High Equilibrium Research Articles

Using the Method of Measuring the Microhardness of Different Zones of Welded Joints to Assess the Strength Properties

Corrosion-resistant steels with a high nitrogen content are used as structural materials for high-load critical products. Their high strength and ductility, austenite stability, corrosion and wear resistance are highly relevant for parts and structures operating in marine environments. In addition to a high level of operational properties, they are subject to the requirement of manufacturability, including weldability. Welding of such steels, due to the high concentration of nitrogen, is a complex technological operation, and it is necessary to avoid the appearance of gas nitrogen pores, hot cracks, a sharp drop in mechanical properties in any zones of welded joint. In this work, we investigated the regularities of changes in microhardness in different zones of welded joints (base metal, heat-affected zone of the weld, fusion zone and weld metal) of two grades of austenitic Cr-Ni-Mn-Mo-N high-strength steels with a high equilibrium nitrogen content (up to 0.6%). They fundamentally differ in the structural state of the base metal being welded: deformed (hot-rolled sheet) and cast (metal of a heat-treated cast plate). It has been shown that despite the use of different welding methods (MIG, MMA and TIG), the options for welding fillers and the type of weld groove, there are general patterns for each of the two types of base metal. The work also evaluated the correlation between these regularities and such basic characteristics of the structure and properties of rolled and cast metal of welded joints, such as the grain size and values ​​of the yield stress.

Dynamic Covalent Reactions Controlled by Ring‐Chain Tautomerism of 2‐Formylbenzoic Acid

AbstractDynamic covalent chemistry (DCC) is an intensive area of research as it has found utility in the creation of molecular assemblies, complex systems, and ordered frameworks. Herein we demonstrate the development of dynamic covalent reactions (DCRs) of common N‐, O‐, and S‐mononucleophiles by controlling ring‐chain tautomerism of 2‐formylbenzoic acid. The regulation of distinct dual reactivity of interconverting open aldehyde and cyclic hemiacetal forms, the thermodynamic stabilization through chelation and delocalization, as well as the kinetic effect resulting from neighboring group participation, enabled the realization of DCRs of a broad range of alcohols, thiols, primary amines, and secondary amines exhibiting high efficiency and fast equilibrium. The dynamic nature of the system was verified through component exchange, and the switch of DCRs was achieved through the manipulation of substrate selectivity. The investigation of mechanism shed insights on the dependence of reaction pathways on nucleophiles, laying the foundation for future design and application.

Carbon nanotubes decorated hollow metal–organic frameworks for efficient solar-driven atmospheric water harvesting

• Hollow MIL-101(Cr) is formed by etching for fast water capture and release. • Carbon nanotubes decorated hollow MIL-101 promotes photothermal performance. • The hierarchical porous structure enhances the water affinity under low humidity. • The water uptake and release rates are the highest among those reported. High equilibrium uptake capacity and rapid adsorption/desorption kinetics are essential to achieve efficient atmospheric water harvesting. In this work, carbon nanotubes decorated hollow MIL-101(Cr) particles (HMC-2) are prepared and utilized for solar-driven atmospheric water harvesting with nice water adsorption capacity and fast kinetics. The hierarchical porous hollow MIL-101(Cr) particles formed by post-etching show highly active defect sites and low mass transfer resistance, which promotes the adsorption and diffusion of water molecules. The resulted HMC-2 demonstrates a maximum water uptake of 1.074 g/g at 25 °C, 90% RH. Notably, the water adsorption capacity of HMC-2 in low humidity (40% RH) are increased by 113% and 202.6% compared to pure MIL-101(Cr) and carbon nanotubes decorated MIL-101(Cr). Due to the synergistic effect of CNTs and hollow MIL-101(Cr), the HMC-2 composites generate sufficient solar thermal heat and improve the desorption kinetics. The maximum adsorbed water of HMC-2 can be completely desorbed within 90 min under one sunlight. A single cycle of sorption–desorption of HMC-2 can be achieved within 210 min. This means that if the water harvesting cycle is performed three times daily, it is possible to harvest 3.22 L of water per kilogram of adsorbent at the area with high humidity. The water uptake and release rates of HMC-2 are competitive with even superior to most those reported. This may demonstrate a promising potential for atmospheric water generators.

