High Load Levels Research Articles

The Effect of Reducing the Bone to Cast Distance in an Equine Transfixation Pin Cast: An Ex Vivo Biomechanical Study.

The aim of this study was to evaluate the effect of reducing the bone to cast distance on the resistance of the pin to cyclic loading in equine transfixation pin casts. Eleven pairs of cadaveric equine third metacarpal bones were prepared and one 6.3/8.0 mm transfixation pin was placed in standard fashion 10 mm proximal to the distal physeal scar into each bone. One metacarpus of each pair was tested with a distance of 10 mm (10 mm group) and the contralateral metacarpus with a distance of 20 mm (20 mm group) between the outer cortex of the bone and the fixation of the pin. Eight pairs were tested using a simplified test set-up in which the pins were fastened at both ends to polyoxymethylene-copolymer sleeves. The pins of the remaining three pairs of bones were incorporated into a fibreglass cast. All specimens were tested under cyclic loading until failure of the pin in axial compression. All pins failed uni- or bilaterally at clinically relevant load levels. Pins of the 10 mm group endured significantly (p < 0.05) higher load levels and total number of cycles until failure compared with the pins of the 20 mm group. The distance between the bone surface and the cast at the location of pin insertion has a significant effect on resistance of the pins to cyclic loading. Therefore, the amount of padding applied underneath an equine transfixation pin cast can have an influence on the overall stability and durability of the construct.

Effect of Transition Metal Substitution on the Flexibility and Thermal Properties of MOF-Based Solid-Solid Phase Change Materials.

A series of azobenzene-loaded metal-organic frameworks were synthesized with the general formula M2(BDC)2(DABCO)(AB)x (M = Zn, Co, Ni, and Cu; BDC = 1,4-benzenedicarboxylate; DABCO = 1,4-diazabicyclo[2.2.2]octane; and AB = azobenzene), herein named M-1⊃ABx. Upon occlusion of AB, each framework undergoes guest-induced breathing, whereby the pores contract around the AB molecules forming a narrow-pore (np) framework. The loading level of the framework is found to be very sensitive to the synthetic protocol and although the stable loading level is close to M-1⊃AB1.0, higher loading levels can be achieved for the Zn, Co, and Ni frameworks prior to vacuum treatment, with a maximum composition for the Zn framework of Zn-1⊃AB1.3. The degree of pore contraction upon loading is modulated by the inherent flexibility of the metal-carboxylate paddlewheel unit in the framework, with the Zn-1⊃AB1.0 showing the biggest contraction of 6.2% and the more rigid Cu-1⊃AB1.0 contracting by only 1.7%. Upon heating, each composite shows a temperature-induced phase transition to an open-pore (op) framework, and the enthalpy and onset temperatures of the phase transition are affected by the framework flexibility. For all composites, UV irradiation causes trans → cis isomerization of the occluded AB molecules. The population of cis-AB at the photostationary state and the thermal stability of the occluded cis-AB molecules are also found to correlate with the flexibility of the framework. Over a full heating-cooling cycle between 0 and 200 °C, the energy stored within the metastable cis-AB molecules is released as heat, with a maximum energy density of 28.9 J g-1 for Zn-1⊃AB1.0. These findings suggest that controlled confinement of photoswitches within flexible frameworks is a potential strategy for the development of solid-solid phase change materials for energy storage.

Quantification of protein cargo loading into engineered extracellular vesicles at single-vesicle and single-molecule resolution.

Extracellular Vesicles (EVs) have been intensively explored for therapeutic delivery of proteins. However, methods to quantify cargo proteins loaded into engineered EVs are lacking. Here, we describe a workflow for EV analysis at the single‐vesicle and single‐molecule level to accurately quantify the efficiency of different EV‐sorting proteins in promoting cargo loading into EVs. Expi293F cells were engineered to express EV‐sorting proteins fused to green fluorescent protein (GFP). High levels of GFP loading into secreted EVs was confirmed by Western blotting for specific EV‐sorting domains, but quantitative single‐vesicle analysis by Nanoflow cytometry detected GFP in less than half of the particles analysed, reflecting EV heterogeneity. Anti‐tetraspanin EV immunostaining in ExoView confirmed a heterogeneous GFP distribution in distinct subpopulations of CD63+, CD81+, or CD9+ EVs. Loading of GFP into individual vesicles was quantified by Single‐Molecule Localization Microscopy. The combined results demonstrated TSPAN14, CD63 and CD63/CD81 fused to the PDGFRβ transmembrane domain as the most efficient EV‐sorting proteins, accumulating on average 50–170 single GFP molecules per vesicle. In conclusion, we validated a set of complementary techniques suitable for high‐resolution analysis of EV preparations that reliably capture their heterogeneity, and propose highly efficient EV‐sorting proteins to be used in EV engineering applications.

