118-b-PEOX97. The micelles with nano-scale size in the range of 15–80 nm and having high drug loading rate of ca. 48.9 % can be formed by self-assembly of the amphiphilic diblock copolymers in n-hexane. The drug cumulative release rate can be increased with an increase in the proportion of PEOX segments, due to the strong interaction between ibuprofen and the PEOX segments. The hydrophilicity of the PIB-b-PEOX diblock copolymer surfaces can be improved after ethanol vapor induction. The PIB-b-PEOX diblock copolymers behave biocompatibility and good anti-protein adsorption property. The amphiphilic PIB-b-PEOX diblock copolymer/Ag nanoparticle composites exhibit high antibacterial efficiency for Gram-negative bacterium (E. coli) and Gram-positive bacterium (S. aureus). To the best of our knowledge, this is the first example of PIB-b-PEOX diblock copolymer/Ag nanoparticle (6.4 ± 2.6 nm) composites synthesized in-situ with good biocompatibility, anti-protein adsorption, and antibacterial properties, which would have potential applications for drug delivery and anti-protein coating in biomedical areas.

Response of food waste anaerobic digestion to the dimensions of micron-biochar under 30 g VS/L organic loading rate: Focus on gas production and microbial community structure

Biochar modification is an effective approach to enhance its ability to promote anaerobic digestion (AD). Focusing on the physical properties of biochar, the impact of different particle sizes of biochar on AD of food waste (FW) at high organic loading rate (OLR) was investigated. Four biochar with different sizes (40–200 mesh) were prepared and used in AD systems at OLR 30 g VS/L. The research results found that biochar with a volume particle size of 102 μm (RBC-P140) had top-performance in promoting cumulative methane production, increasing by 13.20% compared to the control group. The analysis results of the variety in volatile acids and alkalinity in the system did not show a correlation with the size of biochar, but small size has the potential to improve the environmental tolerance of the system to high acidity. Microbial community analysis showed that the abundance of aceticlastic methanogen and the composition of zoogloea were optimized through relatively small-sized biochar. Through revealing the effect of biochar particle size on AD system at high OLR, this work provided theoretical guidance for regulating fermentation systems using biochar.

Fabrication and building energy-saving performance evaluation of polyethylene glycol/polymethyl methacrylate/expanded graphite thermal enhanced shape-stable phase change material

Integrating Phase Change Material (PCM) with building envelope is a promising way to reduce building energy consumption. However, leakage and insufficient PCM loading rate for existing encapsulation strategies limit its further application. In this work, a safer and easier way to fabricate Shape-Stable Phase Change Material (SSPCM) is proposed, whose products combine the outstanding leakage-proof property and high PCM loading rate. With the method of in-situ polymerization, not only the Polyethylene Glycol (PEG) is packaged by Polymethyl Methacrylate (PMMA), but the Expanded Graphite (EG) also has a chance to be added as the property regulator. The prepared SSPCMs are proved to be shape-stable over melting temperature with a leakage rate under 1 %. The characterization test reveals that with EG mass fraction increase from 0 to 2.5 %, the thermal conductivity augments from 0.23 to 1.73 W/(m·K) while the phase change latent enthalpy changes from 85.11 kJ/kg to 116.10 kJ/kg. Notably, the EG is more than a thermal conductivity enhancer, it also plays an important role in the modification of comprehensive properties. To optimize the building energy-saving performance of SSPCMs, the factors affecting building cooling electricity consumption like deployment position and thermal properties are evaluated in detail. The simulation results show that the optimum strategy is employing SSPCM with 2.0 wt% EG in the middle of the envelope, the cooling electricity consumption can be reduced by 8.64 % compared with the benchmark. The physical mechanism of energy-saving is also discussed from multiple angles. From a statistical view, sensitivity and uncertainty analysis of the simulation results is completed, to identify the influence of input parameters and validate the reliability of the simulation results. Finally, an economic analysis is carried out, proving the economic feasibility for further application. This research provides valuable insights for SSPCM’s application and design of energy-efficient buildings.

