High Frustration Research Articles

BRUNNER SYNDROME: FROM GENETICS TO PSYCHIATRY - CASE REPORT

IntroductionMonoaminergic neurotransmitters affect motor control, emotions and cognitive functions. Their relative abundance depends on the action of monoamine oxidase A (MAOA) which catalyses their degradation into inactive metabolites. Brunner syndrome is a rare chromosome X-linked recessive inheritance genetic disorder, which causes loss of function of the MAOA gene, leading to a relative increase in monoamines in affected individuals (typically males). It manifests with moderate intellectual developmental disturbance associated with maladaptive externalising behaviours, low frustration tolerance and marked impulsivity.ObjectivesTo present a clinical case of patient diagnosed with Brunner Syndrome presenting with suicidal and homicidal ideation and to discuss it based on a non-systematic review of the literature.MethodsCase report and non-systematic review of the literature.Results: Case ReportMale born with neonatal asphyxia that consequently presented developmental retardation characterised by learning difficulties and emotional dysregulation. At 18 years of age, he began follow-up in Psychiatry due to self-injurious behaviours and several reactive suicide attempts (SA), being diagnosed with Intellectual Disability. At 22, he was hospitalised due to reactive depression, being discharged doing well with valproate, fluoxetine and olanzapine. Shortly after, he was arrested (aged 23-28) for attempted murder followed by SA. During imprisonment, he was diagnosed with Brunner’s Syndrome after his younger brother diagnosis. At 31, he was hospitalised for suicidal and homicidal ideation, revealing high impulsiveness and low frustration tolerance, and was discharged with compulsory psychiatric treatment. Three weeks later he was again hospitalised for symptoms recurrence having improved on Sertraline 50mg and Aripiprazole 400mg monthly.DiscussionAlthough scarce, the available evidence suggests that dietary modifications and the use of selective serotonin reuptake inhibitors may improve behaviour, reduce serotoninergic symptoms and possibly reverse some neurochemical abnormalities.ConclusionsBrunner syndrome is a rare genetic disorder with neuropsychiatric manifestations, whose course, treatment and prognosis are currently poorly known. Thus, the current treatment is empirical and further studies are needed.Disclosure of InterestNone Declared

Stressors and learned resourcefulness in baccalaureate nursing students: alongitudinal study.

This correlational longitudinal study examined levels and relationships of Learned Resourcefulness (LR), stressors, and academic performance in baccalaureate nursing students at a North Carolina university. Gadzella's Student-life Stress Inventory (SSI) and Rosenbaum's Self-Control Scale (SCS) administered to 85 students in two groups upon admission and graduation. LR increased, while stress decreased significantly in both groups (p < 0.05). Both groups (95.3% female, 85.8% Caucasian) reported similarly high frustration, pressure, and emotional reactions to stress. Significant relationship between taking tests and stress (p < 0.01). Stressors (p < 0.05) and age (p < 0.01) significant predictors of academic performance. Significant correlations of LR and work status (p < 0.01), and increased self-esteem (p<0.05). No significant relationships among LR, stressors, and academic performance. Results validate high levels of stress and suggest that higher LR enhances coping skills and decreases stress longitudinally, which can improve academic performance and retention. Trends and relationships in stressors and LR should be explored internationally in larger, more diverse samples of college students in nursing and other majors in relation to depression, anxiety, health-related behaviors, demographics, and academic performance. LR can be assessed, taught, learned, and enhanced. Greater numbers of qualified, competent nursing graduates with stronger clinical judgment, coping, and problem-solving skills will address the critical global nursing shortage and improve the quality, safety, and access of health care worldwide.

Application of Digital Twin and Heuristic Computer Reasoning to Workflow Management: Gastroenterology Outpatient Centers Study

The workflow in a large medical procedural suite is characterized by high variability of input and suboptimum throughput. Today, Electronic Health Record systems do not address the problem of workflow efficiency: there is still high frustration from medical staff who lack real-time awareness and need to act in response of events based on their personal experiences rather than anticipating. In a medical procedural suite, there are many nonlinear coupling mechanisms between individual tasks that could go wrong and therefore is difficult for any individual to control the workflow in real-time or optimize it in the long run. We propose a system approach by creating a digital twin of the procedural suite that assimilates Electronic Health Record data and supports the process of making rational, datadriven, decisions to optimize the workflow on a continuous basis. In this paper, we focus on long term improvements of gastroenterology outpatient centers as a prototype example and use six months of data acquisition in two different clinical sites to validate the artificial intelligence algorithms.

