High Flexibility Research Articles

Toehold Strand Displacement-Mediated Exponential HCR for Highly Sensitive and Specific Analysis of miRNA in Living Cells.

As an important disease biomarker, the development of sensitive detection strategies for miRNA, especially intracellular miRNA imaging strategies, is helpful for early diagnosis of diseases, pathological research, and drug development. Hybridization chain reaction (HCR) is widely used for miRNA imaging analysis because of its high specificity and lack of biological enzymes. However, the classic HCR reaction exhibits linear amplification with low efficiency, limiting its use for the rapid analysis of trace miRNA in living cells. To address this problem, we proposed a toehold-mediated exponential HCR (TEHCR) to achieve highly sensitive and efficient imaging of miRNA in living cells using β-FeOOH nanoparticles as transfection vectors. The detection limit of TEHCR was as low as 92.7 fM, which was 8.8 × 103 times lower compared to traditional HCR, and it can effectively distinguish single-base mismatch with high specificity. The TEHCR can also effectively distinguish the different expression levels of miRNA in cancer cells and normal cells. Furthermore, TEHCR can be used to construct OR logic gates for dual miRNA analysis without the need for additional probes, demonstrating high flexibility. This method is expected to play an important role in clinical miRNA-related disease diagnosis and drug development as well as to promote the development of logic gates.

Aircraft Wing Morphing Using Auxetic Structures

Cellular materials exhibit two key properties: structures and mechanisms. This allows for the design of structures using cellular materials while effectively controlling both stiffness and flexibility, based on the connectivity of the struts. This study aims to explore the in-plane flexible properties of cellular materials dominated by bending under macroscopic deformation. Additionally, it seeks to establish a method for designing a passive morphing airfoil with flexible cellular cores. The investigation focuses on airfoils featuring re-entrant and S-shaped cellular cores, analyzing their behavior under static loads by examining the deformation of the cellular cores subjected to aerostatic loads. In the context of the airfoil's deformation with flexible cellular cores under aerostatic loading, shear emerges as the predominant deformation mode for the cores of the airfoil. Wings of conventional aircraft are optimized for only a few conditions, not for the entire flight envelope. Therefore, it is necessary to develop the morphing airfoil with smart structures for the next generation of excellent aircraft. In this project, this was made possible using, re-entrant and S-shaped auxetic structures as a member of the meta- material family, with negative Poisson's ratio to enable an effortless passive morphing mechanism as it has high flexibility along in-plane direction (chord-wise). The 3D CAD Models of Re-entrant and S-shaped auxetic airframes were designed and analyzed. Initially, Static Structural analysis is performed on both airframes to observe the structure’s behavior, and design modification and optimization are performed in different iterations. With a reduction in maximum equivalent stress by 20%, the Re-entrant airframe exhibits lower stress and hence more flexibility. The wings were modeled with a span of 1m using auxetic airframes, air pressure was generated using CFD analysis with MACH 0.45. Finally, the fluid-structure interaction was done by importing the air pressure and performing static structural analysis for the structural performance of wings using auxetic airframes. It was found that Re-entrant auxetic wing showed an increase of 9.99% in load carrying capacity, accompanied by a decrease of 389 grams of weight when compared to S-shaped auxetic wing. Considering the deformation of the airframe with flexible cellular cores under a load, the re-entrant honeycomb core shows the highest flexibility in shear and causes lower stress than the S-auxetic cores. This implies that the re-entrant honeycomb core has the potential for passive morphing.

RFX-mod2 as a flexible device for reversed-field-pinch and low-field tokamak research

The RFX-mod2 installation is planned to be completed by 2024 and the start of operations is expected in 2025. The high flexibility of the machine (already tested in the previous RFX-mod experiment) allows operation in Reversed Field Pinch and tokamak configuration as well as ultra-low q pulses. In this work we present predictive analysis on transport, performances and plasma control in RFX-mod2 in view of the first experimental campaigns.