Long-term and multiscale assessment of methanogenesis enhancement mechanisms in magnetite nanoparticle-mediated anaerobic digestion reactor

Magnetite nanoparticles (Fe3O4-NPs) have been demonstrated to be involved in direct interspecies electron transfer between syntrophic bacteria, yet a comprehensive assessment of the ability of Fe3O4-NPs to cope with process instability and volatile fatty acids (VFAs) accumulation in scaled-up anaerobic reactors is still lacking. Here, we investigated the start-up characteristics of an expanded granular sludge bed (EGSB) with Fe3O4-NPs as an adjuvant at high organic loading rate (OLR). The results showed that the methane production rate of R1 (with Fe3O4-NPs) was approximately 1.65 folds of R0 (control), and effluent COD removal efficiency was maintained at approximately 98.32% upon 20 kg COD/(m3·d) OLR. The components of volatile fatty acids are acetate and propionate, and the rapid scavenging of propionate accumulation was the difference between R1 and the control. The INT-ETS activity of R1 was consistently higher than that of R0 and R2, and the electron transfer efficiencies increased by 68.78% and 131.44%, respectively. Meanwhile, the CV curve analysis showed that the current of R1 was 40% higher than R3 (temporary addition of Fe3O4-NPs), indicating that multiple electron transfer modes might coexist. High-throughput analysis further revealed that it was difficult to reverse the progressive deterioration of system performance with increasing OLR by simply reconfiguring bacterial community structure and abundance, demonstrating that the Fe3O4-NPs-mediated DIET pathway is a prerequisite for establishing multiple electron transfer systems. This study provides a long-term and multi-scale assessment of the gaining effect of Fe3O4-NPs in anaerobic digestion scale-up devices, and provides technical support for their practical engineering applications.

CO2 emissions of fuel-cell battery hybrid system for large ships

ABSTRACT The needs of solid oxide fuel cells (SOFC) and batteries in large ships are analyzed by estimating the amount of fuel consumption and CO2 emissions. Three types of systems are proposed: 1) fuel cells-battery-generator engine system, 2) battery-generator engine system, and 3) generator engine system. This study is based on the time-varying electric power demand and adopted the sequential quadratic programming (SQP) method to find the optimal power distribution of mixed power sources. CO2 emissions in the SOFC hybrid system are 11.6% lower than in the conventional generator engine system, and those in the battery-generator engine system are 5.1% lower than in the conventional system. The reduction of CO2 emissions come from three factors: the operation of the generator engine at a relatively high load rate, the battery sharing the operation of the generator engine, and the high efficiency of the SOFC running. The SOFC hybrid system can be a sustainable technology in large vessels.

A Flexible Multifunctional Cyanoethyl-Modified Bacterial Cellulose Nanofiber Framework for High-Energy and High-Power Density Aqueous Li-Ion Batteries.

Aqueous rechargeable lithium-ion batteries (ARLIBs) are extensively researched due to their inherent safety, typical affordability, and potential high energy density. However, fabricating ARLIBs with both high energy density and power performance remains challenging. Herein, based on cyanoethyl-modified bacterial cellulose nanofibers (CBCNs), a multifunctional fast ion transport framework is developed to construct the flexible free-standing ARLIBs with high areal loading and excellent rate performance. Benefiting from the unique merits of CBCNs, such as ultra-high aspect ratio, excellent toughness, superior adhesion, good lithiophilicity and ideal stability, the flexible free-standing and highly robust electrodes are fabricated and exhibit a long-term stable cycling of 1200 cycles with a high specific capacity of 117 mAh∙g-1 at 15 C. Remarkably, the corresponding full cell with the free-standing high mass loading (45.5 mg∙cm-2) electrodes under the condition of ultra-low addition of battery binder demonstrates a cycle lifespan of over 1000 cycles with a specific capacity of 120 mAh∙g-1 and a capacity decay as low as 0.03% per cycle, which is far superior to those of almost all previous reports. This work provides a strategy for constructing ARLIBs with high energy density and power performance by introducing a unique fast ion transport nanofiber framework.