Control of Mullins stress softening in silicone elastomer composites by rational design of fumed silica fillers

The influence of fumed silica as reinforcement filler is investigated on the Mullins stress softening in composite silicone elastomers. Especially, the impact of surface area, loading level, surface chemistry, and structure modification of fumed silica is evaluated on the fatigue behavior of high consistency silicone rubber. It is observed that high loading level and large surface area of fumed silica increase the energy loss during initial loading cycles which is related to disruptions in filler-polymer interactions. Addition of a processing aid or hydrophobization of the silica surface decrease the brittleness and energy loss of the compounds. A close correlation between Shore A hardness and energy loss is found confirming the contribution of the filler-polymer interactions on Mullins stress-softening. At the same time, the permanent set remains almost independent of the surface hydrophobicity of the filler indicating a breakdown of the structured silica agglomerates during initial deformation. To improve the fatigue resistance of the silicone elastomer, a structure modified and hydrophobic silica, AEROSIL® R 8200, was used leading to the lowest permanent set even at high loading levels in combination with good mechanical reinforcement. The reduction in energy loss and permanent set is attributed to the combination of hydrophobic surface and low aggregate structure of the silica preventing agglomerate breakdown and chain disentanglements at the silica surface. This study provides fundamental understanding on the relation between filler-polymer interactions, filler morphology and Mullins stress softening for the rational design of future filler particles in reinforced elastomer composites with improved fatigue resistance.

Characterisation of damage evolution in plain weave SiC/SiC composites using in situ X-ray micro-computed tomography

The paper presents the investigation of microstructures and tensile damage evolution of plain weave SiC fibre reinforced SiC matrix (SiC/SiC) composites using X-ray computed tomography (CT). A miniature high-precision in situ X-ray CT test fixture has been developed to conduct micro X-ray CT in-situ tensile tests. Through the image reconstruction of the CT data, the actual microstructures and the damage evolution of the material under six successive loading levels have been revealed precisely. Deep-learning-based image segmentation has been employed to recognise material damages, including transverse matrix cracking, longitudinal matrix cracking, and fibre pull-outs. Three-dimensional rendering models of these damages have been created to quantify the damage initiation and evolution. Both transverse and longitudinal matrix cracking initiates and propagates gradually at the intermediate loading level, but rapidly at the high loading level. The volume fraction of longitudinal matrix cracks is much larger than that of its transverse counterpart. It indicates that the longitudinal matrix cracking is much severer damage than transverse tracking. The lengths of fibre pull-outs at the fracture surface of fibre tows are in a broad range and on average they are in the order of a hundred microns.

Digital Image Correlation for Evaluation of Cracks in Reinforced Concrete Bridge Slabs

In proof-loading of concrete slab bridges, advanced monitoring methods are required for identification of stop criteria. In this study, Two-Dimensional Digital Image Correlation (2D DIC) is investigated as one of the governing measurement methods for crack detection and evaluation. The investigations are deemed to provide valuable information about DIC capabilities under different environmental conditions and to evaluate the capabilities in relation to stop criterion verifications. Three Overturned T-beam (OT) Reinforced Concrete (RC) slabs are used for the assessment. Of these, two are in situ strips (0.55 × 3.6 × 9.0 m) cut from a full-scale OT-slab bridge with a span of 9 m and one is a downscaled slab tested under laboratory conditions (0.37 × 1.7 × 8.4 m). The 2D DIC results includes full-field plots, investigation of the time of crack detection and monitoring of crack widths. Grey-level transformation was used for the in situ tests to ensure sufficient readability and results comparable to the laboratory test. Crack initiation for the laboratory test (with speckle pattern) and in situ tests (plain concrete surface) were detected at intervals of approximately 0.1 mm to 0.3 mm and 0.2 mm to 0.3 mm, respectively. Consequently, the paper evaluates a more qualitative approach to DIC test results, where crack indications and crack detection can be used as a stop criterion. It was furthermore identified that crack initiation was reached at high load levels, implying the importance of a target load.

