The sensing performance of the Bragg fiber having a defect layer in the cladding region is optimized for brain cancer cell detection using the refractive index of brain lesions fluids. The optimization is achieved by comparing the confinement loss of low contrast and a high contrast defected Bragg fiber with similar standard Bragg fiber. Using the transfer matrix method and matching the fields at various interfaces equation of confinement loss is obtained in presence of a defect layer. It is observed that the sensing performance of low contrast waveguide is better than high contrast waveguide in the absence of the defect layer but the situation become reversed in presence of a defect layer. Wavelength interrogation shows high sensing performance with the variation of defect layer refractive index while intensity interrogation shows high sensing performance with the variation of core refractive index. Here wavelength interrogation of high contrast defected Bragg fiber is demonstrated to detect normal and abnormal brain tissues due to its feasibility. Our analysis shows that the respective maximum sensitivity, detection accuracy, and quality parameters are 12.1519 nm/RIU, 4365.7235, and 41.6161 RIU−1 in the benign stage corresponding to the wall of brain and 11.0233 nm/RIU, 4242.7191 and 38.8281 RIU−1 in the malignant stage corresponding to low-grade glioma.
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