The formation of tonalitic and granodioritic melt from Venusian basalt

The crust of Venus is composed of the low lying volcanic planitiae and the elevated, deformed tesserae. It is thought that the tesserae may be composed of silicic igneous rocks and that it may resemble proto-continental crust. The initial development of terrestrial continental crust is likely due to melting and deformation of primitive mafic crust via mantle-plume upwelling and collisional plate processes. Unlike Earth, the lithosphere of Venus is not divided into plates and therefore evolved continental crust, if present, developed primarily by melting of pre-existing mafic crust. Here, we report the results of high pressure equilibrium partial melting experiments using a parental composition similar to the basalt measured at the Venera 14 landing site in order to determine if silicic melts can be generated. It was found that at pressures of 1.5 GPa and 2.0 GPa and temperatures of 1080 °C, 1090 °C, and 1285 °C that tonalitic and granodioritic melts can be generated. The experimental results indicate that silicic rocks may be able to form in the crust of Venus providing the thermal regime is suitable and that the lower crust is basaltic. The implication is that the older, thicker regions of Venusian crust may be partially composed of silicic igneous rocks.

Competition Between Hospitals Under Bundled Payments and Fee-for-Service: An Equilibrium Analysis of Insurer’s Choice

Problem definition: We consider the quality competition between two hospitals under the plan of one insurer. The insurer aims to maximize the overall achievable quality in the system by selecting either the fee-for-service (FFS) or the bundled payment (BP) scheme to compensate each hospital. The demand, the costs, and the probability of successfully treating patients depend on a hospital’s chosen quality. Under such a setting, we use game theoretic models to study the choice of insurer and the impact of payment schemes on the equilibrium qualities of hospitals. Our models seek answers to the following questions. Is BP (FFS) payment scheme always associated with high (low) equilibrium quality? What factors affect the equilibrium qualities of competing hospitals and the choice of the insurer and how? Academic/practical relevance: Competing hospitals under same or different payment models from an insurer is rather common for healthcare delivery in the United States. However, there is a lack of understanding about the impact of payment schemes on quality outcomes from both the hospital’s and the insurer’s perspective. To the best of our knowledge, ours is the first paper to incorporate competition and the insurer’s perspective to study the impact of different payment models on quality. Methodology: Game theory, equilibrium analysis. Results: We show that BP (FFS) is not always associated with high (low) equilibrium quality and that the equilibrium qualities of the two hospitals are strategic complements. We characterize when the insurer might assign the BP to both hospitals, the FFS to both hospitals, or the BP to one and the FFS to the other hospital. Managerial implications: Our findings provide prescriptive guidelines to an insurer choosing payment models. We also show that a specific quality outcome is achievable not by choosing any payment model but by a careful design of its parameters. Our numerical studies show that hospital readmission reduction initiatives are most effective when run in conjunction with cost reduction initiatives.

Methane Adsorption Behavior and Energy Variations of Brittle Tectonically Deformed Coal under High Temperature and High Pressure.

This paper aims to reveal the methane adsorption characteristics of brittle tectonically deformed coal (TDC) under high temperature and high equilibrium pressure and the surface free energy changes during methane adsorption. Taking the anthracite of the Yangquan mining area of China as the research object, methane adsorption tests of high temperature and high pressure were conducted to discuss the influences of coal deformation, temperature, and pressure on the gas adsorption behaviors of coal under the in situ conditions of deep coal seams. Results indicated that coal deformation and pressure had positive effects on the methane adsorption capacity of coal, whereas temperature showed negative effects. Meanwhile, the negative influences of temperature rise on gas adsorption gradually increased with the equilibrium pressure and the enhancement of coal deformation. In a given adsorption system, the adsorption potential decreased with increasing pressure while increased with temperature. In contrast, the adsorption space increased with increasing pressure and decreased with temperature rise. Meanwhile, adsorption potential decreased with the increase in adsorption space. In the process of methane adsorption, with increasing adsorption pressure, the cumulative reduction of surface free energy gradually increased, whereas the surface free energy reduction at each pressure point decreased. The cumulative and incremental reduction of surface free energy at each pressure point gradually decreased with the increase in temperature. The reduction of adsorption space and cumulative surface free energy and the changes in surface free energy at each pressure point of brittle TDCs were higher than those of primary structure coal, and the changes in the strongly deformed coal (granulitic and mortar coal) were more significant than those of the weakly deformed coal (cataclastic coal). Based on the adsorption potential theory, we drew the adsorption characteristic curves and established adsorption capacity prediction models of primary structure coal and brittle TDCs.