Biological and Physiochemical Conditions of the Surface Waters of the Cauca River in the Urban Area of Popayán, Colombia

The homes and companies located on the banks of the Cauca River have altered the conditions of the quality of the water generated by residual discharges. Therefore, this paper proposes to analyze the biological and physicochemical conditions of the surface waters that cross the urban area of Popayán, Colombia, and determine if they are suitable for human consumption. For this, an in-situ sampling was carried out in the two river stations. The two points were covered taking into account the dry and rainy seasons. At each point, the parameters were measured to calculate the contamination indicators. Likewise, Ph, diluted oxygen, conductivity and temperature parameters were measured, also other physicochemical parameters such as total alkalinity, total hardness, total phosphorus and suspended total solids were measured as well as the microbiological parameters like total coliforms. It was found that the water source contains high levels of pollutant load and that biological discharge is one of the main causes that alters the quality of the water for drinking. The number of macroinvertebrates in the river decreases by 48% as the river advances through the urban area of the city. According to the BMWP values, highly contaminated carbonated waters enter the urban area. However, due to the flow throughout the water source, the Cauca River can regulate the pollution load according to the result evidenced in the Icomi, Icomo, and Icosus indices.

Cognitive Load of Assigned EFL Textbooks for Al-Azhar Secondary School Students: An Analytical Study

Abstract Textbook is one of the media used in English language learning. A great number of EFL textbook evaluation have been done to find the most suitable textbook for English language teaching. The present study aimed to determine the cognitive load involved in the textbook for Al-Azhar secondary school students. Therefore, a content analysis instrument has been designed to analyze the second-year of secondary English textbook. The instrument has been distributed on the first participants in this study, (100) secondary EFL students selected out of (1143) secondary EFL students of (13) public secondary schools in Juhaina to be the purposeful sample in this study. The second participants in this study are (20) secondary EFL teachers selected out of (52) secondary English language teachers working in (13) public secondary schools in Juhaina to be the purposeful sample in this study. The results showed high levels of cognitive load in the EFL current textbook. In general, most of teachers and students think that the current EFL textbook involves high levels of cognitive load. Implications for foreign language instruction in this regard are provided.

Task Load Estimation from Multimodal Head-Worn Sensors Using Event Sequence Features

For longitudinal behavior analysis, task type is an inevitable and important variable. In this article, we propose an event-based behavior modeling approach and employ non-invasive wearable sensing modalities (eye activity, speech and head movement) to recognize task load level under four different task load types. The novelty lies in converting physiological and behavioral signals into meaningful events and utilizing their sequence across multiple modalities to distinguish load levels and types. We evaluated this approach on head-worn sensor data from 24 participants completing four different tasks for recognizing (i) low and high load level for a given task load type, (ii) low and high load level regardless of load type, and (iii) both load level and load type. Findings show that the recognition rate is reasonable in (i), close to chance level in (ii), and well above chance level in (iii) for 8 classes using participant-dependent and -independent schemes. Further, a fusion of the proposed event-based features and conventional continuous features achieved the best or similar performance in most cases. These results suggest that task type needs to be considered when using continuous features and that the proposed event-based modeling paradigm is promising for longitudinal behavior analysis.

SEISMIC PERFORMANCE OF GFRP-RC RECTANGULAR COLUMNS: NUMERICAL STUDY

Composite materials like glass fiber-reinforced polymer (GFRP) is becoming widely acceptable to be used as a reinforcing material due to its high ultimate tensile strength-to-weight ratio and excellent resistance to corrosion. However, the seismic behavior of GFRP-reinforced concrete columns has not been fully investigated yet. This paper presents the results of a numerical analysis of full-size GFRP-RC rectangular columns under cyclic loading. The simulated column depicts the lower part of a building column between the foundation and the point of contra-flexure at the mid-height of the column. GFRP reinforcement properties and concrete modeling based on fracture energy have been incorporated in the numerical model. Experimental validation has been used to examine the accuracy of the constructed finite element models (FEMs) using a commercially available software. The validated FEM was used to perform a parametric study, considering several concrete strength values and axial load levels, to study its influence on the performance of the GFRP-reinforced concrete columns under cyclic loading. It was concluded that the hysteretic dissipation capacity deteriorates under high axial load level due to severe softening of the concrete. The FE results showed a substantial improvement of the lateral load-carrying capacities by increasing concrete compressive strength.

