Phaseolus vulgaris is the most important legume for its nutritional value and health benefits in Mexico. In this research mineral content, bioactive compounds and antioxidant activity of 18 bean collections were analyzed. Different grain beans were collected in rural communities in 12 municipalities of the state of Tabasco, Mexico and carried out from March to June 2018. They were analyzed for mineral content (N, P, K, Ca, Mg, Fe, Zn, Mn and Ni), proximal bromatological analysis (ash, crude fat, crude fiber and protein), phenolic compounds content (total phenols, flavonoids and anthocyanins) and antioxidant activity. The contents of zinc were low in all bean collections; additionally, collections C104, C109 and C113 recorded the highest concentration of total phenols (55.45 mg GA g-1), flavonoids (1.46 mg CE g-1) and anthocyanins (2.87 mg C3G g-1) and antioxidant capacity (91.05%) respectively. This study has shown that common bean varieties grown in the state of Tabasco have high biological and antioxidant potential that could be beneficial to human health when consumed as nutraceutical foods.