Selective crystal growth of indium selenide compounds from saturated solutions grown in a selenium vapor

Indium selenide compounds are promising materials for energy conversion, spintronic applications, and chemical sensing. However, it is difficult to grow stoichiometric indium selenide crystals due to the high equilibrium selenium vapor pressure and the complicated phase equilibrium system of indium selenide compounds. In this paper, we apply a novel and convenient crystal growth method, in which the saturated solution is grown by the application of a selenium vapor. In this method, selenium vapor at a pressure higher than the saturated vapor pressure is applied to molten indium, such that the selenium continuously dissolves into the indium solution until the solubility at the growth temperature is reached; then a slow cooling process results in crystallization. The selenium dose is matched to its solubility so that indium selenide compounds can be selectively grown just by controlling the temperature without the need to consider the chemical ratio in the solution. The pressure of the vapor is controlled during the whole growth process so that any deviation from a stoichiometric composition in the crystal can be controlled. Both InSe and In2Se3 were successfully grown using this method, and we have investigated the growth mechanism and found the growth window for each compound. This study presents a novel and convenient approach to fabricating transitional metal chalcogenides without deficiencies in the chalcogen element.

On the persistence of lower-dimensional tori in reversible systems with high dimensional degenerate equilibrium under small perturbations

<p style='text-indent:20px;'>This paper focuses on the persistence of lower-dimensional tori in reversible systems with high dimensional degenerate equilibrium under small perturbations. By an improved KAM iteration and Topological degree theory, we prove that the invariant torus with given frequency persists under small perturbations. Our result is a generalization of X. Wang et al [On the persistence of degenerate lower-dimensional tori in reversible systems, Ergodic Theory Dynam. Systems, 35(2015), 2311-2333].</p>

Metal oxide-based macroporous ordered double affinity molecularly imprinted polymer for specific separation and enrichment of glycoprotein from food samples: a co-modification of DMSA and boronate affinity.

Metal oxide-based macroporous ordered double affinity molecularly imprinted polymers (D-MIPs) were developed as solid phase extraction (SPE) adsorbents for the specific identification of ovalbumin (OVA) under physiological pH conditions prior to ultraviolet visible (UV-vis) spectrophotometric detection. Herein, macroporous alumina (MA) was used as a matrix; dimercaptosuccinic acid (DMSA) and 3-aminophenylboric acid (APBA) were employed as dual-functional monomers; APBA is a self-polymerizing monomer. The effects of synthesis conditions, SPE conditionsas well as selectivity, reproducibility, and reusability were studied. The co-modification of DMSA and boronate affinity renders the adsorbent exhibiting a high adsorption capacity (114.4mgg-1) and short equilibrium time (30min). The surface imprinting technology causes the adsorbent to have high selectivity towards OVA. The OVA recovery range is 91.1-99.6%. This study provides a promising method for the enrichment of OVA and other cis-diol-containing analytes in complex biological samples. A novel metal oxide-based macroporous ordered nanoparticle with a combination of DMSA and boronate affinity was successfully prepared for specific separation and enrichment of glycoprotein from complex biological samples.

Pyrazine-cored covalent organic frameworks for efficient CO2 adsorption and removal of organic dyes

Two pyrazine-cored COFs have been synthesized, and show high CO2 uptake and rapid adsorption equilibrium and high adsorption capacity for rhodamine B, methylene blue, Congo red and gentian violet.

BIFURCATIONS AND EXACT TRAVELING WAVE SOLUTIONS FOR THE GENERALIZED NONLINEAR SCHRÖDINGER EQUATION WITH WAVE OPERATOR

<abstract> In this paper, we investigate the dynamical bifurcations and exact traveling wave solutions for the generalized nonlinear Schrödinger equation with wave operator under different parametric conditions by means of the theory of singular system. We analyse the high order equilibrium point and give the phase portraits. We obtain many results under different values of the parameter $ p $ reflecting the strength of the nonlinearity in the model. For $ p = 1 $, we find explicit exact solutions of Jacobian elliptic functions type which is corresponding to the curves given by $ H(\phi, y) = h $. According to the qualitative analysis of the phase portraits, we give the conclusions on the existence of solitary wave solutions and periodic wave solutions when $ p\geq\frac{1}{2} $. In addition, we obtain the only explicit exact solitary wave solution corresponding to the curves given by $ H(\phi, y) = 0 $ for any $ p $. Especially, we obtain some explicit exact double periodic solutions of elliptic functions type for $ p = \frac{1}{2} $. </abstract>

Unblocking a rigid purine MOF for kinetic separation of xylenes.