Bacterial navigation for tumor targeting and photothermally-triggered bacterial ghost transformation for spatiotemporal drug release

Cancer chemotherapy is confronted with challenges regarding the effective delivery of chemotherapeutics into tumor cells after systemic administration. Herein, we propose a strategy to load drugs into probiotic E. coli Nissle 1917 (EcN) for self-guided navigation to tumor tissues and subsequently release the drugs with in situ transformation into bacterial ghosts (BGs). Chemotherapeutic agent 5-fluorouracil (FU) and macrophage phenotype regulator zoledronic acid (ZOL) are loaded into EcN through electroporation, followed by decoration of Au nanorods on the ECN surface to construct EcNZ/F@Au. High loading levels of 5FU (8.8%) and ZOL (10.5%) are achieved as well as high retention rates of bacterial viability (87%) and motion velocity (88%). Under near infrared (NIR) illumination the photothermal effect of Au nanorods elevates the local temperature to induce the transformation of live EcN into BGs. The created transmembrane channels initiate the gradual drug release from BGs, thus representing the first attempt to control the drug release via a biological evolution. An intermittent NIR illumination causes stepwise increases in the BG formation and drug release, which could implement an external on-off control and spatiotemporal drug release. Self-guided motion of EcN promotes efficient extravasation across blood vessels and preferential accumulation of drugs in tumors. In addition to the chemotherapeutic effect of FU, the local release of ZOL from EcNZ/F@Au enhances valid polarization of tumor-associated macrophages toward the M1 phenotype and an effective production of proinflammatory cytokines, leading to a synergistic efficacy on tumor growth inhibition. Thus, this study demonstrates a feasible strategy to integrate chemotherapy, immunotherapy, and photothermal effects in a concise manner for effective cancer treatment with few side effects. Statement of SignificanceBacteria are capable to trace and colonize in hypoxic tumor tissues. Bacterial drug carriers indicate limitations in efficient drug loading and effective release modulation. Herein, we propose a strategy to load drugs into bacteria for self-guided delivery and subsequently release the drugs in tumors with in situ transformation into bacterial ghost (BGs). Drugs are loaded into live bacteria through electroporation and Au nanorods are decorated on the bacterial surface, wherein the photothermal effect, chemotherapy, and immunotherapy are integrated in a concise manner. NIR illmumination of Au nanorods elevates the local temparature, induces the BG tranformation, and activates the spatiotemporal drug release, representing the first attempt of release modulation via a biological evolution.

Preparation and characterization of topical solid lipid nanoparticles containing deferoxamine

Introduction: Deferoxamine mesylate increases hypoxia inducible factor-1 alpha transactivation by preventing iron-catalyzed reactive oxygen stress, so it can be used to improve diabetic ulcer healing. This study was undertaken to develop and study physicochemical properties of topical deferoxamine-loaded solid lipid nanoparticles.&#x0D; Method: Solid lipid nanoparticles were prepared using cold homogenization technique and full factorial design to evaluate the effect of surfactant type and amount of lipid. In-vitro characterization of formulations including particle size and distribution, thermal behavior using Differential Scanning Calorimetry, entrapment efficiency, and release profile were carried out.&#x0D; Results: The results showed an acceptable range of particle size (2.88–174 nm), a narrow size distribution, and an average of 60% for drug entrapment efficiency which is significant for a hydrophilic drug. The results from release study showed an initial burst release followed by a slow and prolonged manner. Differential Scanning Calorimetry results also confirmed the results obtained from loading and release evaluations. The best formulation which had a high level of drug loading and the lowest drug release rate contained compritol and oleic acid in the amount of 8% of the total formula, as well as tween 80 and lecithin as a mixture of surfactants.&#x0D; Conclusions: The study demonstrated deferoxamine could be loaded in solid lipid nanoparticles to deliver topically.

An experimental study on the fatigue failure of steel fibre reinforced concrete at a single fibre level

A series of experimental fatigue tests were performed on pre–slipped, hooked–end steel fibre reinforced concrete (SFRC) at a single fibre level. The fatigue tests were conducted at load levels of 50%, 70% and 85%, with the pre–slip varying from 0.6 mm, 1.2 mm, 1.8 mm and 2.5 mm. The tests were loaded at a frequency of 6 Hz, up to two million cycles or until failure. Two types of failure mechanisms were found, namely fibre rupture and fibre pull–out. At low load levels and small pre–slip, there were little to no failures. As the load level and pre–slip increased, fibre rupture became the common failure mechanism. At the highest load level and pre–slip, fibre pull–out was the dominant failure mechanism. The results also showed that the static load–displacement curve formed an envelope for the fatigue pull–out failure. Furthermore, X-ray Computed Tomography (CT) scans were used to validate the various degrees of pre–slip, as well as the failure mechanisms of tested specimens.

