High Fasting Blood Sugar Levels Research Articles

Serum growth hormone and insulin in females without glucose intolerance

In the absence of glucose intolerance, fasting blood sugar levels are significantly higher in nonobese women in succeeding age decades. This upward trend with age in fasting blood sugar levels is not evident in obesity but such women, compared to the nonobese group, already have higher fasting blood sugar levels when they are just in the third decade of life. With but minor exceptions, the serum growth hormone and the serum insulin responses to an oral carbohydrate load recorded in nonobese women without glucose intolerance are of the same order of magnitude irrespective of age. This is also true in obese women without glucose intolerance. Obesity in women is associated with serum growth hormone levels which during fasting are lower than those observed in nonobese women. In obesity the peak growth hormone levels and the sum of the growth hormone levels recorded during an oral glucose tolerance test are lower than those observed in females of normal weight. During the first two hours of a normal oral glucose tolerance test in obese women a true and absolute hyperinsulinemia is recorded, but this is then replaced by waning of serum insulin below levels characteristic of a nonobese control group.

Manic-depressive illness, diabetes mellitus, and lithium carbonate.

OUR interest in the glucose metabolism of manic-depressive patients originated with the discovery of a diabetic condition in a patient whose complaints of polyuria, thirst, fatigue, and spells of profuse perspiration were initially interpreted as toxic manifestations of lithium carbonate therapy. In addition to a diabetic response to the glucose tolerance tests, a review of her hospital record revealed high-fasting blood sugar levels on several previous admissions. Similar findings among other manic-depressive patients formed the rationale of the following studies. Procedures Repeated glucose tolerance tests were performed on 42 manic-depressive patients hospitalized at Norwich Hospital. The diagnoses of these patients were independently agreed upon by the referring hospital and research staff, and confirmed by their past histories as documented in their hospital records. Most of these patients were readmissions and not on medication. Some patients were receiving lithium carbonate. A second glucose tolerance survey was carried out on

Edgar Schnohr. Diabetes treatment. (Acta chir Scand. V. LXXVIII, issue V-VI, pp. 513-544)

In diabetics who have various complications abscesses, arteriosclerotic or wet gangrene, etc., protamine insulinate acts more evenly and lastingly than ordinary insulin. With the administration of regular insulin in the morning and protamine insulinate in the evening, very high fasting blood sugar levels are reduced, without sharp fluctuations in blood sugar throughout the day.