Heterogeneous Texture Research Articles

Bioremediation of petroleum-contaminated soil based on both toxicity risk control and hydrocarbon removal-progress and prospect.

Petroleum contamination remains a worldwide issue requiring cost-effective bioremediation techniques. However, establishing a universal bioremediation strategy for all types of oil-polluted sites is challenging. This difficulty arises from the heterogeneity of soil textures, the complexity of oil products, and the variations in local climate and environment across different oil-contaminated regions. Several factors can impede bioremediation efficacy: (i) differences in bioavailability and biodegradability between aliphatic and aromatic fractions of crude oil; (ii) inconsistencies between hydrocarbon removal efficiency and toxicity attenuation during remediation; (iii) varying adverse effect of aliphatic and aromatic fractions on soil microorganisms. This review examines the ecotoxicity risk of petroleum contamination to soil fauna and flora. It also discusses three primary bioremediation strategies: biostimulation with nutrients, bioaugmentation with petroleum degraders, and phytoremediation with plants. Based on current research and state-of-the-art challenges, we highlighted future research scopes should focus on (i) exploring the ecotoxicity differentiation of aliphatic and aromatic fractions of crude oil, (ii) establishing unified risk factors and indicators for evaluating oil pollution toxicity, (iii) determining the fate and transformation of aliphatic and aromatic fractions of crude oil using advanced analytical techniques, and (iv) developing combined bioremediation techniques that improve petroleum removal and ecotoxicity attenuation.

Texture analysis can predict response to etoposide-doxorubicin-cisplatin in patients with adrenocortical carcinoma.

The adrenocortical carcinoma (ACC) is a rare and highly aggressive malignancy originating from the adrenal cortex. These patients usually undergo chemotherapy with etoposide, doxorubicin, cisplatin and mitotane (EDP-M) in case of locally advanced or metastatic ACC. Computed tomography (CT) radiomics showed to be useful in adrenal pathologies. The study aimed to analyze the association between response to EDP-M treatment and CT textural features at diagnosis in patients with locally advanced or metastatic ACCs. We enrolled 17 patients with advanced or metastatic ACC who underwent CT before and after EDP-M therapy. The response to treatment was evaluated according to RECIST 1.1, Choi, and volumetric criteria. Based on the aforementioned criteria, the patients were classified as responders and not responders. Textural features were extracted from the biggest lesion in contrast-enhanced CT images with LifeX software. ROC curves were drawn for the variables that were significantly different (p < 0.05) between the two groups. Long-run high grey level emphasis (LRHGLE_GLRLM) and histogram kurtosis were significantly different between responder and not responder groups (p = 0.04) and the multivariate ROC curve combining the two features showed a very good AUC (0.900; 95%IC: 0.724-1.000) in discriminating responders from not responders. More heterogeneous tissue texture of initial staging CT in locally advanced or metastatic ACC could predict the positive response to EDP-M treatment. Adrenal texture is able to predict the response to EDP-M therapy in patients with advanced ACC.

Tunable Topological Wetting State of Water Droplets on Planar Surfaces: Closed-Loop Chemical Heterogeneity by Design.

Understanding droplet wetting on surfaces has broad implications for surface science and engineering. Here, we report a joint theoretical/experimental study of the topological wetting states of water droplets on chemically heterogeneous closed-loop and planar surfaces. Interestingly, we provide both simulation and experimental evidence of biloop or even multiloop transition wetting states of water droplets. Specifically, in our molecular dynamics simulations, we designed surfaces patterned with alternating closed-loop superhydrophilic and hydrophobic nanobands. On these surfaces, we find that the contact shape and contact angle of water nanodroplets can be tailored by changing the shape of the nanobands. Overall, the contact angle of the droplets is dependent on the initial location of the water droplet, the interaction between the water molecules and hydrophobic particles, and the width of the superhydrophilic and hydrophobic nanobands. The wetting-state transition dynamics is also dependent on the nanoband shape. In the biloop or multiloop transition wetting states, the three-phase contact line is not limited to only one loop nanoband but can be located at two or more distinct loops. Guided by the simulation results, the corresponding experiments confirmed the presence of topological wetting states and multiloop wetting states on planar chemically heterogeneous surfaces with closed-loop microbands. Importantly, we provide an explanation of the mechanism of the topological wetting state formation and transition. Our study facilitates a deeper understanding of the droplet-surface interactions and offers an alternative way to tune the droplet shape and contact angle on planar surfaces by engineering chemically heterogeneous surface textures.