Suppression of hydrolytic degradation in labile polymer networks via integrated styrenic nanogels

ObjectiveThe objective of this study was to demonstrate an approach with potential to increase the life of dental restorative polymers in water, by maintaining their strength and toughness with varied content of inert or reactive styrenic pre-polymeric additives. It was hypothesized that addition of styrene-co-divinylbenzene nanogels to a conventional dimethacrylate resin (e.g. TEGDMA) would reduce its susceptibility towards hydrolytic degradation, while maintaining equivalent mechanical properties. MethodsPolymerization kinetics and functional group conversions were determined by Fourier transform infrared spectroscopy. Triple-detection gel permeation chromatography was used for nanogel particle characterization. A goniometer was used to measure water contact angle on experimental and control photocured polymers. Hydrolytic degradation and mass loss evaluation was performed after extended water storage of an intentionally hydrolytically degradable polymer. Resin viscosity was determined rheometrically and polymer mechanical properties were evaluated using three-point flexural testing with TEGDMA-nanogel formulations. ResultsThe polymer network with highest level of nanogel loading (50 wt%) and the highest level of internal nanogel crosslinking (50 mol%) had the lowest degree of equilibrium swelling ratio and mass loss. The flexural modulus and ultimate strength of polymerized TEGDMA and styrenic nanogel-modified TEGDMA were not statistically different (p > 0.05). SignificanceDue to improved shielding throughout the bulk of methacrylate-based polymers, including an example with an intentionally hydrolytically labile network structure, and a dramatic decrease of water uptake while maintaining equivalent mechanical properties, styrenic nanogel additives especially in high loading levels provide an excellent alternative to eliminate the adverse effects of water and presumably salivary fluids.

Impact Resistance of Fibre Reinforced Composite Railway Freight Tank Wagons

The use of fibre reinforced composite materials is one method by which the lightweighting of rail vehicles can be achieved. However, the issue of impact damage, amongst other challenges, limits their safety certification. This issue is accentuated by the high levels of loading a rail vehicle may be subjected to during service. This paper addresses the significance of pre-tension on large composite structures, specifically for a composite redesign of a pressure vessel for a freight tank wagon. Preloading was determined to be detrimental to the overall impact resistance of a large composite vessel. At 15.71 J of impact energy, there was a 22% increase in mean absorbed energy for a uniaxially loaded panel over an unloaded panel. However, there was only a 4% difference in penetration depth between uniaxial and biaxial loading. A novel finding from these results is that the effects of preloading are more profound if the loading does not act parallel to a principal fibre direction. Matrix cracking and delaminations are the most common failure modes observed for specimens under low-velocity impact and are intensified by preload.

Experimental Study on Crack Characteristics of Damaged Reinforced Concrete Beams strengthened with CFRP

The bending tests of 2 control beams and 6 damaged beams strengthened with CFRP (DBSC) were carried out to study the effects of adhesive layer thickness, number of CFRP layers and reinforcement ratio on crack characteristics of DBSC. The test results show that the crack development of the DBSC is accelerated and the crack resistance of the DBSC is reduced compared with the intact beam. With the increase of the thickness of the adhesive layer, the crack development of the DBSC is slowed down and the crack resistance is improved. Increasing the number of CFRP layers is helpful to restrain the crack development of DBSC under high load level. The increase of reinforcement ratio can significantly improve the crack resistance of DBSC.

Strength Weakening Effect of High Prestatically Loaded Marble Subjected to Low-Frequency Dynamic Disturbance under Point Load