Conformational Heterogeneity and Frustration of the Tumor Suppressor p53 as Tuned by Punctual Mutations.

The conformational heterogeneity of the p53 tumor suppressor, the wild-type (p53wt) and mutated forms, was investigated by a computational approach, including the modeling and all atoms of the molecular dynamics (MD) simulations. Four different punctual mutations (p53R175H, p53R248Q, p53R273H, and p53R282W) which are known to affect the DNA binding and belong to the most frequent hot-spot mutations in human cancers, were taken into consideration. The MD trajectories of the wild-type and mutated p53 forms were analyzed by essential dynamics to extract the relevant collective motions and by the frustration method to evaluate the degeneracy of the energy landscape. We found that p53 is characterized by wide collective motions and its energy landscape exhibits a rather high frustration level, especially in the regions involved in the binding to physiological ligands. Punctual mutations give rise to a modulation of both the collective motions and the frustration of p53, with different effects depending on the mutation. The regions of p53wt and of the mutated forms characterized by a high frustration level are also largely involved in the collective motions. Such a correlation is discussed also in connection with the intrinsic disordered character of p53 and with its central functional role.

THE INTERNATIONAL FRAMEWORK OF WOMEN PRISONER'S RIGHTS AND THE IMPACT OF COVID

Overall these decades we have witnessed uncertainty and dynamic change which has increased the rate of crime in our country. Religiously, the Indian women create life, guard and strengthen it, but in the wake of westernization, industrialization, and civilization, there has been a rapid growth in crime done by the women due to different issues related to marital discoordination, disorganization, and managing families, high aspiration level and frustration where they are failing in this coping process and are getting involved in criminal activities and the managerial area of it. This article gathers the approach to the conditions faced by the women Prisoners in Indian society established on the base of different international universal declarations applicable to the women living in any country even in these crucial days of Covid-19 where their rights are frequently not fulfilled by prisons regimes that are dominantly designed by men for male prisoners.

Connecting Hodge and Sakaguchi-Kuramoto through a mathematical framework for coupled oscillators on simplicial complexes

Phase synchronizations in models of coupled oscillators such as the Kuramoto model have been widely studied with pairwise couplings on arbitrary topologies, showing many unexpected dynamical behaviors. Here, based on a recent formulation the Kuramoto model on weighted simplicial complexes with phases supported on simplices of any order k, we introduce linear and non-linear frustration terms independent of the orientation of the k + 1 simplices, as a natural generalization of the Sakaguchi-Kuramoto model to simplicial complexes. With increasingly complex simplicial complexes, we study the the dynamics of the edge simplicial Sakaguchi-Kuramoto model with nonlinear frustration to highlight the complexity of emerging dynamical behaviors. We discover various dynamical phenomena, such as the partial loss of synchronization in subspaces aligned with the Hodge subspaces and the emergence of simplicial phase re-locking in regimes of high frustration.

High-Pressure Synthesis and Physical Properties of a Spinel Compound FeAl2S4.

A spinel compound FeAl2S4 was successfully synthesized under high-pressure and high-temperature conditions and was systematically characterized via the structural, magnetic, and specific heat measurements. It crystallizes into a cubic structure with the space group Fd3̅m (no. 227) and the lattice constant a = 10.0207(2) Å. A Fe/Al site inversion is found; that is, the molecular formula can be rewritten as (Fe1-xAlx)(Al2-xFex)S4, and the inversion parameter x is about 0.22. Magnetic susceptibility measurements indicate that FeAl2S4 undergoes a spin glass behavior, which is confirmed by ac susceptibility and specific heat measurements. The freezing temperature Tf ∼ 10.5 K and Weiss temperature Tθ ∼ -107.4 K lead to a high frustration parameter f = |Tθ/Tf| of about 10, which suggests that FeAl2S4 is a high-frustration magnet. Our results indicate that high pressure can help stabilize the spinel structure with small R̅σ and the cation inversion plays an important role in the formation of the spin glass state.

