Hypergolic bipropellant engines are extensively used in spacecraft operations. In these engines, the combustion reaction is initiated by the impinging jets of the oxidizer and fuel in the liquid phase. The most commonly used hypergolic fuels, hydrazine and monomethylhydrazine, as well as the oxidizer, nitrogen tetroxide, are all in liquid state under room temperature and atmospheric pressure conditions. However, as these engines are operated in a space vacuum, a portion of the propellant inevitably evaporates because of low-pressure boiling immediately after engine start-up. The mixing of gas with liquid propellant results in unstable combustion, and minimizing this effect is critical for the engine design. Particularly, preventing high-frequency combustion instability is essential as it can be detrimental to the engine. This paper presents a mechanism that activates high-frequency combustion instability, realized by analyzing the pressure within the combustion chamber during artificially induced unstable combustion. Furthermore, the methodology for establishing operational constraints based on the proposed mechanism is clarified, along with the method for collecting test data. The study findings provide important indicators for the design criteria of bipropellant engines, contributing to the diversification and complexity of space development programs.