The Valorization of Fruit and Vegetable Wastes Using an Anaerobic Fixed Biofilm Reactor: A Case of Discarded Tomatoes from a Traditional Market

Tomato waste, characterized by high organic matter and moisture content, offers a promising substrate for anaerobic digestion, though rapid acidification can inhibit methanogenic activity. This study investigated the performance of a 10.25 L anaerobic fixed biofilm reactor for biogas production using liquid tomato waste, processed through grinding and filtration, at high organic loading rates, without external pH control or co-digestion. Four scouring pads were vertically installed as a fixed bed within a fiberglass structure. Reactor performance and buffering capacity were assessed over three stages with progressively increasing organic loading rates (3.2, 4.35, and 6.26 gCOD/L·d). Methane yields of 0.419 LCH4/gCOD and 0.563 LCH4/g VS were achieved during the kinetic study following stabilization. Biogas production rates reached 1586 mL/h, 1804 mL/h, and 4117 mL/h across the three stages, with methane contents of 69%, 65%, and 72.3%, respectively. Partial alkalinity fluctuated, starting above 1500 mg CaCO3/L in Stage 1, dropping below 500 mg CaCO3/L in Stage 2, and surpassing 3000 mg CaCO3/L in Stage 3. Despite periods of forced acidification, the system demonstrated significant resilience and high buffering capacity, maintaining stability through hydraulic retention time adjustments without the need for external pH regulation. The key stability indicators identified include partial alkalinity, effluent chemical oxygen demand, pH, and one-day cumulative biogas. This study highlights the effectiveness of anaerobic fixed biofilm reactors in treating tomato waste and similar fruit and vegetable residues for sustainable biogas production.

Wavelet-based convolutional neural network for non-intrusive load monitoring of next generation shipboard Power Systems

In this study, a non-intrusive load monitoring (NILM) framework is developed for next generation shipboard power systems (SPS) based on a discrete wavelet transform signal processing and a convolutional neural network (CNN). We have applied the developed NILM method to a four-zone medium voltage direct current (MVDC) SPS to evaluate the effectiveness of the proposed method. Each zone of the MVDC SPS consists of multiple components, such as propulsion load, pulsed load, high ramp rate load, cooling load, and hotel load. The current signals from the main generators are the main inputs to the NILM model. The current signals are first processed through a discrete wavelet transform to create a coefficient vector that reflects the status of all the components in each zone. Then, a multi-class classification problem is formulated and solved using a CNN architecture model to monitor the load statuses in real time. The results of case studies show that the developed NILM model in comparison with benchmark methods can (i) accurately monitor the status of all components with a total accuracy of over 98%, (ii) identify unique pulsed loads with a total accuracy of over 99%, and (iii) sustain the functionality of load monitoring under extreme events such as cyber/physical attacks, load uncertainty, and noisy inputs.

Dynamic tensile behaviour of rocks under confining pressure and high-rate loadings

Dynamic tensile behaviour of rocks under confining pressure and high-rate loadings

Mixed-mode crack-tip stress intensity factors measurements by caustics method: A comparison between low and high loading rate conditions

Mixed-mode crack-tip stress field is different in low and high loading rate conditions, resulting in different mixed-mode stress intensity factors (SIFs) measurements. How to correctly measure mixed-mode SIFs in different loading rate conditions is of critical importance. To this end, mixed-mode SIFs are measured and compared by optical caustics method with high-speed photography, specifically by the interpretation of crack-tip optical image, i.e., caustics pattern which reflects crack-tip stress field. Different mixed-mode caustics patterns in shape are observed in drop weight and blast loading conditions, indicating that corresponding crack-tip stress field and mixed-mode SIFs measurements are different. Under drop weight loading, mixed-mode caustics patterns are consistent with the classical caustics interpretation for SIFs measurements, while those under reflected P wave loading in blasts are not consistent. Therefore, a modified mixed-mode caustics interpretation is proposed and verified to be available for SIFs measurements in blast loading condition. Finally, underlying reasons for different mixed-mode SIFs measurements in low and high loading rate conditions are discussed, and it is concluded that in low loading rate condition, a longer loading time results in crack-tip K-dominated stress field which is suitable for the classical caustics interpretation, while in high loading rate condition, the loading time is too short to form K-dominated stress field in the crack tip, hence a modified caustics interpretation is necessary. This paper benefits correct applications of caustics method to mixed-mode SIFs measurements in different loading rate conditions.