Reinforced nanowrinkle electrospun photothermal membranes via solvent‐induced recrystallization

AbstractWearable photothermal materials can capture light energy in nature and convert it into heat energy, which is critical for flexible outdoor sports. However, the conventional flexible photothermal membranes with low specific surface area restrict the maximum photothermal capability, and loose structure of electrospun membrane limits durability of wearable materials. Here, an ultrathin nanostructure candle soot/multi‐walled carbon nanotubes/poly (L‐lactic acid) (CS/MWCNTs/PLLA) photothermal membrane is first prepared via solvent‐induced recrystallization. The white blood cell membrane‐like nanowrinkles with high specific surface area are achieved for the first time and exhibit optimal light absorption. The solvent‐induced recrystallization also enables the membrane to realize large strength and durability. Meanwhile, the membranes also show two‐sided heterochromatic features and transparency in thick and thin situations, respectively, suggesting outstanding fashionability. The nano‐wrinkled photothermal membranes by novel solvent‐induced recrystallization show high flexibility, fashionability, strength, and photothermal characteristics, which have huge potential for outdoor warmth and winter sportswear.image

The effect of cognitive flexibility on students’ spatial visualization abilities and computational thinking skills in a three-dimensional design and coding training

ABSTRACT Aim and background Today, students are encouraged to develop spatial visualization ability to meet the challenges of digital technologies impacting their daily life and education when exposed more time to a virtual 3D environment. This study investigated the effect of cognitive flexibility levels on students’ spatial visualization abilities and computational thinking skills in three-dimensional design and coding training. In addition, this study examined the effect of the training on the spatial visualization abilities and computational thinking skills of the students. Method The study employed a one-group pre-test/post-test quasi-experimental design. A total of 60 university students (51 female and 9 male) participated in this study. University students received three-dimensional design and coding training by using Tinkercad. The Spatial Visualization Test, the Cognitive Flexibility Scale, the Computational Thinking Scale and semi-structured interview form were used to collect data. Paired samples t-test and one-way ANCOVA were used for the data analysis. Results and discussion Results from the training indicated that the students’ spatial visualization abilities improved. Their spatial visualization abilities and computational thinking skills were related to their cognitive flexibility levels. The training also improved the spatial visualization abilities and computational thinking skills of students with high cognitive flexibility. 3D design and coding education could be more effective for students with high cognitive flexibility. The qualitative findings supported the results of the study.

High-performance flexible p-type Ce-filled Fe3CoSb12 skutterudite thin film for medium-to-high-temperature applications

P-type Fe3CoSb12-based skutterudite thin films are successfully fabricated, exhibiting high thermoelectric performance, stability, and flexibility at medium-to-high temperatures, based on preparing custom target materials and employing advanced pulsed laser deposition techniques to address the bonding challenge between the thin films and high-temperature flexible polyimide substrates. Through the optimization of fabrication processing and nominal doping concentration of Ce, the thin films show a power factor of >100 μW m−1 K−2 and a ZT close to 0.6 at 653 K. After >2000 bending cycle tests at a radius of 4 mm, only a 6 % change in resistivity can be observed. Additionally, the assembled p-type Fe3CoSb12-based flexible device exhibits a power density of 135.7 µW cm−2 under a temperature difference of 100 K with the hot side at 623 K. This work fills a gap in the realization of flexible thermoelectric devices in the medium-to-high-temperature range and holds significant practical application value.

An Intelligent Non-Invasive Blood Pressure Monitoring System Based on a Novel Polyvinylidene Fluoride Piezoelectric Thin Film

Hypertension is a common cause of cardiovascular diseases, closely associated with the high mortality and disability rates of cardiovascular diseases such as stroke and coronary heart disease. Therefore, developing a comfortable and sustainable device for monitoring human pulse signals holds practical significance for the prevention and treatment of hypertension and cardiovascular diseases. PVDF flexible pressure sensors possess the characteristics of high sensitivity, good flexibility, and strong biocompatibility, thereby demonstrating extensive application potential in areas such as health monitoring, wearable devices, and electronic skins. This paper focuses on the development of a modified piezoelectric polymer and its application in an intelligent blood pressure monitoring system, demonstrating its outstanding performance and feasibility through a series of experiments. This research provides innovative material choices for the development of intelligent medical devices and offers beneficial guidance for the design and application of future intelligent health monitoring systems.