The prognostic value of [18F]FDG PET/CT texture analysis prior to transplantation for unresectable colorectal liver metastases.

To determine whether heterogeneity in colorectal liver metastases (CRLM) 18F fluorodeoxyglucose [18F]FDG distribution is predictive of disease-free survival (DFS) and overall survival (OS) following liver transplantation (LT) for unresectable CRLM. The preoperative [18F]FDG positron emission tomography/computed tomography examinations of all patients in the secondary cancer 1 and 2 studies were retrospectively assessed. Maximum standardized uptake value (SUVmax), metabolic tumour volume (MTV), and six texture heterogeneity parameters (joint entropyGLCM, dissimilarityGLCM, grey level varianceSZM, size zone varianceSZM, and zone percentageSZM, and morphological feature convex deficiency) were obtained. DFS and OS for patients over and under the median value for each of these parameters were compared by using the Kaplan Meier method and log rank test. Twenty-eight out of 40 patients who underwent LT for unresectable CRLM had liver metastases with uptake above liver background and were eligible for inclusion. Low MTV (p < 0.001) and dissimilarityGLCM (p = 0.016) were correlated to longer DFS. Low MTV (p < 0.001) and low values of the texture parameters dissimilarityGLCM (p = 0.038), joint entropyGLCM (p = 0.015) and zone percentageSZM (p = 0.037) were significantly correlated to longer OS. SUVmax was not correlated to DFS and OS. Although some texture parameters were able to significantly predict DFS and OS, MTV seems to be superior to predict both DFS and OS following LT for unresectable CRLM.

Assessing abdominal aortic aneurysm growth using radiomic features of perivascular adipose tissue after endovascular repair

ObjectivesThe study aimed to investigate the relationship between the radiomic features of perivascular adipose tissue (PVAT) and abdominal aortic aneurysm (AAA) growth after endovascular aneurysm repair (EVAR).MethodsPatients with sub-renal AAA who underwent regular follow-up after EVAR between March 2014 and March 2024 were retrospectively collected. Two radiologists segmented aneurysms and PVAT. Patients were categorised into growing and non-growing groups based on volumetric changes observed in two follow-up computed tomography examinations. One hundred seven radiomic features were automatically extracted from the PVAT region. Univariable and multivariable logistic regression was performed to analyse radiomic features and clinical characteristics. Furthermore, the performance of the integrated clinico-radiological model was compared with models using only radiomic features or clinical characteristics separately.ResultsA total of 79 patients (68 ± 9 years, 89% men) were enroled in this study, 19 of whom had a growing aneurysm. Compared to the non-growing group, PVAT of growing AAA showed a higher surface area to volume ratio (non-growing vs growing, 0.63 vs 0.70, p = 0.04), and a trend of low dependence and high dispersion manifested by texture features (p < 0.05). The area under the curve of the integrated clinico-radiological model was 0.78 (95% confidence intervals 0.65–0.91), with a specificity of 87%. The integrated model outperformed models using only radiomic or clinical features separately (0.78 vs 0.69 vs 0.69).ConclusionsHigher surface area to volume ratio and more heterogeneous texture presentation of PVAT were associated with aneurysm dilation after EVAR. Radiomic features of PVAT have the potential to predict AAA progression.Clinical relevance statementRadiomic features of PVAT are associated with AAA progression and can be an independent risk factor for aneurysm dilatation to assist clinicians in postoperative patient surveillance and management.Key PointsAfter EVAR for AAA, patients require monitoring for progression.PVAT surrounding growing AAA after EVAR exhibits a more heterogeneous texture.Integrating PVAT-related features and clinical features results in better predictive performance.Graphical

Enhancing permeability estimation methods in Brazilian pre-salt complex carbonate reservoirs