The deep high prestatically loaded rock is often subjected to low-frequency dynamic disturbance and exhibits unusual strength characteristics, and thus, it is important to investigate the strength characteristics under the coupling effect of prestatic load and low-frequency dynamic disturbance loading conditions. In this study, a series of point load tests were conducted on the high prestatically loaded marble subjected to low-frequency disturbance by the MTS system, focusing on exploring the role of prestatic load level and low-frequency disturbance frequency in the process of rock strength change. Based on the average static failure load (Fmax) of samples under the static point loading, the high prestatic load levels (Fp) were selected as 70%, 80%, and 90% of Fmax, the corresponding low-frequency dynamic disturbance was loaded by sinusoidal waves with amplitudes of 60%, 40%, and 20% of Fmax, and the low-frequency dynamic disturbance frequencies (f) are 1, 2, 5, and 10 Hz. The change curve of the point load strength with the prestatic load level or the disturbance frequency was analyzed, which indicates that the point load strength under the coupled high prestatic load and low-frequency dynamic disturbance load was significantly lower than that under the pure static loading, presenting a significant point load strength weakening effect. Only when Fp or f reaches a certain level, the point load strength decreases significantly as f or Fp increases. Moreover, the point load strength weakening rate was proposed to characterize the degree of strength weakening. The comprehensive analysis demonstrates that Fp has a greater effect on the point load strength weakening effect than f, which is mainly reflected in the point load strength weakening level dominated by the Fp, and the weakening degree is affected by f.

Measuring tibial hemodynamics and metabolism at rest and after exercise using near-infrared spectroscopy.

The bone vascular system is important, yet evaluation of bone hemodynamics is difficult and expensive. This study evaluated the utility and reliability of near-infrared spectroscopy (NIRS), a portable and relatively inexpensive device, in measuring tibial hemodynamics and metabolic rate. Eleven participants were tested twice using post-occlusive reactive hyperemia technique with the NIRS probes placed on the tibia and the medial gastrocnemius (MG) muscle. Measurements were made at rest and after 2 levels of plantarflexion exercise. The difference between oxygenated and deoxygenated hemoglobin signal could be reliably measured with small coefficients of variation (CV; range 5.7-9.8%) and high intraclass correlation coefficients (ICC; range 0.73-0.91). Deoxygenated hemoglobin rate of change, a potential marker for bone metabolism, also showed good reliability (CV range 7.5-9.8%, ICC range 0.90-0.93). The tibia was characterized with a much slower metabolic rate compared with MG (p< 0.001). While exercise significantly increased MG metabolic rate in a dose-dependent manner (all p< 0.05), no changes were observed for the tibia after exercise compared with rest (all p> 0.05). NIRS is a suitable tool for monitoring hemodynamics and metabolism in the tibia. However, the local muscle exercise protocol utilized in the current study did not influence bone hemodynamics or metabolic rate. Novelty: NIRS can be used to monitor tibial hemodynamics and metabolism with good reliability. Short-duration local muscle exercise increased metabolic rate in muscle but not in bone. High level of loading and exercise volume may be needed to elicit measurable metabolic changes in bone.

Behavior of Polygonal Shells of Complex Geometry, Taking into Account the History of a High Level of Loading

The paper presents the results of the study of the stress-strain state of polygonal shells of positive and negative curvature with different geometric shape of the plan, taking into account the influence of the prehistory of a high loading level. To derive the resolving equation, equation, a mixed-type equation of the moment theory of shells was used. The calculation of the investigated out according to the moment theory, taking into account the influence of a complex stress state edge effect. The numerical implementation of this solution is carried out in relation to hinged and restrained shells. The bearing capacity of short-term and long-term loaded reinforced concrete polygonal shells was investigated by the method of limiting equilibrium.

Multilayered graphene/boron nitride/thermoplastic polyurethane composite films with high thermal conductivity, stretchability, and washability for adjustable-cooling smart clothes

Polymers having high filler loading levels are not able to meet the increasing requirements of thermal interface materials by themselves; therefore, fillers and structures with unique advantages have been developed. In this study, mechanical mixing was used to disperse graphene nanoplatelets (GNPs) and boron nitride (BN) fillers inside thermoplastic polyurethane (TPU)-based films, which were then compounded into a multilayered structure. The multilayered BN-GNP/TPU composite film created during this study exhibited a high thermal conductivity of 6.86 W m−1 K−1 at a low filler loading of 20 wt% BN with 20 wt% GNP, which was significantly higher (2844%) than that of the neat TPU film. The composite film also had good durability to flexural fatigue and laundering. This was exhibited by maintaining thermal conductivity values of 6.25 W m−1 K−1 after 5000 cycles of the flexural fatigue test, and 6.85 W m−1 K−1 after 10 cycles of laundering, respectively. Furthermore, enhanced thermal stability, cooling, and hydrophobic properties of the multilayered BN-GNP/TPU composite films were also observed with the resulting composite film. Overall, such a system provides a facile approach that is applicable for the fabrication of multifunctional materials as thermal interface materials within smart cooling garments.