Research Status and Development Trend of Multi-arm Collaborative Robots

Abstract: Industrial robots are mainly used in metal forming, automotive, and electrical and electronics industries. After decades of unremitting efforts, industrial robots have achieved great success. However, problems such as low safety, weak environmental adaptability, and insufficient humancomputer interaction ability of industrial robots have greatly limited the application of industrial robots, and multi-arm collaborative robots came into being in this case. Multi-arm collaborative robots offer high flexibility and precision. Over the years, the application and development of multiarm collaborative robots have been paid more and more attention. This paper aims to summarize the patents related to multi-arm cooperative robots, including their principles, classification, latest progress and future development, in order to meet the needs of the real world. According to the structural characteristics of multi-arm collaborative robots and the requirements of multi-arm collaborative robots application field, the most typical mobile collaborative robots and stationary dual-arm collaborative robots in multi-arm collaborative robots are summarized. By investigating various patents of multi-arm collaborative robots the main problems of multi-arm collaborative robots are summarized and analyzed, such as collisions or conflicts between robotic arms, low power-to-weight ratio, loose structures, and heavy weight of the robot body. In addition, the development trend of multi-arm collaborative robots is also discussed. Multi-arm robots have broad prospects and potential in future applications and development. With the advancement of new technologies, multi-arm collaborative robots will become more efficient, intelligent, safe, and flexible. More relevant patents are expected to be invented in the future.

Characterization Data for the Establishment of Scale-Up and Process Transfer Strategies between Stainless Steel and Single-Use Bioreactors

The reliable transfer of bioprocesses from single-use bioreactors (SUBs) of different scales to conventional stainless steel stirred-tank bioreactors is of steadily growing interest. In this publication, a scale-up study for SUBs with volumes of 200 L and 2000 L and the transfer to an industrial-scale conventional stainless steel stirred-tank bioreactor with a volume of 15,000 L is presented. The scale-up and transfer are based on a comparison of mixing times and the modeling of volumetric mass transfer coefficients kLa, measured in all three reactors in aqueous PBS/Kolliphor solution. The mass transfer coefficients are compared with the widely used correlation of van’t Riet at constant stirrer tip speeds. It can be shown that a van’t Riet correlation enables a robust and reliable prediction of mass transfer coefficients on each scale for a wide range of stirrer tip speeds and aeration rates. The process transfer from single-use bioreactors to conventional stainless steel stirred-tank bioreactors is proven to be uncritical concerning mass transfer performance. This provides higher flexibility with respect to bioreactor equipment considered for specific processes.

Phytochemicals as Adjuvant Therapies in RND Efflux Mediated Multidrug Resisting Pseudomonas Aeruginosa Infections and Evaluations Techniques of Efflux Inhibitory Activities in Bacteria:

Abstract: One of the top-listed opportunistic pathogens that are frequently found in medical devices such as ventilation systems is Pseudomonas aeruginosa. These bacteria often cause infections in the lungs (pneumonia), blood after surgery, and other parts of the body. Extreme susceptibility to P. aeruginosa infection primarily exists in immunosuppressed individuals, and long-term evolution has led to the development of genetic resistance mechanisms that have high genetic flexibility against damaging antibiotics. Several lines of research evidence point to efflux as the primary reason for the organism's effectiveness against antibiotic treat-ment in infections caused by this bacterium. Drug Efflux pumps play a crucial role in medicine because they expulse a variety of unique and unrelated chemical structures with either antibi-otics or antimicrobials before they reach the concentration necessary to kill bacteria, confer-ring multiple resistance to more than one class of antibiotics. Targeting this mechanism for example by blocking the most active efflux pump MexAB-orpM would probably lead to the discovery of new ways to circumvent the bacterial system of antibiotic resistance and boost treatment effectiveness.

All-optical driven soft crawler with complex motion capabilities

ABSTRACT The emergence of millimeter-scale soft actuators has significantly expanded the potential applications in areas such as search and rescue, drug delivery, and human assistance, due to their high flexibility. Despite these advancements, achieving precise control over the intricate movements of soft crawlers poses a significant challenge. In this study, we have developed an all-optical approach that enables manipulation of propulsive forces by simultaneously modifying the magnitude and direction of friction forces, thereby enabling complex motions of soft actuators. Importantly, the approach is not constrained by specific actuator shapes, and theoretically, any elongated photothermal actuator can be employed. The actuator was designed with an isosceles trapezoid shape, featuring a top width of 2 mm, a bottom width of 4 mm, and a length of 8 mm. Through our manipulation approach, we showcase a proof-of-concept for complex soft robotic motions, including crawling (achieving speeds of up to 2.25 body lengths per minute), turning, avoiding obstacles, handling and transferring objects approximately twice its own weight, and navigating narrow spaces along programmed paths. Our results showcase this all-optical manipulation approach as a promising, yet unexplored tool for the precision and wireless control for the development of advanced soft actuators.