Preparation of ceftiofur-encapsulated hen-egg low-density lipoproteins and their antibacterial effects on intracellular Staphylococcus aureus

Hen egg low-density lipoprotein (heLDL), as alternative of serum-derived LDL, was used as drug delivery system of ceftiofur (CEF). The CEF-loaded hen egg low-density lipoprotein (CEF-heLDL) with complete apolipoprotein structure and high drug loading rate was synthesized, possesses suitable particle size. CEF-heLDL undergoes cellular uptake and colocalizes with lysosomes in vitro. An intracellular infection model of the bovine endometrial epithelial cells and a coeliac-induced inflammation model of mice by Staphylococcus aureus (S. aureus) were established, and significantly lower intracellular S. aureus levels of CEF-heLDL group than CEF-free group (P < 0.001) was observed. The antibacterial efficacy was sustained for 24 h. Up to 400 mg/kg of CEF-heLDL, 20 times the clinical practice, were intraperitoneally administrated, and no significant toxicity signs on mice were observed. HeLDLs is an effective, safe, and cheap drug carrier, and could also be used for transmembrane delivering other antibiotics.

Porous silica-based platform bearing Au/Ag nanosheets for targeted combination therapy and fluorescence imaging

A versatile delivery platform combining gold-coated silver triangular nanosheets (Ag@Au NSs) and silver sulfide (Ag2S) quantum dots (QDs) embedded porous silica (Ag2S/pSiO2) carriers was developed for combination therapy and fluorescence imaging. The Ag@Au NSs exhibited excellent biocompatibility and photothermal efficiency. After combining the Ag2S/pSiO2 carriers with Ag@Au NSs (Ag2S/pSiO2/Ag@Au), a high drug loading rate of 25.48 % for doxorubicin hydrochloride (DOX) was attained. After loading DOX, Ag2S/pSiO2/Ag@Au was coated with hyaluronic acid (HA) (DOX-Ag2S/pSiO2/Ag@Au/HA), which could target CD44 receptors that are overexpressed in cancer cells. The Ag@Au NSs maintained the impressive surface plasmon resonance (LSPR) of Ag NSs, enabling them to function as SERS substrate. During DOX release, the released DOX was detected through Raman technique. The Ag2S/pSiO2/Ag@Au/HA system demonstrated excellent performance in thermo-chemotherapy and allowed visualization of drug release behavior and vector imaging using Raman and fluorescence imaging technologies. These results demonstrated the potential of the Ag2S/pSiO2/Ag@Au/HA system as an effective carrier for therapeutic application.

Insight into the dynamic tensile behavior of deep anisotropic shale reservoir after water-based working fluid cooling

During deep shale gas production, flowing water-based working fluid inevitably cools shale reservoirs around boreholes and some fractures, and possible extraction methods induce dynamic stresses. To understand the dynamic tensile behavior of deep anisotropic shale reservoir after water-based working fluid cooling, a split Hopkinson pressure bar was used for performing the dynamic Brazilian tests on shale samples with bedding angles of 0°, 30°, 45°, 60° and 90° after reservoir temperature realization (25–200 °C) and water cooling. The results illustrate that dynamic tensile strength of shale samples decreases gradually as reservoir temperature increases under the loading rates 100–1000 GPa/s. From room temperature to 200 °C the most strength deterioration appears on samples with the bedding angle of 90°. A dynamic tensile strength deterioration model for deep shale reservoirs after water-based working fluid cooling is proposed considering the influence of loading rate and bedding angle. Geometrical trajectories of the main failure cracks are separated into three types, i.e., fully central tensile failure, tensile-shear failure and fully shear failure (sliding of bedding planes). For samples with bedding angles of 30°, 45° and 60°, increasing reservoir temperature encourages tensile failure to change into shear failure. The roles that bedding planes play in interacting with failure crack growth are summarized as IP mode (intersecting propagation), TP mode (turning propagation) and PP mode (promoting propagation). Anisotropic dynamic tensile strength responses are systematically discussed by using thermal stress simulation in ABAQUS, microstructure analyses, crack interaction conditions and the one-dimensional stress wave propagation theory. Based on experimental observations, field implications in borehole stability and fracturing of deep shale reservoirs are proposed under medium and high loading rates. This work is instrumental in providing valuable information and technology assistance for real deep shale gas production projects.