The separation of xylene isomers still remains an industrially challenging task. Here, porous purine-based metal-organic frameworks (MOFs) have been synthesized and studied for their potential in xylene separations. In particular, Zn(purine)I showed excellent para-xylene/ortho-xylene separation capability with a diffusion selectivity of 6 and high equilibrium adsorption selectivity as indicated by coadsorption experiments. This high selectivity is attributed to the shape and size of the channel aperture within the rigid framework of Zn(purine)I.

DETERMINANTS OF THE PERFORMANCE OF MICROFINANCE BANKS IN CANE ENHANCING AND ITS IMPACT ON SUGAR INDUSTRY OF SINDH

Sugar cane is the second biggest cash crop of Pakistan, which contributes 3.4% to national income and 0.7 percent in gross domestic product as well sugar cane provides ecologically best stimulus for economic development. We cannot refute the importance of sugar cane cultivator’s participation in this sector. This research study is organized to identify Determinants of the Performance Microfinance Banks in Cane Enhancing and its Impact on Sugar Industry of Sindh. Data was collected from 250 respondents were interviewed Sugar Cane Growers (SCG) and Agriculture Expert (AE) as well-structured through purposive sampling technique within asymmetric survey methodology conducted. SCG and AE remains 63% respondents were illiterate and their main occupation crop cultivation of sugar cane crop 76.7% respondents cultivating less than 12.5 acres and 20% respondents cultivating less than 25.0 acres in Sindh which is the largest population around 70% families stays in below the poverty line. This area demand attention. Sugar Cane is an integral part of agriculture and this sector is fulfilling the provincial demand of the country. State should support and privilege the efforts of the SCG and AE for grow up and help them to crop cultivation for extent of the on-farm practices on high input cost and equal income equilibrium as far as cultivation high input costing so they can get guidance of Prudential Regulations and Agriculture Financing for the take care of them, on farm activities and pricing should have to subsidized. Micro finance institutions should play an integral part for sustainable economic agriculture development, going forward research emphasis to empower sugar cane population in which the segment should grow. The government and Microfinance banks should focus on promotion and paid participation in agricultural activities, monetary benefits as well as power of decision making with the recognition of their work. Keywords: Production Cost, Agricultural Labor Markets, Support Price, Agriculture, Irrigation, Research and Development.

Passivation of Recirculating Open Water Cooling Systems Using New Organic Passivator

It is well know that recirculating open cooling water system at metal/ water surface contact appear frequent corrosion products, like scales, foaling and material losses which are have great effect on cooling process. Passivation helps to maintain clean heat transfer surface by inhibiting oxides scales through creating outer passive layer. Passivators are substances which usually have a sufficiently high equilibrium potential and sufficiently low over potential decrease corrosion rate on attainment of passivity. One of the most popular passivator is organic phosphate Phosphinosuccinic oligomer C15H14O4P component (PSO) The study of passivation of carbon steel pipe line in recirculating open cooling water system was the aim of this present work. Maximum efficiency of passivator was determined and surface morphology were investigated using optical, scanning microscopy, phase analysis of the formed protective layer was exam by XRD and EDX. Corrosion in running water with and without PSO at 2 m3/hr flow rate was investigated using corrosion coupon rack. It was found that 200 ppm (PSO) decreases corrosion rate of carbon steel pipe in 3.5% NaCL solution from 23 to 7 mpy in stagnate water corrosion testing, while in running water in 3.5% NaCL solution it decreases from 45 to 18 mpy. XDR showed that the protective layer due to passivation is mainly Magnetite (Fe3O4) compound.

