ISEE-210 Objective: Inhalation of hexavalent chromium [Cr(VI)] has been shown to cause lung cancer among workers in certain industries. Incidental ingestion and redistribution of inhaled particles to the gastrointestinal track theoretically exposes stomach tissue to airborne Cr(VI). Numerous epidemiologic studies have examined the association between occupational exposure to Cr(VI) and stomach cancer, and a previous meta-analysis included studies evaluating cancer risk from both hexavalent and trivalent forms. However, to date, no consensus regarding causality has been reached. We conducted a meta-analysis of 34 epidemiologic studies that evaluated occupational exposure to Cr(VI) and risk of stomach cancer. Material and Methods: Cohort and case-control studies that were published in the scientific literature between January 1, 1900, and December 1, 2006, were included. We used a random-effects model to calculate meta-SMRs for results abstracted from (1) the entire cohort, (2) a subcohort of workers considered to be more likely exposed to Cr(VI), and (3) subgroups of studies based on design, origin of study, level of exposure, and control for potential confounding from smoking or socioeconomic status (SES). We evaluated heterogeneity across studies and conducted sensitivity and influence analyses. Results: The meta-analysis for stomach cancer produced meta-SMR estimates of 0.95 (95% CI 0.82–1.11) for the total cohort, and 0.99 (95% CI 0.83–1.18) for the subcohort of workers more likely to be exposed. Meta-SMR results did not vary by level of exposure to Cr(VI) (high, medium, or low), region of the world where the cohort was located (Asia, Europe, North America, Scandinavia), or statistical control applied in analyses for SES or smoking. Conclusions: This meta-analysis of occupational studies of workers does not provide support of a causal association between exposure to Cr(VI) and stomach cancer.