Anisotropic and shape-stable sugarcane-based phase change composites in the application of solar thermal energy storage

The study of anisotropically thermal conductive phase change composites (PCCs) with shape-stability is of great importance to improve the intermittent issues in solar thermal utilization, while some drawbacks like the high cost, low thermal conductivity, and poor durability of current PCCs restrains their practical applications. Herein, a cheap and scalable biomass-based PCC containing carbonized sugarcane (CSC), polyethylene glycol (PEG), and graphene (GF) is proposed. The abundant vessels inside CSC result in a high PEG loading rate of 82.48 %. The naturally occurring anisotropic structure inside CSC can drive GF to be oriented along the lengthwise direction, which gives PCC a high thermal conductivity anisotropy degree of 1.45. The prominent anisotropy improves the lengthwise thermal diffusion and restrains the transverse heat leakage to the environment. Besides, the loaded GF can further enhance the light absorption of PCC to 98 %. As a result, the prepared PCC can achieve high solar-thermal energy storage efficiencies of 79.3–91.7 % with variable solar intensity from 1 to 2 suns. Meanwhile, good anti-leakage and durability performances promote the practical utilization of PCCs. The present work paves a promising road for manufacturing biomass-based anisotropic PCCs in efficient solar thermal energy storage.

Study on signal characteristics of burst tendency coal under different loading rates

In order to study the mechanics, acoustic emission (AE) and electromagnetic emission (EME) response law of bursting liability coal at different loading rates, uniaxial compression tests were carried out on coal mass from Konggu Coal Mine. The corresponding relations among mechanical properties, AE and EME signals in the process of coal failure under loading were analyzed, and the energy evolution law of coal failure with bursting liability under loading rate was discussed. The results show that within a certain range of loading rate, the higher the loading rate, the higher the compressive strength and peak load of bursting liability coal, and the shorter the time for coal to reach the peak load. Under different loading rates, the mechanics, AE and EME signals of coal samples can be well corresponded. When the loading rate is low, the number of blocks destroyed of coal sample is large and the block size is relatively small, and the blocks are mainly scattered around the test platform. When the loading rate is high, the number of damaged blocks is relatively small and the block size is relatively large, and the blocks are far away from the test bench. When loading at a low rate, the internal cracks in coal can be fully developed and connected, and the energy release rate is relatively uniform in the process of loading and failure of coal sample. In the case of high loading rate, the energy release rate of coal sample in the loading process is much smaller than that in the moment of failure. Combining the above test results with the actual situation of the working face, it can be concluded that the total energy stored in the coal of fast mining increases and the threshold of impact decreases compared with that of slow mining. Therefore, under the disturbance of external dynamic load, rapid mining is more likely to induce rock burst.

Unraveling the Complexities of Silica Nanoparticle Adsorption onto Polymer Latexes in Pickering Emulsion Polymerization.