Carbonate pre-salt reservoirs pose formidable challenges for formation evaluation and estimation of petrophysical properties such as rock flow capacity. The high complexity of the pore system and its textural heterogeneity often lead to poor predictions when using conventional formation evaluation methods. This paper discusses and tests the applicability of two approaches to calculate the absolute permeability curves for the carbonate reservoirs of the Barra Velha Formation in the Santos Basin, proposing a fine-tuned workflow for these complex rocks. In developing our workflow, we used data from a case study well, comprising a complete well log suite and two formation tests, and routine core analysis results (RCAL) in core plugs and sidewall cores. Our workflow consists of: (1) reinterpreting the nuclear magnetic resonance (NMR) log in vugular intervals by decomposing the transversal relaxation time spectra; (2) calculating the absolute permeability by the Timur–Coates model and adjusting the coefficients with the RCAL results from representative samples; (3) applying the Flow Zone Indicator (FZI) method for rock typing to optimally define Hydraulic Flow Units (HFU); (4) checking the consistency of HFUs regarding pore geometry and lithological characteristics; (5) evaluating the performance of the models against core data and formation tests. The predicted permeability curves performed well for the NMR and FZI models when compared to the RCAL data from representative samples, with mean absolute errors for the logarithm of permeabilities equal to 0.78 and 0.87, respectively. This represents an improvement of 15% and 5% when compared to the simplistic approach that uses a power law to relate porosity to permeability from RCAL. These curves also reasonably reproduce the results from the formation tests for the top part of the reservoir, where matrix porosity dominates the flow. However, the NMR and FZI permeability curves underestimate the test results at the bottom part of the reservoir, where karstic and fracture features dominate, demonstrating limitations in these permeability estimation methods for this specific scenario. From our observations, we propose several improvements to enhance the current methods for estimating absolute permeability in pre-salt carbonate reservoirs. In the case of the NMR approach, it is essential to consider the effects of mud invasion in vugs for the correct estimation of the proportions of free and irreducible fluids. In the FZI approach, optimization in defining the quantity and limits of hydraulic flow units is important, which shows that four units are sufficient to represent the reservoir interval.

Hierarchical modification of bimodal grain structure in Al/Ti laminated composites for extraordinary strength-ductility synergy

Al/Ti laminates with altering Al grain sizes was fabricated via hot press sintering. Fine Al powders results in low sintering density and obvious cracks at Al/Ti interface. Large Al powders greatly increased the grain size, grain aspect ratio, LAGBs fraction, and recrystallization fraction of the Al layers. The texture heterogeneity is also significant, with rolling texture in Ti layer and random texture in Al layer. Ti5Si3 phase precipitated at Al/Ti interface, and it gradually partitioned Ti atoms from TiAl3 and hindered the formation of TiAl3. Moreover, numerous stacking faults, dislocation loops, dislocation pinning, and dislocation tangles were observed at Al/Ti interface, resulting in an increased back stress. Large Al grains contributes the highest bending strength of 734.8 MPa, tensile strength of 753.2 MPa, and fracture strain of 62 %. The effect of grain size on work hardening was attributed to the fraction of LAGBs, dislocation storage capacity and additional HDI strengthening.

Synchronous improvement in strength and ductility of Cu-bearing stainless steels through formation of bimodal grain structure induced by short-time electric pulses

Excellent strength and favorable formability are two important mechanical properties of stainless steel, but there is usually a trade-off between both properties. However, it has been suggested in recent studies that preparing microstructures with a non-homogeneous structure can effectively achieve strength-ductility synergy. Given these facts, a microstructure with bimodal grain structures was prepared in this study by short-time electric pulse treatment (EPT). Besides, the evolution of microstructures and mechanical properties of Cu-bearing stainless steel during EPT was analyzed. The results demonstrated that the non-uniform heating in the EPT process can rapidly promote localized grain growth, thus forming a bimodal grain structure compared with conventional heat treatment. The microstructure of the fine grains formed random textures, while the coarsened grains showed stronger textures. After EPT, the amount of S {123} < 634 < 634 >-type textures increased significantly, with the proportion reaching up to 30.1 %. There was also a certain amount of brass {110} < 112 >- and copper {112} < 111 >-type textures. Compared with the solution-treated samples, the best overall mechanical properties were detected under the optimal electric pulse parameters, which ultimately realized a synergistic increase of 11.8 % and 10.2 % in the ultimate tensile strength and ductility. The excellent strength-ductility synergy was closely related to heterogeneous deformation-induced (HDI) strengthening and textures induced by the bimodal grain structure. This finding may provide novel insights for enhancing the formability of biomedical metallic materials.

Textural heterogeneity of liver lesions in CT imaging - comparison of colorectal and pancreatic metastases.