Lessons from the Japanese ninja: on achieving a higher trade equilibrium under anarchy and private constitutions

This paper investigates the possibility of anarchy achieving a high trade equilibrium via the example of ninja communities in Japan. Initially, ninjas in the mountainous regions of Iga and Kōka were stateless, constantly feuded, and had few opportunities for exchange. With the advent of civil war in the sixteenth century, ninjas’ economic conditions changed. The mercenary market significantly expanded and presented great profit opportunities for the ninjas. However, instead of creating a formal government to move to a higher trade equilibrium, the ninjas resorted to forming voluntary confederations held together by private constitutions. I argue that this development was possible because the institutional environment of the Sengoku period enabled a framework of self-governing institutions and principles. The ninjas were able to build on this framework with very low organizational costs. As a result, the ninjas were able to reap large economic gains on the mercenary market while remaining stateless—a seemingly paradoxical development that goes against the standard dichotomy of “states and thick markets” versus “anarchy and thin markets.”

Male Age and Wolbachia Dynamics: Investigating How Fast and Why Bacterial Densities and Cytoplasmic Incompatibility Strengths Vary.

ABSTRACTEndosymbionts can influence host reproduction and fitness to favor their maternal transmission. For example, endosymbiotic Wolbachia bacteria often cause cytoplasmic incompatibility (CI) that kills uninfected embryos fertilized by Wolbachia-modified sperm. Infected females can rescue CI, providing them a relative fitness advantage. Wolbachia-induced CI strength varies widely and tends to decrease as host males age. Since strong CI drives Wolbachia to high equilibrium frequencies, understanding how fast and why CI strength declines with male age is crucial to explaining age-dependent CI’s influence on Wolbachia prevalence. Here, we investigate if Wolbachia densities and/or CI gene (cif) expression covary with CI-strength variation and explore covariates of age-dependent Wolbachia-density variation in two classic CI systems. wRi CI strength decreases slowly with Drosophila simulans male age (6%/day), but wMel CI strength decreases very rapidly (19%/day), yielding statistically insignificant CI after only 3 days of Drosophila melanogaster adult emergence. Wolbachia densities and cif expression in testes decrease as wRi-infected males age, but both surprisingly increase as wMel-infected males age, and CI strength declines. We then tested if phage lysis, Octomom copy number (which impacts wMel density), or host immune expression covary with age-dependent wMel densities. Only host immune expression correlated with density. Together, our results identify how fast CI strength declines with male age in two model systems and reveal unique relationships between male age, Wolbachia densities, cif expression, and host immunity. We discuss new hypotheses about the basis of age-dependent CI strength and its contributions to Wolbachia prevalence.

Two-Dimensional Nanomaterials for the Removal of Pharmaceuticals from Wastewater: A Critical Review

The removal of pharmaceuticals from wastewater is critical due to their considerable risk on ecosystems and human health. Additionally, they are resistant to conventional chemical and biological remediation methods. Two-dimensional nanomaterials are a promising approach to face this challenge due to their combination of high surface areas, high electrical conductivities, and partially optical transparency. This review discusses the state-of-the-art concerning their use as adsorbents, oxidation catalysts or photocatalysts, and electrochemical catalysts for water treatment purposes. The bibliographic search bases upon academic databases including articles published until August 2021. Regarding adsorption, high removal capacities (&gt;200 mg g−1) and short equilibrium times (&lt;30 min) are reported for molybdenum disulfide, metal-organic frameworks, MXenes, and graphene oxide/magnetite nanocomposites, attributed to a strong adsorbate-adsorbent chemical interaction. Concerning photocatalysis, MXenes and carbon nitride heterostructures show enhanced charge carriers separation, favoring the generation of reactive oxygen species to degrade most pharmaceuticals. Peroxymonosulfate activation via pure or photo-assisted catalytic oxidation is promising to completely degrade many compounds in less than 30 min. Future work should be focused on the exploration of greener synthesis methods, regeneration, and recycling at the end-of-life of two-dimensional materials towards their successful large-scale production and application.

Equilibrium, Kinetic and Thermodynamic Studies on Adsorption of Penoxsulam in Punjab Soils

ABSTRACT Adsorption desorption behavior of herbicide in soil plays important role in assessing the fate of herbicide. Batch equilibrium method was used to assess the effect of physicochemical properties of soil and temperature on adsorption-desorption of penoxsulam in Punjab soils under laboratory conditions. The adsorption of penoxsulam in studied soils followed pseudo-second-order kinetics and fitted well into Freundlich and Langmuir model. Freundlich adsorption coefficient varied from 0.858 to 1.585 µg1−1/n g−1ml1/n indicating strong binding of penoxsulam on soil matrix. Adsorption increased with increase in temperature and thermodynamic parameters showed that adsorption process was feasible, spontaneous and endothermic. Desorption was slow with hysteresis coefficient ranging from 0.016 to 0.207. Adsorption was dominant by surface adsorption at low equilibrium concentration while partition at high equilibrium concentration. Principal component analysis (PCA) indicated that penoxsulam was moderately mobile in soil and can potentially contaminate groundwater. Highest leachability of penoxsulam was in loamy sand followed by sandy loam, loam, silt loam and clay loam. Remedial methods like the addition of organic amendments helps in reducing downward movement of penoxsulam and avoid its potential adverse effects.