Incorporating unmodified silica nanoparticles onto polymer latexes to fabricate aqueous polymer dispersions without relying on electrostatic attraction during the Pickering emulsion polymerization process still faces challenges. For negatively charged silica nanoparticles to successfully adsorb onto polymer latexes, particularly in an anionic initiator emulsion polymerization system, they have remained elusive without the use of auxiliary monomers and cationic initiators. This study investigates various experimental parameters, such as emulsion polymerization temperature, monomer solubility, salt concentration, and cation type, to elucidate the factors influencing the adsorption of unmodified silica nanoparticles in Pickering emulsion polymerization. While poly(methyl methacrylate) (PMMA)/SiO2 hybrid latexes can be obtained under pH conditions of 5-6 and at temperatures of 65 °C or below, the loading rate of silica nanoparticles decreases as the reaction temperature increases, resulting in bare PMMA latexes without silica nanoparticle adsorption at temperatures exceeding 70 °C. Introducing styrene (St) into the monomer mixture with methyl methacrylate in a ratio of up to 10 wt % leads to a gradual decrease in silica nanoparticle loading rate, from 27.3 to 8.2 wt %, attributed to the low solubility of St in water. Furthermore, the presence of sodium ions (Na+) is found to be crucial for silica nanoparticle adsorption onto PMMA latexes, as the sodium ions have a stabilizing effect on both the silica nanoparticles and the silica nanoparticle-armored latexes. These findings highlight the complex nature of Pickering emulsion polymerization in the presence of unmodified silica nanoparticles, demonstrating that the loading rate of silica nanoparticles onto polymer latexes is influenced by various factors. These insights pave the way for developing aqueous polymer dispersions with high silica nanoparticle loading rates onto polymer latexes, which is a desirable trait in the coating industry.

Sustainable carbon retention from water input to wetlands at two temporal scales

Wetlands retain carbon from flowing water through biomass accumulation and deposition processes. However, the contributions of accumulated carbon from water to carbon storage and cycling in wetland ecosystems remain unclear. Moreover, there are no comprehensive estimates of the stability and sustainability of wetland performance in retention of carbon from water on different time scales. We conducted a meta-analysis (2889 paired observations) to estimate the stability and sustainability of constructed wetlands in retention of carbon from input water on short and long time scales. This study showed that the efficiency of carbon retention from water in wetlands significantly increased on short time scales, whereas it remained stable on long time scales and among different seasons. The usage of grave, alum sludge and all types of plant had higher effect sizes on short-term wetland water carbon retention, but the long-term stability of water carbon retention was not affected by substrates or plant types. Variations in precipitation as well as air temperature affected the short-term water carbon retention in wetlands, but they did not affect long-term water carbon retention in wetlands. However, on long time scale, the stability of water carbon retention in wetlands was challenged by operation time, low water temperature and high hydraulic load rate, which posed a threat to the sustainability of wetland performance in water carbon retention. In summary, this study demonstrated the stability and sustainability of carbon retention from water and proved the contribution of accumulated carbon from water to the carbon pool in wetland ecosystems.

A computer-aided, heterodimer-based “triadic” carrier-free drug delivery platform to mitigate multidrug resistance in lung cancer and enhance efficiency

Co-delivering multiple drugs or circumventing the drug efflux mechanism can significantly decrease multidrug resistance (MDR), a major cause of cancer treatment failure. In this study, we designed and fabricated a universal “three-in-one” self-delivery system for synergistic cancer therapy using a computer-aided strategy. First, we engineered two glutathione (GSH)-responsive heterodimers, ERL-SS-CPT (erlotinib [ERL] linked with camptothecin [CPT] via a disulfide bond [SS]) and CPT-SS-ERI (CPT conjugated with erianin [ERI]), which serve as both cargo and carrier material. Next, molecular dynamics simulations indicated that multiple noncovalent molecular forces, including π-π stacking, hydrogen bonds, hydrophobic interactions, and sulfur bonds, drive the self-assembly process of these heterodimers. We then explored the universality of the heterodimers and developed a “triadic” drug delivery platform comprising 40 variants. Subsequently, we conducted case studies on docetaxel (DTX)-loaded ERL-SS-CPT nanoparticles (denoted as DTX@ERL-SS-CPT NPs) and curcumin (CUR)-loaded ERL-SS-CPT NPs (identified as CUR@CPT-SS-ERI NPs) to comprehensively investigate their self-assembly mechanism, physicochemical properties, storage stability, GSH-responsive drug release, cellular uptake, apoptosis effects, biocompatibility, and cytotoxicity. Both NPs exhibited well-defined spherical structures, high drug loading rates, and excellent storage stability. DTX@ERL-SS-CPT NPs exhibited the strongest cytotoxicity in A549 cells, following the order of DTX@ERL-SS-CPT NPs > ERL-SS-CPT NPs > CPT > DTX > ERL. Conversely, DTX@ERL-SS-CPT NPs showed negligible cytotoxicity in normal human bronchial epithelium cell line (BEAS-2B), indicating good biocompatibility and safety. Similar observations were made for CUR@CPT-SS-ERI NPs regarding biocompatibility and cytotoxicity. Upon endocytosis and encountering intracellular overexpressed GSH, the disulfide-bond linker is cleaved, resulting in the release of the versatile NPs into three parts. The spherical NPs enhance water solubility, reduce the required dosage of free drugs, and increase cellular drug accumulation while suppressing P-glycoprotein (P-gp) expression, leading to apoptosis. This work provides a computer-aided universal strategy—a heterodimer-based “triadic” drug delivery platform—to enhance anticancer efficiency while reducing multidrug resistance.

