It is common practice in earthquake-prone areas to design structures with earthquake loading in mind. The severity of the damage to a structure depends on the earthquake's magnitude and the type of structure. Sometimes, a high-intensity earthquake can trigger explosive materials to explode inside structures. This combination of loading scenarios could lead to an overall increase in damage to the structures. So, it is essential to study the vulnerability analysis of the structures subjected to multi-hazard loading scenarios. This study mainly discusses the combined effect of the earthquake followed by the blast loading on the reinforced concrete structure. The results show that damage to the structure increases under combined earthquake and blast loading. Furthermore, the earthquake-induced vibrations in the structure intensify after the blast load. A parametric study of the structure is also performed, taking into account the possible load combinations of earthquake and blast loading. Moreover, this study discusses a numerical solution to the aforementioned problem, which strengthens fundamental knowledge and provides structural engineers with a deeper insight regarding the multi-hazard loading scenario considered in this study.