Multi‐armed bandit based online model selection for concept‐drift adaptation

AbstractEnsemble methods are among the most effective concept‐drift adaptation techniques due to their high learning performance and flexibility. However, they are computationally expensive and pose a challenge in applications involving high‐speed data streams. In this paper, we present a computationally efficient heterogeneous classifier ensemble entitled OMS‐MAB which uses online model selection for concept‐drift adaptation by posing it as a non‐stationary multi‐armed bandit (MAB) problem. We use a MAB to select a single adaptive learner within the ensemble for learning and prediction while systematically exploring promising alternatives. Each ensemble member is made drift resistant using explicit drift detection and is represented as an arm of the MAB. An exploration factor controls the trade‐off between predictive performance and computational resource requirements, eliminating the need to continuously train and evaluate all the ensemble members. A rigorous evaluation on 20 benchmark datasets and 9 algorithms indicates that the accuracy of OMS‐MAB is statistically at par with state‐of‐the‐art (SOTA) ensembles. Moreover, it offers a significant reduction in execution time and model size in comparison to several SOTA ensemble methods, making it a promising ensemble for resource constrained stream‐mining problems.

Nano-Formulation Approaches to Enhance Transdermal Drug Delivery-An Updated Review of Nanovesicular Carrier "Transethosomes".

Transdermal drug delivery is an attractive and patient-friendly route for administering therapeutic agents. However, the skin's natural barrier, the stratum corneum, restricts the passage of many drugs, limiting their effectiveness. To overcome this challenge, researchers have developed various nanocarriers to enhance drug penetration through the skin. Transethosomes, a novel and promising drug delivery system, have emerged as an innovative solution for improving transdermal drug delivery. Transethosomes are a hybrid of two established nanocarriers: ethosomes and transfersomes. Ethosomes are lipid-based vesicles that can accommodate lipophilic and hydrophilic drugs, while transfersomes are deformable lipid vesicles designed to enhance skin penetration. Transethosomes combine the advantages of both systems, making them ideal candidates for efficient transdermal drug delivery. They are composed of phospholipids, ethanol, and water and exhibit high flexibility, enabling them to squeeze through the tight junctions of the stratum corneum. This abstract reviews the key characteristics of transethosomes, including their composition, preparation methods, mechanisms of action, characterization parameters, and prospects. Moreover, the recent advancements and applications of transethosomes in delivering various therapeutic agents, such as analgesics, anti-inflammatories, hormones, and skincare products, are explored. The enhanced skin penetration capabilities of transethosomes can potentially reduce systemic side effects and improve patient compliance, making them a valuable tool in the field of transdermal drug delivery. In conclusion, transethosomes represent a promising platform for overcoming the challenges of transdermal drug delivery. Their unique properties enable efficient drug permeation through the skin, offering a more controlled and effective means of administering a wide range of pharmaceutical and cosmetic products. This abstract highlights the potential of transethosomes as a valuable addition to the field of transdermal drug delivery and paves the way for further research and development in this area.

Chaos generation of superconducting quantum bits coupled with LC resonant circuits

The dynamics of chaos have been widely used in nonlinear science, such as neural networks, extreme event statistics, and the biophysics of chaos self-organization. Superconducting qubits are artificial atoms based on the Josephson junction structure of nonlinear superconducting devices, offering high design flexibility and ease of coupling and control. In this paper, the generation of chaos through the coupling between superconducting qubits and LC resonant circuits is investigated. By varying the ratio of Josephson energy to charge energy, the coupling coefficient, and the energy of the external driving field, the generation and control of chaos within the system are numerically analyzed. This study provides theoretical support for parameter selection ensuring the confidentiality and fidelity of quantum information transmission based on the chaotic dynamics of superconducting qubits.