Self‐Organized Kagomé‐Lattice in a Conductive Metal‐Organic Monolayer

AbstractThe on‐surface synthesis of metal‐organic covalent coordination networks with a dense Kagomé lattice of metallic centers is reported. Tetrahydroxyquinone and metal atoms (M = Cu or Mn) are codeposited on Ag(111) substrate to build well‐ordered 2D lattices M3C6O6. The surface is studied by scanning tunneling microscopy, low‐energy electron diffraction, and X‐ray photoelectron spectroscopy (XPS). Density functional theory (DFT) reveals a Cu+ charge state and no local magnetic moments for the Cu‐organic network. For the Mn‐organic network, the charge state Mn2+ and a local spin S = 5/2 are found. Charge transfer stabilizes the Cu+ and Mn2+ charge states. DFT calculations show a Dirac point, i.e., a band crossing with linear electron dispersion at the K‐point of the Brillouin zone. This Dirac point is at the Fermi level without charge transfer but drops by 100 meV if electron doping of Cu3C6O6 on Ag(111) surface is acknowledged. The magnetic couplings of an isolated Mn3C6O6 monolayer to be short range and antiferromagnetic leading to high frustration at the Kagomé lattice and a tendency toward a spin‐liquid ground state are predicted. In the case of hole transfer from the substrate, ferromagnetic ordering is introduced, making Mn3C6O6 an interesting candidate for the quantum anomalous Hall effect.

An Authentic Inner Compass and Need Satisfaction as Wellbeing Resources in Bedouin Teaching Students During the COVID-19.

A growing body of literature suggests that students from underserved backgrounds are more vulnerable to the adverse economic, emotional, and academic effects of the current COVID-19 pandemic. While this vulnerability was attributed to multiple structural and socio-cultural barriers, little attention has been paid to the role of psychological resources in preserving wellbeing in times of crisis and change. Guided by the Self-Determination Theory (SDT), the current study examined the role of the authentic inner compass (AIC) and need-satisfaction in predicting the wellbeing of Bedouin students attending teachers' higher education institutes in the south of Israel during the COVID-19. Participants were 84 Bedouin teaching students (84.1% female) who completed online questionnaires addressing the sense of AIC, need-based experiences, psychological distress, and positive affect. Consistent with the propositions of the SDT, we found that a strong and clear sense of AIC, as well as high need satisfaction and low need frustration, were associated with lower distress and higher positive effect in Bedouin teaching students. We have also found that need satisfaction moderated the effect of the AIC on students' wellbeing so that AIC better predicted lower distress and higher positive effect when students' levels of need satisfaction were higher. Our findings lend further support to the importance of the AIC and need satisfaction to optimal functioning even in collectivist cultural contexts that do not prioritize values of autonomy. The current study provides insight into the interplay between AIC and need-based experience by describing the conditions under which AIC may be beneficial for wellbeing in times of crisis.

Anisotropic deconfined criticality in Dirac spin liquids

We analyze a Higgs transition from a U(1) Dirac spin liquid to a gapless ℤ2 spin liquid. This ℤ2 spin liquid is of relevance to the spin S = 1/2 square lattice antiferromagnet, where recent numerical studies have given evidence for such a phase existing in the regime of high frustration between nearest neighbor and next-nearest neighbor antiferromagnetic interactions (the J1-J2 model), appearing in a parameter regime between the vanishing of Néel order and the onset of valence bond solid ordering. The proximate Dirac spin liquid is unstable to monopole proliferation on the square lattice, ultimately leading to Néel or valence bond solid ordering. As such, we conjecture that this Higgs transition describes the critical theory separating the gapless ℤ2 spin liquid of the J1-J2 model from one of the two proximate ordered phases. The transition into the other ordered phase can be described in a unified manner via a transition into an unstable SU(2) spin liquid, which we have analyzed in prior work. By studying the deconfined critical theory separating the U(1) Dirac spin liquid from the gapless ℤ2 spin liquid in a 1/Nf expansion, with Nf proportional to the number of fermions, we find a stable fixed point with an anisotropic spinon dispersion and a dynamical critical exponent z ≠ 1. We analyze the consequences of this anisotropic dispersion by calculating the angular profiles of the equal-time Néel and valence bond solid correlation functions, and we find them to be distinct. We also note the influence of the anisotropy on the scaling dimension of monopoles.

Alcohol Use of German Adults during Different Pandemic Phases: Repeated Cross-Sectional Analyses in the COVID-19 Snapshot Monitoring Study (COSMO).