Efficient alleviation granular sludge floatation in a high-rate anammox reactor by dosing folate

Although granular floatation has been recognized as a significant issue hindering the application of high-rate anammox biotechnology, limited knowledge is available about its causes and control strategies. This study proposed a novel control strategy by adding folate, and demonstrated its role in the granular floatation alleviation through long-term operation and granular characterizations. It was found that the floatation of anammox granular sludge was obviously relieved with the decreased sludge floatation potential by 67.1% after dosing with folate (8 mg/L) at a high nitrogen loading rate of 12.3 kg-N/(m3·d). Physiochemical analyses showed that the decrease of extracellular polymeric substances (EPS) content (mainly protein), the alleviation of granular surface pore plugging in conjunction with the smooth discharge of generated nitrogen gas were collectively responsible for efficient floatation control. Moreover, metagenomic analysis suggested that the synergistic interactions between anammox bacteria and their symbionts were attenuated after dosing exogenous folate. Anammox bacteria would reduce their synergistic dependence on the symbionts, and decline the supply of metabolites (e.g., amino acids and carbohydrates in EPS) to symbiotic bacteria. The declined EPS excretion contributed to the alleviation of granular floatation by dredging pores blockage, thus leading to a stable system performance. The findings not only offer insights into the role of microbial interaction in granular sludge floatation, but also provide a feasible approach for controlling the floatation issue in anammox granular-based processes.

Influence of interfacial bond between rebar and concrete on the lateral resistance of RC columns under different loading rates

The interfacial bond between rebar and concrete is a critical factor that influences the performance of reinforced concrete (RC) structures because it affects the effective force transfer between concrete and rebar and hence the composite actions. In finite element modelling of RC structures, the bond-slip relation between rebar and concrete is generally neglected due to the increased model complexity by considering debonding behaviours. Limited studies show the debonding performance is loading rate dependent, neglecting it in numerical modelling may lead to inaccurate structural response predictions, but there is no systematic investigation of bonding performance on responses of structures under load of different loading rates. The influences of neglecting debonding in structural response analysis are therefore not properly defined yet. In this study, the finite element model was established and validated by the available impact test data. The lateral resistance and damage modes of the column considering and neglecting bond-slip behaviour between rebar and concrete were examined under various loading rates ranging from 50 kN/s to 1.0 × 106 kN/s. It is found that neglecting bond-slip relation in finite element modelling of RC columns leads to underprediction of the peak force and damage. The assumption of perfect bond has a significant influence on predicting the peak force and damage of column under low loading rates, but its influence reduces with the increase in loading rate, especially when the loading rate exceeds 1.0 × 105 kN/s. The maximum relative difference in peak force between considering and neglecting bond-slip at 50 kN/s is 18.63 %. Parametric studies were conducted to investigate the effects of bonding performance on columns of different width, depth, height, and concrete strength. Based on the numerical results, an analytical formula is developed to quantitatively predict the errors in peak force predictions by neglecting debonding between concrete and rebars of RC columns. The results highlight the importance of considering bond-slip in finite element modelling of RC structures subjected to quasi-static and low-rate dynamic loadings, and demonstrate it is reasonable to neglect debonding in structural response analysis under high-rate dynamic loadings.