Estimation of adaptability parameters of collection hulled oats varieties according to productivity in the Kirov region

The current paper has presented the study results conducted on the experimental plot of the Falenskaya breeding station of the branch of the FSBI FANC of the North-East in 2021–2023. The purpose of the study was to evaluate the collection hulled oat varieties according to grain productivity and adaptability parameters in the soil and climatic conditions of the Kirov region. The materials for the study were 9 collection oat varieties and the standard variety ‘Krechet’. According to the trait ‘productivity’, there have been estimated adaptability parameters. During the testing years, the studied variety samples differed significantly in productivity variability (V = 16.8–30.0 %). The factor ‘year’ had the greatest effect on the formation of oat yields (90.3 %). In the arid year of 2021, the varieties’ productivity was low (276–401 g/m2), with a negative index of environmental conditions (Ij = -163), in the most favorable year of 2022, it was 463–682 g/m2 and Ij = 104, respectively. The variety samples ‘k-3967 0144’ (-190 g/m2) and ‘15584 Mutant 258’ (-214 g/m2) were characterized by high stress resistance. High genetic flexibility of mean productivity under contrasting conditions was established in the variety samples ‘15472 Sumphony’ (504 g/m2), ‘k-3967 0144’ (496 g/m2) and ‘15340 Uran’ (487 g/m2). There have been identified such gene sources as plastic ‘k-3967 0144’, ‘15472 Sumphony’, ‘15340 Uran’, ‘k-3951 0146’, ‘k-3954 0149’ (IEP = 1.13–1.0), and with high stability of the trait ‘productivity’ ‘k-3967 0144’, ‘15584 Mutant 258’, ‘k-3954 0149’ (SF = 1.47–1.78). Low variability and high homeostaticity were found in the variety samples ‘k-3967 0144’, ‘15584 Mutant 258’, ‘k-3954 0149’ (V = 16.8–22.8 %; Hom = 31.31–20.75) with a high stability index (Is = 5.95–4.38). The adaptability coefficient has confirmed the high adaptability of variety samples ‘k-3967 0144’, ‘15472 Sumphony’ and ‘15340 Uran’ (KA =112.3–108 %). In adaptive breeding for further work, the varieties ‘k-3967 0144’, ‘15584 Mutant 258’, ‘k-3954 0149’, ‘15472 Sumphony’, ‘15340 Uran’ are of great interest, since they are the most adaptive in terms of the sum of ranks. Based on a comprehensive estimation of productivity and adaptability parameters, ‘k-3967 0144’ was recognized as the best variety sample, which can give a large mean productivity (526 g/m2) in changing weather conditions.

An Ergonomic Flexible Multi-Fire Clip Applier With Multiple Degrees-of-Freedom for Minimally Invasive Surgery to Improve Hemostatic Efficiency

Abstract Hemorrhage can lead to shock and even death of patients, making one of the main risks in surgical procedures. Most traditional clip appliers are rigid, have limited flexibility, and can only fire a single clip within each insertion, which cannot meet the needs of surgeons to efficiently and flexibly control bleeding vessels. In this study, a novel hand-held Hem-o-lok clip applier is proposed, which is designed to have a high flexibility and allow multiple fires of clips. The wrist at the end effector consists of discrete joints and a flexible shaft, allowing bending in two directions. The tong head at the end effector enables multiple fires of hemostats and can be delivered to different positions for clamping blood vessels and human tissues. It also can be driven to rotate by the flexible shaft. Additionally, an ergonomic handle is designed to control the multiple degrees-of-freedom (DOFs) movements of the instrument tip. Finally, the effectiveness of the entire system is evaluated through performance experiments. The bending angle of end effector was about ±70 deg in both directions (yaw and pitch), and the rotation angle was ±160 deg. The measured gripping forces of the applier ranged from 16.70 N to 24.93 N, and the average time to complete three consecutive clamping was 8.67 s. The proposed clip applier could improve the hemostatic efficiency and allow an intuitive and flexible operation in the meantime.

Metal-Halogen Interactions Inducing Phase Separation for Self-Healing and Tough Ionogels with Tunable Thermoelectric Performance.

Ionic liquid-based thermoelectric gels become a compelling candidate for thermoelectric power generation and sensing due to their giant thermopower, good thermal stability, high flexibility, and low-cost production. However, the materials reported to date suffer from canonical trade-offs between self-healing ability, stretchability, strength, and ionic conductivity. Herein, a self-healing and tough ionogel (PEO/LiTFSI/EmimCl) with tunable thermoelectric properties by tailoring metal-halogen bonding interactions, is developed. Different affinities between polymer matrix and salts are exploited to induce phase separation, resulting in simultaneous enhancement of ionic conductivity and mechanical strength. Molecular dynamics (MD) simulations and spectroscopic analyses show that Cl- ions impair the lithium-ether oxygen coordination, leading to changes in chain conformation. The migration difference between cations and anions is thus widened and a transition from n-type to p-type thermoelectric ionogels is realized. Furthermore, the dynamic interactions of metal-ligand coordination and hydrogen bonding yield autonomously self-healing capability, large stretchability (2000%), and environment-friendly recyclability. Benefiting from these fascinating properties, the multifunctional PEO-based ionogels are applied in sensors, supercapacitors, and thermoelectric power generation modules. The strategy of tuning solvation dominance to address the trade-offs in thermoelectric ionogels and optimize their macroscopic properties offers new possibilities for the design of advanced ionogels.