Tumoral heterogeneity poses a challenge for personalized cancer treatments. Especially in metastasized cancer, it remains a major limitation for successful targeted therapy, often leading to drug resistance due to tumoral escape mechanisms. This work explores a non-invasive radiomics-based approach to capture textural heterogeneity in liver lesions and compare it between colorectal cancer (CRC) and pancreatic cancer (PDAC). In this retrospective single-center study 73 subjects (42 CRC, 31 PDAC) with 1291 liver metastases (430 CRC, 861 PDAC) were segmented fully automated on contrast-enhanced CT images by a UNet for medical images. Radiomics features were extracted using the Python package Pyradiomics. The mean coefficient of variation (CV) was calculated patient-wise for each feature to quantify the heterogeneity. An unpaired t-test identified features with significant differences in feature variability between CRC and PDAC metastases. In both colorectal and pancreatic liver metastases, interlesional heterogeneity in imaging can be observed using quantitative imaging features. 75second-order features were extracted to compare the varying textural characteristics. In total, 18 radiomics features showed a significant difference (p < 0.05) in their expression between the two malignancies. Out of these, 16 features showed higher levels of variability within the cohort of pancreatic metastases, which, as illustrated in a radar plot, suggests greater textural heterogeneity for this entity. Radiomics has the potential to identify the interlesional heterogeneity of CT texture among individual liver metastases. In this proof-of-concept study for the quantification and comparison of imaging-related heterogeneity in liver metastases a variation in the extent of heterogeneity levels in CRC and PDAC liver metastases was shown.

Morphological and immunohistochemical characteristics of diffuse seminoma in horses: A case report.

The present study describes the morphological and immunohistochemical characteristics of a case of diffuse seminoma in a 16-year-old male mixed-breed horse. According to the owner, the animal's left testicle had been gradually increasing in size over a period of 2 months. On palpation, the testicle had a firm consistency, with no sensitivity to digital pressure, was adhered to the scrotum and measuring 16 cm × 8 cm. In the ultrasound examination, it presented a heterogeneous texture and areas of hypoechogenic echogenicity without visualization of the mediastinum. Therefore, the bilateral orchiectomy was performed. After the surgical procedure, it was found that the affected testicle presented a firm mass measuring 9 cm × 7 cm × 3.5 cm. Histologically, a multilobulated, non-encapsulated and invasive tumour mass was found, which replaced the seminiferous tubules, consisting of polygonal cells arranged in a mantle that varied from cohesive to loosely cohesive, supported by a scarce fibrous stroma. In the immunohistochemical examination, the neoplastic cells showed positive immunolabelling for OCT4 and C-KIT. In this report, the physical examination combined with the ultrasonographic examination were fundamental to the therapeutic management of the case, and the final diagnosis was made after histopathological and immunohistochemical tests.

Combined conventional factors and the radiomics signature of coronary plaque texture could improve cardiac risk prediction

ObjectivesThis study aims to investigate how radiomics analysis can help understand the association between plaque texture, epicardial adipose tissue (EAT), and cardiovascular risk. Working with a Photon-counting CT, which exhibits enhanced feature stability, offers the potential to advance radiomics analysis and enable its integration into clinical routines.MethodsCoronary plaques were manually segmented in this retrospective, single-centre study and radiomic features were extracted using pyradiomics. The study population was divided into groups according to the presence of high-risk plaques (HRP), plaques with at least 50% stenosis, plaques with at least 70% stenosis, or triple-vessel disease. A combined group with patients exhibiting at least one of these risk factors was formed. Random forest feature selection identified differentiating features for the groups. EAT thickness and density were measured and compared with feature selection results.ResultsA total number of 306 plaques from 61 patients (mean age 61 years +/− 8.85 [standard deviation], 13 female) were analysed. Plaques of patients with HRP features or relevant stenosis demonstrated a higher presence of texture heterogeneity through various radiomics features compared to patients with only an intermediate stenosis degree. While EAT thickness did not significantly differ, affected patients showed significantly higher mean densities in the 50%, HRP, and combined groups, and insignificantly higher densities in the 70% and triple-vessel groups.ConclusionThe combination of a higher EAT density and a more heterogeneous plaque texture might offer an additional tool in identifying patients with an elevated risk of cardiovascular events.Clinical relevance statementCardiovascular disease is the leading cause of mortality globally. Plaque composition and changes in the EAT are connected to cardiac risk. A better understanding of the interrelation of these risk indicators can lead to improved cardiac risk prediction.Key PointsCardiac plaque composition and changes in the EAT are connected to cardiac risk.Higher EAT density and more heterogeneous plaque texture are related to traditional risk indicators.Radiomics texture analysis conducted on PCCT scans can help identify patients with elevated cardiac risk.Graphical

