Objective: In medical education, empathy is an essential element of professionalism; however, medical students are sometimes advised to limit empathy. Excessive empathy might be linked to burnout and trigger negative consequences such as low mood and quality of life. Due to limited data regarding the association between empathy and burnout, this study aimed to examine the relationship between levels of empathy and burnout with their respective subscales, among medical students.Material and Methods: This cross-sectional study was conducted at the clinical level of medical students currently undergoing medical training at the Faculty of Medicine, Prince of Songkla University, at the end of the 2020 academic year. Medical students aged more than 20 years who completed the questionnaires were included. The questionnaires comprised 1) demographic data, 2) The Toronto Empathy Questionnaire, 3) The Maslach Burnout Inventory (Thai version), and 4) The Thai Mental Health Indicator-15. Associations between empathy and burnout including emotional exhaustion, depersonalisation, and personal accomplishment subscales were investigated using linear regression analysis. Results: From the three-year clinical level, 91.9% (466 of 507) of medical students completed the questionnaires, with a mean age of 23.1±1.4 years. In the linear regression analyses, empathy scores were positively associated with emotional exhaustion and negatively associated with depersonalisation and low personal accomplishment (Adjusted coefficient 0.18 (0.02, 0.33), -0.09 (-0.18, -0.01), and -0.42 (-0.52, -0.31), respectively). Among the empathy subscales, altruism was significantly correlated with personal accomplishment (r=-0.41, p-value<0.001).Conclusion: The study revealed a negative correlation between empathy and overall burnout. While a high level of empathy was found to prevent depersonalisation and enhance personal accomplishment, it did not significantly hinder the emotional exhaustion associated with burnout. Empathy, particularly altruism, was related to personal accomplishments. Our findings suggest that empathy is a crucial determinant of burnout prevention; therefore, optimal levels of empathy should be taught to medical students during medical training to prevent emotional exhaustion. However, the evaluation of further causal explanations is recommended.
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