There is little evidence on how different COVID-19 pandemic phases influence the alcohol use behaviour of adults. The objective of this study is to investigate alcohol use frequency over different COVID-19 pandemic phases and to identify vulnerable subgroups for risky use behaviour in the German adult population. Survey waves of 14/15 April 2020 (n = 1032), 23/24 June 2020 (n = 993), and 26/27 January 2021 (n = 1001) from the COVID-19 Snapshot Monitoring (COSMO) were analysed. The mean age was 46 ± 15.3 years in April, 46 ± 15.5 years in June, and 45 ± 15.5 years in January. The gender ratio was mostly equal in each survey wave. Descriptive analyses and univariate and multivariate logistic regression analyses for individuals with increased alcohol use frequency (AUF) were performed. 13.2% in April (lockdown), 11.3% in June (easement), and 8.6% in January (lockdown) of participants showed an increased AUF. Individuals with perceived burden, high frustration levels due to protective measures, and young to middle-aged adults were more likely to increase their AUF during different pandemic phases. In conclusion, unfavourable alcohol behaviour might occur as a potentially maladaptive coping strategy in pandemics. Because of potential negative long-term consequences of problematic alcohol use behaviour on health, public health strategies should consider mental health consequences and target addictive behaviour, while also guiding risk groups towards healthy coping strategies such as physical activities during pandemics/crises.

How long can I wait and how much frustration can I stand? Volitional traits and students’ PhD-intention and pursuit

The purpose of the present investigation is to analyze the relation of frustration tolerance and delay of gratification with PhD-intention and expectations. We conducted one correlational and two experimental studies. In Study 1 (N1 = 171 undergraduates), we found the hypothesized positive association between delay of gratification and frustration tolerance and the intention to obtain a PhD. In Studies 2 and 3, we used experimental vignette designs. In Study 2, doctoral students and postdocs (N2 = 180) evaluated a fictitious student regarding PhD-intention and a successful PhD-process. As expected, students with high gratification delay and frustration tolerance were judged as more likely to start and complete a PhD than students described low in these volitional traits. In Study 3, we contrasted Study 2’s findings by asking employees of the private sector (N3 = 150) to rate the same students’ intention to join a company instead. None of the factors influenced participants’ judgments when it comes to a non-academic career track.

Caregivers of children feel confident about using the Internet for health information.

Caregivers of children may rely on internet sources, health care providers, peers or family for health information. To examine the impact of sociodemographic factors on the use of the internet for health information by caregivers of children, and the impact on self-efficacy, effort and frustration. Using data from the 2019 Health Information National Trends Survey, the effects of information source on self-efficacy, effort and frustration was examined using the complex samples module of SPSS. The internet was the most common source of health information for caregivers of children (n=247), with high confidence, low frustration and effort reported. Younger, higher educated and higher income caregivers were significantly more likely to use the internet for health information. Information from Health Care Providers (HCPs) was associated with greater confidence, and information from peers associated with lesser effort and frustration. No significant effects on self-efficacy, effort or frustration for online health information was noted compared to other sources. Efforts to reduce barriers to online health information may be required for some groups of caregivers, and health care providers may have a role to play in this.

Magnetism of BiFe0.9Cr0.1O3 studied experimentally and with Monte Carlo simulations