Peculiarities of the examination of citrus fruits (mandarins) during the forensic examination

In today’s environment, the issue of ensuring the identification and safety of imported products is of particular relevance, which is aimed at the successful functioning of the state in the global economy and the reduction of technical barriers to trade. The article discusses the peculiarities of conducting an examination of citrus fruits, in particular, tangerines, with a view to their further classification in the Ukrainian Classifier of Goods for Foreign Economic Activity. Approaches to the classification of citrus fruits in the process of commodity examination are summarized. The diagnostic tasks to be solved by the forensic expert during the study of citrus fruits are defined, which will allow to have more analytical information from this category of goods. The main identification tasks of the commodity examination of citrus fruits, in particular mandarins, are: determination of the variety or species of mandarins, detection of certain quality markers, determination of origin, assessment of the degree of freshness and maturity, detection of deviations from standards. Modern methods of analysis are indicated, which allow to carry out research on tangerines at the molecular, chemical and morphological levels in order to obtain objective information about their quality, safety and other characteristics that may be important in court proceedings. The main aspects of microbiological methods during the examination include: detection of pathogenic microorganisms (analysis for the presence of pathogenic bacteria such as Salmonella, E. coli and Listeria monocytogenes), determination of the level of the total microbial flora, assessment of the degree of rot and mold, determination of the effectiveness of preservatives and other preservation methods, assessment of compliance with food safety standards. Systematization of information data on characteristic defects of citrus fruits (tangerines), namely: rot, mold, mechanical damage, weak skin color, increased acidity, defects in shape or size (identified defects are of natural origin) is presented. Defects that are characteristic of low-quality products with signs of deterioration: rot, mold, mechanical damage, signs of drying or desiccation, heterogeneity in color and texture. The mechanism of forensic commodity examination of citrus fruits (tangerines) is described.

MDB-94. RADIOMICS-BASED DECISION SUPPORT FOR PEDIATRIC MEDULLOBLASTOMA RISK STRATIFICATION ON MULTI-PARAMETRIC MRI

Abstract BACKGROUND Medulloblastoma (MB) is the most common pediatric brain malignancy. Accurate risk stratification is crucial for prescribing appropriate therapy. However, current risk stratification into standard or high-risk groups is limited in scope and does not accurately address the unique biological behavior of each specific tumor, with approximately 30% of children diagnosed with MB suffering from treatment failure. We developed a radiomic tool to more accurately risk stratify children with MB. METHODS We collected 1.5T/3T MRI (Siemens, Philips, or GE scanners) and clinical data from 80 patients with MB treated at Children’s Healthcare of Atlanta. Radiomic features that quantify textural heterogeneity including first and second order statistics, Haralick’s features from Gray Level Co-occurrence Matrices, and CoLIAge were extracted from tumor volumes segmented by a board-certified radiologist from multi-parametric MRI data including Apparent Diffusion Coefficient (ADC), T2, and post-contrast T1 sequences. Continuous survival models were built using the Cox proportional hazard method with 70% of the data for progression free survival (PFS) and overall survival (OS) using the 5 most predictive features obtained by univariate analysis after removing correlated features within the training data. RESULTS We developed three models with T1, T2, and ADC separately to evaluate predictive power of radiomic signatures. Three models for predicting MB OS delivered Harrel’s concordance indices (C-index) of 0.72 and 0.61 (T1); 0.70 and 0.65 (T2); and 0.80 and 0.76 (ADC) for training and test, respectively. C-indices for PFS were 0.70 and 0.69 (T1); 0.73 and 0.67 (T2); and 0.63 and 0.61 (ADC). CONCLUSIONS Our preliminary results show the feasibility and efficacy of our approach for predicting MB OS and PFS. Future studies will build an integrated model combining T1,T2, ADC, and other clinical information for predicting MB OS and PFS using a large multi-center validation cohort.

