The results obtained in this paper are related to the Palis-Pugh problem on the existence of an arc with finitely or countably many bifurcations which joins two Morse-Smale systems on a closed smooth manifold M n . Newhouse and Peixoto showed that such an arc joining flows exists for any n and, moreover, it is simple. However, there exist isotopic diffeomorphisms which cannot be joined by a simple arc. For n = 1, this is related to the presence of the Poincare rotation number, and for n = 2, to the possible existence of periodic points of different periods and heteroclinic orbits. In this paper, for the dimension n = 3, a new obstruction to the existence of a simple arc is revealed, which is related to the wild embedding of all separatrices of saddle points. Necessary and sufficient conditions for a Morse-Smale diffeomorphism on the 3-sphere without heteroclinic intersections to be joined by a simple arc with a “source-sink” diffeomorphism are also found.