Robust and porous 3D-printed multifunctional hydrogels for efficient removal of cationic and anionic dyes from aqueous solution

A porous multi-layered nanocomposite hydrogel, made of poly (ethylene oxide) (PEO) and cellulose nanocrystals (CNCs), suitable for the selective adsorption of different organic dyes has been developed via 3D printing. To obtain cationic and anionic CNCs and to facilitate the adsorption of positive and negative dyes, CNCs were modified. The cross-linked nanocomposite bioink was 3D printed to form a porous multilayered hydrogel with oppositely charged layers. SEM images revealed that surface charge has a predominant effect on the porous structure of hydrogel layers. The cationic hydrogel layer exhibited a large degree of randomness in pore size and geometry, however, ionic layers displayed well-organized pore structure. The cationic and anionic layer presented pore size in the range of 10–40 μm, and 10–30 μm, respectively. Surprisingly, the observed distance between adjacent layers and delamination phenomenon suggested missing adherence between layers due to long printing time, cooling temperature, and different chemical structures in adjacent layers. 3D printed hydrogels exhibited high equilibrium swelling ratios at different levels of pH (i.e., 4, 5, 8, and 9), while fastest swelling was observed at pH 8 and pH 9.An approximate 75% of maximum adsorption ratios was observed within the first 3 h of exposure. The hydrogel exhibited almost twice the adsorption capacity for MB in comparison with MG in the pH levels studied in this work. The maximum adsorption capacity for MB and MG was observed at pH 9 for 95.23 and 82.39%, respectively. The kinetics of adsorption was analyzed via pseudo-first and second orders, and Langmuir models. The adsorption kinetics followed the pseudo-second-order model well while equilibrium adsorption from the pseudo-first order and Langmuir exhibited a large difference with experimental data. The work provides promising results for the development of CNC-PEO materials as a multilayered adsorbent for effective and efficient dye decontamination of the wastewater. • A novel CNC hydrogel with positive and negative layers was fabricated via bioprinting. • Well organized porous structure was observed in anionic hydrogel layers. • The cationic hydrogel layer exhibited a non-uniform pore size and geometry. • The hydrogel exhibited excellent adsorption capacity for cationic and anionic dye particles in an aqueous solution. • The sorption kinetic follows pseudo-second-order model.

Photo-crosslinked hyaluronic acid hydrogel as a biomimic extracellular matrix to recapitulate in vivo features of breast cancer cells

2D cell culture is widely utilized to develop anti-cancer drugs and to explore the mechanisms of cancer tumorigenesis and development. However, the findings obtained from 2D culture often fail to provide guidance for clinical tumor treatments since it cannot precisely replicate the features of real tumors. 3D tumor models capable of recapitulating native tumor microenvironments have been proved to be a promising alternative technique. Herein, we constructed a breast tumor model from novel hyaluronic acid (HA) hydrogel which was prepared through photocrosslinking of methacrylated HA. The hydrogel was used as a biomimetic extracellular matrix to incubate MCF-7 cells. It was found that methacrylation degree had great effects on hydrogel’s microstructure, mechanical performances, and liquid-absorbing and degradation abilities. Optimized hydrogel exhibited highly porous morphology, high equilibrium swelling ratio, suitable mechanical properties, and hyaluronidase-responsive degradation behavior. The results demonstrated that the HA hydrogel facilitated MCF-7 cell proliferation and growth in an aggregation manner. Furthermore, 3D-cultured MCF-7 cells not only up-regulated the expression of VEGF, bFGF and interleukin-8 but exhibited greater invasion and tumorigenesis capabilities compared with 2D-cultured cells. Therefore, the HA hydrogel is a reliable substitute for tumor model construction.