Optical coherence tomography-derived texture-based radiomics features identify eyes with intraocular inflammation in the HAWK clinical trial

Background and objectiveIntravitreal injection of anti-VEGF agents is the first-line treatment for patients with neovascular-age related macular degeneration (nAMD). One unique serious adverse event that may be associated with these agents is intraocular inflammation (IOI). The main purpose of this analysis was to evaluate the potential presence of texture-based radiomics features characterizing heterogeneity within the vitreous compartment of spectral domain optical coherence tomography (SD-OCT) images that may precede or develop in association with IOI and might serve as OCT biomarkers for IOI. MethodsThis is a post-hoc analysis of a subset of cases (N = 67) involving IOI, endophthalmitis, and/or retinal vascular occlusion in the phase 3 HAWK trial. These were investigator determined diagnoses that were also confirmed by the safety review committee. Intraocular inflammation was any signs of inflammation within the eye, endophthalmitis was inflammation associated with presumed infection, and retinal vascular occlusions consisted of intraocular inflammation with concurrent vascular occlusions/vasculitis. Out of 67 eyes, 34 belonged to the Safety group with an IOI event and 33 were propensity-matched Controls. A total of 481 texture-based radiomics features were extracted from the vitreous compartment of the SD-OCT scans at pre-IOI time point (i.e., much earlier than the actual event). Most discriminating five features, selected by the Wilcoxon Rank Sum feature selection were evaluated using Random Forest (RF) classifier on the training set (Str, N = 47) to differentiate between the two patient groups. Classifier performance was subsequently validated on the independent test set (St, N = 20). Additionally, the classifier performance in discriminating the Control and Safety group was also validated on St at the IOI event timepoint. ResultsThe RF classifier yielded area under the Receiver Operating Characteristics curve (AUC) of 0.76 and 0.81 on St using texture-based radiomics features at pre-IOI and event time-point, respectively. ConclusionsIn this analysis, the presence of a pre-IOI safety signal was detected in the form of textural heterogeneity within the vitreous compartment even prior to the actual event being identified by the investigator. This finding may help the clinicians to assess for underlying posterior inflammation.

How Effective Is Radiotherapy in the Ultrasonographic Structural Characteristics of the Submandibular Glands?

Radiotherapy affects salivary glands more intensely than it does other organs, and salivary gland dysfunction can continue during or after treatment. The aim of this study was to examine structural alterations in submandibular glands through ultrasonography following head-neck radiotherapy in patients and to evaluate the impact of radiation dose on these modifications. Forty-six submandibular glands were assessed ultrasonographically for the changes in echogenicity, echotexture, and margin and the influence of the radiation dose on these changes before radiotherapy at 3 time points: the second and sixth months following starting treatment. Statistical analysis of the data was performed using a chi-square test. Significant relationship in 3 ultrasonographic structural characteristics-echogenicity, echotexture, and margin- of submandibular glands (P < .001, P < .001, and P < .001, respectively) were observed before and at the second and sixth months after radiotherapy. There was found a significant correlation between the radiation dose groups in the change of echotexture at 2 different time periods after radiotherapy (P < .001, P < .05, respectively) and in the change of margin at the second month after radiotherapy onset (P < .05). Preceding radiotherapy, submandibular glands typically exhibited hyperechoic echogenicity, homogeneous ecotextures, and regular margins. However, after radiotherapy, there was an observable transformation characterized by isoechoic/hypoechoic features, heterogeneous textures, and irregular margins. With the passage of time following radiotherapy, there was a tendency for the parenchyma structure to gradually revert to a normal state. Also, the radiation dose generally has an effect on the structural changes of the submandibular glands.

Retention of 226Ra in the sandy Opalinus Clay facies from the Mont Terri rock laboratory, Switzerland