Multi-frequency composite wearable antenna for wireless communications

Abstract This paper proposes a multi-band composite wearable antenna for wireless communication, which uses a monopole structure as the radiating body and achieves multi-band characteristics through slit-loading and multi-branching methods. A polymer composite substrate with high dielectric constant and low dielectric loss was prepared using in situ polymerization, and the optimal dielectric constant and loss angle tangent were obtained by controlling the coating ratio of melamine formaldehyde resin (MF) to carbon nanotubes (MWCNTs) and the filler doping rate to achieve miniaturization of the antenna. Comparative experimental results show that the obtained composites have high flexibility and good dielectric properties. The antenna operates in the frequency bands of 2.21-2.52
GHz, 3.07-3.87 GHz, and 4.36-6.03 GHz, which cover the frequency bands of WLAN and WiMAX and 5G applications. The antenna was fabricated and tested, and its performance roughly matched the simulation results. Meanwhile, the antenna has passed the SAR safety test and maintained a stable performance under different curvatures, so it has potential applications in the wireless communication system.

DEVELOPMENT OF HIGH-PERFORMANCE THERMOELECTRIC POLYMERS VIA DOPING OR DEDOPING ENGINEERING.

It is of great significance to develop high-performance thermoelectric (TE) materials, because they can be used to harvest waste heat into electricity and there is abundant waste heat on earth. The conventional TE materials are inorganic semimetals or semiconductors like Bi2Te3 and its derivatives. However, they have problems of high cost, scare/toxic elements, high thermal conductivity, and poor mechanical flexibility. Organic TE materials emerged as the next-generation TE materials because of their merits including solution processability, low cost, abundant element, low intrinsic thermal conductivity, and high mechanical flexibility. Organic TE materials are mainly conducting polymers because of their high conductivity. Both the conductivity and Seebeck coefficient depend on the doping level, and they are interdependent. Hence, the TE properties of polymers can be improved through doping/dedoping engineering. There are three types of doping forms, oxidative (or reductive) doping, protonic acid doping, and charge transfer doping. Accordingly, they can be dedoped by different approaches. In this article, we review the methods to dope and dedope p-type and n-type TE polymers and the combination of doping and dedoping to optimize their TE properties. Secondary doping is also covered, since it can significantly enhance the conductivity of some TE polymers.

Analytical Modeling and Validation of New Prismatic Compliant Joints Based on Zero Poisson’s Ratio Lattice Structures

Abstract The design and analysis of prismatic compliant joints have received less attention compared to that given to revolute compliant joints, thus limiting their implementation in compliant mechanisms beyond translational stages. Lattice structures have been used effectively to increase flexibility and stiffness ratios in compliant joints. Considering these, new prismatic compliant joints based on zero Poisson’s ratio lattice structures (ZP-PCJ) are proposed. Lattices with three different cell arrangements are considered: single cells, 2×2, and 3×3 lattices. Additionally, unit cells with three different geometries are studied: triangular, chamfer, and cosine. The compliance matrices of the ZP-PCJs are assembled analytically using Castigliano’s second theorem and compliance series–parallel simplification. The compliance ratios along the three orthogonal axes of the ZP-PCJs are computed varying their geometric parameters. Finite element models are constructed to validate the analytical results. Experimental tests are performed on additively manufactured ZP-PCJs to corroborate the compliance coefficients. Results showed that analytical models can predict the ZP-PCJ’s elastic properties accurately, differences less than 3% and 12% were obtained when compared to computational and experiments, respectively. Based on the compliance ratios obtained, the ZP-PCJs are suitable for two-dimensional applications. Finally, the ZP-PCJs are implemented in a compliant mechanism to evaluate their behavior, analytically and computationally. The ZP-PCJs have advantages such as eliminating axis drift and high flexibility in motion-direction while maintaining stiffness in other directions. The differences observed when comparing the analytically obtained estimations with simulations and experimental data suggest that ZP-PCJ analytical models are reliable for estimating their performance in compliant systems.