The sol-gel technique is used in this paper to prepare Cr-doped $\mathrm{BiFe}{\mathrm{O}}_{3}$. The magnetism of $\mathrm{Bi}{\mathrm{Fe}}_{1\text{\ensuremath{-}}\mathrm{x}}{\mathrm{Cr}}_{\mathrm{x}}{\mathrm{O}}_{3}$ with a distorted rhombohedral perovskite structure has been studied for $x=0.1$. X-ray diffraction analysis reveals that the sample is rhombohedral with the space group ${R}_{3}C$ and contains some impurity phases. The M\"ossbauer spectra at 300 and 500 K are used to determine the magnetic and impurity phase proportion as well as the valence state, electric field gradient, internal magnetic field, and electron cloud distribution of ${\mathrm{Fe}}^{3+}\mathrm{ions}$ in $\mathrm{Bi}{\mathrm{Fe}}_{0.9}{\mathrm{Cr}}_{0.1}{\mathrm{O}}_{3}$. The magnetic properties of $\mathrm{Bi}{\mathrm{Fe}}_{0.9}{\mathrm{Cr}}_{0.1}{\mathrm{O}}_{3}$ are complex. Through the zero-field-cooled/field-cooled magnetization curve, the magnetism of $\mathrm{Bi}{\mathrm{Fe}}_{0.9}{\mathrm{Cr}}_{0.1}{\mathrm{O}}_{3}$ is analyzed. According to the first-order differential of magnetization to temperature, the N\'eel temperature is determined to be $\ensuremath{\sim}134\phantom{\rule{0.16em}{0ex}}\mathrm{K}$. It is speculated that a partial relaxation structure may exist in the system. Then the Heisenberg model simulation and experimental data are approximated using the particle swarm optimization algorithm to further analyze the magnetism and calculate the more precise phase transformation temperature. It has been determined that the exchange constants for cubic structure and relaxation structure are ${J}_{\mathrm{Fe}\text{\ensuremath{-}}\mathrm{Cr}}=6.75\phantom{\rule{0.16em}{0ex}}\mathrm{meV}, {J}_{\mathrm{Fe}\text{\ensuremath{-}}\mathrm{Fe}}=\ensuremath{-}6.13\phantom{\rule{0.16em}{0ex}}\mathrm{meV}, {J}_{\mathrm{Fe}\text{\ensuremath{-}}\mathrm{Fe}}^{{}^{\ensuremath{'}}}=\ensuremath{-}1.16\phantom{\rule{0.16em}{0ex}}\mathrm{meV}$, and ${J}_{\mathrm{Fe}\text{\ensuremath{-}}\mathrm{Cr}}^{{}^{\ensuremath{'}}}=\ensuremath{-}1.54\phantom{\rule{0.16em}{0ex}}\mathrm{meV}$. The cubic and relaxation structures contribute 0.71 and 0.29 to magnetism, respectively. According to the Heisenberg model, the Curie temperature should be $\ensuremath{\sim}606\phantom{\rule{0.16em}{0ex}}\mathrm{K}$, and the N\'eel temperature should be $\ensuremath{\sim}116\phantom{\rule{0.16em}{0ex}}\mathrm{K}$. The ratio of the Curie temperature to the Weiss constant is significantly &gt;5, implying that the entire spin system is in a state of high frustration.

Double frustration and magnetoelectroelastic excitations in collinear multiferroic materials

We discuss a model scenario for multiferroic systems of type II (collinear spins) where the electric dipolar order competes with a frustrated magnetic order in determining the elastic distortions of the lattice ion positions. High magnetic frustration due to second-neighbors exchange and small spin easy-axis anisotropy lead to the appearance of the so-called quantum magnetic plateau states. Increasing the magnetic field above the plateau border produces composite excitations, where fractionalized spin tertions arise together with spontaneous dipolar flips (in the form of domain walls) and enhanced localized elastic distortions. This peculiar magnetoelectric effect may be described by magneto-electric-elastic quasiparticles that could be detected by x-ray and neutron diffraction techniques. Our results are supported by extensive DMRG computations on the spin sector and self-consistent equations for the lattice distortions.

Phonon spectrum of Pr2Zr2O7 and Pr2Ir2O7 as evidence of coupling of the lattice with electronic and magnetic degrees of freedom

Magnetic materials with pyrochlore crystal structure form exotic magnetic states due to the high lattice frustration. In this work we follow the effects of coupling of the lattice and electronic and magnetic degrees of freedom in two praseodymium-based pyrochlores ${\mathrm{Pr}}_{2}{\mathrm{Zr}}_{2}{\mathrm{O}}_{7}$ and ${\mathrm{Pr}}_{2}{\mathrm{Ir}}_{2}{\mathrm{O}}_{7}$. In either of these materials, the presence of magnetic interactions does not lead to magnetically ordered low temperature states; however, their electronic properties are different. A comparison of Raman phonon spectra of ${\mathrm{Pr}}_{2}{\mathrm{Zr}}_{2}{\mathrm{O}}_{7}$ and ${\mathrm{Pr}}_{2}{\mathrm{Ir}}_{2}{\mathrm{O}}_{7}$ allows us to identify magnetoelastic coupling in ${\mathrm{Pr}}_{2}{\mathrm{Zr}}_{2}{\mathrm{O}}_{7}$ that elucidates its magnetic properties at intermediate temperatures and allows us to characterize phonon-electron scattering in the semimetallic ${\mathrm{Pr}}_{2}{\mathrm{Ir}}_{2}{\mathrm{O}}_{7}$. We also show that the effects of random disorder on the Raman phonon spectra is small.