The safety assessment of deep geological disposal of nuclear waste requires a sound understanding of radionuclide retention in the repository host rocks. Here, we investigate the retention behaviour of the safety relevant radionuclide 226Ra in the heterogeneous sandy facies of the Opalinus Clay (OPA-SF) at the Mont Terri underground rock laboratory. Various rock samples were selected from a drill core (BAD-1) located in the lower sandy facies, which were representative for its textural and mineralogical heterogeneity. The samples were carefully characterized with respect to mineralogy and chemistry using X-Ray diffraction and electron microscopy. The amounts of quartz, carbonates and clay minerals in the samples ranged between 58 wt.% – 65 wt.%, 13 wt.% – 35 wt.% and 5 wt.% – 25 wt.%, respectively, underpinning the mineralogical heterogeneity. Rare (Ba,Sr)-sulphate precipitates were identified in the clay matrix by electron microscopy. The uptake behaviour of Ra was evaluated using batch sorption experiments. Corresponding to the mineralogical variability of the rock samples, the measured distribution ratios Rd for the 226Ra retention varied between 20 L kg−1 and 260 L kg−1 after 120 days. The experimental results and thermodynamic modelling approaches suggest that various processes contribute to the uptake of 226Ra on different time scales: fast cation exchange and surface complexation reactions by clay minerals and the (slower) formation of solid solutions during recrystallisation of (Ba,Sr)-sulphates as well as retention by carbonate minerals; the latter mechanism still requiring further investigation.

Radiomics to Detect Inflammation and Fibrosis on Magnetic Resonance Enterography in Stricturing Crohn's Disease.

Non-invasive cross-sectional imaging via magnetic resonance enterography [MRE] offers excellent accuracy for the diagnosis of stricturing complications in Crohn's disease [CD] but is limited in determining the degrees of fibrosis and inflammation within a stricture. We developed and validated a radiomics-based machine-learning model for separately characterizing the degree of histopathological inflammation and fibrosis in CD strictures and compared it to centrally read visual radiologist scoring of MRE. This single-centre, cross-sectional study included 51 CD patients [n = 34 for discovery; n = 17 for validation] with terminal ileal strictures confirmed on diagnostic MRE within 15 weeks of resection. Histopathological specimens were scored for inflammation and fibrosis and spatially linked with corresponding pre-surgical MRE sequences. Annotated stricture regions on MRE were scored visually by radiologists as well as underwent 3D radiomics-based machine learning analysis; both were evaluated against histopathology. Two distinct sets of radiomic features capturing textural heterogeneity within strictures were linked with each of severe inflammation or severe fibrosis across both the discovery (area under the curve [AUC = 0.69, 0.83] and validation [AUC = 0.67, 0.78] cohorts. Radiologist visual scoring had an AUC = 0.67 for identifying severe inflammation and AUC = 0.35 for severe fibrosis. Use of combined radiomics and radiologist scoring robustly augmented identification of severe inflammation [AUC = 0.79] and modestly improved assessment of severe fibrosis [AUC = 0.79 for severe fibrosis] over individual approaches. Radiomic features of CD strictures on MRE can accurately identify severe histopathological inflammation and severe histopathological fibrosis, as well as augment performance of the radiologist visual scoring in stricture characterization.

An Integrated Petrographic, Geomatic and Geophysical Approach for the Characterization of the Carbonate Rocks of the Calcari di Cagliari Formation

Non-invasive techniques, such as close-range photogrammetry (CRP) and 3D ultrasonic tomography complemented with optical and scanning electron microscopy and mercury porosimetry, were applied to characterize the carbonate rock samples of the Calcari di Cagliari formation. The integrated approach started with the computation of high-resolution 3D models of the carbonate samples using the CRP technique to produce 3D high-resolution models texturized both with natural colors and intensity. Starting from the 3D models from previous techniques, a 3D ultrasonic tomography on each rock sample was accurately planned and carried out in order to detect the elastic properties of such rocks and relate them to textural heterogeneity or internal defects. The results indicate that the relationship between longitudinal velocity and rock properties is complex even in the same carbonate formation. Understanding the relationship between the geomatic and geophysical responses in the investigated rock properties, such as textural characteristics and especially structure and geometry of pores, type of pores, tortuosity and cementing material, is important for many practical applications and especially in the diagnostic process of the conservation state of monumental structures. The integration of the above non-invasive techniques complemented by petrographical–petrophysical data proved to be a powerful method to associate each lithotype with a different susceptibility to degradation. The results presented in this paper demonstrate that the proposed integrated use of complementary methodologies would guarantee the reproducibility of the measurements both at the laboratory and field scale for the monitoring in time of the rock condition while giving a useful contribution in making decisions on an appropriate remedial strategy.

Understanding the strain localization in additively manufactured materials: Micro-scale tensile tests and crystal plasticity modeling

Metallic parts fabricated by additive manufacturing (AM) usually exhibit unique microstructures and non-negligible residual stresses compared with the counterparts produced by conventional manufacturing. These inherent microstructural factors strongly affect the mechanical response of the as-built AM parts. In this study, we focus on the strain localization behavior of 316L stainless steel produced by laser powder-bed-fusion. In-situ tensile tests under a scanning electron microscope are performed, and the digital image correlation method is used to measure the strain distribution combined with electron backscatter diffraction. Meanwhile, a dislocation-based crystal plasticity finite element model incorporating residual stresses is developed to study the origins of the strain localization in the AM material. The results indicate that strain localization in AM materials is closely associated with microstructural features, encompassing behaviors related to slip activities, interactions with neighboring grains and dislocation evolutions. Additionally, the columnar grain features also render the strain distribution sensitive to the loading direction. The strain localization is serious in some small grains with high residual stresses, while in large grains the effect is less significant. These factors collectively contribute to the increasing likelihood of strain localization occurring in the AM microstructures with heterogeneous grain size and texture distribution. This work provides detailed insights into the strain localization in AM materials and would facilitate the manufacturing parameter optimization of AM materials by tuning the microstructure to reduce deformation inhomogeneity.

Abstract 894: Radiomics at baseline MRI are associated with tumor shrinkage in patients with unresectable renal cell carcinoma treated with neo-adjuvant Cabozantinib

Abstract Background: Neoadjuvant Cabozantinib targeted therapy (nCabo) has been shown to facilitate tumor size reduction in patients with renal cell carcinoma (RCC). However, there is unmet clinical need to identify pre-treatment markers predictive of response to nCabo to limit financial, dose-related toxicity. We investigated computationally derived radiomic signatures from baseline magnetic resonance imaging (MRI) for their association with response to tumor shrinkage following nCabo.Methods Seventeen patients with non-metastatic, clinical stage ≥T3, biopsy-confirmed clear cell RCC were enrolled in a phase II clinical trial (NCT04022343) examining primary tumor response to nCabo. Patients underwent 3 Tesla MRI at baseline, 6 and 12 weeks. Partial response (PR) or stable disease (SD) was determined per Response Evaluation Criteria in Solid Tumors at 12 weeks. Tumor regions of interest (ROI) were delineated on axial, arterial phase T1-weighted (T1W) series under the guidance of expert radiologist. T1W were normalized with respect to enhancement in cortex region of kidney. 75 radiomic features quantifying texture heterogeneity were derived from tumor ROI on a per-voxel basis at baseline. Wilcoxon ranksum test was used to evaluate significant differences in radiomics between patient groups PR and SD. Results: Following nCabo, 6/17 patients experienced PR. 22 radiomic features from T1W quantifying intensity based heterogeneity showed significant differences between patients with SD and PR after nCabo (p&amp;lt;0.05; top 3 in Table). None of the clinical variables showed significant differences between SD and PR. Conclusion: In this proof-of-concept preliminary study, we observed that radiomics at baseline MRI may allow for identifying RCC patients who would favorably respond to nCabo in terms of tumor shrinkage. Future studies will include analysis on longitudinal data, correlation against survival on large-scale datasets. Association between tumor shrinkage following nCabo and radiomic features, clinical variables Stable Disease (N=6) Partial Response (N=11) Category Feature P-value median IQR median IQR Radiomic Haralick 0.01 1.50 0.51 2.31 0.51 Gradient Filter 0.02 88.06 107.28 289.58 107.28 CoLlAGe 0.03 224.28 10.73 210.50 10.73 Clinical Age 0.12 56.00 14.00 52.50 14.00 BMI 0.48 29.90 8.50 27.30 8.50 modified Glasgow Prognostic Score 0.21 1.00 1.00 0.00 1.00 Baseline Tumor Size (cm) 0.48 9.50 5.15 9.50 5.15 ECOG PS at presentation 0.23 0.00 1.00 0.00 1.00 Charlson Comorbidity Index 0.72 6.00 6.00 4.00 6.00 Citation Format: Liping LI, Edouard Nicaise, Benjamin Schmeusser, Abhishek Midya, Amir Davarpanahfakhr, Anant Madabhushi, Mehmet Asim Bilen, Viraj A. Master, Rakesh Shiradkar. Radiomics at baseline MRI are associated with tumor shrinkage in patients with unresectable renal cell carcinoma treated with neo-adjuvant Cabozantinib [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 894.