Residue-Frustration-Based Prediction of Protein-Protein Interactions Using Machine Learning.

The study of protein-protein interactions (PPIs) is important in understanding the function of proteins. However, it is still a challenge to investigate the transient protein-protein interaction by experiments. Hence, the computational prediction for protein-protein interactions draws growing attention. Statistics-based features have been widely used in the studies of protein structure prediction and protein folding. Due to the scarcity of experimental data of PPI, it is difficult to construct a conventional statistical feature for PPI prediction, and the application of statistics-based features is very limited in this field. In this paper, we explored the application of frustration, a statistical potential, in PPI prediction. By comparing the energetic contribution of the extra stabilization energy from a given residue pair in the native protein with the statistics of the energies, we obtained the residue pair's frustration index. By calculating the number of residue pairs with a high frustration index, the highly frustrated density, a residue-frustration-based feature, was then obtained to describe the tendency of residues to be involved in PPI. Highly frustrated density, as well as structure-based features, were then used to describe protein residues and combined with the long short-term memory (LSTM) neural network to predict PPI residue pairs. Our model correctly predicted 75% dimers when only the top 2‰ residue pairs were selected in each dimer. Our model, which considers the statistics-based features, is significantly different from the models based on the chemical features of residues. We found that frustration can effectively describe the tendency of residue to be involved in PPI. Frustration-based features can replace chemical features to combine with machine learning and realize the better performance of PPI prediction. It reveals the great potential of statistical potential such as frustration in PPI prediction.

Localization of Energetic Frustration in Proteins.

We present a detailed heuristic method to quantify the degree of local energetic frustration manifested by protein molecules. Current applications are realized in computational experiments where a protein structure is visualized highlighting the energetic conflicts or the concordance of the local interactions in that structure. Minimally frustrated linkages highlight the stable folding core of the molecule. Sites of high local frustration, in contrast, often indicate functionally relevant regions such as binding, active, or allosteric sites.

Expanding Alternating Spherical and Cylindrical Regions by Tailoring Binary Symmetric ABC/ABC Blends

The self-assembly of a binary blend composed of two different symmetric ABC triblock copolymers has been investigated using self-consistent field theory in the grand canonical ensemble, aiming to expand the phase regions of alternating spherical and cylindrical phases by tailoring the molecular parameters. Our study confirms that the region of the spherical phase is expanded by the effect of bidispersity in which the long and short A-blocks (or C-blocks) form a core–shell distribution within the spherical domain to increase the spontaneous curvature. The bidispersity effect also expands the phase region of the alternating cylinders. In contrast to the spherical phase, the cylindrical region can be expanded by another effect of bidisperse B-blocks to release the high packing frustration of the low-coordinated tetragonal array of alternating A/C cylinders. With optimized parameters, the regions of both the spherical and cylindrical phases are tremendously expanded to such large volume fractions that the spheres and cylinders are remarkably deformed. Our work not only deepens the understanding on the self-assembly mechanism of ABC/ABC blends but also provides a valuable guide for the fabrication of alternating spherical and cylindrical morphologies with large volume fractions.

A Geometrically Frustrated Family of MIIMIIIF5(H2O)2 Mixed-Metal Fluorides with Complex Magnetic Interactions.

Inverse weberites are of interest as geometrically frustrated magnetic materials due to their unique cation arrangement. We have synthesized nine isostructural materials that adopt the inverse weberite crystal structure, which consists of cross-linked kagome layers. These materials, having the general formula MIIMIIIF5(H2O)2 (MII = Co, Mn, Ni, Zn; MIII = Ga, Cr, Fe, V), were synthesized using mild hydrothermal conditions, which yielded phase-pure samples after optimization of the reaction conditions. Their crystal structures and optical, thermal, and magnetic behavior were characterized using single-crystal X-ray diffraction, UV-vis spectroscopy, thermogravimetric analysis, and measurement of the magnetic susceptibility and isothermal magnetization data, respectively. Three distinct types of magnetism were observed, including simple paramagnetism, antiferromagnetism, and canted antiferromagnetism; the last type is accompanied by a high frustration index fin the range 4.16-8.09. We demonstrated that the magnetic behavior of inverse weberites depends on the presence or absence of unpaired-electron-containing cations on the two distinct crystallographic sites, which can be employed for the prediction of the magnetic properties of other compounds in this rich and diverse family.